Estrogen/progestogen Receptor

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1191 Fulvestrant <1 mg/mL 100 mg/mL 100 mg/mL
S1972 Tamoxifen Citrate <1 mg/mL 100 mg/mL 100 mg/mL
S1227 Raloxifene HCl <1 mg/mL 100 mg/mL <1 mg/mL
S1709 Estradiol <1 mg/mL 54 mg/mL 5 mg/mL
S2606 Mifepristone <1 mg/mL 85 mg/mL 19 mg/mL
S8372 AZD9496 <1 mg/mL 88 mg/mL 88 mg/mL
S1776 Toremifene Citrate <1 mg/mL 100 mg/mL <1 mg/mL
S1251 Dienogest <1 mg/mL 62 mg/mL <1 mg/mL
S2128 Bazedoxifene HCl <1 mg/mL 101 mg/mL <1 mg/mL
S2604 Dehydroepiandrosterone (DHEA) <1 mg/mL 57 mg/mL 57 mg/mL
S1376 Gestodene <1 mg/mL 62 mg/mL 8 mg/mL
S2561 Clomifene citrate <1 mg/mL 120 mg/mL 11 mg/mL
S2450 Equol <1 mg/mL 48 mg/mL 48 mg/mL
S1727 Levonorgestrel <1 mg/mL 45 mg/mL 2 mg/mL
S2567 Medroxyprogesterone acetate <1 mg/mL 12 mg/mL 12 mg/mL
S2473 Hexestrol <1 mg/mL 42 mg/mL 42 mg/mL
S1377 Drospirenone <1 mg/mL 73 mg/mL 11 mg/mL
S1705 Progesterone <1 mg/mL 22 mg/mL 63 mg/mL
S1304 Megestrol Acetate <1 mg/mL 33 mg/mL 15 mg/mL
S3081 Ulipristal <1 mg/mL 83 mg/mL 14 mg/mL
S2466 Estriol <1 mg/mL 57 mg/mL 10 mg/mL
S1859 Diethylstilbestrol <1 mg/mL 54 mg/mL 54 mg/mL
S1625 Ethinyl Estradiol <1 mg/mL 59 mg/mL 59 mg/mL
S3149 Estradiol valerate <1 mg/mL 71 mg/mL <1 mg/mL
S1914 Pregnenolone <1 mg/mL 22 mg/mL 22 mg/mL
S1665 Estrone <1 mg/mL 54 mg/mL <1 mg/mL
S2125 Mestranol <1 mg/mL 15 mg/mL 25 mg/mL
S2167 Bazedoxifene Acetate <1 mg/mL 100 mg/mL 25 mg/mL
S4110 Estradiol Benzoate <1 mg/mL 75 mg/mL <1 mg/mL
S3167 Altrenogest <1 mg/mL 62 mg/mL 2 mg/mL
S4629 Chlorotrianisene <1 mg/mL 76 mg/mL <1 mg/mL
S7827 4-Hydroxytamoxifen <1 mg/mL 77 mg/mL <1 mg/mL
S4046 Estradiol Cypionate <1 mg/mL 79 mg/mL 55 mg/mL
S4638 Desogestrel <1 mg/mL 62 mg/mL 62 mg/mL
S2314 Kaempferol <1 mg/mL 57 mg/mL 3 mg/mL
S4674 Hydroxyprogesterone caproate <1 mg/mL 85 mg/mL 85 mg/mL
S4507 17-Hydroxyprogesterone <1 mg/mL 66 mg/mL 66 mg/mL
S4673 Etonogestrel <1 mg/mL 64 mg/mL 64 mg/mL
S7828 Licochalcone A <1 mg/mL 67 mg/mL 67 mg/mL
S1238 Tamoxifen <1 mg/mL 74 mg/mL 74 mg/mL
S7839 Endoxifen HCl <1 mg/mL 74 mg/mL 74 mg/mL
S3160 Ethynodiol diacetate 77 mg/mL 77 mg/mL <1 mg/mL
S4285 Ospemifene <1 mg/mL 75 mg/mL 71 mg/mL
S2611 Ethisterone <1 mg/mL 0.05 mg/mL <1 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S1191

Fulvestrant

Fulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.94 nM in a cell-free assay.

S1972

Tamoxifen Citrate

Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.

S1227

Raloxifene HCl

Raloxifene is an estrogen antagonist, which inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.

S1709

Estradiol

Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.

S2606

Mifepristone

Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.

S8372New

AZD9496

AZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.

S1776

Toremifene Citrate

Toremifene Citrate is an oral selective estrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.

S1251

Dienogest

Dienogest is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.

S2128

Bazedoxifene HCl

Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.

S2604

Dehydroepiandrosterone (DHEA)

Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.

S1376

Gestodene

Gestodene is a progestogen hormonal contraceptive.

S2561

Clomifene citrate

Clomifene Citrate is a selective estrogen receptor modulator, used in the treatment of ovulation induction.

S2450

Equol

Equol ,a metabolite of soybeans, is an important isoflavone in humans,specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.

S1727

Levonorgestrel

Levonorgestrel is a female hormone that prevents ovulation.

S2567

Medroxyprogesterone acetate

Medroxyprogesterone acetate (MPA) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.

S2473

Hexestrol

Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

S1377

Drospirenone

Drospirenone is a synthetic progestin that is an analog to spironolactone.

S1705

Progesterone

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

S1304

Megestrol Acetate

Megestrol acetate is a synthetic progestogen, used to treat breast cancer and loss of appetite.

S3081

Ulipristal

Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.

S2466

Estriol

Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

S1859

Diethylstilbestrol

Diethylstilbestrol is a synthetic nonsteroidal estrogen, used to prevent miscarriage and other pregnancy complications.

S1625

Ethinyl Estradiol

Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.

S3149

Estradiol valerate

Estradiol is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.

S1914

Pregnenolone

Pregnenolone is an endogenous steroid hormone, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries.

S1665

Estrone

Estrone is an estrogenic hormone.

S2125

Mestranol

Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.

S2167

Bazedoxifene Acetate

Bazedoxifene Acetate is a third generation selective estrogen receptor modulator (SERM).

S4110

Estradiol Benzoate

Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.

S3167

Altrenogest

Altrenogest is a progestogen structurally related to veterinary steroid trenbolone.

S4629

Chlorotrianisene

Chlorotrianisene is a synthetic, non-steroidal estrogen. It is a selective estrogen receptor modulator.

S7827

4-Hydroxytamoxifen

4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.

S4046

Estradiol Cypionate

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.

S4638

Desogestrel

Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.

S2314

Kaempferol

Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.

S4674

Hydroxyprogesterone caproate

Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibits ovulation and an alteration in the cervical mucus and endometrium.

S4507

17-Hydroxyprogesterone

17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

S4673

Etonogestrel

Etonogestrel is a synthetic form of the naturally occurring female sex hormone progesterone. It binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression.

S7828

Licochalcone A

Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.

S1238

Tamoxifen

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

S7839

Endoxifen HCl

Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.

S3160

Ethynodiol diacetate

Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills.

S4285

Ospemifene

Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM), used for the treatment of dyspareunia.

S2611

Ethisterone

Ethisterone is a progestogen hormone being considered to treat prostate cancer.