Tamoxifen

Catalog No.S1238 Synonyms: ICI 46474

Tamoxifen Chemical Structure

Molecular Weight(MW): 371.51

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

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  • E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.

    Oncotarget, 2015, 6(4):2315-30.. Tamoxifen purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells M{K5[mZ2dmO2aX;uJIF{e2G7 Mki1SYZn\WO2aY\lJINwdmOnboTyZZRqd25iYXfhbY5{fCCPQ1[tO{BjemWjc4SgeJVud3JiY3XscJMhfXOrbnegUWNHNTdiYYPzZZktKEWFNUC9NE4xOSEQvF2= MUOxNlgzPTl|NR?=
MCF7 cells NYTB[3VKS3m2b4TvfIlkcXS7IHHzd4F6 MXe0PEBp Mn\xR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUCuNFI4KM7:TR?= NXS2TVdiOjJ2N{KwOFU>
Ishikawa cells MmTDSpVv[3Srb36gZZN{[Xl? Mmj6R49v[2WwdILheIlwdiCxZjDjc41xd3WwZDDy[ZF2cXKnZDD0c{BqdmS3Y3WgOVAhLSCxZjD0bIUhdWG6aX31cUB{fGmvdXzheIlwdiCxZjDhcItidGmwZTDwbI9{eGijdHHz[UBi[3Srdnn0fUBqdiCLc3jpb4F4[SClZXzsd{whTUN3ME2wMlA{OyEQvF2= M2P3elgzODF3OEe=
HEK293T cells MVHGeY5kfGmxbjDhd5NigQ>? M16yNWFvfGGpb37pd5Qh[WO2aY\peJkh[XRiR3HsOEBFSkRvZoXz[YQhcHWvYX6gSXJidHCqYTDMRmQh\XiycnXzd4VlKGmwIFjFT|I6O1RiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBme3S{YXTpc4wucW6mdXPl[EB1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBi\nSncjCyNEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVAvODN7IN88US=> NUTq[ZNMOjN5OE[0OVI>
MDA-MB-435 cells Mn7rSpVv[3Srb36gZZN{[Xl? NUT6NIt3UW6qaXLpeIlwdiCxZjDNSGEuVUJvNEO1JIJz\WG|dDDjZY5k\XJiY3XscEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwMEWg{txO MmrxNVQ6PzF6OUm=
MDA-MB-231 cells M1fMSGZ2dmO2aX;uJIF{e2G7 Mo\BTY5pcWKrdHnvckBw\iCnc4Tyc4dmdiC{ZXPldJRweiCwZXfheIl3\SCPRFGtUWIuOjNzIHLy[YF{fCClYX7j[ZIh[2WubDDwdo9tcW[ncnH0bY9vNCCLQ{WwQVAvODhizszN M1G3d|E1QTdzOEm5
T47D cells Ml\uSpVv[3Srb36gZZN{[Xl? MlrWRY51cWW|dILv[4VvcWNiYXP0bZZqfHliaX6gbJVu[W5iVES3SEBk\WyuczDlfJBz\XO|aX7nJIV{fHKxZ3XuJJJm[2WydH;yJIF{e2W|c3XkJIF{KGW|dILv[4VvNWSncHXu[IVvfCC2cnHud4NzcXC2aX;uJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1yLkGg{txO NEnsRXgyQTF|MUK0PC=>
Ishikawa cells M4TifmZ2dmO2aX;uJIF{e2G7 MXm3NkBp NUjCTok{SW62aXXzeJJw\2WwaXOgZYN1cX[rdImgbY4hcHWvYX6gTZNpcWujd3GgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCnc4Tyc4dmdi2rbnT1Z4VlKGGua3HsbY5mKHCqb4PwbIF1[XOnIHHjeIl3cXS7IHHmeIVzKDd{IHjyd{whUUN3ME2wMlE4KM7:TR?= NFH5WIYyQDh|NUG3Oi=>
MCF-7-2a cells MlnFSpVv[3Srb36gZZN{[Xl? MmDyRY51cWW|dILv[4VvcWNiYXP0bZZqfHliaX6gUWNHNTdvMnGgZ4VtdHNiYYOgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2ViZYP0doFlcW:uIHXm[oVkfCCkeTC1NEUtKEmFNUC9NE42KM7:TR?= NIfiSnkyOjR|MUC2Ny=>
EL4 cell Mn\ZVJJwdGmoZYLheIlwdiCjc4PhfS=> M2juV2lvcGmkaYTpc44hd2ZiW{PIYZRpgW2rZHnu[UBqdmOxcoDvdoF1cW:wIHnueI8hTUx2IHPlcIwheHKxbHnm[ZJifGmxbjygbYM2OD1yLkWzOUDPxE1? M{Xtd|E2PzN4M{C=
HeLa cells Mnv6SpVv[3Srb36gZZN{[Xl? NXn2fGl2UW6qaXLpeIlwdiCxZjCxO{1j\XSjLXXzeJJi\GmxbDDt[YRq[XSnZDDseYNq\mW{YYPlJJRz[W6|Y4LpdJRqd25iaX6gTIVN[SClZXzsd{BmgHC{ZYPzbY5oKGi3bXHuJIV{fHKxZ3XuJJJm[2WydH;yJIFteGijOzDFVmUh[XO|YYmsJGlEPTB;MD62NlIh|ryP M2TSZ|E2PjV6OEWx
MDA-MB-231 cells MoTIVJJwdGmoZYLheIlwdiCjc4PhfS=> MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTBwNk[g{txO MmLvNlA1PTF|OEC=
T47D cells MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoTpO|IhcA>? M1TTPWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJIV{fHKxZ3XuMYRmeGWwZHXueEBVPDeGIHPlcIx{KGGodHXyJFczKGi{czygTWM2OD1zIN88US=> MUCxPVE{OTJ2OB?=
yeast AH109 cells MULGeY5kfGmxbjDhd5NigQ>? NF2xTVkzPCCq NWf5doRQSW62YXfvcol{fCCjY4Tpeol1gSCjdDDFVoJmfGFicnXj[ZB1d3JiTFLEJIV5eHKnc4Pl[EBqdiC7ZXHzeEBCUDFyOTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGmwdHXyZYN1cW:wIIfpeIghW1KFMTDh[pRmeiB{NDDodpMh[nliYXzwbIEu\2GuYXP0c5Nq\GG|ZTDhd5NigSxiSVO1NF0yNjZ4IN88US=> MWWyNlY1PzJzNx?=
GBM2 cells NEfTbI1Rem:uaX\ldoF1cW:wIHHzd4F6 MVm3NkBp M3vpbmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1LNNkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgW3NVNTFibXX0bI9lNCCLQ{WwQVMvPSEQvF2= Mn3GNlY{PTV3M{K=
NCI-H460 cells MnnzSpVv[3Srb36gZZN{[Xl? NGPKOGUzPCCq NWnO[lJLSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:PC52ODFOwG0> M3PjT|E6PzN|MEi1
GBM3 cells NED2dGVRem:uaX\ldoF1cW:wIHHzd4F6 NWPBSlM2PzJiaB?= MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeETUOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IGfTWE0yKG2ndHjv[EwhUUN3ME20Mlch|ryP NFnpbJgzPjN3NUWzNi=>
DLD1 cells NUTQNGttS3m2b4TvfIlkcXS7IHHzd4F6 NG\ISmY6PiCq Ml34R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSGxFOSClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUSuO|gh|ryP MWSyNlc1QTN7Mh?=
ScN2a-cl3 cells NILPWnFEgXSxdH;4bYNqfHliYYPzZZk> NXW0b|FQPSCmYYnz MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDkbZZq\GmwZzDTZ24z[S2lbEOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPSCmYYnzJIJ6KGOjbHPlbY4uSU1ic4ThbY5qdmdvYnHz[YQh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVQvQDlizszN MnfGNlQyQDN3OEm=
K562 cells NGriXWJRem:uaX\ldoF1cW:wIHHzd4F6 M2TZOVczKGh? MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUWuNkDPxE1? NUjVdnZqOjV2MkCxO|U>
MDA-MB-435S cells NXSwV3FiS3m2b4TvfIlkcXS7IHHzd4F6 MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEO1V{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDifUBOXFRiYYPzZZktKEmFNUC9OU42KM7:TR?= MV:yOlA4QTB7MB?=
DU145 cells M4XoXnBzd2yrZnXyZZRqd25iYYPzZZk> MYi0PEBp MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PS53IN88US=> M3LTZVI{Ojh5MEW3
HepG2 cells MnzyVJJwdGmoZYLheIlwdiCjc4PhfS=> MnHHOFghcA>? NInTS2NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;Nj6zJO69VQ>? NGnHeHIzOzJ6N{C1Oy=>
SKOV3 cells NV;QXYRmTnWwY4Tpc44h[XO|YYm= MUOyOEBp MYTBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1vPWlMh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IGPSRkBie3OjeTygTWM2OD14LkSg{txO NWfONVBlOTl5M{OwPFU>
PC3 cells MWHQdo9tcW[ncnH0bY9vKGG|c3H5 M4n4VlI1KGh? MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVch|ryP NYjFN2ZxOjR6OECyN|A>
NIH/3T3 cells NV3pZYlCS3m2b4TvfIlkcXS7IHHzd4F6 NWjsT4t5QTZiaB?= M{Do[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJG5KUC9|VEOgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF04NjJ4IN88US=> MWmyNlc1QTN7Mh?=
GBM1 cells NFrnW4hRem:uaX\ldoF1cW:wIHHzd4F6 MlfxO|IhcA>? NHvtWHlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfCUVEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHdUXC1zIH3leIhw\CxiSVO1NF04NjVizszN MUWyOlM2PTV|Mh?=
518A2 cells Moi3R5l1d3SxeHnjbZR6KGG|c3H5 M4TFOVk3KGh? MmO5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gOVE5STJiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME23MlYzKM7:TR?= NETrdnUzOjd2OUO5Ni=>
A2780 cells MmnIR5l1d3SxeHnjbZR6KGG|c3H5 M2POXVk3KGh? MnXiR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI4QDBiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME23Mlc4KM7:TR?= M2nLSlIzPzR7M{my
A549 cells MXnDfZRwfG:6aXPpeJkh[XO|YYm= NULQboo1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCkeTDNWHQh[XO|YYmsJGlEPTB;OD60JO69VQ>? MYOyOlA4QTB7MB?=
Lipo cells MYfDfZRwfG:6aXPpeJkh[XO|YYm= MlTvPVYhcA>? NHS2UoVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNcXCxIHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9PE43PCEQvF2= MUeyNlc1QTN7Mh?=
A253 cells NVLjSI5TS3m2b4TvfIlkcXS7IHHzd4F6 NIPG[IE6PiCq NFnUfpJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCOjV|IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9PE46OiEQvF2= NGLyTGYzOjd2OUO5Ni=>
HT-29 cells MlrYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoG1S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTHQuOjliY3XscJMtKEmFNUC9PU42KM7:TR?= NGTXRlkzOzRyM{C4OC=>
LNCAP cells MnrPVJJwdGmoZYLheIlwdiCjc4PhfS=> NGP5WIs1QCCq MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyQQ1HQJINmdGy|IHX4dJJme3OrbnegZY5lem:pZX6gdoVk\XC2b4KgbY5kfWKjdHXkJJdqfGhiMD62JI5OKG:oIHXzeJJi\GmxbDDhcoQhOC55IH7NJI9nKHSnc4Tvd5Rmem:wZTDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3ME2xNEDPxE1? MkXwNlE2OTN{N{W=
M21 cells M2e0emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWDHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNNlEh[2WubIOsJGlEPTB;MUGg{txO NHnENIkzOzRyM{C4OC=>
850C cells NX6yV5ZiS3m2b4TvfIlkcXS7IHHzd4F6 M3LZSVk3KGh? Ml\SR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gPFUxSyClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUGxMlA6KM7:TR?= MYiyNlc1QTN7Mh?=
HL60 cells Mn;ZR5l1d3SxeHnjbZR6KGG|c3H5 NVT4TIxxPzJiaB?= M{TPPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHdUXDFiYYPzZZkhcW5icILld4Vv[2Vib3[gNlAmKE[EUzygTWM2OD1zND6zJO69VQ>? NUjEe4V1OjJ7MEG4PVU>
MSTO-211H cells NF;QWnpRem:uaX\ldoF1cW:wIHHzd4F6 M3zhcFczKGh? MmrwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPU2TPMVIyOUhiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JJRzgXCjbjDicJVmKGG|c3H5MEBKSzVyPUKzMlMh|ryP NGK5N|EzOzd|NUiyPS=>
HepG2 cells MYPDfZRwfG:6aXPpeJkh[XO|YYm= NUn1PW5iOjRiaB?= NFP3d2JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhS2WubGTpeIVzNUKudXXD[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{41|ryP NHHGNWozODV2NUOzOC=>
KIF5 cells NULEcWdjS3m2b4TvfIlkcXS7IHHzd4F6 MVGyOEBp M{TUenRwgGmlaYT5JIFo[Wmwc4SgbJVu[W5iS1nGOUBk\WyuczDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCFZXzsWIl1\XJiQnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOy55NTFOwG0> NYf6XYM4OjJ5N{W0O|Q>

... Click to View More Cell Line Experimental Data

In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

+ Expand
  • Animal Models: Pdx1PB-CreERTm mice
  • Formulation: filter-sterilized corn oil
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Ethanol 74 mg/mL (199.18 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
Synonyms ICI 46474

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00026585 Completed Bipolar Disorder National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) November 9, 2001 Phase 2
NCT03024580 Not yet recruiting Breast Neoplasm Instituto Nacional de Cancer, Brazil|Cancer Research UK Cambridge Institute March 2017 Phase 2
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID