Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1472 Safinamide Mesylate 80 mg/mL 80 mg/mL 13 mg/mL
S2102 Rasagiline Mesylate 53 mg/mL 53 mg/mL 53 mg/mL
S4246 Tranylcypromine (2-PCPA) HCl 33 mg/mL 33 mg/mL 33 mg/mL
S3212 Moclobemide (Ro 111163) <1 mg/mL 53 mg/mL 10 mg/mL
S4033 Sennoside A <1 mg/mL 100 mg/mL <1 mg/mL
S3740 Selegiline HCl 44 mg/mL <1 mg/mL <1 mg/mL
S3690 Pargyline hydrochloride 39 mg/mL 39 mg/mL 39 mg/mL
S2302 Glycyrrhizin (Glycyrrhizic Acid) <1 mg/mL 100 mg/mL 100 mg/mL
S2339 Paeonol <1 mg/mL 33 mg/mL 33 mg/mL
S4717 Isatin <1 mg/mL 29 mg/mL 10 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations

Safinamide Mesylate

Safinamide Mesylate is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3.


Rasagiline Mesylate

Rasagiline Mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.


Tranylcypromine (2-PCPA) HCl

Tranylcypromine is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.


Moclobemide (Ro 111163)

Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.


Sennoside A

Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.


Selegiline HCl

Selegiline (L-deprenyl) is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B) with selectivity for MAO-B vs MAO-A and used in the treatment of Parkinson's disease.


Pargyline hydrochloride

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.


Glycyrrhizin (Glycyrrhizic Acid)

Glycyrrhizin (Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).



Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.



Isatin is an endogenous MAO inhibitor and more active against MAO-B than MAO-A