Evista(Raloxifene Hydrochloride) Chemical Structure
Fulvestrant (Faslodex) is a Synthetic estrogen receptor antagonist(SERD)
Dienogest is an orally active synthetic progesterone (or progestin).
LY500307 (SERBA-1) is a potent, selective estrogen receptor β agonist with an EC50 of 0.66 nM.
Hexestrol(Bibenzyl) is a novel type of 17βhydroxysteroid dehydrogenase, AKR1C1and AKR1C2 potent inhibitor with IC50 of 0.8, 9.5, 2.8 µM, respectively and exhibits strong affinity for estrogen receptors.
Andarine (GTX-007) is an investigational selective androgen receptor modulator (SARM) and an active partial agonist.
An androgen receptor modulator (SARM)
Anastrozole inhibits the enzyme aromatase.
Fulvestrant (Faslodex) is a Synthetic estrogen receptor antagonist(SERD)
Exemestane was found to inhibit human placental aromatase with IC50 of 42 nM.
Finasteride is an inhibitor of steroid Type II 5α-reductase.
Raloxifene has estrogen and tamoxifen-like effects on bone and serum cholesterol levels in ovariectomized rats. At 5 weeks, ovariectomy induced a 9% and 18% decrease in the bone mineral density of the lumbar vertebrae L1-4 and proximal tibiae, respectively. Raloxifene prevented this loss of bone with EC50=0.3 mg/kg/day for both the axial and appendicular skeleton. [1]
Raloxifene, which demonstrated an extremely low IC50 value of 2.9 nM for phthalazine oxidase in human liver cytosol. [2]
| Molecular Weight (WM): | 510.04 |
|---|---|
| Formula: | C28H27NO4S.HCl |
| CAS No.: | 82640-04-8 |
| Synonyms: |
Raloxifene Hydrochloride, keoxifene
|
| Dissolve in (25°C): | DMSO ≥102mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
A collection of 864 bioactive compounds
A collection of 481 inhibitors
A collection of 194 kinase inhibitors
A collection of 85 tyrosine kinase inhibitors.
A collection of 426 FDA approved drugs
A collection of 139 natural products
A collection of 40 chemotherapeutic agents
A unique collection of 17 small molecule modulators
A unique collection of 47 small molecule inhibitors
A unique collection of 63 GPCR small molecules
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