Calcium Channel

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S1356

Levetiracetam

Levetiracetam is an anticonvulsant medication used to treat epilepsy.

S1813

Amlodipine Besylate

Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.

S1293

Cilnidipine

Cilnidipine is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.

S1811

Amiloride HCl

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).

S1425

Ranolazine 2HCl

Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.

S8380New

YM-58483 (BTP2)

YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes.

S4727New

Cinnarizine

Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.

S4648New

Dantrolene sodium

Dantrolene sodium ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.

S4626New

Ethosuximide

Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.

S4597New

Lercanidipine hydrochloride

Lercanidipine is a calcium channel blocker of the dihydropyridine class.

S7999New

SKF96365

SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.

S4202

Verapamil HCl

Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.

S1799

Ranolazine

Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.

S1662

Isradipine

Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.

S1905

Amlodipine

Amlodipine is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.

S1885

Felodipine

Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.

S1748

Nisoldipine

Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.

S1747

Nimodipine

Nimodipine is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.

S2535

Econazole nitrate

Econazole Nitrate is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.

S2721

Nilvadipine

Nilvadipine is a potent calcium channel blocker with an IC50 of 0.03 nM.

S1994

Lacidipine

Lacidipine is a L-type calcium channel blocker, used for treating high blood pressure.

S2114

Dronedarone HCl

Dronedarone HCl is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).

S4181

Nicardipine HCl

Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.

S1808

Nifedipine

Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.

S2080

Clevidipine Butyrate

Clevidipine Butyrate is a dihydropyridine calcium channel blocker, uses as an agent for the reduction of blood pressure.

S2017

Benidipine HCl

Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.

S2918

HC-030031

HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.

S2030

Flunarizine 2HCl

Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.

S2491

Nitrendipine

Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.

S3053

Azelnidipine

Azelnidipine is a dihydropyridine calcium channel blocker.

S2573

Tetracaine HCl

Tetracaine HCl is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.

S1865

Diltiazem HCl

Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.

S3045

Cinepazide maleate

Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.

S2403

Tetrandrine

Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.

S4084

Lomerizine HCl

Lomerizine dihydrochloride is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine.

S2446

Levosimendan

Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.

S1911

Disodium Cromoglycate

Disodium Cromoglycate is an antiallergic drug with IC50 of 39 μg/mL.

S2050

Strontium Ranelate

Strontium Ranelate is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM.

S8073

Optovin

Optovin is a reversible photoactivated TRPA1 activator.

S4209

Chlorocresol

Chlorocresol is an activator of ryanodine receptor.

S2482

Manidipine 2HCl

Manidipine 2HCl is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.

S2481

Manidipine

Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.

Catalog No. Information Product Use Citations Product Validations
S1356

Levetiracetam

Levetiracetam is an anticonvulsant medication used to treat epilepsy.

S1813

Amlodipine Besylate

Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.

S1293

Cilnidipine

Cilnidipine is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.

S1811

Amiloride HCl

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).

S1425

Ranolazine 2HCl

Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.

S8380New

YM-58483 (BTP2)

YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes.

S4727New

Cinnarizine

Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.

S4648New

Dantrolene sodium

Dantrolene sodium ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.

S4626New

Ethosuximide

Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.

S4597New

Lercanidipine hydrochloride

Lercanidipine is a calcium channel blocker of the dihydropyridine class.

S7999New

SKF96365

SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.

S4202

Verapamil HCl

Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.

S1799

Ranolazine

Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.

S1662

Isradipine

Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.

S1905

Amlodipine

Amlodipine is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.

S1885

Felodipine

Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.

S1748

Nisoldipine

Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.

S1747

Nimodipine

Nimodipine is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.

S2535

Econazole nitrate

Econazole Nitrate is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.

S2721

Nilvadipine

Nilvadipine is a potent calcium channel blocker with an IC50 of 0.03 nM.

S1994

Lacidipine

Lacidipine is a L-type calcium channel blocker, used for treating high blood pressure.

S2114

Dronedarone HCl

Dronedarone HCl is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).

S4181

Nicardipine HCl

Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.

S1808

Nifedipine

Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.

S2080

Clevidipine Butyrate

Clevidipine Butyrate is a dihydropyridine calcium channel blocker, uses as an agent for the reduction of blood pressure.

S2017

Benidipine HCl

Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.

S2918

HC-030031

HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.

S2030

Flunarizine 2HCl

Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.

S2491

Nitrendipine

Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.

S3053

Azelnidipine

Azelnidipine is a dihydropyridine calcium channel blocker.

S2573

Tetracaine HCl

Tetracaine HCl is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.

S1865

Diltiazem HCl

Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.

S3045

Cinepazide maleate

Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.

S2403

Tetrandrine

Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.

S4084

Lomerizine HCl

Lomerizine dihydrochloride is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine.

Catalog No. Information Product Use Citations Product Validations
S2050

Strontium Ranelate

Strontium Ranelate is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM.

S8073

Optovin

Optovin is a reversible photoactivated TRPA1 activator.

S4209

Chlorocresol

Chlorocresol is an activator of ryanodine receptor.

Catalog No. Information Product Use Citations Product Validations
S2482

Manidipine 2HCl

Manidipine 2HCl is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.

S2481

Manidipine

Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.

Catalog No. Information Product Use Citations Product Validations
S2446

Levosimendan

Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.

S1911

Disodium Cromoglycate

Disodium Cromoglycate is an antiallergic drug with IC50 of 39 μg/mL.