P-gp

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P-gp Inhibitors | Modulators (3)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1481 Zosuquidar (LY335979) 3HCl Zosuquidar (LY335979) 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.
  • Biochem Pharmacol, 2015, 93(2):210-20
  • J Lipid Res, 2014, 56(1):60-9
  • Pharmacol Res, 2013, 67(1):79-83
S8028 Tariquidar Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.
  • Vet Parasitol, 2015, 211(1-2):80-8
S7772 Elacridar (GF120918) Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1481 Zosuquidar (LY335979) 3HCl 23 mg/mL 100 mg/mL <1 mg/mL
S8028 Tariquidar <1 mg/mL 52 mg/mL <1 mg/mL
S7772 Elacridar (GF120918) <1 mg/mL 41 mg/mL <1 mg/mL
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