MAO

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1472 Safinamide Mesylate 80 mg/mL 80 mg/mL 13 mg/mL
S2102 Rasagiline Mesylate 53 mg/mL 53 mg/mL 53 mg/mL
S4246 Tranylcypromine (2-PCPA) HCl 33 mg/mL 33 mg/mL 33 mg/mL
S3212 Moclobemide (Ro 111163) <1 mg/mL 53 mg/mL 10 mg/mL
S4856 Iproniazid 35 mg/mL 35 mg/mL 35 mg/mL
S3868 Harmine -1 mg/mL 42 mg/mL -1 mg/mL
S3740 Selegiline HCl 44 mg/mL <1 mg/mL <1 mg/mL
S3690 Pargyline hydrochloride 39 mg/mL 39 mg/mL 39 mg/mL
S4033 Sennoside A <1 mg/mL 100 mg/mL <1 mg/mL
S2302 Glycyrrhizin (Glycyrrhizic Acid) <1 mg/mL 100 mg/mL 100 mg/mL
S2339 Paeonol <1 mg/mL 33 mg/mL 33 mg/mL
S4717 Isatin <1 mg/mL 29 mg/mL 10 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S1472

Safinamide Mesylate

Safinamide Mesylate is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3.

S2102

Rasagiline Mesylate

Rasagiline Mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.

S4246

Tranylcypromine (2-PCPA) HCl

Tranylcypromine is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.

S3212

Moclobemide (Ro 111163)

Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.

S4856New

Iproniazid

Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.

S3868New

Harmine

Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but not the variant MAO-B.

S3740New

Selegiline HCl

Selegiline (L-deprenyl) is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B) with selectivity for MAO-B vs MAO-A and used in the treatment of Parkinson's disease.

S3690New

Pargyline hydrochloride

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.

S4033

Sennoside A

Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.

S2302

Glycyrrhizin (Glycyrrhizic Acid)

Glycyrrhizin (Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).

S2339

Paeonol

Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.

S4717

Isatin

Isatin is an endogenous MAO inhibitor with an IC50 of 15 μM and more active against MAO-B than MAO-A.