Catalog No.S1304 Synonyms: BDH1298, SC10363
Molecular Weight(MW): 384.51
Megestrol acetate is a synthetic progestogen, used to treat breast cancer and loss of appetite.
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HEC-1A cells were treated with pterostilbene (75 μM), megestrol acetate (75 μM) or the combination for 24 h. Whole cell lysates were collected and measured for the change of cell cycle and apoptosis pathways by Western blot. Results are representative of 3 or more preparations.
Sci Rep, 2017, 7(1):12754. Megestrol Acetate purchased from Selleck.
Kaempferol and ER/PR inhibitor suppress the migration and Rho activity of MCF-7 cells. Notes: (A) MCF-7 ER+/PR+ breast cancer cells were allowed to migrate in response to 20 μmol/L kaempferol and/or 0.1 nmol/L AZD9496 (ER inhibitor) and 200 μmol/L megestrol acetate (PR inhibitor) for 6 h. Results are presented as mean ± SD of 5 independent experiments. (B, C) MCF-7 cells were incubated with 20 μmol/L kaempferol and/or 0.1 nmol/L AZD9496 and 200 μmol/L MA for 1 h, and then subjected to the RhoA (B) and Rac1 (C) activity assays. The relative levels of Rho activity were normalized to the average value of controls. Results are presented as mean ± SD of 3 independent experiments. Abbreviations: AZD, AZD9496; Ctrl, control; ER, estrogen receptor; MA, megestrol acetate; ns, no significance; PR, progesterone receptor.
Onco Targets Ther, 2017, 10:4809-4819. Megestrol Acetate purchased from Selleck.
Purity & Quality Control
Choose Selective Estrogen/progestogen Receptor Inhibitors
|Description||Megestrol acetate is a synthetic progestogen, used to treat breast cancer and loss of appetite.|
Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBPβ in reperfusion injury-induced ischemic rat hippocampus.  Megestrol acetate significantly increases the proliferation, migration, and adipogenic differentiation of adipose-derived stem cells (ASCs) in a dose-dependent manner. Megestrol acetate also upregulates genes downstream of glucocorticoid receptor (GR) in ASCs. 
|In vivo||Megestrol acetate significantly decreases the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-ketotestosterone (11-KT) in male fish. Megestrol acetate exposure significantly downregulates the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis.  Megestrol acetate produces a progressive deterioration in glucose tolerance, with a significant increase in mean fasting plasma glucose concentrations and decrease in mean plasma glucose clearance rates after 6 months and 12 months of treatment in cats. Megestrol acetate also produces a progressive decrease in both resting plasma cortisol concentrations and cortisol concentrations after ACTH stimulation in cats.  Megestrol acetate (50 mg/kg/day) for 9 days significantly increases food and water intake compared with untreated controls. Megestrol acetate (50 mg/kg/day) significantly (90-140%) increases in neuropeptide Y concentrations in the arcuate nucleus (where neuropeptide Y is synthesized), in the lateral hypothalamic area (through which arcuate neurones project) and in the medial preoptic area, ventromedial nucleus and dorsomedial nucleus in rats. |
-  Kelicen Ugur P, et al. Eur J Pharmacol, 2011, 654(3), 217-225.
-  Sung JH, et al. Stem燙ells燭ransl Med,?015, 4(7), 789-799.
-  Han J, et al. Aquat Toxicol,?014, 150, 66-72.
|In vitro||DMSO||33 mg/mL (85.82 mM)|
|Ethanol||15 mg/mL (39.01 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03024580||Recruiting||Breast Neoplasm||Instituto Nacional de Cancer Brazil|Cancer Research UK Cambridge Institute||March 6 2017||Phase 2|
|NCT03241914||Recruiting||Endometrial Neoplasm Malignant Stage I||Fudan University||July 4 2017||Phase 2|Phase 3|
|NCT03241888||Recruiting||Atypical Endometrial Hyperplasia||Fudan University|Shanghai 6th People''s Hospital|Zhejiang Cancer Hospital|Shanghai Changning Maternity & Infant Health Hospital||July 4 2017||Phase 2|Phase 3|
|NCT01670656||Completed||Dysmenorrhea||Merck Sharp & Dohme Corp.||January 21 2013||Phase 2|
|NCT03531437||Terminated||Contraception|Hypercoagulability||Mahidol University||March 2016||Phase 4|
|NCT02619266||Unknown status||Anorexia|Cancer Cachexia||Xinqiao Hospital of Chongqing|Chengdu University of Traditional Chinese Medicine||December 2015||Phase 2|Phase 3|
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