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Fulvestrant (Faslodex) Chemical Structure
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Biological Activity
Fulvestrant (Faslodex) is a synthetic estrogen receptor antagonist or selective estrogen receptor down-regulator (SERD). Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. [1] Fulvestrant is used for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. [2]
Chemical Information
| Molecular Weight (WM): | 606.77 |
|---|---|
| Formula: | C32H47F5O3S |
| CAS No.: | 129453-61-8 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥121mg/mL |
| Water <1mg/mL | |
| Ethanol ≥121mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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