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Vepdegestrant (ARV471)
Vepdegestrant (ARV471) is an orally bioavailable estrogen receptor-targeting (ER-targeting) PROTAC for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer.
Vepdegestrant (ARV471) Chemical Structure
CAS: 2229711-68-4
Purity & Quality Control
Vepdegestrant (ARV471) Related Products
| Related Targets | Estrogen receptor Progesterone receptor ERR | Click to Expand |
|---|---|---|
| Related Products | Cholesterol Endoxifen HCl G15 Licochalcone A AZD9496 PHTPP Liquiritigenin Brilanestrant (GDC-0810) Pregnenolone Estriol Lasofoxifene Tartrate Equol Genistin (Genistoside) Erteberel (LY500307) GSK5182 | Click to Expand |
| Related Compound Libraries | FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Exosome Secretion Related Compound Library Human Hormone Related Compound Library | Click to Expand |
Signaling Pathway
Choose Selective Estrogen/progestogen Receptor Inhibitors
Biological Activity
| Description | Vepdegestrant (ARV471) is an orally bioavailable estrogen receptor-targeting (ER-targeting) PROTAC for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer. | ||
|---|---|---|---|
| Targets |
|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06125522 | Not yet recruiting | Breast Cancer |
Pfizer|Arvinas Estrogen Receptor Inc.|Carrick Therapeutics Limited |
November 10 2023 | Phase 2 |
| NCT05930925 | Completed | Healthy |
Pfizer|Arvinas Estrogen Receptor Inc. |
June 12 2023 | Phase 1 |
| NCT05654623 | Recruiting | Advanced Breast Cancer |
Pfizer|Arvinas Estrogen Receptor Inc. |
March 3 2023 | Phase 3 |
| NCT05573555 | Recruiting | Breast Cancer |
Pfizer|Arvinas Estrogen Receptor Inc. |
March 1 2023 | Phase 2 |
Chemical Information & Solubility
| Molecular Weight | 723.9 | Formula | C45H49N5O4 |
| CAS No. | 2229711-68-4 | SDF | -- |
| Storage (From the date of receipt) | 3 years -20°C powder | ||
|
In vitro |
DMSO : 100 mg/mL ( (138.14 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Water : Insoluble Ethanol : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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