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AChR agonists/antagonist

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S6887 Clozapine N-oxide (CNO chemical) CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared.
Theranostics, 2025, 15(5):1822-1841
STAR Protoc, 2025, 6(1):103542
Theranostics, 2024, 14(7):2881-2896
S2462 Donepezil HCl Donepezil HCl is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.This product is not soluble in PBS solution. Please do not dissolve it in PBS for administration.
Sci Adv, 2025, 11(14):eads7191
Theranostics, 2023, 13(6):1826-1842
J Cell Physiol, 2023, 10.1002/jcp.31057
Verified customer review of Donepezil HCl
S2497 Pancuronium dibromide Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.
Nat Commun, 2025, 16(1):7764
J Immunother Cancer, 2024, 12(11)e009805
Imaging Neurosci (Camb), 2024, 2imag-2-00314
S2629 PNU-120596 PNU-120596 (Nsc 216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
Front Med (Lausanne), 2021, 8:642960
J Leukoc Biol, 2020, 10.1002/JLB.6MA0720-344RRR
Pharmacol Biochem Behav, 2020, 10.1016/j.pbb.2020.172916
Verified customer review of PNU-120596
S4231 Pilocarpine HCl Pilocarpine HCl (NSC 5746) is a selective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
Viruses, 2024, 16(10)1559
Heliyon, 2024, 10(1):e23945
Theranostics, 2021, 11(12):5986-6005
S2508 Scopolamine (LSM-4015) HBr Scopolamine HBr (LSM-4015,NSC 61806,(-)-Scopolamine hydrobromide, Hyoscine hydrobromide, Scopine hydrobromide) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.
Heliyon, 2024, 10(1):e23945
Zool Res, 2023, 44(4):712-724
Exp Ther Med, 2020, 20(4):3625-3632
S2452 Amfebutamone (Bupropion) HCl Amfebutamone (Bupropion) HCl(Wellbutrin) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.
Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433
Front Microbiol, 2020, 10:2936
G3 (Bethesda), 2014, 4(6):1081-9
S4162 Benzethonium Chloride Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.
Nat Commun, 2023, 10.1038/s41467-023-42332-0
Nat Commun, 2023, 14(1):6690
iScience, 2023, 26(8):107477
S2614 Arecoline HBr Arecoline(NSC-31750) is a muscarinic acetylcholine receptor agonist.
Antioxidants (Basel), 2024, 13(4)430
Int J Oral Sci, 2024, 16(1):17
Oncogene, 2020, 39(11):2437-2449
Verified customer review of Arecoline HBr
S5073 Donepezil Donepezil (Aricept, Donepezilo) is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type.
Cell Biosci, 2024, 14(1):146
Theranostics, 2023, 13(6):1826-1842
Front Bioeng Biotechnol, 2022, 10:855755

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