Tamoxifen

Catalog No.S1238 Synonyms: ICI 46474

Tamoxifen Chemical Structure

Molecular Weight(MW): 371.51

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

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  • E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.

    Oncotarget, 2015, 6(4):2315-30.. Tamoxifen purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells NXLGSnVkTnWwY4Tpc44h[XO|YYm= MXnF[oZm[3SrdnWgZ49v[2WwdILheIlwdiCjZ3HpcpN1KE2FRj23JIJz\WG|dDD0eY1weiClZXzsd{B2e2mwZzDNR2YuPyCjc4PhfUwhTUN3ME2wMlAyKM7:TR?= M4TMOVEzQDJ3OUO1
MCF7 cells MnzBR5l1d3SxeHnjbZR6KGG|c3H5 MXO0PEBp MkfxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUCuNFI4KM7:TR?= MoHINlI1PzJyNEW=
Ishikawa cells NITzZ4lHfW6ldHnvckBie3OjeR?= M3HTZmNwdmOnboTyZZRqd25ib3[gZ49ueG:3bnSgdoVyfWm{ZXSgeI8hcW6mdXPlJFUxKCVib3[geIhmKG2jeHnteY0he3SrbYXsZZRqd25ib3[gZYxs[WyrbnWgdIhwe3CqYYThd4Uh[WO2aY\peJkhcW5iSYPobYtif2FiY3XscJMtKEWFNUC9NE4xOzNizszN NFewfHk5OjBzNUi3
HEK293T cells M1jSV2Z2dmO2aX;uJIF{e2G7 M1jZd2FvfGGpb37pd5Qh[WO2aY\peJkh[XRiR3HsOEBFSkRvZoXz[YQhcHWvYX6gSXJidHCqYTDMRmQh\XiycnXzd4VlKGmwIFjFT|I6O1RiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBme3S{YXTpc4wucW6mdXPl[EB1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBi\nSncjCyNEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVAvODN7IN88US=> MnLKNlM4QDZ2NUK=
MDA-MB-435 cells M4DFOWZ2dmO2aX;uJIF{e2G7 MXfJcohq[mm2aX;uJI9nKE2GQT3NRk01OzViYoLlZZN1KGOjbnPldkBk\WyuIIDyc4xq\mW{YYTpc44tKEmFNUC9NE4xPSEQvF2= MoTLNVQ6PzF6OUm=
MDA-MB-231 cells MoXNSpVv[3Srb36gZZN{[Xl? MmfCTY5pcWKrdHnvckBw\iCnc4Tyc4dmdiC{ZXPldJRweiCwZXfheIl3\SCPRFGtUWIuOjNzIHLy[YF{fCClYX7j[ZIh[2WubDDwdo9tcW[ncnH0bY9vNCCLQ{WwQVAvODhizszN NITP[YIyPDl5MUi5PS=>
T47D cells M1v6eGZ2dmO2aX;uJIF{e2G7 MUDBcpRq\XO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCWNEfEJINmdGy|IHX4dJJme3Orbneg[ZN1em:pZX6gdoVk\XC2b4KgZZN{\XO|ZXSgZZMh\XO2cn;n[Y4u\GWyZX7k[Y51KHS{YX7zZ5JqeHSrb36gZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxRTBwMTFOwG0> NFTPXocyQTF|MUK0PC=>
Ishikawa cells MV;GeY5kfGmxbjDhd5NigQ>? MY[3NkBp M2\0fGFvfGmnc4Tyc4dmdmmlIHHjeIl3cXS7IHnuJIh2dWGwIFnzbIls[XejIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh\XO2cn;n[Y4ucW6mdXPl[EBidGujbHnu[UBxcG:|cHjheIF{\SCjY4Tpeol1gSCjZoTldkA4OiCqcoOsJGlEPTB;MD6xO{DPxE1? NWSwUmRKOTh6M{WxO|Y>
MCF-7-2a cells NUiyeFVOTnWwY4Tpc44h[XO|YYm= MoPzRY51cWW|dILv[4VvcWNiYXP0bZZqfHliaX6gUWNHNTdvMnGgZ4VtdHNiYYOgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2ViZYP0doFlcW:uIHXm[oVkfCCkeTC1NEUtKEmFNUC9NE42KM7:TR?= MYmxNlQ{OTB4Mx?=
EL4 cell MWnQdo9tcW[ncnH0bY9vKGG|c3H5 NFT6doRKdmirYnn0bY9vKG:oIGuzTH11cHmvaXTpcoUhcW6lb4Lwc5JifGmxbjDpcpRwKEWONDDj[YxtKHC{b3zp[oVz[XSrb36sJIlkPTB;MD61N|Uh|ryP MXKxOVc{PjNy
HeLa cells MnG3SpVv[3Srb36gZZN{[Xl? M{G1c2lvcGmkaYTpc44hd2ZiMUetZoV1[S2nc4TyZYRqd2xibXXkbYF1\WRibIXjbYZmemG|ZTD0doFve2O{aYD0bY9vKGmwIFjlUIEh[2WubIOg[ZhxemW|c3nu[{BpfW2jbjDld5Rzd2enbjDy[YNmeHSxcjDhcJBp[TtiRWLFJIF{e2G7LDDJR|UxRTBwNkKyJO69VQ>? NYLUSm56OTV4NUi4OVE>
MDA-MB-231 cells MUfQdo9tcW[ncnH0bY9vKGG|c3H5 MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTBwNk[g{txO NUTNSld1OjB2NUGzPFA>
T47D cells Mmf5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX\neHQ4PzJiaB?= MYrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDld5Rzd2enbj3k[ZBmdmSnboSgWFQ4TCClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:OSEQvF2= MmrrNVkyOzF{NEi=
yeast AH109 cells MVnGeY5kfGmxbjDhd5NigQ>? M{HtTVI1KGh? M4D5RmFvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLi[ZRiKHKnY3XweI9zKEyERDDlfJBz\XO|ZXSgbY4hgWWjc4SgRWgyODliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBqdnSncnHjeIlwdiC5aYToJHNTSzFiYX\0[ZIhOjRiaILzJIJ6KGGucHjhMYdidGGldH;zbYRie2ViYYPzZZktKEmFNUC9NU43PiEQvF2= MVqyNlY1PzJzNx?=
GBM2 cells M{nIb3Bzd2yrZnXyZZRqd25iYYPzZZk> Mom4O|IhcA>? NIiwW4hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfCUVIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHdUXC1zIH3leIhw\CxiSVO1NF0{NjVizszN NXfOcIdrOjZ|NUW1N|I>
NCI-H460 cells NYHMOJllTnWwY4Tpc44h[XO|YYm= NIDCSmkzPCCq Mny5RY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JPDZyIHPlcIx{KGGodHXyJFI1KGi{czDifUBUWkJiYYPzZZktKEmFNUC9OE41QCEQvF2= MnziNVk4OzNyOEW=
GBM3 cells NYDvXHNtWHKxbHnm[ZJifGmxbjDhd5NigQ>? Ml;1O|IhcA>? NI\Xe4RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfCUVMh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHdUXC1zIH3leIhw\CxiSVO1NF01NjdizszN MojDNlY{PTV3M{K=
DLD1 cells MnLyR5l1d3SxeHnjbZR6KGG|c3H5 M37rZlk3KGh? MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEUGQyKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;ND63PEDPxE1? NWD1SnlrOjJ5NEmzPVI>
ScN2a-cl3 cells MlLCR5l1d3SxeHnjbZR6KGG|c3H5 NY[5PJhjPSCmYYnz NIHKdYNEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBlcX[rZHnu[{BU[05{YT3jcFMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNTDkZZl{KGK7IHPhcINmcW5vQV2gd5RicW6rbnetZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTRwOEmg{txO NHj4WGszPDF6M{W4PS=>
K562 cells M{WyN3Bzd2yrZnXyZZRqd25iYYPzZZk> NVfufmxiPzJiaB?= MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUWuNkDPxE1? MVqyOVQzODF5NR?=
MDA-MB-435S cells Mn3rR5l1d3SxeHnjbZR6KGG|c3H5 MlHlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOXMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZpkhVVSWIHHzd4F6NCCLQ{WwQVUvPSEQvF2= MlT5NlYxPzlyOUC=
DU145 cells NGnKUnVRem:uaX\ldoF1cW:wIHHzd4F6 M{nCUVQ5KGh? NETiPIFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NT61JO69VQ>? M4S3d|I{Ojh5MEW3
HepG2 cells NWTrUYtpWHKxbHnm[ZJifGmxbjDhd5NigQ>? MWW0PEBp NWDR[ZJwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPU[uN{DPxE1? NXXP[5NXOjN{OEewOVc>
SKOV3 cells MVPGeY5kfGmxbjDhd5NigQ>? NEjkPIgzPCCq MnXJRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLU3Y{KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;Nj60JO69VQ>? NH3jR5YyQTd|M{C4OS=>
PC3 cells M4Wy[HBzd2yrZnXyZZRqd25iYYPzZZk> NWfmeGZKOjRiaB?= MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVch|ryP M3ns[lI1QDhyMkOw
NIH/3T3 cells NVfwVGtwS3m2b4TvfIlkcXS7IHHzd4F6 M4XJVlk3KGh? NEPJSpFEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBPUUhxM2SzJINmdGy|IHHmeIVzKDl4IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:Py5{NjFOwG0> MVSyNlc1QTN7Mh?=
GBM1 cells NEPK[2FRem:uaX\ldoF1cW:wIHHzd4F6 MVu3NkBp MnnSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCJQl2xJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDXV3QuOSCvZYToc4QtKEmFNUC9O{42KM7:TR?= M3niVFI3OzV3NUOy
518A2 cells NH\K[21EgXSxdH;4bYNqfHliYYPzZZk> MljpPVYhcA>? MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjC1NVhCOiClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUeuOlIh|ryP MV2yNlc1QTN7Mh?=
A2780 cells M2XITmN6fG:2b4jpZ4l1gSCjc4PhfS=> M1rFd|k3KGh? M4fqbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPzhyIHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9O{44PyEQvF2= NGm0fXQzOjd2OUO5Ni=>
A549 cells MYTDfZRwfG:6aXPpeJkh[XO|YYm= MojER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBjgSCPVGSgZZN{[XluIFnDOVA:QC52IN88US=> MkPGNlYxPzlyOUC=
Lipo cells M4LJc2N6fG:2b4jpZ4l1gSCjc4PhfS=> NI\zSlk6PiCq MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMbZBwKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;OD62OEDPxE1? MnG1NlI4PDl|OUK=
A253 cells MnnqR5l1d3SxeHnjbZR6KGG|c3H5 MkPTPVYhcA>? M2Dzc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPTNiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME24MlkzKM7:TR?= NH7nNGgzOjd2OUO5Ni=>
HT-29 cells NHuwfIxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1jkNmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhVNTJ7IHPlcIx{NCCLQ{WwQVkvPSEQvF2= NEX6[|gzOzRyM{C4OC=>
LNCAP cells M{fWbHBzd2yrZnXyZZRqd25iYYPzZZk> NXXI[3ZqPDhiaB?= NWTNcGJFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMUmNCWCClZXzsd{BmgHC{ZYPzbY5oKGGwZILv[4VvKHKnY3XweI9zKGmwY4XiZZRm\CC5aYToJFAvPiCwTTDv[kBme3S{YXTpc4wh[W6mIECuO{BvVSCxZjD0[ZN1d3O2ZYLvcoUh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFnDOVA:OTBizszN Mn\3NlE2OTN{N{W=
M21 cells MlviS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWWwU44xT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVTJzIHPlcIx{NCCLQ{WwQVEyKM7:TR?= MXOyN|QxOzB6NB?=
850C cells NGHqZ2lEgXSxdH;4bYNqfHliYYPzZZk> NGnLb2k6PiCq MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjC4OVBEKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MUGuNFkh|ryP NVjjUG9MOjJ5NEmzPVI>
HL60 cells NH7RfWFEgXSxdH;4bYNqfHliYYPzZZk> MofQO|IhcA>? M2PMd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHdUXDFiYYPzZZkhcW5icILld4Vv[2Vib3[gNlAmKE[EUzygTWM2OD1zND6zJO69VQ>? NWLCNIhEOjJ7MEG4PVU>
MSTO-211H cells M4mzOXBzd2yrZnXyZZRqd25iYYPzZZk> NY\KWoo4PzJiaB?= Mlr0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPU2TPMVIyOUhiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JJRzgXCjbjDicJVmKGG|c3H5MEBKSzVyPUKzMlMh|ryP M3y4NFI{PzN3OEK5
HepG2 cells NXPzN21lS3m2b4TvfIlkcXS7IHHzd4F6 NYrhOXFqOjRiaB?= Mny2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGNmdGyWaYTldk1DdHWnQ3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuOO69VQ>? MVuyNFU1PTN|NB?=
KIF5 cells M3jKcWN6fG:2b4jpZ4l1gSCjc4PhfS=> MV6yOEBp MmjaWI95cWOrdImgZYdicW6|dDDoeY1idiCNSV[1JINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KEOnbHzUbZRmeiCEbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI{Njd3IN88US=> NEfVbFczOjd5NUS3OC=>

... Click to View More Cell Line Experimental Data

In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

+ Expand
  • Animal Models: Pdx1PB-CreERTm mice
  • Formulation: filter-sterilized corn oil
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Ethanol 74 mg/mL (199.18 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00026585 Completed Bipolar Disorder National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) November 9, 2001 Phase 2
NCT03024580 Not yet recruiting Breast Neoplasm Instituto Nacional de Cancer, Brazil|Cancer Research UK Cambridge Institute March 2017 Phase 2
NCT02993159 Not yet recruiting Ductal Breast Carcinoma In Situ|Estrogen Receptor Positive National Cancer Institute (NCI) March 2017 Phase 2
NCT02988986 Not yet recruiting Estrogen Receptor Positive Breast Cancer Jenny C. Chang, MD|Millennium Pharmaceuticals, Inc.|The Methodist Hospital System February 2017 Phase 2
NCT02903121 Not yet recruiting Bleeding|Implants|Breakthrough Bleeding Oregon Health and Science University|Merck Womens Health Investigator Initiated Studies Program January 2017 Phase 2
NCT02690870 Not yet recruiting Infertility Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Sun Yat-sen University January 2017 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID