Estradiol

Catalog No.S1709

Estradiol Chemical Structure

Molecular Weight(MW): 272.38

Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.

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In DMSO USD 270 In stock
USD 97 In stock
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Biological Activity

Description Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.
Targets
Estrogen receptor [1]
In vitro

Estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. Estradiol treatment resulted in a 46% increase in NMDA receptor binding. Estradiol treatment increases NMDA receptor binding in parallel with dendritic spine and synapse density. Estradiol treatment results in increased sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and that this increase is well correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. [1] 17 beta-estradiol is found to reduce Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. 17 alpha-Estradiol also reduces Ba2+ currents but is significantly less effective than 17 beta-estradiol in rat neostriatal neurons. [2] 17 beta-estradiol exerts a dose-dependent inhibition of IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. Estradiol inhibits both TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF-7 cells MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV7TWZVWT3Kxd4ToJJJme3CxboPlJIlvKGO3bIT1doV{KG:oIF3DSk04KCiqdX3hckBjemWjc4SgZ4Fv[2W{IHPlcIwhdGmwZTmgZ4VtdHNuIFXDOVA:OS53MnWtNFYh|ryP NYrr[nNtQTN3N{WzNy=>
human MCF7 cells NUfwZoFuTnWwY4Tpc44h[XO|YYm= M3nDUVYh\GG7cx?= M4XmXWV{fHKxZ3XubYMh[WO2aY\peJkhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiNjDkZZl{KGK7IGfTWFgh[XO|YYmsJGVEPTB;Mz63[U0xPiEQvF2= MojzNVg4PjB4MEO=
human U2-OS cells NGTLfplHfW6ldHnvckBie3OjeR?= NFzNNJZC[3SrdnH0bY9vKG:oIHj1cYFvKEWUYXzwbIEh\XiycnXzd4VlKGmwIHj1cYFvKFV{LV;TJINmdGy|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSC{ZXzheIl3\SC2bzD1cpRz\WG2ZXSgZ49vfHKxbDygSWM2OD12ZT2wOkDPxE1? M2LZe|I{ODR|MkSy
MCF7 cells MlzCVJJwdGmoZYLheIlwdiCjc4PhfS=> MlLUO|IhcA>? NGDmSmNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIV{fHKxZ3XuMYRm\mmlaXXueEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;Nj60[U0xPiEQvF2= NHXERWQzOjR4NE[4NS=>
HeLa cells MVLGeY5kfGmxbjDhd5NigQ>? MnzqRYN1cX[jdHnvckBw\iCnc4Tyc4dmdiC{ZYPwc45{\SCnbHXt[Y51KGmwIFjlUIEh[2WubIOgd5Ri[my7IITyZY5{\mWldHXkJJdqfGhiaIXtZY4hTXO2cn;n[Y4hemWlZYD0c5Ih[WyyaHGsJGVEPTB;MnWtNFUh|ryP Mnj5NVE6ODZ{OEC=
HEK293 cells MWjGeY5kfGmxbjDhd5NigQ>? MXzB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIFXSZYxxcGFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9Nk41\S1yNTFOwG0> NF3kWpkzPTNyNU[4PC=>
human Ishikawa cells MVzGeY5kfGmxbjDhd5NigQ>? NHu5U404OiCq MYLFd5Rzd2enbnnjJIFkfGm4aYT5JIF1KGW|dILv[4VvKHKnY3XweI9zKGmwIHj1cYFvKEm|aHnrZZdiKGOnbHzzJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDhcItidGmwZTDwbI9{eGijdHHz[UBmgHC{ZYPzbY9vKGGodHXyJFczKGi{czDifUBucWO{b4DsZZRmKHKnYXTldkwhTUN3ME2yMlQ3\S1yNTFOwG0> MoizNlI1PjR4OEG=
CHO-K1 cells MUnGeY5kfGmxbjDhd5NigQ>? M3eyfVI1KGh? MX3UdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDv[kBGWmKndHGgdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEOKTz3LNUBk\WyuczDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUOuOoUuODVizszN NIjne3YzOjZ2N{KxOy=>
T47D cells NX\CNVQxTnWwY4Tpc44h[XO|YYm= NY\aV3Z[SWexbnnzeEBm\m[nY4Sgc44hfHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iVES3SEBk\WyuczDlfJBz\XO|aX7nJIV{fHKxZ3XuJJJm[2WydH;yJIFteGijLDDFR|UxRTenLUC1JO69VQ>? NV\VXpZtOTJ2NUmwNVc>
human HEC1 cells NGnUb3lHfW6ldHnvckBie3OjeR?= NEe1WZIzPCCq MUXB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIH\1cIwudGWwZ4ToJGVT[WyyaHGgdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKGi3bXHuJGhGSzFiY3XscJMh[29vZYjwdoV{e2mwZzCoSXJGMTJvcGOyMYx2[yCpZX7lJIF{e2W|c3XkJIF{KHS{YX7zZ5JqeHSrb37hcEBi[3SrdnH0bY9vKGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:QWVvMEWg{txO M{izclIyPDhzNEm3
human SK-BR-3 cells NGfrWpVHfW6ldHnvckBie3OjeR?= MV60PEBp NXT3[mx1UW6qaXLpeIlwdiCxZjDjbIVud2G2dILhZ5RidnRvaX7keYNm\CClZXzsJI1q\3KjdHnvckBw\iCqdX3hckBUUy2EUj2zJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC2cnHud5dmdGxibXnndoF1cW:wIHHzd4F6NCCLQ{WwQVAvOSCwTR?= M4KyZVE3PTJyN{Oz
UAS cells MUnGeY5kfGmxbjDhd5NigQ>? NH[3WIwyQCCq NHHSXVFC\2:waYP0JIFkfGm4aYT5JIF1KEWUYnX0ZUBmgHC{ZYPz[YQhcW5iVVHTJINmdGy|IHPvMYV5eHKnc4Ppcoch[mW2YT3sZYN1[W2jc3WgZYZ1\XJiMUigbJJ{KGK7IHLleIEudGGldHHtZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5{NTDuUS=> M1HyOFIyQDh3Mke5
COS7 cells MXjGeY5kfGmxbjDhd5NigQ>? M1HLR2Rqe3CuYXPlcYVvfCCxZjDFNk1CdGW6YU[zN{Bnem:vIFfGVE11[WepZXSgSXJidHCqYTDlfJBz\XO|ZXSgbY4hS0:VNzDj[YxteyCkeTDGRWNUNCCNaU2wMlMhdk1? MYmxOlUzODd|Mx?=
AH109 cells M3PXTGZ2dmO2aX;uJIF{e2G7 MWKyOEBp M1;jWWFod26rc4SgZYN1cX[rdImgZZQhTVKjbIDoZUBz\WOncITvdkBNSkRiZYjwdoV{e2WmIHnuJJlm[XO2IFHINVA6KGOnbHzzJIF{e2W|c3XkJIF{KGmwdHXyZYN1cW:wIIfpeIghW1KFMTDh[pRmeiB{NDDodpMh[nliYXzwbIEu\2GuYXP0c5Nq\GG|ZTDhd5NigSxiRVO1NF0yNjB3IH7N MmXKNlI3PDd{MUe=
HepG2 cells MWHGeY5kfGmxbjDhd5NigQ>? Mlf0NlQhcA>? MmPNRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDFVoFteGijIHX4dJJme3OnZDDpckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTJwMjDuUS=> NXTBdXBzOjJ{OEOzNlg>
COS-1 cells NInyNZRHfW6ldHnvckBie3OjeR?= NEDtSYxKdiC4aYTyc{Bi\2:waYP0JIFkfGm4aYT5JIZweiCnc4Tyc4dmdiC{ZXPldJRweiCjbIDoZUBmgHC{ZYPz[YQhcW5iQ1;TMVEh[2WubIOsJGVEPTB;Mj60JI5O MXSxOVcyOzRyNx?=
SAOS-2 cells MnnPSpVv[3Srb36gZZN{[Xl? M1rRO2Z2dmO2aX;uZYwhTXO2cn;n[Y4hemWlZYD0c5Ih[mW2YTDhZ5Rqfmm2eTDifUBu\XSjbHzveIhqd26naX6gbY5lfWO2aX;uJIlvKFODT2OtNkBk\WyuczygSWQ2OD12Lkegcm0> NVKzW2RIOTJ6MkSwOFM>
MDA-MB-231 cells MnLuVJJwdGmoZYLheIlwdiCjc4PhfS=> NWrhbpQ6OiCmYYnz MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDoeY1idiCHUj3u[YdifGm4ZTDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDJiZHH5d{BjgSCPVGSgZZN{[XluIFnDOVA:OzNwNE[g{txO NX;z[pRxOjV{MkK4O|Y>

... Click to View More Cell Line Experimental Data

In vivo Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. [4] Estradiol alone can reverse the ovariectomy-induced decrease in spine density. Estradiol combined with Progesterone initially increases spine density for a period of 2 to 6 hours but then results in a much sharper decrease than is observed following estradiol alone. [5]

Protocol

Solubility (25°C)

In vitro DMSO 54 mg/mL (198.25 mM)
Ethanol 5 mg/mL (18.35 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 272.38
Formula

C18H24O2

CAS No. 50-28-2
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01923298 Active, not recruiting Estrogen Levels Among Breast Cancer Patients University of Arizona August 9, 2013 Phase 2
NCT00370019 Withdrawn Premature Ovarian Failure Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) August 25, 2006 Phase 2
NCT03043924 Not yet recruiting Polycystic Ovary Syndrome University Hospital, Lille|National Research Agency, France March 2017 --
NCT03018366 Recruiting Estrogen Deficiency|Cardiovascular Disease (CVD)|Hypothalamic Amenorrhea Cedars-Sinai Medical Center January 2017 Phase 2
NCT03003949 Not yet recruiting Perimenopausal Disorder|Stress, Emotional University of North Carolina, Chapel Hill|National Institute of Mental Health (NIMH) January 2017 --
NCT02792153 Recruiting Anorexia Nervosa Johns Hopkins University December 2016 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID