Estrogen/progestogen Receptor

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Estrogen/progestogen Receptor Inhibitors | Agonists | Antagonists | Chemicals | Modulators (36)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1191 Fulvestrant Fulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.94 nM in a cell-free assay.
  • Oncotarget, 2015, 6(4):2315-30
  • Mol Cancer Ther, 2014, 13(1):230-8
  • PLoS One, 2011, 6(7):e21112
S1972 Tamoxifen Citrate Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.
  • University of North Texas, 2014, Timothy E. Richardson
S1227 Raloxifene HCl Raloxifene is an estrogen antagonist, which inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.
  • Med Oncol, 2015, 32(6):577
  • University of North Texas, 2014, Health Science Center at Fort Worth
S1709 Estradiol Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.
S2606 Mifepristone Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.
  • Hippocampus, 2014, 24(5):528-40
  • PLoS One, 2014, 9(8):e105528
S1776 Toremifene Citrate Toremifene Citrate is an oral selective estrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.
S1251 Dienogest Dienogest is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.
S2128 Bazedoxifene HCl Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.
  • J Med Chem, 2014, 57(3):632-41
  • J Med Chem, 2014, 57(3):632-41
S2604 Dehydroepiandrosterone (DHEA) Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.
S1376 Gestodene Gestodene is a progestogen hormonal contraceptive.
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2561 Clomifene citrate Clomifene Citrate is a selective estrogen receptor modulator, used in the treatment of ovulation induction.
S1727 Levonorgestrel Levonorgestrel is a female hormone that prevents ovulation.
S2567 Medroxyprogesterone acetate Medroxyprogesterone acetate (MPA) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.
S2450 Equol Equol ,a metabolite of soybeans, is an important isoflavone in humans,specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.
  • ACS Chem Biol, 2015, 10.1021/cb5009487
S2473 Hexestrol Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
S1377 Drospirenone Drospirenone is a synthetic progestin that is an analog to spironolactone.
S1705 Progesterone Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.
S2832 Epiandrosterone Epiandrosterone is a steroid hormone with weak androgenic activity, is a natural metabolite of DHEA.
S3081 Ulipristal Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
S1304 Megestrol Acetate Megestrol acetate is a synthetic progestogen, used to treat breast cancer and loss of appetite.
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1859 Diethylstilbestrol Diethylstilbestrol is a synthetic nonsteroidal estrogen, used to prevent miscarriage and other pregnancy complications.
S1625 Ethinyl Estradiol Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.
S1914 Pregnenolone Pregnenolone is an endogenous steroid hormone, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries.
S3149 Estradiol valerate Estradiol is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.
S2466 Estriol Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
S1665 Estrone Estrone is an estrogenic hormone.
S2125 Mestranol Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.
S2167 Bazedoxifene Acetate Bazedoxifene Acetate is a third generation selective estrogen receptor modulator (SERM).
S3167 Altrenogest Altrenogest is a progestogen structurally related to veterinary steroid trenbolone.
S1238 Tamoxifen Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
  • Oncotarget, 2015, 6(4):2315-30
  • University of North Texas, 2014, Timothy E. Richardson
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2611 Ethisterone Ethisterone is a progestogen hormone being considered to treat prostate cancer.
S3160 Ethynodiol diacetate Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills.
S4046 Estradiol Cypionate Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.
S4285 Ospemifene Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM), used for the treatment of dyspareunia.
S7828 Licochalcone A Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.
S7839 Endoxifen HCl Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1191 Fulvestrant <1 mg/mL 100 mg/mL 100 mg/mL
S1972 Tamoxifen Citrate <1 mg/mL 100 mg/mL <1 mg/mL
S1227 Raloxifene HCl <1 mg/mL 100 mg/mL <1 mg/mL
S1709 Estradiol <1 mg/mL 54 mg/mL 5 mg/mL
S2606 Mifepristone <1 mg/mL 85 mg/mL 19 mg/mL
S1776 Toremifene Citrate <1 mg/mL 100 mg/mL <1 mg/mL
S1251 Dienogest <1 mg/mL 62 mg/mL <1 mg/mL
S2128 Bazedoxifene HCl <1 mg/mL 101 mg/mL <1 mg/mL
S2604 Dehydroepiandrosterone (DHEA) <1 mg/mL 57 mg/mL 57 mg/mL
S1376 Gestodene <1 mg/mL 62 mg/mL 8 mg/mL
S2561 Clomifene citrate <1 mg/mL 120 mg/mL 11 mg/mL
S1727 Levonorgestrel <1 mg/mL 45 mg/mL 2 mg/mL
S2567 Medroxyprogesterone acetate <1 mg/mL 12 mg/mL 12 mg/mL
S2450 Equol <1 mg/mL 48 mg/mL 48 mg/mL
S2473 Hexestrol <1 mg/mL 42 mg/mL 42 mg/mL
S1377 Drospirenone <1 mg/mL 73 mg/mL 11 mg/mL
S1705 Progesterone <1 mg/mL 22 mg/mL 63 mg/mL
S2832 Epiandrosterone <1 mg/mL 29 mg/mL 58 mg/mL
S3081 Ulipristal <1 mg/mL 83 mg/mL 14 mg/mL
S1304 Megestrol Acetate <1 mg/mL 33 mg/mL 15 mg/mL
S1859 Diethylstilbestrol <1 mg/mL 54 mg/mL 54 mg/mL
S1625 Ethinyl Estradiol <1 mg/mL 59 mg/mL 59 mg/mL
S1914 Pregnenolone <1 mg/mL 22 mg/mL 22 mg/mL
S3149 Estradiol valerate <1 mg/mL 71 mg/mL <1 mg/mL
S2466 Estriol <1 mg/mL 57 mg/mL 10 mg/mL
S1665 Estrone <1 mg/mL 54 mg/mL <1 mg/mL
S2125 Mestranol <1 mg/mL 15 mg/mL 25 mg/mL
S2167 Bazedoxifene Acetate <1 mg/mL 100 mg/mL 25 mg/mL
S3167 Altrenogest <1 mg/mL 62 mg/mL 2 mg/mL
S1238 Tamoxifen <1 mg/mL 74 mg/mL 74 mg/mL
S2611 Ethisterone <1 mg/mL 0.05 mg/mL <1 mg/mL
S3160 Ethynodiol diacetate 77 mg/mL 77 mg/mL <1 mg/mL
S4046 Estradiol Cypionate <1 mg/mL 79 mg/mL 55 mg/mL
S4285 Ospemifene <1 mg/mL 75 mg/mL 71 mg/mL
S7828 Licochalcone A <1 mg/mL 67 mg/mL 67 mg/mL
S7839 Endoxifen HCl <1 mg/mL 74 mg/mL 74 mg/mL
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