Home Biosimilar Antibodies Protein Tyrosine Kinase c-Met inhibitor Davutamig (Anti-cMet)
For research use only. Not for use in humans.

Davutamig (Anti-cMet)

Synonyms: REGN5093

Davutamig is a human bispecific IgG4-kappa antibody that binds to two distinct epitopes of MET, blocking ligand binding and inducing MET internalization and degradation. It demonstrates antineoplastic activity. MW: 144.89 KD.

Davutamig (Anti-cMet)

Quality Control

  • Cited in Nature Medicine for its top-tier quality
  • SDS
  • Datasheet

Specificity

Name Citation c-Met Others
Foretinib 94 KDR,Tie-2,VEGFR3/FLT4
PHA-665752 96 RON,Flk1
SU11274 67
SGX-523 136
BMS-777607 63 Axl,RON,Tyro3
Tivantinib 49
JNJ-38877605 54
PF-04217903 22
MGCD-265 analog 12 RON,VEGFR1,VEGFR2
BMS-754807 54 Insulin Receptor,IGF-1R,TrkB
BMS-794833 2 VEGFR2
AMG-208 0
MK-2461 4 c-Met (Y1235D),c-Met (Y1230C),c-Met (N1100)
Golvatinib (E7050) 8 VEGFR2
AMG-458 0
Tepotinib 23
NVP-BVU972 1
XL092 0 VEGFR2,AXL,MER
UNC2025 7 FLT3,Mer,Axl
Ningetinib 0 Axl,VEGFR2
Elzovantinib (TPX-0022) 0 SRC,CSF1R
AMG-1 0 RON
Pamufetinib (TAS-115) 0 recombinant VEGFR2
JNJ-38877618(OMO-1) 0 MET (M1268T)
Altiratinib 3 MET Y1230C,TrkA,TrkC
SAR125844 0 MET Y1235D,MET M1250T,TRKA/NTRK1
Glumetinib 1
Savolitinib (AZD6094) 19 p-Met
CEP-40783 (RXDX-106) 7 Axl,Tyro3,MER
S49076 1 Mer,Axl,FGFR3
Merestinib (LY2801653) 11 DDR1,AXL,FLT3
AMG 337 2
NPS-1034 3 Axl
Amuvatinib (MP-470) 21 c-RET,RAD51,c-Kit (D816H)
Glesatinib 1 SMO
Terevalefim 1
Licochalcone D 0 Caspase,EGFR,JAK2
BAY-474 0
Bozitinib 1
Pulsatilla saponin D 1
Sodium L-ascorbyl-2-phosphate 3
Norcantharidin 3 EGFR
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Davutamig is a human bispecific IgG4-kappa antibody that binds to two distinct epitopes of MET, blocking ligand binding and inducing MET internalization and degradation. It demonstrates antineoplastic activity. MW: 144.89 KD.

Product Details

CAS No. 2648058-48-2
Source CHO
Storage
(From the date of receipt)		 -80℃(avoid freeze-thaw cycles)

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.