- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S1168||Valproic acid sodium salt (Sodium valproate)||33 mg/mL||33 mg/mL||33 mg/mL|
|S1332||Flumazenil||<1 mg/mL||5 mg/mL||<1 mg/mL|
|S1338||Gabapentin HCl||42 mg/mL||<1 mg/mL||<1 mg/mL|
|S1329||Etomidate||<1 mg/mL||49 mg/mL||49 mg/mL|
|S2133||Gabapentin||34 mg/mL||<1 mg/mL||<1 mg/mL|
|S3634||6-Hydroxyflavone (6-HF)||<1 mg/mL||47 mg/mL||<1 mg/mL|
|S7071||(+)-Bicuculline||<1 mg/mL||21 mg/mL||<1 mg/mL|
|S1969||Nefiracetam||5 mg/mL||49 mg/mL||49 mg/mL|
|S3072||(R)-baclofen||8 mg/mL||<1 mg/mL||<1 mg/mL|
|S3018||Niflumic acid||<1 mg/mL||56 mg/mL||<1 mg/mL|
|S4574||Piperazine||17 mg/mL||8 mg/mL||17 mg/mL|
|S2026||Ginkgolide A||<1 mg/mL||81 mg/mL||2 mg/mL|
|S2269||Baicalin||<1 mg/mL||89 mg/mL||<1 mg/mL|
|S4645||Armodafinil||<1 mg/mL||54 mg/mL||20 mg/mL|
|S2399||Dihydromyricetin||<1 mg/mL||64 mg/mL||64 mg/mL|
|S4661||Tiagabine hydrochloride||11 mg/mL||82 mg/mL||82 mg/mL|
|S4197||Bemegride||<1 mg/mL||31 mg/mL||31 mg/mL|
|S4270||Oxiracetam||31 mg/mL||31 mg/mL||<1 mg/mL|
|S4700||4-Aminobutyric acid||20 mg/mL||<1 mg/mL||<1 mg/mL|
- GABA Receptor Inhibitors (21)
- New GABA Receptor Products
|Catalog No.||Information||Product Use Citations||Product Validations|
Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
(A,B) Wild-type C57BL/6 male mice were treated with vehicle (saline) or 10 mg/kg of paraquat (PQ) for 3 days, and mice received VPA (3.5 mg/kg) or anacardic acid (5 mg/kg) starting 24 and 1 h before PQ injection. IL-6 mRNA expression was determined by real-time PCR.
Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.
Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.
Etomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative.
Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.
6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors.
(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine.
Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.
(R)-baclofen is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.
Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.
Piperazine, GABA receptor agonist, is an anthelmintic used in the treatment of the intestinal nematodes Ascaris lumbricoides and Enterobius vermicularis.
Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.
Pentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.
Baicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors.
Armodafinil is the R-enantiomer of the racemic synthetic agent modafinil with central nervous system (CNS) stimulant and wakefulness-promoting activities.
Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
A. Cal27 cells transfected with GFP-LC3 plasmid were treated with different concentration of DHM for 24 h. The formation of GFP-LC3 puncta were examined using immunofluorescence and quantified. Scale bar 50 μm.
Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.
Oxiracetam, a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning.
Gamma-Aminobutyric Acid is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.