OX Receptor

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S3054

Alverine Citrate

Alverine citrate is a drug used for functional gastrointestinal disorders.

S7279

Suvorexant (MK-4305)

Suvorexant (MK-4305) is a potent dual OX receptor antagonist with Ki of 0.55 nM and 0.35 nM for OX1 receptor and OX2 receptor, respectively. Phase 3.

S7585

SB-334867

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

S1545

SB408124

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

S2160

Almorexant HCl

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

Catalog No. Information Product Use Citations Product Validations
S7279

Suvorexant (MK-4305)

Suvorexant (MK-4305) is a potent dual OX receptor antagonist with Ki of 0.55 nM and 0.35 nM for OX1 receptor and OX2 receptor, respectively. Phase 3.

2016, 10.1038/nsmb.3183

S7585

SB-334867

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

S1545

SB408124

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

S2160

Almorexant HCl

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

Catalog No. Information Product Use Citations Product Validations
S3054

Alverine Citrate

Alverine citrate is a drug used for functional gastrointestinal disorders.