P-gp Permeability Glycoprotein

Cat.No.	Product Name	Solubility (25°C)
S1481	LY335979 (Zosuquidar 3HCl)	23 mg/mL	127 mg/mL	<1 mg/mL
S1082	Vismodegib (GDC-0449)	<1 mg/mL	84 mg/mL	4 mg/mL

Cat.No.	Product Name	Information	Product Citations
S1481	LY335979 (Zosuquidar 3HCl)	LY335979 (Zosuquidar) is a potent modulator of P-glycoprotein-mediated multidrug resistance with K_i of 60 nM.	Pharmacol Res, 2013, 67(1):79-83
S8028	Tariquidar
S1082	Vismodegib (GDC-0449)	GDC-0449 (Vismodegib, HhAntag691) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM.	Gastroenterology, 2012, 143(5):1319-29.e1-11 Hepatology, 2011, 54(5):1580-90 Gut, 2012, 61(9):1323-9