AChR

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2462 Donepezil HCl 5 mg/mL <1 mg/mL <1 mg/mL
S2547 Tiotropium Bromide hydrate <1 mg/mL 8 mg/mL <1 mg/mL
S2251 (-)-Huperzine A (HupA) <1 mg/mL 0.66 mg/mL <1 mg/mL
S2497 Pancuronium dibromide 100 mg/mL 100 mg/mL 100 mg/mL
S2550 Tolterodine tartrate 17 mg/mL 95 mg/mL 6 mg/mL
S3701 Benactyzine hydrochloride 72 mg/mL 72 mg/mL 72 mg/mL
S2240 Fesoterodine Fumarate 100 mg/mL 100 mg/mL 100 mg/mL
S3005 Paroxetine HCl 1 mg/mL 73 mg/mL 35 mg/mL
S2629 PNU-120596 <1 mg/mL 62 mg/mL 1 mg/mL
S1754 Oxybutynin <1 mg/mL 71 mg/mL 71 mg/mL
S2452 Amfebutamone (Bupropion) HCl <1 mg/mL 8 mg/mL <1 mg/mL
S3048 Solifenacin succinate 96 mg/mL 3 mg/mL 5 mg/mL
S1440 Varenicline Tartrate 72 mg/mL 1 mg/mL <1 mg/mL
S1339 Galanthamine HBr 36 mg/mL <1 mg/mL <1 mg/mL
S1405 Vecuronium Bromide 4 mg/mL 100 mg/mL 100 mg/mL
S1683 Ipratropium Bromide 83 mg/mL 83 mg/mL 83 mg/mL
S2549 Trospium chloride 86 mg/mL 41 mg/mL 42 mg/mL
S2130 Atropine sulfate monohydrate 139 mg/mL 139 mg/mL 139 mg/mL
S4031 Aclidinium Bromide <1 mg/mL 113 mg/mL <1 mg/mL
S1397 Rocuronium Bromide 122 mg/mL 122 mg/mL 122 mg/mL
S1978 Methscopolamine 67 mg/mL 79 mg/mL <1 mg/mL
S3047 Otilonium Bromide 113 mg/mL 113 mg/mL 113 mg/mL
S2508 Scopolamine HBr 76 mg/mL 76 mg/mL <1 mg/mL
S2455 Bethanechol chloride 39 mg/mL 39 mg/mL 39 mg/mL
S2471 Gallamine Triethiodide 100 mg/mL 100 mg/mL <1 mg/mL
S1608 Pyridostigmine Bromide 52 mg/mL 52 mg/mL 52 mg/mL
S2659 5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM) <1 mg/mL 68 mg/mL 68 mg/mL
S2614 Arecoline HBr 47 mg/mL 47 mg/mL 10 mg/mL
S4231 Pilocarpine HCl 48 mg/mL 48 mg/mL 48 mg/mL
S2087 Rivastigmine Tartrate 80 mg/mL 42 mg/mL 80 mg/mL
S1929 Irsogladine <1 mg/mL 2 mg/mL <1 mg/mL
S2490 Neostigmine Bromide 60 mg/mL <1 mg/mL <1 mg/mL
S3144 Darifenacin HBr <1 mg/mL 100 mg/mL <1 mg/mL
S3202 Catharanthine <1 mg/mL 67 mg/mL 3 mg/mL
S4575 Pralidoxime chloride 34 mg/mL <1 mg/mL 1 mg/mL
S4014 Hyoscyamine <1 mg/mL 58 mg/mL 58 mg/mL
S4023 Procaine HCl 55 mg/mL 55 mg/mL <1 mg/mL
S4024 Homatropine Methylbromide 74 mg/mL 74 mg/mL 10 mg/mL
S4025 Homatropine Bromide 71 mg/mL 71 mg/mL <1 mg/mL
S4027 Flavoxate HCl 10 mg/mL 3 mg/mL <1 mg/mL
S4121 Succinylcholine Chloride Dihydrate 79 mg/mL 1 mg/mL <1 mg/mL
S2054 Orphenadrine Citrate <1 mg/mL 92 mg/mL <1 mg/mL
S4034 Diphemanil Methylsulfate 28 mg/mL 25 mg/mL <1 mg/mL
S4617 Dextromethorphan hydrobromide hydrate <1 mg/mL 74 mg/mL 74 mg/mL
S1832 Atracurium Besylate 33 mg/mL 100 mg/mL 100 mg/mL
S4143 Pentoxyverine Citrate 100 mg/mL 100 mg/mL 8 mg/mL
S4619 Itopride hydrochloride 78 mg/mL 78 mg/mL 38 mg/mL
S4422 Nitenpyram 54 mg/mL 54 mg/mL 54 mg/mL
S7366 LY2119620 <1 mg/mL 87 mg/mL 10 mg/mL
S4162 Benzethonium Chloride 90 mg/mL 90 mg/mL 90 mg/mL
S2287 Cytisine 38 mg/mL 38 mg/mL 38 mg/mL
S4171 Choline Chloride 28 mg/mL 28 mg/mL 28 mg/mL
S4069 Hexamethonium Dibromide 73 mg/mL <1 mg/mL <1 mg/mL
S4660 Glycopyrrolate 79 mg/mL 65 mg/mL 59 mg/mL
S4072 Decamethonium Bromide 84 mg/mL 34 mg/mL 25 mg/mL
S4505 Vinblastine sulfate <1 mg/mL 100 mg/mL <1 mg/mL
S3117 Oxybutynin chloride 4 mg/mL 79 mg/mL 79 mg/mL
S4542 Trihexyphenidyl hydrochloride <1 mg/mL 7 mg/mL 24 mg/mL
S2082 Adiphenine HCl 70 mg/mL 30 mg/mL 18 mg/mL
S4718 Acetylcholine iodide 54 mg/mL 54 mg/mL 54 mg/mL
S4292 Diphenidol HCl 13 mg/mL 69 mg/mL 36 mg/mL
S1913 Tropicamide <1 mg/mL 57 mg/mL 57 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S2462

Donepezil HCl

Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.

S2547

Tiotropium Bromide hydrate

Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.

S2251

(-)-Huperzine A (HupA)

(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.

S2497

Pancuronium dibromide

Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.

S2550

Tolterodine tartrate

Tolterodine tartrate is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist.

S3701New

Benactyzine hydrochloride

Benactyzine hydrochloride is a centrally acting muscarinic antagonist. It is used as an antidepressant in the treatment of depression and associated anxiety.

S2240

Fesoterodine Fumarate

Fesoterodine Fumarate is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.

S3005

Paroxetine HCl

Paroxetine HCl is an antidepressant drug of the SSRI type.

S2629

PNU-120596

PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.

S1754

Oxybutynin

Oxybutynin is a competitive antagonist of the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor, used to relieve urinary and bladder difficulties.

S2452

Amfebutamone (Bupropion) HCl

Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.

S3048

Solifenacin succinate

Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.

S1440

Varenicline Tartrate

Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.

S1339

Galanthamine HBr

Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.

S1405

Vecuronium Bromide

Vecuronium is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.

S1683

Ipratropium Bromide

Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).

S2549

Trospium chloride

Trospium chloride is a competitive muscarinic cholinergic receptor antagonist.

S2130

Atropine sulfate monohydrate

Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.

S4031

Aclidinium Bromide

Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.

S1397

Rocuronium Bromide

Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia.

S1978

Methscopolamine

Methscopolamine is a muscarinic acetylcholine receptor blocker.

S3047

Otilonium Bromide

Otilonium bromide is an antimuscarinic.

S2508

Scopolamine HBr

Scopolamine HBr is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 nM.

S2455

Bethanechol chloride

Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.

S2471

Gallamine Triethiodide

Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM.

S1608

Pyridostigmine Bromide

Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.

S2659

5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM)

5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.

S2614

Arecoline HBr

Arecoline is a muscarinic acetylcholine receptor agonist.

S4231

Pilocarpine HCl

Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.

S2087

Rivastigmine Tartrate

Rivastigmine Tartrate is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.

S1929

Irsogladine

Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.

S2490

Neostigmine Bromide

Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.

S3144

Darifenacin HBr

Darifenacin is a selective M3 muscarinic receptor antagonist with pKi of 8.9.

S3202

Catharanthine

Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.

S4575

Pralidoxime chloride

Pralidoxime is an antidote to organophosphate pesticides and chemicals; An acetylcholinesterase (AChE) reactivator.

S4014

Hyoscyamine

Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.

S4023

Procaine HCl

Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.

S4024

Homatropine Methylbromide

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

S4025

Homatropine Bromide

Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

S4027

Flavoxate HCl

Flavoxate is a muscarinic AChR antagonist with IC50 of 12.2 μM.

S4121

Succinylcholine Chloride Dihydrate

Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.

S2054

Orphenadrine Citrate

Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.

S4034

Diphemanil Methylsulfate

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).

S4617

Dextromethorphan hydrobromide hydrate

Dextromethorphan is an antitussive (cough suppressant) drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses).

S1832

Atracurium Besylate

Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.

S4143

Pentoxyverine Citrate

Pentoxyverine Citrate is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold.

S4619

Itopride hydrochloride

Itopride hydrochloride is an AChE inhibitor. The IC50 of itopride with AChE is 2.04 +/- 0.27 μM.

S4422

Nitenpyram

Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.

S7366

LY2119620

LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.

S4162

Benzethonium Chloride

Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.

S2287

Cytisine

Cytisine is a nicotinic acetylcholine receptor agonist.

S4171

Choline Chloride

Choline chloride is a quaternary ammonium salt used as an additive for animal feed. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

S4069

Hexamethonium Dibromide

Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.

S4660

Glycopyrrolate

Glycopyrrolate is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.

S4072

Decamethonium Bromide

Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.

S4505

Vinblastine sulfate

Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.

S4687

Rivastigmine

Rivastigmine is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM).

S3117

Oxybutynin chloride

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.

S4542

Trihexyphenidyl hydrochloride

Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.

S2082

Adiphenine HCl

Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.

S4718

Acetylcholine iodide

Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.

S4292

Diphenidol HCl

Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.

S1913

Tropicamide

Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.