Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Psoralidin

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Psoralidin Estrogen/progestogen Receptor agonist

Cat.No.S5464

Psoralidin, a naturally occurring coumestan isolated from the fractions of organic solvents such as ethylacetate, hexane, or n-butanol of the seed extract of Psoralea corylifolia L., has a variety of biological activities such as anticancer, antioxidant, antibacterial, antidepressant, anti-inflammatory activities, and regulation of insulin signaling. It is an agonist for both estrogen receptor (ER)α and ERβ with binding affinities (IC50s) of 1.03 and 24.6 μM, respectively.
Psoralidin Estrogen/progestogen Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 336.34

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Quality Control

Batch: S546401 DMSO]67 mg/mL]false]Ethanol]1 mg/mL]false]Water]Insoluble]false Purity: 99.96%
99.96

Solubility

In vitro
Batch:

DMSO : 67 mg/mL (199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 1 mg/mL

Water : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 336.34 Formula

C20H16O5

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 18642-23-4 -- Storage of Stock Solutions

Synonyms N/A Smiles CC(=CCC1=CC2=C(C=C1O)OC(=O)C3=C2OC4=C3C=CC(=C4)O)C

Mechanism of Action

Targets/IC50/Ki
ERα
(Cell-free)
1.03 μM
ERβ
(Cell-free)
24.6 μM
In vitro
Psoralidin has been characterized as a full ER agonist, which activates the classical ER-signaling pathway in both ER-positive human breast and endometrial cell lines as well as non-human cultured cells transiently expressing either ERα or ERβ. This compound was also able to induce the endogenous estrogen-responsive gene, pS2, in human breast cancer cells MCF-7. The IC50 values for this chemical to replace the binding of E2 to both receptors were 1.03 and 24.6 μM, respectively. It is able to bind to both receptors within the micromolar range and has preferential affinity for ERα over ERβ.
In vivo
Acute and subchronic administrations of psoralidin produced a significant reduction in immobility time in the mouse forced swimming test. This compound dose-dependently increased swimming and failed to affect climbing.
References

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