Research Area
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United States ( Change Country )
WAY-100635 Chemical Structure
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Biological Activity
WAY-100635 is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ± 0.12 nM for 5-HT. Intravenous administration of WAY-100635 (0.025-0.5 mg/kg) markedly improved neuronal activity. The stimulatory action of WAY-100635 was evident during wakefulness (when serotonergic neurons typically display a relatively high level of activity) but not during sleep (when serotonergic neurons display little or no spontaneous activity). WAY-100635 at doses as low as 0.1 mg/kg i.v. completely blocked the action of 8-hydroxy-2-(di-n-propylamino)tetralin. The antagonist action of WAY-100635 at 5-HT1A autoreceptors closely paralleled its ability to increase neuronal activity. [1] WAY-100635 affected neither the blackage of action potential frequency adaptation and slow afterhyperpolarization produced by 5-HT (15 μM) nor the hyperpolarization and decrease in membrane input resistance evoked by bath application of GABA(B) receptor agonist baclofen (10 μM). [2][3]
References on WAY-100635
- [1] Br J Pharmacol. 1998 Feb;123(3):449-62.
- [2] J Pharmacol Exp Ther. 1996 Aug;278(2):679-88.
- [3] J Pharmacol Exp Ther. 1996 Aug;278(2):752-62.
Chemical Information
| Molecular Weight (WM): | 422.56 |
|---|---|
| Formula: | C25H34N4O2 |
| CAS No.: | 162760-96-5 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥85mg/mL |
| Water ≥20mg/mL | |
| Ethanol ≥85mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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