- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S2493||Olanzapine||<1 mg/mL||62 mg/mL||9 mg/mL|
|S1763||Quetiapine Fumarate||<1 mg/mL||36 mg/mL||<1 mg/mL|
|S3163||Benztropine mesylate||81 mg/mL||50 mg/mL||81 mg/mL|
|S2456||Chlorpromazine HCl||71 mg/mL||71 mg/mL||71 mg/mL|
|S1444||Ziprasidone HCl||<1 mg/mL||90 mg/mL||<1 mg/mL|
|S4732||MPTP hydrochloride||41 mg/mL||20 mg/mL||41 mg/mL|
|S2452||Amfebutamone (Bupropion) HCl||<1 mg/mL||8 mg/mL||<1 mg/mL|
|S1726||Levodopa||<1 mg/mL||<1 mg/mL||<1 mg/mL|
|S3201||Trifluoperazine 2HCl||96 mg/mL||88 mg/mL||96 mg/mL|
|S2461||Domperidone||<1 mg/mL||48 mg/mL||1 mg/mL|
|S2451||Amantadine HCl||38 mg/mL||38 mg/mL||38 mg/mL|
|S1280||Amisulpride||<1 mg/mL||73 mg/mL||73 mg/mL|
|S1724||Paliperidone||<1 mg/mL||4 mg/mL||<1 mg/mL|
|S1920||Haloperidol||<1 mg/mL||75 mg/mL||8 mg/mL|
|S2011||Pramipexole 2HCl Monohydrate||60 mg/mL||41 mg/mL||<1 mg/mL|
|S1771||Chlorprothixene||<1 mg/mL||6 mg/mL||28 mg/mL|
|S4251||Phenothiazine||<1 mg/mL||40 mg/mL||<1 mg/mL|
|S4096||Droperidol||<1 mg/mL||76 mg/mL||<1 mg/mL|
|S3044||Lurasidone HCl||<1 mg/mL||1 mg/mL||<1 mg/mL|
|S2104||Levosulpiride||<1 mg/mL||69 mg/mL||<1 mg/mL|
|S2460||Pramipexole||<1 mg/mL||42 mg/mL||42 mg/mL|
|S2529||Dopamine HCl||38 mg/mL||38 mg/mL||<1 mg/mL|
|S4086||Loxapine Succinate||<1 mg/mL||89 mg/mL||2 mg/mL|
|S4000||Pergolide Mesylate||82 mg/mL||10 mg/mL||<1 mg/mL|
|S4569||Fluphenazine dihydrochloride||100 mg/mL||100 mg/mL||30 mg/mL|
|S4731||Perphenazine||<1 mg/mL||74 mg/mL||74 mg/mL|
|S4618||Fenoldopam mesylate||<1 mg/mL||80 mg/mL||<1 mg/mL|
|S7993||SKF38393 HCl||<1 mg/mL||58 mg/mL||6 mg/mL|
|S4151||Penfluridol||<1 mg/mL||100 mg/mL||100 mg/mL|
|S2437||Rotundine||<1 mg/mL||8 mg/mL||<1 mg/mL|
|S1642||Methyldopa||<1 mg/mL||2 mg/mL||<1 mg/mL|
|S4631||Prochlorperazine dimaleate salt||<1 mg/mL||74 mg/mL||2 mg/mL|
|S4639||Brexpiprazole||<1 mg/mL||24 mg/mL||<1 mg/mL|
|S4257||Alizapride HCl||70 mg/mL||42 mg/mL||<1 mg/mL|
|S4655||Sulpiride||<1 mg/mL||68 mg/mL||<1 mg/mL|
|S1789||Tetrabenazine (Xenazine)||<1 mg/mL||58 mg/mL||32 mg/mL|
|S2168||PD128907 HCl||50 mg/mL||12 mg/mL||<1 mg/mL|
|S4219||Azaperone||<1 mg/mL||65 mg/mL||34 mg/mL|
|S8097||C-DIM12||<1 mg/mL||71 mg/mL||71 mg/mL|
|S4274||Rotigotine||<1 mg/mL||63 mg/mL||63 mg/mL|
|S4289||Metoclopramide HCl||67 mg/mL||67 mg/mL||67 mg/mL|
|S3189||Ropinirole HCl||60 mg/mL||10 mg/mL||<1 mg/mL|
|S3188||(+,-)-Octopamine HCl||38 mg/mL||38 mg/mL||11 mg/mL|
- Dopamine Receptor Inhibitors (43)
- New Dopamine Receptor Products
|Catalog No.||Information||Product Use Citations||Product Validations|
Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.
Olanzapine and aripiprazole differentially regulate cellular glucose uptake of PBMC. Bar graphs depict cellular glucose uptake assessed by 18F-FDG in PBMC after 72 h of stimulation with the indicated concentrations of olanzapine (Olan, A) or aripiprazole (Arip, B) relative to corresponding DMSO controls (Ctrl) and normalized to protein content. Data are depicted as mean ± SD. P-values were computed by one-way ANOVA followed by Dunnett's Multiple Comparison Test. ***P < 0.001, **P < 0.01, *P < 0.05 versus control; results were obtained from n ¼ 4e6 independent cell isolations measured in duplicate.
Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression and shows affinity for various neurotransmitter receptors including serotonin, dopamine, histamine, and adrenergic receptors.
Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.
Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.
Low-micromolar amounts of chlorpromazine inhibit SARS-CoV-induced cytopathology. Vero E6 cells in 96-well plates were infected with SARS-CoV isolate Frankfurt-1 (MOI, 0.005) in the presence of 0 to 16 μM CPZ (B), given at t of +1 h p.i. Cells were incubated for 3 days, and viability was monitored using an MTS assay. In parallel, potential compound cytotoxicity was monitored in mock-infected Vero E6 cells. Graphs show the results (averages and SD) of a representative experiment that was performed in quadruplicate. All experiments were repeated at least twice. For each compound, the EC50, CC50, and SI values are given.
Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.
MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism.
Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.
Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.
(A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. *p < 0.05; ***p < 0.001 versus the control of each group.
Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.
Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.
Amantadine HCl is used to treat or prevent infections of the respiratory tract caused by a certain virus.
Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.
Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.
Haloperidol (Haldol) is an antipsychotic and butyrophenone.
Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.
Phenothiazine is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain.
Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system.
Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.
Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent.
Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.
Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.
Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits Histamine H1 Receptor.
Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
Fenoldopam is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.
SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.
Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist.
Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors.
Alizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting.
Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
Tetrabenazine(Nitoman, Xenazine) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2; Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2.
PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
Azaperone crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.
Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.
Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.
Ropinirole a selective dopamine D2 receptors agonist with Ki of 29 nM.
Octopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates.