Estradiol

Catalog No.S1709

Estradiol Chemical Structure

Molecular Weight(MW): 272.38

Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.

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In DMSO USD 270 In stock
USD 97 In stock
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Biological Activity

Description Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.
Targets
Estrogen receptor [1]
In vitro

Estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. Estradiol treatment resulted in a 46% increase in NMDA receptor binding. Estradiol treatment increases NMDA receptor binding in parallel with dendritic spine and synapse density. Estradiol treatment results in increased sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and that this increase is well correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. [1] 17 beta-estradiol is found to reduce Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. 17 alpha-Estradiol also reduces Ba2+ currents but is significantly less effective than 17 beta-estradiol in rat neostriatal neurons. [2] 17 beta-estradiol exerts a dose-dependent inhibition of IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. Estradiol inhibits both TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF-7 cells M3jPfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX;xcXNPT3Kxd4ToJJJme3CxboPlJIlvKGO3bIT1doV{KG:oIF3DSk04KCiqdX3hckBjemWjc4SgZ4Fv[2W{IHPlcIwhdGmwZTmgZ4VtdHNuIFXDOVA:OS53MnWtNFYh|ryP MYi5N|U4PTN|
human MCF7 cells MknqSpVv[3Srb36gZZN{[Xl? NXLDR5ZLPiCmYYnz M4\o[2V{fHKxZ3XubYMh[WO2aY\peJkhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiNjDkZZl{KGK7IGfTWFgh[XO|YYmsJGVEPTB;Mz63[U0xPiEQvF2= MXWxPFc3ODZyMx?=
human U2-OS cells M2m3eWZ2dmO2aX;uJIF{e2G7 NHv5OZJC[3SrdnH0bY9vKG:oIHj1cYFvKEWUYXzwbIEh\XiycnXzd4VlKGmwIHj1cYFvKFV{LV;TJINmdGy|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSC{ZXzheIl3\SC2bzD1cpRz\WG2ZXSgZ49vfHKxbDygSWM2OD12ZT2wOkDPxE1? M{\OOlI{ODR|MkSy
MCF7 cells Mnr3VJJwdGmoZYLheIlwdiCjc4PhfS=> Mn\GO|IhcA>? M3LZcmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[ZN1em:pZX6t[IVncWOrZX70JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygSWM2OD14LkTlMVA3KM7:TR?= MXmyNlQ3PDZ6MR?=
HeLa cells NV\OUoQ3TnWwY4Tpc44h[XO|YYm= MlXERYN1cX[jdHnvckBw\iCnc4Tyc4dmdiC{ZYPwc45{\SCnbHXt[Y51KGmwIFjlUIEh[2WubIOgd5Ri[my7IITyZY5{\mWldHXkJJdqfGhiaIXtZY4hTXO2cn;n[Y4hemWlZYD0c5Ih[WyyaHGsJGVEPTB;MnWtNFUh|ryP M2D4XVEyQTB4Mkiw
HEK293 cells MVjGeY5kfGmxbjDhd5NigQ>? Ml3lRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDFVoFteGijIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVIvPGVvMEWg{txO NHnrTHQzPTNyNU[4PC=>
human Ishikawa cells MVfGeY5kfGmxbjDhd5NigQ>? NH;sZ5U4OiCq MmmySZN1em:pZX7pZ{Bi[3Srdnn0fUBifCCnc4Tyc4dmdiC{ZXPldJRweiCrbjDoeY1idiCLc3jpb4F4[SClZXzsd{Bie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZYxs[WyrbnWgdIhwe3CqYYThd4Uh\XiycnXzd4lwdiCjZoTldkA4OiCqcoOgZpkhdWmlcn;wcIF1\SC{ZXHk[ZItKEWFNUC9Nk41PmVvMEWg{txO M4q3UlIzPDZ2Nkix
CHO-K1 cells NY\6OnlkTnWwY4Tpc44h[XO|YYm= NGX6[YUzPCCq M4jwfnRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJI9nKEWUYnX0ZUBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ1jPMWsyKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9N{43\S1yNTFOwG0> M1:wR|IzPjR5MkG3
T47D cells NGrnSYNHfW6ldHnvckBie3OjeR?= MmO5RYdwdmm|dDDl[oZm[3Rib36geJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hXDR5RDDj[YxteyCneIDy[ZN{cW6pIHXzeJJw\2WwIILlZ4VxfG:{IHHsdIhiNCCHQ{WwQVdmNTB3IN88US=> MYixNlQ2QTBzNx?=
human HEC1 cells Mm\xSpVv[3Srb36gZZN{[Xl? M4C0cFI1KGh? M2DwXWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6g[pVtdC2uZX7neIghTVKjbIDoZUBz\WOncITvdkBmgHC{ZYPz[YQhcW5iaIXtZY4hUEWFMTDj[YxteyClbz3lfJBz\XO|aX7nJEhGWkVrMj3wV|IudHWlIHflcoUh[XO|ZYPz[YQh[XNidILhcpNkemmydHnvcoFtKGGldHn2ZZRqd25iYX\0[ZIhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD17ZT2wOUDPxE1? M4\rWlIyPDhzNEm3
human SK-BR-3 cells NUnvc3NTTnWwY4Tpc44h[XO|YYm= NFz1W481QCCq NHfqR5BKdmirYnn0bY9vKG:oIHPo[Y1w[XS2cnHjeIFvfC2rbnT1Z4VlKGOnbHygcYloemG2aX;uJI9nKGi3bXHuJHNMNUKULUOgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHS{YX7ze4VtdCCvaXfyZZRqd25iYYPzZZktKEmFNUC9NE4yKG6P MVexOlUzODd|Mx?=
UAS cells MUTGeY5kfGmxbjDhd5NigQ>? MmDBNVghcA>? NHPJb2VC\2:waYP0JIFkfGm4aYT5JIF1KEWUYnX0ZUBmgHC{ZYPz[YQhcW5iVVHTJINmdGy|IHPvMYV5eHKnc4Ppcoch[mW2YT3sZYN1[W2jc3WgZYZ1\XJiMUigbJJ{KGK7IHLleIEudGGldHHtZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5{NTDuUS=> MWeyNVg5PTJ5OR?=
COS7 cells NGPLfFFHfW6ldHnvckBie3OjeR?= NXHER4xLTGm|cHzhZ4Vu\W62IH;mJGUzNUGuZYjhOlM{KG[{b32gS2ZRNXSjZ3fl[EBGWmGucHjhJIV5eHKnc4Pl[EBqdiCFT2O3JINmdGy|IHL5JGZCS1NuIFvpQVAvOyCwTR?= MlnxNVY2OjB5M{O=
AH109 cells Ml22SpVv[3Srb36gZZN{[Xl? NYrpc4Z7OjRiaB?= MVLB[49vcXO2IHHjeIl3cXS7IHH0JGVT[WyyaHGgdoVk\XC2b4KgUGJFKGW6cILld5Nm\CCrbjD5[YF{fCCDSEGwPUBk\WyuczDhd5Nme3OnZDDhd{BqdnSncnHjeIlwdiC5aYToJHNTSzFiYX\0[ZIhOjRiaILzJIJ6KGGucHjhMYdidGGldH;zbYRie2ViYYPzZZktKEWFNUC9NU4xPSCwTR?= NILCZpAzOjZ2N{KxOy=>
HepG2 cells NG\kcFBHfW6ldHnvckBie3OjeR?= M4XIOVI1KGh? NYXOdVZwSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBGWmGucHjhJIV5eHKnc4Pl[EBqdiCKZYDHNkBk\WyuczDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUKuNkBvVQ>? NV\UPVRWOjJ{OEOzNlg>
COS-1 cells NV[4SnNTTnWwY4Tpc44h[XO|YYm= NVnSeHV3UW5idnn0do8h[WexbnnzeEBi[3Srdnn0fUBnd3JiZYP0do9o\W5icnXj[ZB1d3JiYXzwbIEh\XiycnXzd4VlKGmwIFPPV{0yKGOnbHzzMEBGSzVyPUKuOEBvVQ>? NXfPOFZEOTV5MUO0NFc>
SAOS-2 cells MXvGeY5kfGmxbjDhd5NigQ>? NVj2PJpoTnWwY4Tpc45idCCHc4Tyc4dmdiC{ZXPldJRweiCkZYThJIFkfGm4aYT5JIJ6KG2ndHHscI91cGmxbnXpckBqdmS3Y4Tpc44hcW5iU1HPV{0zKGOnbHzzMEBGTDVyPUSuO{BvVQ>? MkHrNVI5OjRyNEO=
MDA-MB-231 cells NEHpVHhRem:uaX\ldoF1cW:wIHHzd4F6 MoLONkBl[Xm| M4fmfWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIh2dWGwIFXSMY5m\2G2aY\lJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiMjDkZZl{KGK7IF3UWEBie3OjeTygTWM2OD1|Mz60OkDPxE1? NUe3THVPOjV{MkK4O|Y>

... Click to View More Cell Line Experimental Data

In vivo Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. [4] Estradiol alone can reverse the ovariectomy-induced decrease in spine density. Estradiol combined with Progesterone initially increases spine density for a period of 2 to 6 hours but then results in a much sharper decrease than is observed following estradiol alone. [5]

Protocol

Solubility (25°C)

In vitro DMSO 54 mg/mL (198.25 mM)
Ethanol 5 mg/mL (18.35 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 272.38
Formula

C18H24O2

CAS No. 50-28-2
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01923298 Active, not recruiting Estrogen Levels Among Breast Cancer Patients University of Arizona August 9, 2013 Phase 2
NCT00370019 Withdrawn Premature Ovarian Failure Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) August 25, 2006 Phase 2
NCT03043924 Not yet recruiting Polycystic Ovary Syndrome University Hospital, Lille|National Research Agency, France March 2017 --
NCT03018366 Recruiting Estrogen Deficiency|Cardiovascular Disease (CVD)|Hypothalamic Amenorrhea Cedars-Sinai Medical Center January 2017 Phase 2
NCT03003949 Not yet recruiting Perimenopausal Disorder|Stress, Emotional University of North Carolina, Chapel Hill|National Institute of Mental Health (NIMH) January 2017 --
NCT02792153 Recruiting Anorexia Nervosa Johns Hopkins University December 2016 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID