Licensed by Pfizer Catalog No.S1727

Levonorgestrel  Chemical Structure

Molecular Weight(MW): 312.45

Levonorgestrel is a female hormone that prevents ovulation.

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In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Levonorgestrel is a female hormone that prevents ovulation.
Progesterone receptor [1]
In vitro

Levonorgestrel suppresses the stimulation of progesterone secretion induced by oLH, dibutyryl-cAMP and Pregnenolone in rats luteal cells. [1] Levonorgestrel also inhibits constrictions evoked by either a high potassium (K(+)) solution or phorbol myristate acetate (PMA) in the absence and presence of extracellular calcium (Ca(2+)). Levonorgestrel depresses contractions evoked by Ca(2+) and reduces (45)Ca(2+) influx in depolarized veins. Levonorgestrel increases levels of cyclic AMP and inhibits PMA-induced activation of protein kinase C in veins. Levonorgestrel causes endothelium-independent relaxations of jugular veins via inhibition of Ca(2+) entry and of protein kinase Cactivation. [2] Levonorgestrel inhibition of both estrogen-induced pituitary weight increment and hyperprolactinemia is reduced by mifepristone, whereas Flutamide is unable to block Levonorgestrel effects [3]

In vivo Levonorgestrel down-regulates the mRNA expression of follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. [4] Levonorgestrel causes a significant upregulation of the mRNA expression of the gene encoding luteinising hormone β-subunit (lhβ) and the suppression of the mRNA expression of the gene encoding follicle-stimulating hormone β-subunit (fshβ) in the pituitary of both male and female roach. Levonorgestrel disrupts the reproductive system of pubertalroach by affecting the pituitary gonadotropin expression and the sex steroid levels in pubertal roach (Rutilus rutilus). [5]


Solubility (25°C)

In vitro DMSO 45 mg/mL (144.02 mM)
Ethanol 2 mg/mL (6.4 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 312.45


CAS No. 797-63-7
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03557619 Not yet recruiting Hematologic Malignancies AbbVie November 9 2018 Phase 1
NCT03547024 Recruiting Healthy Janssen-Cilag International NV June 8 2018 Phase 1
NCT02903888 Completed Intrauterine Devices Medicated Bayer September 8 2016 --
NCT02577601 Completed Contraception Oregon Health and Science University|Society of Family Planning September 8 2015 Phase 4
NCT02722421 Active not recruiting HIV|Contraception University of Nebraska|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Infectious Diseases Institute Uganda|University of Liverpool|Feinberg School of Medicine Northwestern University April 6 2017 Phase 2
NCT01254292 Completed Contraception Bayer January 6 2011 Phase 3

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Estrogen/progestogen Receptor Signaling Pathway Map

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