Estradiol valerate

Catalog No.S3149

Estradiol valerate Chemical Structure

Molecular Weight(MW): 356.5

Estradiol is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Estradiol is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.
Targets
ER [1]
In vitro

Estradiol (10 nM) rapidly activates sphingosine kinase isoenzyme SphK1 as determined by enhanced phosphorylation on Ser225 in MCF-7 cells. Estradiol (20 nM) stimulates rapid release of sphingosine 1-phosphate (S1P) and dihydro-S1P from MCF-7 cells. SphK1 and estrogen receptor α are mainly responsible for formation of S1P and dihydro-S1P. Down-regulation of ABCC1 or ABCG2 with siRNAs or pharmacological inhibitors decreases Estradiol (10 nM)-mediated release of S1P or dihydro-S1P from MCF-7 cells. [1] Estradiol (10 nM) inhibits miR-21 expression in MCF-7 human breast cancer cells mediated by estrogen receptor α. Estradiol (10 nM) activates several miR-21 target gene reporters activity in MCF-7 cells through inhibiting miR-21 expression. Estradiol (10 nM) increases endogenous miR-21 target genes expression in protein but not RNA levels in MCF-7 cells. [2]

In vivo Estradiol (80 μg/kg/day, s.c.) significantly decreases the absolute numbers of total peritoneal cell and macrophages, characterized by a double F4/80- and CD11b-positive staining, in ovariectomized C57BL/6J mice. Estradiol (80 μg/kg/day, s.c.) enhances the LPS-induced expression of proinflammatory cytokines by TGC-elicited macrophages through inhibition of PI3K activity in ovariectomized C57BL/6J mice. Proinflammatory effect of Estradiol is abolished by downregulate estrogen receptor α activity in thioglycolate-elicited macrophages. [3]

Protocol

Solubility (25°C)

In vitro DMSO 71 mg/mL (199.15 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 356.5
Formula

C23H32O3

CAS No. 979-32-8
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02845388 Completed Infertility Omar Ahmed El Sayed Saad|Ain Shams Maternity Hospital September 2015 Phase 2
NCT02458404 Recruiting Luteal Phase Defect Reproductive Medicine Associates of New Jersey March 2015 --
NCT02352090 Recruiting Contraception Helsinki University Central Hospital|Oulu University Hospital February 2015 Phase 4
NCT02330757 Recruiting Infertility Mansoura University January 2015 Phase 4
NCT02272647 Recruiting Healthy Mayo Clinic December 2014 Phase 1
NCT02406690 Enrolling by invitation Endometrial Dysfunction Reproductive Medicine Associates of New Jersey November 2014 --

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Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID