Tamoxifen

Catalog No.S1238 Synonyms: ICI 46474

Tamoxifen Chemical Structure

Molecular Weight(MW): 371.51

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

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  • E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.

    Oncotarget, 2015, 6(4):2315-30.. Tamoxifen purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Targets
estrogen receptor [1]
In vitro

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification[2]. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells NHHi[olHfW6ldHnvckBie3OjeR?= NInZTYlG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiRVO1NF0xNjBzIN88US=> Mn\TNVI5OjV7M{W=
MCF7 cells M3j6dGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXi3UJMxPDhiaB?= NVPDUnd6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODJ5IN88US=> MW[yNlQ4OjB2NR?=
Ishikawa cells NXrxcJJxTnWwY4Tpc44h[XO|YYm= NUO2enZUS2:wY3XueJJifGmxbjDv[kBkd22yb4Xu[EBz\XG3aYLl[EB1dyCrbnT1Z4UhPTBiJTDv[kB1cGVibXH4bY12dSC|dHnteYxifGmxbjDv[kBidGujbHnu[UBxcG:|cHjheIF{\SCjY4Tpeol1gSCrbjDJd4hqc2G5YTDj[YxteyxiRVO1NF0xNjB|MzFOwG0> Mn[5PFIxOTV6Nx?=
HEK293T cells Mn\zSpVv[3Srb36gZZN{[Xl? NF61SXJCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFfhcFQhTEKGLX\1d4VlKGi3bXHuJGVT[WyyaHGgUGJFKGW6cILld5Nm\CCrbjDISWszQTOWIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh\XO2cnHkbY9tNWmwZIXj[YQhfHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44h[W[2ZYKgNlAhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NF0xNjB|OTFOwG0> NUOyPY5tOjN5OE[0OVI>
MDA-MB-435 cells NWXIT5R{TnWwY4Tpc44h[XO|YYm= M2fTcWlvcGmkaYTpc44hd2ZiTVTBMW1DNTR|NTDidoVie3RiY3HuZ4VzKGOnbHygdJJwdGmoZYLheIlwdixiSVO1NF0xNjB3IN88US=> M1r6OFE1QTdzOEm5
MDA-MB-231 cells MUPGeY5kfGmxbjDhd5NigQ>? MnvJTY5pcWKrdHnvckBw\iCnc4Tyc4dmdiC{ZXPldJRweiCwZXfheIl3\SCPRFGtUWIuOjNzIHLy[YF{fCClYX7j[ZIh[2WubDDwdo9tcW[ncnH0bY9vNCCLQ{WwQVAvODhizszN NXuzNYpyOTR7N{G4PVk>
T47D cells Mn7ZSpVv[3Srb36gZZN{[Xl? NW\xNYlkSW62aXXzeJJw\2WwaXOgZYN1cX[rdImgbY4hcHWvYX6gWFQ4TCClZXzsd{BmgHC{ZYPzbY5oKGW|dILv[4VvKHKnY3XweI9zKGG|c3Xzd4VlKGG|IHXzeJJw\2WwLXTldIVv\GWwdDD0doFve2O{aYD0bY9vKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME2wMlEh|ryP M3XXSVE6OTNzMkS4
Ishikawa cells MlTQSpVv[3Srb36gZZN{[Xl? M1;aT|czKGh? NULYVVhtSW62aXXzeJJw\2WwaXOgZYN1cX[rdImgbY4hcHWvYX6gTZNpcWujd3GgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCnc4Tyc4dmdi2rbnT1Z4VlKGGua3HsbY5mKHCqb4PwbIF1[XOnIHHjeIl3cXS7IHHmeIVzKDd{IHjyd{whUUN3ME2wMlE4KM7:TR?= NIf2N2QyQDh|NUG3Oi=>
MCF-7-2a cells Mm\YSpVv[3Srb36gZZN{[Xl? NXzrV2tSSW62aXXzeJJw\2WwaXOgZYN1cX[rdImgbY4hVUOILUetNoEh[2WubIOgZZMh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bz\WS3Y3Wg[ZN1emGmaX;sJIVn\mWldDDifUA2OCVuIFnDOVA:OC53IN88US=> M3PPSVEzPDNzME[z
EL4 cell MX7Qdo9tcW[ncnH0bY9vKGG|c3H5 MVXJcohq[mm2aX;uJI9nKFt|SG30bJlucWSrbnWgbY5kd3Kyb4LheIlwdiCrboTvJGVNPCClZXzsJJBzd2yrZnXyZZRqd25uIHnjOVA:OC53M{Wg{txO MYKxOVc{PjNy
HeLa cells NIjGZ2tHfW6ldHnvckBie3OjeR?= NELmem9KdmirYnn0bY9vKG:oIEG3MYJmfGFvZYP0doFlcW:uIH3l[IlifGWmIHz1Z4ln\XKjc3WgeJJidnOlcnnweIlwdiCrbjDI[WxiKGOnbHzzJIV5eHKnc4PpcochcHWvYX6g[ZN1em:pZX6gdoVk\XC2b4KgZYxxcGF9IFXSSUBie3OjeTygTWM2OD1yLk[yNkDPxE1? MnPWNVU3PTh6NUG=
MDA-MB-231 cells NGO4e2JRem:uaX\ldoF1cW:wIHHzd4F6 M1S4ZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;MD62OkDPxE1? NFrWblkzODR3MUO4NC=>
T47D cells MoS5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1Ti[lczKGh? NHPSdmVIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBme3S{b3flck1l\XCnbnTlcpQhXDR5RDDj[YxteyCjZoTldkA4OiCqcoOsJGlEPTB;MTFOwG0> M4rQcVE6OTNzMkS4
yeast AH109 cells NUS1WWpsTnWwY4Tpc44h[XO|YYm= M{DHflI1KGh? MmnMRY51[WexbnnzeEBi[3Srdnn0fUBifCCHUnLleIEhemWlZYD0c5IhVEKGIHX4dJJme3OnZDDpckB6\WG|dDDBTFExQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIlvfGW{YXP0bY9vKHerdHigV3JEOSCjZoTldkAzPCCqcoOgZpkh[WyyaHGt[4Ft[WO2b4Pp[IF{\SCjc4PhfUwhUUN3ME2xMlY3KM7:TR?= NV;NTGhyOjJ4NEeyNVc>
GBM2 cells NH7WW5ZRem:uaX\ldoF1cW:wIHHzd4F6 NETtOHM4OiCq MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeETUKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IGfTWE0yKG2ndHjv[EwhUUN3ME2zMlUh|ryP MXiyOlM2PTV|Mh?=
NCI-H460 cells MUnGeY5kfGmxbjDhd5NigQ>? NWrk[|lZOjRiaB?= MXzBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME20MlQ5KM7:TR?= NEPBWlQyQTd|M{C4OS=>
GBM3 cells MofyVJJwdGmoZYLheIlwdiCjc4PhfS=> NVzVSoo5PzJiaB?= NETCfplCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfCUVMh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHdUXC1zIH3leIhw\CxiSVO1NF01NjdizszN NFXHR2YzPjN3NUWzNi=>
DLD1 cells MWTDfZRwfG:6aXPpeJkh[XO|YYm= MonSPVYhcA>? MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEUGQyKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;ND63PEDPxE1? MVOyNlc1QTN7Mh?=
ScN2a-cl3 cells NHzZcnREgXSxdH;4bYNqfHliYYPzZZk> NE\0ZpQ2KGSjeYO= MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDkbZZq\GmwZzDTZ24z[S2lbEOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPSCmYYnzJIJ6KGOjbHPlbY4uSU1ic4ThbY5qdmdvYnHz[YQh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVQvQDlizszN M3Pve|I1OTh|NUi5
K562 cells M1vNd3Bzd2yrZnXyZZRqd25iYYPzZZk> NWXtR2JmPzJiaB?= MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyPUWuNkDPxE1? NF3qZYwzPTR{MEG3OS=>
MDA-MB-435S cells NHr2enVEgXSxdH;4bYNqfHliYYPzZZk> M1r0ZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20N|VUKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIJ6KE2WVDDhd5NigSxiSVO1NF02NjVizszN NWD6Om94OjZyN{mwPVA>
DU145 cells M3fIUXBzd2yrZnXyZZRqd25iYYPzZZk> NHrTfHo1QCCq NH\VeYZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NT61JO69VQ>? MnrQNlMzQDdyNUe=
HepG2 cells NWLHU4RZWHKxbHnm[ZJifGmxbjDhd5NigQ>? Mk\ZOFghcA>? NYnSNoc1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPU[uN{DPxE1? Ml3KNlMzQDdyNUe=
SKOV3 cells M3fpd2Z2dmO2aX;uJIF{e2G7 NX3yTGhiOjRiaB?= MWfBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1vPWlMh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IGPSRkBie3OjeTygTWM2OD14LkSg{txO NXjaSlZmOTl5M{OwPFU>
PC3 cells MnfHVJJwdGmoZYLheIlwdiCjc4PhfS=> M4HpPFI1KGh? MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVch|ryP NWHTVJI3OjR6OECyN|A>
NIH/3T3 cells MYTDfZRwfG:6aXPpeJkh[XO|YYm= M4XXd|k3KGh? M3vUU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJG5KUC9|VEOgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF04NjJ4IN88US=> M1zPR|IzPzR7M{my
GBM1 cells MkHsVJJwdGmoZYLheIlwdiCjc4PhfS=> NWXrR4NWPzJiaB?= MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeETUGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IGfTWE0yKG2ndHjv[EwhUUN3ME23MlUh|ryP NUDxelU1OjZ|NUW1N|I>
518A2 cells MWLDfZRwfG:6aXPpeJkh[XO|YYm= NUjQcodnQTZiaB?= MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjC1NVhCOiClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUeuOlIh|ryP NV\zd3gxOjJ5NEmzPVI>
A2780 cells NYfFZpUzS3m2b4TvfIlkcXS7IHHzd4F6 MoTVPVYhcA>? M1zD[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPzhyIHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9O{44PyEQvF2= MYSyNlc1QTN7Mh?=
A549 cells MVvDfZRwfG:6aXPpeJkh[XO|YYm= NUfQWogxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCkeTDNWHQh[XO|YYmsJGlEPTB;OD60JO69VQ>? M{[4bVI3ODd7MEmw
Lipo cells NHvQfW9EgXSxdH;4bYNqfHliYYPzZZk> MXK5OkBp NWTtbpQyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVGmybzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVgvPjRizszN M1O5b|IzPzR7M{my
A253 cells MUfDfZRwfG:6aXPpeJkh[XO|YYm= MoHGPVYhcA>? NFLCN5ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCOjV|IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9PE46OiEQvF2= MXeyNlc1QTN7Mh?=
HT-29 cells NIi0PGxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{nx[2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhVNTJ7IHPlcIx{NCCLQ{WwQVkvPSEQvF2= MXGyN|QxOzB6NB?=
LNCAP cells M2LTTXBzd2yrZnXyZZRqd25iYYPzZZk> MnXGOFghcA>? M2DoNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTF7DRXAh[2WubIOg[ZhxemW|c3nu[{BidmS{b3flckBz\WOncITvdkBqdmO3YnH0[YQhf2m2aDCwMlYhdk1ib3[g[ZN1emGmaX;sJIFv\CByLkegcm0hd2ZidHXzeI9{fGW{b37lJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCLQ{WwQVExKM7:TR?= MV[yNVUyOzJ5NR?=
M21 cells NEjxe2pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{jHd2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG0zOSClZXzsd{whUUN3ME2xNUDPxE1? NUnYN|NTOjN2MEOwPFQ>
850C cells MVfDfZRwfG:6aXPpeJkh[XO|YYm= M1rUWVk3KGh? NV[wdXk2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hQDVyQzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVEyNjB7IN88US=> M{\ETlIzPzR7M{my
HL60 cells NFW1O4NEgXSxdH;4bYNqfHliYYPzZZk> MUe3NkBp MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDXV3QyKGG|c3H5JIlvKHC{ZYPlcoNmKG:oIEKwKUBHSlNuIFnDOVA:OTRwMzFOwG0> MXOyNlkxOTh7NR?=
MSTO-211H cells NHHLbndRem:uaX\ldoF1cW:wIHHzd4F6 NG\iVlE4OiCq MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2VVF:tNlEyUCClZXzsd{Bi\nSncjC3NkBpenNiYomgeJJ6eGGwIHLseYUh[XO|YYmsJGlEPTB;MkOuN{DPxE1? NFvVcWszOzd|NUiyPS=>
HepG2 cells NIK0d2NEgXSxdH;4bYNqfHliYYPzZZk> NHTRUYYzPCCq M1mxeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFI1KGi{czDifUBE\WyuVHn0[ZIuSmy3ZVPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKzMlTPxE1? NWPpPYxJOjB3NEWzN|Q>
KIF5 cells NWDmcm1[S3m2b4TvfIlkcXS7IHHzd4F6 MlG1NlQhcA>? M4rZUHRwgGmlaYT5JIFo[Wmwc4SgbJVu[W5iS1nGOUBk\WyuczDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCFZXzsWIl1\XJiQnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOy55NTFOwG0> NHXxXYkzOjd5NUS3OC=>

... Click to View More Cell Line Experimental Data

In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver[2]. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models[4].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: MCF7 and T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48, and 96 h
  • Method:

    48 h before the addition of E2 and TAM, cells were washed with 5 mL phosphate-buffered saline (PBS) and then switched to phenol red-free RPMI-1640 containing 10% charcoal-stripped FBS. E2 and TAM were dissolved in absolute ethanol and diluted in the media at 10<sup>-8</sup> mol/L and 10<sup>-6</sup> mol/L, respectively, and then added to the culture medium at 24, 48, and 96 h.


    (Only for Reference)
Animal Research:

[4]

+ Expand
  • Animal Models: Pdx1PB-CreERTm mice
  • Formulation: filter-sterilized corn oil
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.18 mM)
Ethanol 74 mg/mL (199.18 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.51
Formula

C26H29NO

CAS No. 10540-29-1
Storage powder
in solvent
Synonyms ICI 46474

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03423199 Recruiting Breast Neoplasms National Cancer Center Japan|Pfizer|Korean Cancer Study Group February 9 2018 Phase 3
NCT02089386 Terminated Barrett Metaplasia Washington University School of Medicine July 9 2014 Early Phase 1
NCT00026585 Completed Bipolar Disorder National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) November 9 2001 Phase 2
NCT02291913 Active not recruiting Breast Cancer SCRI Development Innovations LLC|Novartis January 7 2015 Phase 2
NCT02204098 Recruiting Breast Cancer|Breast Carcinoma|Malignant Neoplasm of Breast Washington University School of Medicine|National Cancer Institute (NCI)|The Rising Tide Foundations for Clinical Cancer Research January 7 2015 Phase 1
NCT00310180 Active not recruiting Breast Adenocarcinoma|Estrogen Receptor and/or Progesterone Receptor Positive|HER2/Neu Negative|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage IIIB Breast Cancer AJCC v7 National Cancer Institute (NCI)|American College of Surgeons|Cancer and Leukemia Group B|NSABP Foundation Inc|NCIC Clinical Trials Group|North Central Cancer Treatment Group|Southwest Oncology Group April 7 2006 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • Answer:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID