Dienogest

Synonyms: STS 557

Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.

Dienogest Chemical Structure

Dienogest Chemical Structure

CAS: 65928-58-7

Purity & Quality Control

Batch: Purity: 99.91%
99.91

Dienogest Related Products

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.
Targets
progestogen Receptor [1]
In vitro
In vitro Dienogest activates progesterone receptor (EC50=3.4 or 10.5 nM) with antagonistic activity on androgen receptor (EC50=420.6 or 775.0 nM) but not agonistic nor antagonistic action on GR, MR (3000 nM). [1] Dienogest combined with Oestradiol leads to an increase in the levels of prolactin mRNA and prolactin production in a dose-dependent manner in human endometrial stromal cells (ESC). Dienogest directly acts on endometrial tissue in progestogenic response, such as decidualization, increases prolactin production and growth retardation. [2] Dienogest at concentration of 0.1 μM and 1 μM significantly inhibits BrdU incorporation into DNA at 24 and 48 hours in the cultured endometriotic stromal cells. Dienogest significantly increases the cells in G0/G1 phase and reduces the cells in S phase and G2/M phase in 24 and 48 hours in the cultured endometriotic stromal cells. [3]
In Vivo
In vivo Dienogest (0.1-1 mg/kg per day, p.o.) reduces the endometrial implant volume to the same extent as Danazol (100 mg/kg per day, p.o.) in rats. Dienogest ameliorates the endometrial implant-induced alterations of the immune system: i.e. it increases the natural killer activity of peritoneal fluid cells and splenic cells, decreases the number of peritoneal fluid cells, and decreases interleukin-1beta production by peritoneal macrophages. Dienogest (0.1 mg/kg per day) combined with Buserelin (0.3 mg/kg per day) suppresses the bone mineral loss induced by buserelin alone, with no reduction of the effect on endometrial implants. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04808843 Active not recruiting
Endometriosis Associated Pelvic Pain
Bayer
May 13 2022 --
NCT04901377 Completed
Oral Contraception
Bayer
June 24 2021 --
NCT05272930 Completed
Fibromyalgia|Endometriosis Ovary|Dienogest
Gaziosmanpasa Research and Education Hospital
June 30 2021 --

Chemical Information & Solubility

Molecular Weight 311.42 Formula

C20H25NO2

CAS No. 65928-58-7 SDF Download Dienogest SDF
Smiles CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2(CC#N)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (199.08 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Dienogest | Dienogest ic50 | Dienogest price | Dienogest cost | Dienogest solubility dmso | Dienogest purchase | Dienogest manufacturer | Dienogest research buy | Dienogest order | Dienogest mouse | Dienogest chemical structure | Dienogest mw | Dienogest molecular weight | Dienogest datasheet | Dienogest supplier | Dienogest in vitro | Dienogest cell line | Dienogest concentration | Dienogest nmr