P-gp

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S8028

Tariquidar

Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.

S7772

Elacridar (GF120918)

Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

S7124

SC144

SC144 is an orally active small-molecule gp130 inhibitor.

S1481

Zosuquidar (LY335979) 3HCl

Zosuquidar (LY335979) 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.

Catalog No. Information Product Use Citations Product Validations
S8028

Tariquidar

Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.

S7772

Elacridar (GF120918)

Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

S7124

SC144

SC144 is an orally active small-molecule gp130 inhibitor.

Catalog No. Information Product Use Citations Product Validations
S1481

Zosuquidar (LY335979) 3HCl

Zosuquidar (LY335979) 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.

2015, 93(2):210-20

2014, 56(1):60-9

2013, 67(1):79-83