Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Licochalcone A For research use only.

Licochalcone A

Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.

Licochalcone A Chemical Structure

Licochalcone A Chemical Structure

CAS: 58749-22-7

Selleck's Licochalcone A has been cited by 5 publications

Purity & Quality Control

Batch: S782801 DMSO] 67 mg/mL] false] Ethanol] 67 mg/mL] false] Water] Insoluble] false Purity: 99.93%
99.93

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Signaling Pathway

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Biological Activity

Description Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.
In vitro
In vitro Licochalcone A markedly inhibits the in vitro growth of L. major amastigotes in human MDMs and U937 cells. [1] Licochalcone A shows antibacterial effects against all gram-positive bacteria tested and especially against all Bacillus spp. Tested with MICs of 2 to 3 micrograms/mL. [3] In CT-26 colon cancer cells, Licochalcone A reduces the cell viability and DNA synthesis. [4] Licochalcone A also interferes with MAPK signaling cascades, initiates ROS generation, induces oxidative stress and consequently causes BGC cell apoptosis. [5]
Cell Research Cell lines CT-26 cells
Concentrations ~20 μM
Incubation Time 72 hours
Method The viability of CT-26 mouse colon cancer cells is determined via a MTT assay. In brief, colon cancer cells are seeded onto each well of a 96-well plate with DMEM containing 10% FBS and cultured to adhere overnight. The cells are then treated with various concentrations of LCA in serum-free medium for 24 and 72 hr, respectively. Twenty microlitres of a MTT solution (5 mg/ml) is added to each well, and the cells are incubated for 4 hr at 37°. The medium is then removed, and 200 µL of dimethyl sulfoxide is added to each well. The absorbance is determined at 570 nm using a microplate reader.
In Vivo
In vivo In mice infected with L. major, licochalcone A (5 mg/kg, i.p.) completely prevents lesion development. In mice infected with L. donovani, licochalcone A (150 mg/kg, p.o.) results in > 65 and 85% reductions of parasite loads in the liver and the spleen, respectively. [2] In CT-26 cell-inoculated Balb/c mice, licochalcone A (1 mg/kg, p.o.) inhibits the tumor growth, and alleviates cisplatin-induced nephrotoxicity and hepatotoxicity. [4]
Animal Research Animal Models Mice infected with L. major
Dosages 5 mg/kg/day
Administration i.p. or p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04002024 Completed
Acne Vulgaris|Acne
Mahidol University|Beiersdorf
 June 1 2019 Not Applicable

Chemical Information & Solubility

Molecular Weight 338.4 Formula

C21H22O4
CAS No. 58749-22-7 SDF Download Licochalcone A SDF
Smiles CC(C)(C=C)C1=C(C=C(C(=C1)C=CC(=O)C2=CC=C(C=C2)O)OC)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 67 mg/mL ( (197.99 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 67 mg/mL

Water : Insoluble


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In vivo
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