Home Epigenetics Epigenetic Reader Domain inhibitor YD54 For research use only.

YD54

Synonyms: Flezurafenibum

YD54 is a potent, selective and orally bioavailable PROTAC and a degrader of SMARCA2 with DC50 of 8.1 nM at 24 hours. It exhibits antitumor activity in SMARCA4-mutant lung cancer xenograft models and can be used in research on non-small cell lung cancer.

YD54 Chemical Structure

YD54 Chemical Structure

CAS No. 2951015-30-6

Purity & Quality Control

YD54 Related Products

Signaling Pathway

Epigenetic Reader Domain Signaling Pathways

Epigenetic Reader Domain Signaling Pathway

Biological Activity

Description YD54 is a potent, selective and orally bioavailable PROTAC and a degrader of SMARCA2 with DC50 of 8.1 nM at 24 hours. It exhibits antitumor activity in SMARCA4-mutant lung cancer xenograft models and can be used in research on non-small cell lung cancer.
  • https://pubmed.ncbi.nlm.nih.gov/40280558/

Chemical Information & Solubility

Molecular Weight Formula
CAS No. 2951015-30-6 SDF --
Density g/mL
Storage (From the date of receipt)

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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