EGFR Inhibitors

• Cat.No
• Product Name
• Information
• Publications
• Customer Reviews

• S1025
• Gefitinib (Iressa)
• Gefitinib (Iressa) also known as ZD-1839 & Iressa is a novel potent EGFR tyrosine kinase & Akt phosphorylations inhibitor with IC50 of 37, 26 and 57 nM.
• (5)
• (9)

• S1023
• Erlotinib HCl
• Erlotinib HCl also known as Tarceva, CP-358774, OSI-774, NSC-718781 is a HCL salt with IC50 of 2 nM for HER1/EGFR TK.
• (7)
• (8)

• S1028
• Lapatinib Ditosylate (Tykerb)
• Lapatinib (Tyverb, GW-572016, GW-2016) is a potent purified EGFR and ErbB-2 inhibitor with IC50 of 10.2 and 9.8 nM, respectively.
• (7)
• (6)

• S1011
• BIBW2992 (Afatinib)
• BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFR^wt, EGFR ^L858R , EGFR ^L858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM, 14 nM, respectively.
• (1)
• (3)

• S1046
• Vandetanib (Zactima)
• Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.
• (2)
• (4)

• S1019
• CI-1033 (Canertinib)
• CI-1033 is a potent tyrosine kinase inhibitor of EGFR and erbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.
• (2)
• (4)

• S1173
• WZ4002
• WZ4002 is an EGFR T790M inhibitor(IC50<20nM).
• (1)
• (3)

• S2185
• AST-1306
• (0)
• (0)

• S2755
• ARRY334543
• ARRY334543 is a selective and potent kinase ErbB-1 and ErbB-2 inhibitor with IC50 of 7 nM and 2 nM, respectively.
• (0)
• (0)

• S2728
• AG-1478 (Tyrphostin AG-1478)
• AG-1478 (Tyrphostin AG-1478) is a highly potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with an IC50 of 3 nM.
• (1)
• (0)

• S2727
• PF299804
• PF299804 is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.
• (0)
• (0)

• S2733
• AV-412
• AV-412 is a second-generation, orally bioavailable dual EGFR/HER2 tyrosine kinase inhibitor.
• (0)
• (0)

• S2221
• Apatinib (YN968D1)
• Apatinib (YN968D1) is a small-molecule selective multitargeted tyrosine kinase inhibitor with an IC50 of 2.43 nM for the inhibition of VEGFR2.
• (0)
• (0)

• S2406
• Chrysophanic acid (Chrysophanol)
• Chrysophanic acid (Chrysophanol) is a EGFR/mTOR pathway inhibitor.
• (0)
• (1)

• S2205
• OSI-420 (Desmethyl Erlotinib, CP-473420)
• OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
• (2)
• (0)

• S2216
• Mubritinib (TAK 165)
• Mubritinib (TAK 165) is a potent EGFR and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 μM, respectively
• (0)
• (0)

• S2192
• AZD8931
• AZD8931 is a novel potent reversible small molecule epidermal growth factor receptor, ERBB2 (HER2) and ERBB3 inhibitor with an IC50 of 4, 3, 4 nM, respectively.
• (0)
• (0)

• S1486
• AEE788 (NVP-AEE788)
• AEE788 (NVP-AEE788) is a novel multitargeted human epidermal receptor (HER) 1/2 and vascular endothelil growth factor receptor (VEGFR) 1/2 receptor family tyrosine kinases inhibitor with IC50 of 2, 6, 77, 59 nM for EGFR, ErbB2, KDR, and Flt-1.
• (0)
• (0)

• S1392
• Pelitinib (EKB-569)
• Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
• (0)
• (0)

• S1194
• CUDC-101
• CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
• (0)
• (2)

• S1179
• WZ8040
• WZ8040 is an irreversiblely EGFR T790M inhibitor (IC50<10nM).
• (0)
• (2)

• S1170
• WZ3146
• WZ3146 is an irreversiblely inhibitor against EGFR T790M.
• (0)
• (1)

• S1143
• AG-490
• AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8 μM for EGFR and JAK, respectively.
• (0)
• (0)

• S1083
• XL647
• Inhibitor of the EGFR and ErbB2 with IC50 0.3 and 16 nM respectively.
• (0)
• (0)

• S1079
• PD153035 HCl
• PD153035 HCl is an inhibitor of EGFR, competitive with ATP. EGF Receptor: IC50 = 25 pM (Ki = 6 pM)
• (1)
• (1)

• S1056
• BMS-599626 (AC480)
• BMS-599626 (AC480) is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively.
• (0)
• (1)