OX Receptor

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S7585 SB-334867 <1 mg/mL 63 mg/mL 3 mg/mL
S3054 Alverine Citrate <1 mg/mL 95 mg/mL <1 mg/mL
S1545 SB408124 <1 mg/mL 36 mg/mL <1 mg/mL
S3880 Schisantherin A -1 mg/mL 100 mg/mL -1 mg/mL
S2160 Almorexant HCl <1 mg/mL 72 mg/mL 51 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations


SB-334867 is a selective orexin-1 (OX1) receptor antagonist.


Alverine Citrate

Alverine citrate is a drug used for functional gastrointestinal disorders.



SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.


Schisantherin A

Schisantherin A, also known as Gomisin C, is a dibenzocyclooctadiene that exhibits anti-tussive, sedative, anti-inflammatory, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities.


Almorexant HCl

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.