Progesterone

Catalog No.S1705

Progesterone Chemical Structure

Molecular Weight(MW): 314.46

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 170 In stock
USD 397 In stock
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1 Customer Review

  • SPOP inhibits progesterone-induced S phase entry and Erk1/2 activation. (A) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for 24 hr. The cell cycle percentages was determined by PI staining and FACS; (B) T47D cells were transfected with control siRNAs or SPOP-specific siRNAs. After 48 hr, cells were treated and analyzed as in (A); (C) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for indicated times. Cell lysates were prepared for WB analyses; (D) T47D cells were transfected with control or SPOP-specific siRNA. After 48 hr, cells were treated and analyzed as in (C).

    Am J Cancer Res, 2015, 5(10): 3210-3220.. Progesterone purchased from Selleck.

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Biological Activity

Description Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.
Targets
progestogen Receptor [1]
In vitro

Progesterone has biphasic effects on proliferation of breast cancer cells; it stimulates growth in the first cell cycle, then arrests cells at G1/S of the second cycle accompanied by up-regulation of the cyclin-dependent kinase inhibitor, p21. Progesterone-mediated transcription is further prevented by overexpression of E1A, suggesting that CBP/p300 is required. [1] Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. [2] Progesterone treatment increases the sensitivity of cortical synaptoneurosomes to GABA (i.e., decreased the EC50) and increases the maximal efficacy with which GABA stimulated Cl- transport (i.e., increased the Emax). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human T47D cells NXTHVodMTnWwY4Tpc44h[XO|YYm= Mnq2NlAhcA>? MWfBZ5RqfmG2aX;uJI9nKHC{b3fld5Rmem:wZTDy[YNmeHSxcjDpckBpfW2jbjDUOFdFKGOnbHzzJIFnfGW{IEKwJIhzeyCkeTDQVmUufGGpZ3XkJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjFibl2= NIXLd|AyQTh4M{C4Ny=>
CV-1 cells Mn7kSpVv[3Srb36gZZN{[Xl? NHPJZXhG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDmc5IhcGGuZj3tZZhqdWGuIHHjeIl3[XSrb36gc4YhcHWvYX6gdJJw\2W|dHXyc45mKHKnY3XweI9zKGW6cILld5Nm\CCrbjDDWk0yKGOnbHzzMEBGSzVyPUGuOUBvVQ>? NYnvc2hbQTZ4N{m2PC=>
HEK293 cells NX\S[ZFITnWwY4Tpc44h[XO|YYm= NWjTXldNSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWkeUIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVIhdk1? MXiyOVMxPTZ6OB?=
SF-12 cells MYTGeY5kfGmxbjDhd5NigQ>? NG\xU4hFcXOybHHj[Y1mdnRib3[gSGhVKG[{b32gbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KFOILUGyJINmdGy|LDDLbV06NjVibl2= MojpNVI6PTRyNkK=
CHO cells NFrqNoRHfW6ldHnvckBie3OjeR?= NVfxVVg2SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBVT1J3IHX4dJJme3OnZDDpckBEUE9iY3XscJMh[nlibIXjbYZmemG|ZTDhd5NigSxiRVO1NF0zNjd5IN88US=> MormNVg{ODd{OUS=
human K562/R7 cells NWPFVJpJTnWwY4Tpc44h[XO|YYm= MkTJNUDPxE1? NGP4cpA4OiCq MYHQc5RmdnSrYYTpc44hd2ZiZH;4c5J2[mmlaX6tbY5lfWOnZDDjfZRwfG:6aXPpeJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hUzV4Mj;SO{Bk\WyuczDhd5Nme3OnZDDhd{Bld3ixcoXibYNqdiCLQ{WwJIF1KDFidV2gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMD62JO69VQ>? NGXObpYzPTZ|NEC0NS=>
A2780 cells NFPiO5pHfW6ldHnvckBie3OjeR?= NHj3OlBKdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4h[WS{aXHtfYNqdi2{ZYPpd5RidnRiQUK3PFAh[2WubIOgZpkhUG:nY3jzeEA{OzN2MjDhd5NigSxiSVO1NF01Py56NkOg{txO M4X5O|E5Pjd6NEm1
HeLa cells MkjIR5l1d3SxeHnjbZR6KGG|c3H5 NX30cFNmS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKESQQTDy[ZBtcWOjdHnvckBjgSCrbXHnbY5oKGGwYXz5d4l{ NITDbpoyQDB4NkC1OS=>

... Click to View More Cell Line Experimental Data

In vivo Progesterone blocks the beneficial effect of estrogen on Abeta accumulation but not on behavioral performance in female 3xTg-AD mice. Progesterone significantly reduces tau hyperphosphorylation when administered both alone and in combination with estrogen. [4] Progesterone-treated rats are less impaired on a Morris water maze spatial navigation task than rats treated with the oil vehicle. Progesterone-treated rats also show less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area. [5]

Protocol

Solubility (25°C)

In vitro Ethanol 63 mg/mL (200.34 mM)
DMSO 22 mg/mL (69.96 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 314.46
Formula

C21H30O2

CAS No. 57-83-0
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00370019 Withdrawn Premature Ovarian Failure Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) August 25, 2006 Phase 2
NCT03018249 Not yet recruiting Grade 1 Endometrial Endometrioid Adenocarcinoma|Grade 2 Endometrial Endometrioid Adenocarcinoma|Grade 3 Endometrial Endometrioid Adenocarcinoma|Uterine Corpus Adenosarcoma National Cancer Institute (NCI) August 2017 Phase 2
NCT02579590 Recruiting Female Sexual Function Assiut University March 2017 --
NCT02950935 Not yet recruiting Threatened Abortion in First Trimester IBSA Institut Biochimique SA March 2017 Phase 3
NCT02950948 Not yet recruiting Luteal Phase Defect IBSA Institut Biochimique SA March 2017 Phase 3
NCT03003949 Not yet recruiting Perimenopausal Disorder|Stress, Emotional University of North Carolina, Chapel Hill|National Institute of Mental Health (NIMH) January 2017 --

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Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID