Opioid Receptor

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Opioid Receptor Agonists | Antagonists (9)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2480 Loperamide HCl Loperamide HCl is an opioid-receptor agonist with an ED50 of 0.15 mg/kg.
S3066 Naloxone HCl Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.
S2722 JTC-801 JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ.
S1139 ADL5859 HCl ADL5859 HCl is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel. Phase 2.
  • Expert Opin Investig Drugs, 2012, 21(11):1607-18
S2103 Naltrexone HCl Naltrexone HCl is an opioid receptor antagonist with IC50 of 8 nM used primarily in the management of alcohol dependence and opioid dependence.
  • Sci Rep, 2014, 4:7270
S2322 (+)-Matrine Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.
S2503 Racecadotril Racecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μM
S3204 Meptazinol HCl Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM.
S2085 Trimebutine Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S2480 Loperamide HCl <1 mg/mL 22 mg/mL 4 mg/mL
S3066 Naloxone HCl 73 mg/mL 73 mg/mL <1 mg/mL
S2722 JTC-801 <1 mg/mL 90 mg/mL 31 mg/mL
S1139 ADL5859 HCl 5 mg/mL 86 mg/mL 1 mg/mL
S2103 Naltrexone HCl 14 mg/mL 14 mg/mL <1 mg/mL
S2503 Racecadotril <1 mg/mL 22 mg/mL 77 mg/mL
S3204 Meptazinol HCl 54 mg/mL 54 mg/mL 54 mg/mL
S2085 Trimebutine <1 mg/mL 50 mg/mL <1 mg/mL
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