Catalog No.S1238 Synonyms: ICI 46474
Molecular Weight(MW): 371.51
Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Cited by 2 Publications
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|Description||Tamoxifen is an antagonist of the estrogen receptor in breast tissue.|
TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)
|In vivo||Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models.|
|In vitro||DMSO||74 mg/mL (199.18 mM)|
|Ethanol||74 mg/mL (199.18 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03423199||Recruiting||Breast Neoplasms||National Cancer Center Japan|Pfizer|Korean Cancer Study Group||February 9 2018||Phase 3|
|NCT02089386||Terminated||Barrett Metaplasia||Washington University School of Medicine||July 9 2014||Early Phase 1|
|NCT00026585||Completed||Bipolar Disorder||National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC)||November 9 2001||Phase 2|
|NCT02291913||Active not recruiting||Breast Cancer||SCRI Development Innovations LLC|Novartis||January 7 2015||Phase 2|
|NCT02204098||Recruiting||Breast Cancer|Breast Carcinoma|Malignant Neoplasm of Breast||Washington University School of Medicine|National Cancer Institute (NCI)|The Rising Tide Foundations for Clinical Cancer Research||January 7 2015||Phase 1|
|NCT00310180||Active not recruiting||Breast Adenocarcinoma|Estrogen Receptor and/or Progesterone Receptor Positive|HER2/Neu Negative|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage IIIB Breast Cancer AJCC v7||National Cancer Institute (NCI)|American College of Surgeons|Cancer and Leukemia Group B|NSABP Foundation Inc|NCIC Clinical Trials Group|North Central Cancer Treatment Group|Southwest Oncology Group||April 7 2006||Phase 3|
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Frequently Asked Questions
Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?
Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.