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Britannin

Cat.No.E5556

Britannin is an NLRP3 inhibitor with an IC50 of 3.630 μM, exhibiting anti-inflammatory activity. It inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7. Additionally, this compound demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. It can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. This chemical holds promise for research in the fields of anti-inflammatory and antitumor therapeutics.
Britannin Chemical Structure

Chemical Structure

Molecular Weight: 366.41

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Chemical Information, Storage & Stability

Molecular Weight 366.41 Formula Storage (From the date of receipt)
CAS No. 33627-28-0 -- Storage of Stock Solutions Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

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