Catalog No.S1238 Synonyms: ICI 46474
Molecular Weight(MW): 371.51
Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Cited by 2 Publications
Purity & Quality Control
Choose Selective Estrogen/progestogen Receptor Inhibitors
|Description||Tamoxifen is an antagonist of the estrogen receptor in breast tissue.|
TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)
|In vivo||Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models.|
|In vitro||DMSO||74 mg/mL (199.18 mM)|
|Ethanol||74 mg/mL (199.18 mM)|
|In vivo||Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT00026585||Completed||Bipolar Disorder||National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC)||November 9, 2001||Phase 2|
|NCT03024580||Not yet recruiting||Breast Neoplasm||Instituto Nacional de Cancer, Brazil|Cancer Research UK Cambridge Institute||March 2017||Phase 2|
|NCT02993159||Not yet recruiting||Ductal Breast Carcinoma In Situ|Estrogen Receptor Positive||National Cancer Institute (NCI)||March 2017||Phase 2|
|NCT02988986||Not yet recruiting||Estrogen Receptor Positive Breast Cancer||Jenny C. Chang, MD|Millennium Pharmaceuticals, Inc.|The Methodist Hospital System||February 2017||Phase 2|
|NCT02903121||Not yet recruiting||Bleeding|Implants|Breakthrough Bleeding||Oregon Health and Science University|Merck Womens Health Investigator Initiated Studies Program||January 2017||Phase 2|
|NCT02690870||Not yet recruiting||Infertility||Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Sun Yat-sen University||January 2017||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.
Frequently Asked Questions
Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?
Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.