P2 Receptor

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S1258

Prasugrel

Prasugrel is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.

S1415

Clopidogrel

Clopidogrel is an oral, thienopyridine class antiplatelet agent.

S1984

Ticlopidine HCl

Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.

S4637New

Prasugrel Hydrochloride

Prasugrel hydrochloride is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.

S2855

MRS 2578

MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.

S4079

Ticagrelor

Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist with Ki of 2 nM.

S7705

A-438079 HCl

A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

Catalog No. Information Product Use Citations Product Validations
S1258

Prasugrel

Prasugrel is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.

S1415

Clopidogrel

Clopidogrel is an oral, thienopyridine class antiplatelet agent.

S1984

Ticlopidine HCl

Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.

S4637New

Prasugrel Hydrochloride

Prasugrel hydrochloride is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.

Catalog No. Information Product Use Citations Product Validations
S2855

MRS 2578

MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.

S4079

Ticagrelor

Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist with Ki of 2 nM.

2015, 10.1016/j.jpba.2015.06.009

2015, 10.1016/j.jim.2015.01.006

S7705

A-438079 HCl

A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.