Lidocaine hydrochloride

Catalog No.S4667 Synonyms: Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural

Lidocaine hydrochloride Chemical Structure

Molecular Weight(MW): 270.8

Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.

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Biological Activity

Description Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.
In vitro

Lidocaine above 1.25 g/l reduces cellular viability and triggers apoptosis in HCE cells in a time- and dose-dependent manner. Lidocaine-induced apoptosis is caspase dependent and may be related to mitochondrial pathway[1]. Lidocaine, at the level of tissue concentration under topical or local administration, also has a direct inhibitory effect on the activity of epidermal growth factor receptor (EGFR), which is a potential target for antiproliferation in cancer cells[3].

In vivo Intravenous administration of the local anaesthetic lidocaine has been used to treat neuropathic pain for several decades and significantly improves postoperative pain associated with complex spine surgery and cholecystectomy. It is well established that lidocaine used for regional anaesthesia blocks impulses in peripheral nerves by inhibiting voltage-gated sodium (Na+) channels. Intravenous lidocaine has an analgesic effect on mechanical noxious response, decreases the spinal noxious response induced by peripheral pinch stimuli and the frequency of spontaneous excitatory postsynaptic currents(EPSCs) without changing their amplitude. It has no effect on spontaneous inhibitory postsynaptic currents and produces an outward current in SG neurons[2].

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: Human Corneal Endothelial Cells
  • Concentrations: 0.15625–10.0 g/l
  • Incubation Time: 4-28 hr
  • Method: Cells at logarithmic phase are treated with lidocaine hydrochloride at concentrations (w/v) from 10 to 0.15625 g/l in step dilutions. HCE cells without lidocaine treatment are used as controls. The morphology and growing status of the cells are monitored every 4 hr.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Male Wistar rats
  • Formulation: Saline
  • Dosages: 1, 3, 10 mg/kg
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 54 mg/mL (199.4 mM)
Water 54 mg/mL (199.4 mM)
Ethanol 54 mg/mL (199.4 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 270.8
Formula

C14H22N2O.HCl

CAS No. 73-78-9
Storage powder
Synonyms Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID