HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E1381 NX-2127 NX-2127 is a unique, potent inhibitor of BTK that prevents its functions by catalyzing the ubiquitylation and proteasomal degradation of BTK rather than via direct binding. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells. Aug 02 2023
E1141 KI696 KI696 is a potent and selective inhibitor of KEAP1/NRF2 interaction. KI696 induces the expression of each of the Nqo1, Ho-1, Txnrd1, Srxn1, Gsta3, Gclc genes in a dose-dependent manner. Aug 02 2023
E2995 Formamide deionized Formamide deionized(Methanamide, Formimidic acid) is a clear liquid amide derived from formic acid that serves as an essential solvent for catalytic hydrogenation reactions and acts as a reagent in the creation of diverse organometallic compounds. Aug 01 2023
E1485 IDE397 (GSK-4362676) IDE397 (GSK-4362676) is a potent inhibitor of MAT2A(methionine adenosyltransferase 2A) and exhibits anti-tumor activity in MTAP-deleted PDX models. Jul 31 2023
E1261 Chroman 1 Chroman 1 is a highly potent and selective ROCK inhibitor with IC50 of 1 pM and 52 pM against ROCK2 and ROCK1, respectively. Chroman 1 also inhibits the activity of MRCK with IC50 of 150 nM. Jul 31 2023
E2982 IFN alpha-IFNAR-IN-1 hydrochloride IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor that inhibits the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) with IC50 value of 2-8 μM. Jul 27 2023
E1389 Eeyarestatin I Eeyarestatin I is a potent inhibitor of endoplasmic reticulum-associated protein degradation (ERAD). Eeyarestatin I also inhibits Sec61 translocon. Jul 27 2023
E1406 CRCD2 CRCD2 is an NT5C2 (cytosolic 5’ nucleotidase II) inhibitor with a kd of 70.9 μM. It enhances the cytotoxic effects of 6-MP and effectively reverses thiopurine resistance mediated by genetic and non-genetic mechanisms of NT5C2 activation in ALL. Jul 27 2023
E1427 MRT-2359 MRT-2359 is a potent degrader of GSPT1. It exhibits anti-tumor activity in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. Jul 27 2023
S9468 Colestipol Hydrochloride Colestipol hydrochloride, a salt form of Colestipol, is a high-molecular-weight, insoluble, granular copolymer of tetraethylenepentamine and epichlorohydrin. It functions as an anion-exchange and resin-sequestering agent. Colestipol hydrochloride reduces cholesterol levels without affecting triglycerides. Jul 27 2023
E2988 Sulfosuccinimidyl oleate sodium Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain with IC50 of 4 μM. It inhibits CD36 mediated LCFA transport. It exhibits anti-inflammatory effect. Jul 26 2023
E2945 TMRM Perchlorate TMRM Perchlorate (T668) is a membrane-permeant, cationic, fluorescent dye that can label mitochondria and mark embryonic stem cell/induced pluripotent stem cell-derived cardiomyocytes. It is useful for the isolation of mature cardiomyocytes. It is also used as a sensitive probe for the detection of mitochondrial membrane potential. Jul 25 2023
E0162 Cupric sulfate Cupric sulfate (Copper(II) sulfate) is a salt formed by treating cupric oxide with sulfuric acid. Cupric sulfate is a lewis acid catalyst commonly used to promote acid-catalyzed organic transformations. Jul 25 2023
E2939 Didox Didox (3,4-dihydroxy-benzohydroxamic acid) is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid. Didox inhibits proliferation of tamoxifen-resistant breast cancer cells. Jul 23 2023
E1395 GW806742X GW806742X, is a potent inhibitor of MLKL (Mixed Lineage Kinase Domain-Like protein), and binds to the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X retards MLKL membrane translocation and inhibits necroptosis. Jul 23 2023
E1484 PDS-0330 PDS-0330 is an inhibitor of Claudin-1, which inhibits claudin1-mediated signalling by interfering with its binding to Src. PDS-0330 exhibits an antitumor effect and enhances apoptosis in colorectal cancer cells. Jul 20 2023
E2948 β-Amyloid (25-35) β-Amyloid (25-35) (Amyloid beta-peptide (25-35), Aβ25-35, β-Amyloid peptide (25-35)) , a sequence GSNKGAIIGLM, is a highly toxic synthetic derivative of Amyloid beta-peptide (Aβ-peptides) which forms fibrillary aggregates. β-Amyloid (25-35) is involved in the pathogenesis of Alzheimer's disease. Jul 20 2023
E1322 GS-4224 GS-4224 (Evixapodlin, PD-1/PD-L1-IN 7) is an inhibitor of human PD-1/PD-L1 protein/protein interaction with an IC50 of 0.213 nM. It enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. It exhibits anticancer and antiviral functions. Jul 16 2023
E2958 Toluidine Blue O Toluidine Blue O (Toluidine Blue) is a thiazine dye of the quinone-imine family and is cationic in nature. Toluidine Blue O along with light-emitting diode has been used as a photosensitizer to control in vitro biofilms and to kill gram-negative bacteria. Toluidine Blue has wide applications in vital staining in living tissues and used as a special stain. Jul 13 2023
E1411 Tuvusertib Tuvusertib (M1774, ATR inhibitor 1) is a potent ATR inhibitor, which exhibits anti-proliferative and anti-tumor effects in cancer cell lines. Jul 13 2023