Name: Estriol
Brand: Selleck Chemicals
SKU: S2466
Availability: InStock
Rating: 5 (1 reviews)

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Quality Control

Batch: S246601 DMSO]57 mg/mL]false]Ethanol]10 mg/mL]false]Water]Insoluble]false Purity: 99.34%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS
Datasheet

99.34

Related Targets	Adrenergic Receptor GPR Androgen Receptor Glucocorticoid Receptor ACE RAAS Progesterone Receptor Opioid Receptor PGES THR
Other Estrogen/progestogen Receptor Products	Elacestrant (RAD1901) Dihydrochloride Vepdegestrant (ARV471) MPP dihydrochloride Cholesterol Endoxifen HCl G15 Chrysin Licochalcone A AZD9496 PHTPP

Solubility

In vitro
Batch:

DMSO : 57 mg/mL (197.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	10.000mg/ml (34.68mM)	Taking the 1 mL working solution as an example, add 50 μL of 200 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	288.39	Formula	C₁₈H₂₄O₃	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	50-27-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	NSC-12169			Smiles	CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O

Mechanism of Action

Targets/IC₅₀/Ki	ER
In vitro	MTT assays using G-1 shows that, in SkBr3 cells, the proliferative effect induced by 100 nM G-1 is abolished in the presence of 1 μM estriol which acts as an antagonist of GPR30-dependent pathway. A cell-free transcription assay demonstrates that the antiestrogenic activity exhibited by estriol is because of interferring with estradiol-induced positive cooperative binding and receptor dimerization, binding of hER complexes to ERE, as well as reducing estradiol-dependent transcription in a dose-dependent manner. A recent study shows that estrogen (estrone, estradiol, and estriol) inhibits Alzheimer's disease-associated low-order Aβ oligomer formation, and among them, estriol shows the strongest in vitro activity.
In vivo	In mPTEN+/- mice, estriol treatments resulted in a 187.54% gain in the relative ratio of uterine wet weight to body weight; estriol also increases the ratio to 176.88% in wild-type mice. Estriol treatment (20 mg/kg ip), in vivo, sensitizes Kupffer cells to LPS via mechanisms dependent on an increase in CD14 by elevated portal blood endotoxin caused by increased gut permeability in rats; while one-half of the rats given estriol intraperitoneally 24 hours before an injection of a sublethal dose of LPS (5 mg/kg) died within 24 hours.
References	[1] https://pubmed.ncbi.nlm.nih.gov/20138962/ [2] https://pubmed.ncbi.nlm.nih.gov/9369454/ [3] https://pubmed.ncbi.nlm.nih.gov/21281631/ [4] https://pubmed.ncbi.nlm.nih.gov/16402032/ [5] https://pubmed.ncbi.nlm.nih.gov/20826375/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05000424	Unknown status	Quality of Life\|Pregnancy Related	Franklin Health Research	November 1 2021	Not Applicable
NCT05012072	Recruiting	Mental Health Wellness 1\|Preterm Birth	Microgen LLC	August 1 2021	Phase 2
NCT04305093	Completed	Obesity; Endocrine\|Hormone Disturbance	Precision Analytical Inc.	December 15 2019	--
NCT04267731	Completed	Aging Well	Vemico Ltd.\|University of Roehampton	December 1 2019	Not Applicable
NCT03116022	Unknown status	Dyspareunia\|Menopause\|Sexual Dysfunction	University of Sao Paulo	June 1 2017	Phase 1

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Estriol Estrogen/progestogen Receptor antagonist

Chemical Structure

Molecular Weight: 288.39