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Evista(Raloxifene Hydrochloride) Chemical Structure
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Biological Activity
Raloxifene has estrogen and tamoxifen-like effects on bone and serum cholesterol levels in ovariectomized rats. At 5 weeks, ovariectomy induced a 9% and 18% decrease in the bone mineral density of the lumbar vertebrae L1-4 and proximal tibiae, respectively. Raloxifene prevented this loss of bone with EC50=0.3 mg/kg/day for both the axial and appendicular skeleton. [1]
Raloxifene, which demonstrated an extremely low IC50 value of 2.9 nM for phthalazine oxidase in human liver cytosol. [2]
References on Evista(Raloxifene Hydrochloride)
- [] DMD 2004;32:89–97
Chemical Information
| Molecular Weight (WM): | 510.04 |
|---|---|
| Formula: | C28H27NO4S.HCl |
| CAS No.: | 82640-04-8 |
| Synonyms: |
Raloxifene Hydrochloride, keoxifene
|
| Dissolve in (25°C): | DMSO ≥102mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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