GABA Receptor

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1168 Valproic acid sodium salt (Sodium valproate) 33 mg/mL 33 mg/mL 33 mg/mL
S1332 Flumazenil <1 mg/mL 5 mg/mL <1 mg/mL
S1338 Gabapentin HCl 42 mg/mL <1 mg/mL <1 mg/mL
S1329 Etomidate <1 mg/mL 49 mg/mL 49 mg/mL
S2133 Gabapentin 34 mg/mL <1 mg/mL <1 mg/mL
S3634 6-Hydroxyflavone (6-HF) <1 mg/mL 47 mg/mL <1 mg/mL
S7071 (+)-Bicuculline <1 mg/mL 21 mg/mL <1 mg/mL
S1969 Nefiracetam 5 mg/mL 49 mg/mL 49 mg/mL
S3072 (R)-baclofen 8 mg/mL <1 mg/mL <1 mg/mL
S3018 Niflumic acid <1 mg/mL 56 mg/mL <1 mg/mL
S4574 Piperazine 17 mg/mL 8 mg/mL 17 mg/mL
S2026 Ginkgolide A <1 mg/mL 81 mg/mL 2 mg/mL
S2269 Baicalin <1 mg/mL 89 mg/mL <1 mg/mL
S4645 Armodafinil <1 mg/mL 54 mg/mL 20 mg/mL
S2399 Dihydromyricetin <1 mg/mL 64 mg/mL 64 mg/mL
S4661 Tiagabine hydrochloride 11 mg/mL 82 mg/mL 82 mg/mL
S4197 Bemegride <1 mg/mL 31 mg/mL 31 mg/mL
S4270 Oxiracetam 31 mg/mL 31 mg/mL <1 mg/mL
S4700 4-Aminobutyric acid 20 mg/mL <1 mg/mL <1 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S1168

Valproic acid sodium salt (Sodium valproate)

Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

S1332

Flumazenil

Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.

S1338

Gabapentin HCl

Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.

S1329

Etomidate

Etomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative.

S2133

Gabapentin

Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.

S3634New

6-Hydroxyflavone (6-HF)

6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors.

S7071

(+)-Bicuculline

(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.

S1969

Nefiracetam

Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.

S3072

(R)-baclofen

(R)-baclofen is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.

S3018

Niflumic acid

Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.

S4574

Piperazine

Piperazine, GABA receptor agonist, is an anthelmintic used in the treatment of the intestinal nematodes Ascaris lumbricoides and Enterobius vermicularis.

S2026

Ginkgolide A

Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.

S4587

Pentylenetetrazol

Pentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.

S2269

Baicalin

Baicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors.

S4645

Armodafinil

Armodafinil is the R-enantiomer of the racemic synthetic agent modafinil with central nervous system (CNS) stimulant and wakefulness-promoting activities.

S2399

Dihydromyricetin

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.

S4661

Tiagabine hydrochloride

Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

S4675

Tiagabine

Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

S4197

Bemegride

Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.

S4270

Oxiracetam

Oxiracetam, a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning.

S4700

4-Aminobutyric acid

Gamma-Aminobutyric Acid is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.

Tags: GABA inhibition | GABA receptor activation | GABA function | GABA drugs | GABA activity | GABA pathway | GABA-A receptor function | GABA receptor function | GABA activation | gamma aminobutyric acid function | GABA cancer | GABA assay | GABA receptor drugs | GABA receptor inhibition | GABA receptor signaling | GABA receptors review | GABA agonists list | GABA antagonist drugs | GABA inhibitor drugs | GABA inhibitor review