5-HT Receptor

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5-HT Receptor Inhibitors | Agonists | Antagonists | Modulators (52)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S2459 Clozapine Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis.
S2493 Olanzapine Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.
S2232 Ketanserin Ketanserin is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A.
S1333 Fluoxetine HCl Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI)class.
  • G4-GENES GENOM GENET, 2014, 10.1534/g3.114.010819
S1436 Tianeptine sodium Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE) compound used for treating major depressive episodes.
  • Transl Psychiatry, 2014, 4:e411
S1245 Latrepirdine Latrepirdine is an antihistamine drug.
S2698 RS-127445 RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.
S1243 Agomelatine Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.
S1283 Asenapine Asenapine inhibits adrenergic receptor1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
S1432 Sumatriptan Succinate Sumatriptan Succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.
Cat.No. Product Name Information Product Citations Customer Reviews
S1441 Venlafaxine Venlafaxine is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI).
S2875 Prucalopride Prucalopride is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes.
S1869 Dapoxetine HCl Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor.
S3005 Paroxetine HCl Paroxetine HCl is an antidepressant drug of the SSRI type.
S1615 Risperidone Risperidone is an atypical antipsychotic used to treat schizophrenia.
S2663 WAY-100635 Maleate WAY-100635 Maleate is a potent and selective 5-HT1A receptor agonist with pIC50 of 8.87, exhibits >100-fold selectivity against other 5-HT receptor subtypes and major neurotransmitter receptors.
S1975 Aripiprazole Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.
S1488 Naratriptan Naratriptan is a triptan agent that is used for the treatment of migraine headaches.
S2112 Blonanserin Blonanserin is a novel atypical antipsychotic agent with potent dopamine D2 (Ki, 14.8 nM) and serotonin 5-HT2(Ki, 3.98 nM) receptors antagonist properties.
S8021 Vortioxetine (Lu AA21004) HBr Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
Cat.No. Product Name Information Product Citations Customer Reviews
S1607 Rizatriptan Benzoate Rizatriptan Benzoate is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.
S1649 Zolmitriptan Zolmitriptan is a selective serotonin receptor agonist.
S1336 Fluvoxamine maleate Fluvoxamine maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI).
S1345 Granisetron HCl Granisetron HCl is a serotonin 5-HT3 receptor antagonist.
S1385 Mosapride Citrate Mosapride Citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
S2677 BRL-15572 BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.
S2849 SB269970 HCl SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors,
S2894 SB742457 SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.
S8010 PRX-08066 Maleic acid PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2.
S4109 Lorcaserin HCl Lorcaserin HCl is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM.
Cat.No. Product Name Information Product Citations Customer Reviews
S1390 Ondansetron HCl Ondansetron HCl is a serotonin 5-HT3 receptor antagonist.
S1898 Tropisetron Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
S2541 Clomipramine HCl Clomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.
S3024 Lamotrigine Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
S3180 Eletriptan HBr Eletriptan is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively.
S4053 Sertraline HCl Sertraline HCl is a 5-HT antagonist with Ki of 13 nM.
S4113 Desvenlafaxine Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.
S2084 Duloxetine HCl Duloxetine HCl is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
  • J Pharmacol Exp Ther, 2014, 10.1124/jpet.113.211557
  • Am J Physiol Renal Physiol, 2013, 305(12):F1663-8
S2106 Azasetron HCl Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
S4064 Escitalopram Oxalate Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
Cat.No. Product Name Information Product Citations Customer Reviews
S1996 Ondansetron Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
S2096 Almotriptan Malate Almotriptan Malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
S3183 Amitriptyline HCl Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.
S2856 SB271046 SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes.
S2669 LY310762 LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.
S2582 Trazodone HCl Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.
S2025 Urapidil HCl Urapidil HCl is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively.
S3175 Atomoxetine HCl Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
S2852 BRL-54443 BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively, witha weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors.
S3050 Palonosetron HCl Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
Cat.No. Product Name Information Product Citations Customer Reviews
S2865 VUF 10166 VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
S4112 Desvenlafaxine Succinate Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.
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Tags: 5-HT receptor drugs | Serotonin receptor drugs | 5-HT receptor agonist and antagonist drugs | Serotonin receptor antagonist drugs | Serotonin receptor agonist drugs | 5-HT3 receptor antagonist drugs | 5-HT receptor agonist and antagonist clinical trial | 5-HT receptor agonist and antagonist ic50 | 5-HT receptor agonist and antagonist review