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Neratinib (HKI-272) Chemical Structure
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Biological Activity
Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively.[1] Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.[2]
References on Neratinib (HKI-272)
- [1] J. Med. Chem 2005;48,:1107-1131
- [2] http://en.wikipedia.org/wiki/Neratinib ;
Chemical Information
| Molecular Weight (WM): | 557.04 |
|---|---|
| Formula: | C30H29ClN6O3 |
| CAS No.: | 698387-09-6 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥4mg/mL |
| Water <1mg/mL | |
| Ethanol ≥2mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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