Dopamine Receptor

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S4569New

Fluphenazine dihydrochloride

Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits Histamine H1 Receptor.

S2452

Amfebutamone (Bupropion) HCl

Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.

S3201

Trifluoperazine 2HCl

Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.

S1642

Methyldopa

Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.

S4732New

MPTP hydrochloride

MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism.

S4639New

Brexpiprazole

Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors.

S4618New

Fenoldopam mesylate

Fenoldopam is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.

S1726

Levodopa

Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.

S2451

Amantadine HCl

Amantadine HCl is used to treat or prevent infections of the respiratory tract caused by a certain virus.

S2011

Pramipexole 2HCl Monohydrate

Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.

S2460

Pramipexole

Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

S2529

Dopamine HCl

Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.

S4000

Pergolide Mesylate

Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.

S7993

SKF38393 HCl

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

S2168

PD128907 HCl

PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

S4274

Rotigotine

Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.

S2493

Olanzapine

Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.

S1763

Quetiapine Fumarate

Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.

S3163

Benztropine mesylate

Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.

S2456

Chlorpromazine HCl

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.

S1444

Ziprasidone HCl

Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.

S4631New

Prochlorperazine dimaleate salt

Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist.

S4731New

Perphenazine

Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.

S4655New

Sulpiride

Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.

S2461

Domperidone

Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.

S1280

Amisulpride

Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.

S1724

Paliperidone

Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.

S1771

Chlorprothixene

Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.

S4251

Phenothiazine

Phenothiazine is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain.

S4096

Droperidol

Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system.

S3044

Lurasidone HCl

Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.

S2104

Levosulpiride

Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent.

S4086

Loxapine Succinate

Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.

S4151

Penfluridol

Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.

S2437

Rotundine

Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

S4257

Alizapride HCl

Alizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting.

S4289

Metoclopramide HCl

Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

S3189

Ropinirole HCl

Ropinirole a selective dopamine D2 receptors agonist with Ki of 29 nM.

Catalog No. Information Product Use Citations Product Validations
S4569New

Fluphenazine dihydrochloride

Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits Histamine H1 Receptor.

S2452

Amfebutamone (Bupropion) HCl

Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.

S3201

Trifluoperazine 2HCl

Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.

S1642

Methyldopa

Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.

Catalog No. Information Product Use Citations Product Validations
S2493

Olanzapine

Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.

2014, 15(19):8107-13

S1763

Quetiapine Fumarate

Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.

S3163

Benztropine mesylate

Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.

S2456

Chlorpromazine HCl

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.

2014, 58(8):4875-84

2016, 13:25

S1444

Ziprasidone HCl

Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.

S4631New

Prochlorperazine dimaleate salt

Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist.

S4731New

Perphenazine

Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.

S4655New

Sulpiride

Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.

S2461

Domperidone

Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.

S1280

Amisulpride

Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.

S1724

Paliperidone

Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.

S1771

Chlorprothixene

Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.

S4251

Phenothiazine

Phenothiazine is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain.

S4096

Droperidol

Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system.

S3044

Lurasidone HCl

Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.

S2104

Levosulpiride

Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent.

S4086

Loxapine Succinate

Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.

S4151

Penfluridol

Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.

S2437

Rotundine

Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

S4257

Alizapride HCl

Alizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting.

S4289

Metoclopramide HCl

Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

S3189

Ropinirole HCl

Ropinirole a selective dopamine D2 receptors agonist with Ki of 29 nM.

Catalog No. Information Product Use Citations Product Validations
S4639New

Brexpiprazole

Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors.

S4618New

Fenoldopam mesylate

Fenoldopam is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.

S1726

Levodopa

Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.

S2451

Amantadine HCl

Amantadine HCl is used to treat or prevent infections of the respiratory tract caused by a certain virus.

S2011

Pramipexole 2HCl Monohydrate

Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.

S2460

Pramipexole

Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

S2529

Dopamine HCl

Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.

S4000

Pergolide Mesylate

Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.

S7993

SKF38393 HCl

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

S2168

PD128907 HCl

PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

S4274

Rotigotine

Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.

Catalog No. Information Product Use Citations Product Validations
S4732New

MPTP hydrochloride

MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism.