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(20S)-Protopanaxatriol

Name: (20S)-Protopanaxatriol
Brand: Selleck Chemicals
SKU: S3617
Rating: 5 (1 reviews)

Synonyms: g-PPT, 20(S)-APPT

Catalog No.S3617 Purity: 99.43%

(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).

(20S)-Protopanaxatriol Chemical Structure

CAS: 34080-08-5

Purity & Quality Control

Batch: S361701 DMSO] 95 mg/mL] false] Ethanol] 95 mg/mL] false] Water] Insoluble] false Purity: 99.43%

99.43

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Biological Activity

Description	(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).

In vitro
In vitro	Protopanaxtriol (Ppt) is a neuroprotective ginseng extract. Ppt exerts its antioxidative activity via several mechanisms, such as direct scavenging of free radicals and restoration of succinate dehydrogenase activity. These mechanisms may contribute to its potent antioxidative and putative neuroprotective activities^[1]. Ppt exhibited strong noncompetitive inhibition towards UGT1A1 and competitive inhibition towards UGT2B7. The inhibition kinetic parameters (Ki) were calculated to be 8.8 and 2.2 μM for UGT1A1 and UGT2B7, respectively^[2]. PPT could repress the viability and invasiveness, and promote the apoptosis in A549 and SK-MES-1 cells.
Cell Research	Cell lines	A549 cells or SK-MES-1 cells
	Concentrations	0, 0.4, 4 or 40 uM
	Incubation Time	48 h
	Method	A549 cells or SK-MES-1 cells are seeded in 96-well plates (3×10³ cells/well), and then treated with different concentration of PPD, PPT, G-Rg3 or G-Rh2 (0, 0.4, 4 or 40 μM) for 48 h, with cisplatin (2 ug/ml) as a positive control and 0.1% DMSO as a blank control. Then these cells are collected and detected the viability by the cell-counting Kit-8 (CCK-8) assay.

In Vivo
In vivo	Protopanaxtriol (Ppt) is shown to reduce learning and memory impairment associated with Alzheimer's diseases and protect against 3-NP-induced oxidative stressin the rat model of Huntington's disease, which is associated with its anti-oxidant activity. Ppt prevents short- and long-term memory impairments induced by chronic sleep deprivation probably through antagonizing oxidative stress in the cortex and hippocampus^[1].
Animal Research	Animal Models	ICR male mice
	Dosages	20μmol/kg, 40μmol/kg
	Administration	i.p.

References

Chemical Information & Solubility

Molecular Weight	476.73	Formula	C₃₀H₅₂O₄
CAS No.	34080-08-5	SDF	Download (20S)-Protopanaxatriol SDF
Smiles	CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)O)C)O)C)O)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 95 mg/mL ( (199.27 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 95 mg/mL

Water : Insoluble

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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