COX

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1261 Celecoxib <1 mg/mL 76 mg/mL 33 mg/mL
S1255 Nepafenac <1 mg/mL 50 mg/mL <1 mg/mL
S1638 Ibuprofen <1 mg/mL 41 mg/mL 41 mg/mL
S1723 Indomethacin <1 mg/mL 72 mg/mL 24 mg/mL
S2007 Sulindac <1 mg/mL 71 mg/mL 9 mg/mL
S8433 NS-398 (NS398) <1 mg/mL 62 mg/mL <1 mg/mL
S3043 Rofecoxib <1 mg/mL 63 mg/mL <1 mg/mL
S1734 Meloxicam <1 mg/mL 30 mg/mL <1 mg/mL
S4028 Dexamethasone Sodium Phosphate 103 mg/mL <1 mg/mL <1 mg/mL
S3023 Bufexamac <1 mg/mL 45 mg/mL 3 mg/mL
S3017 Aspirin <1 mg/mL 36 mg/mL 36 mg/mL
S1761 Suprofen <1 mg/mL 52 mg/mL 52 mg/mL
S1713 Piroxicam <1 mg/mL 66 mg/mL 1 mg/mL
S1328 Etodolac <1 mg/mL 58 mg/mL 58 mg/mL
S1645 Ketoprofen <1 mg/mL 51 mg/mL 51 mg/mL
S1903 Diclofenac Sodium 14 mg/mL 64 mg/mL 64 mg/mL
S1518 Ibuprofen Lysine 71 mg/mL <1 mg/mL <1 mg/mL
S2047 Lornoxicam <1 mg/mL 3 mg/mL <1 mg/mL
S1646 Ketorolac <1 mg/mL 75 mg/mL 75 mg/mL
S1626 Naproxen Sodium 50 mg/mL 3 mg/mL <1 mg/mL
S2903 Lumiracoxib <1 mg/mL 59 mg/mL <1 mg/mL
S2531 Asaraldehyde <1 mg/mL 39 mg/mL 16 mg/mL
S1960 Pranoprofen <1 mg/mL 51 mg/mL 6 mg/mL
S3008 Zaltoprofen <1 mg/mL 60 mg/mL 31 mg/mL
S2602 Acemetacin <1 mg/mL 83 mg/mL 58 mg/mL
S1959 Tolfenamic Acid <1 mg/mL 52 mg/mL <1 mg/mL
S4049 Valdecoxib <1 mg/mL 63 mg/mL 18 mg/mL
S2577 Phenacetin <1 mg/mL 36 mg/mL 36 mg/mL
S2040 Nimesulide <1 mg/mL 62 mg/mL <1 mg/mL
S4149 Amfenac Sodium Monohydrate 59 mg/mL 59 mg/mL 4 mg/mL
S4248 Bromfenac Sodium 71 mg/mL 71 mg/mL 2 mg/mL
S4051 Nabumetone <1 mg/mL 46 mg/mL 25 mg/mL
S3018 Niflumic acid <1 mg/mL 56 mg/mL <1 mg/mL
S3173 Antipyrine 38 mg/mL 38 mg/mL 38 mg/mL
S4011 Ampiroxicam <1 mg/mL 90 mg/mL <1 mg/mL
S4032 Bismuth Subsalicylate <1 mg/mL 0.04 mg/mL <1 mg/mL
S4628 (+/-)-Sulfinpyrazone <1 mg/mL 80 mg/mL 64 mg/mL
S4136 Carprofen <1 mg/mL 55 mg/mL 55 mg/mL
S3063 Diclofenac Diethylamine <1 mg/mL 74 mg/mL 74 mg/mL
S4656 Parecoxib <1 mg/mL 74 mg/mL 2 mg/mL
S4609 Diflunisal <1 mg/mL 50 mg/mL 20 mg/mL
S4176 Trometamol 24 mg/mL 2 mg/mL <1 mg/mL
S4078 Mefenamic Acid <1 mg/mL 48 mg/mL <1 mg/mL
S4651 Etoricoxib <1 mg/mL 71 mg/mL 46 mg/mL
S4230 Oxaprozin <1 mg/mL 59 mg/mL 27 mg/mL
S2349 Rutaecarpine <1 mg/mL 24 mg/mL <1 mg/mL
S2351 Salicin 24 mg/mL 57 mg/mL <1 mg/mL
S4526 Fenbufen <1 mg/mL 50 mg/mL 50 mg/mL
S4539 Salicylic acid <1 mg/mL 27 mg/mL 27 mg/mL
S7889 Xanthohumol <1 mg/mL 70 mg/mL 70 mg/mL
S2108 Flunixin Meglumin 98 mg/mL 98 mg/mL 8 mg/mL
S4295 Meclofenamate Sodium 63 mg/mL 63 mg/mL 63 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S1261

Celecoxib

Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.

S1255

Nepafenac

Nepafenac is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery.

S1638

Ibuprofen

Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.

S1723

Indomethacin

Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.

S2007

Sulindac

Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.

S8433New

NS-398 (NS398)

NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively.

S3043

Rofecoxib

Rofecoxib is a COX-2 inhibitor with IC50 of 18 nM.

S1734

Meloxicam

Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.

S4028

Dexamethasone Sodium Phosphate

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

S3023

Bufexamac

Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.

S3017

Aspirin

Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

S1761

Suprofen

Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.

S1713

Piroxicam

Piroxicam is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.

S1328

Etodolac

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain.

S1645

Ketoprofen

Ketoprofen is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.

S1903

Diclofenac Sodium

Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation.

S1518

Ibuprofen Lysine

Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.

S2047

Lornoxicam

Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.

S1646

Ketorolac

Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.

S1626

Naproxen Sodium

Naproxen Sodium is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.

S2903

Lumiracoxib

Lumiracoxib is a novel, selective COX-2 inhibitor with Ki of 0.06 μM. It also inhibits COX1 with Ki of 3 μM.

S2531

Asaraldehyde

Asaraldehyde is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.

S1960

Pranoprofen

Pranoprofen is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.

S3008

Zaltoprofen

Zaltoprofen is an inhibitor of COX-1 and COX-2 for treatment of arthritis.

S2602

Acemetacin

Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

S1959

Tolfenamic Acid

Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM.

S4049

Valdecoxib

Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.

S2577

Phenacetin

Phenacetin is a non-opioid analgesic without anti-inflammatory properties.

S2040

Nimesulide

Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.

S4149

Amfenac Sodium Monohydrate

Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.

S4248

Bromfenac Sodium

Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

S4051

Nabumetone

Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.

S3018

Niflumic acid

Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.

S3173

Antipyrine

Antipyrine is an analgesic and antipyretic agent; selective COX-3 inhibitor.

S4011

Ampiroxicam

Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

S4032

Bismuth Subsalicylate

Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.

S4628

(+/-)-Sulfinpyrazone

Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.

S4136

Carprofen

Carprofen inhibits canine COX2 with IC50 of 30 nM.

S3063

Diclofenac Diethylamine

Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.

S4656

Parecoxib

Parecoxib is a selective COX2 inhibitor.

S4609

Diflunisal

Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.

S4176

Trometamol

Trometamol is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins.

S4078

Mefenamic Acid

Mefenamic Acid is a competitive inhibitor of COX-1 and COX-2.

S4651

Etoricoxib

Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.

S4686

Vitamin E

Vitamin E is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.

S4230

Oxaprozin

Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.

S2349

Rutaecarpine

Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs; a new class of COX-2 inhibitor.

S2351

Salicin

Salicin is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects. It is a natural, non-selective COX-1 and COX-2 inhibitor.

S4526

Fenbufen

Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.

S4539

Salicylic acid

Salicylic acid is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.

S7889

Xanthohumol

Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Phase 1.

S2108

Flunixin Meglumin

Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity.

S4295

Meclofenamate Sodium

Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea.