Catalog No.S2895 Synonyms: SF 6847, RG-50872
Molecular Weight(MW): 282.38
Tyrphostin 9 is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM.
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|Description||Tyrphostin 9 is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM.|
SF 6847 inhibits the replication of herpes simplex virus type 1 (HSV-1) with IC50 of 40 nM. SF 6847 (50 nM) partly reverses sodium orthovanadate induced HSV-1 plaque formation. SF 6847 (< 400 nM) decreases the phosphorylation of viral phosphoproteins in a dose-dependent manner, but the SF 6847 (< 800 nM)-induced reduction of protein synthesis is not dose-dependent.  SF 6847 prevents PDGF-induced tyrosine phosphorylation of LRP in caveolae in human fibroblasts suggesting that PDGF-BB-mediated LRP activation requires tyrosine phosphorylation and therefore activation of PDGFR-β.  SF 6847 (1 mM) blocks the strain-induced stimulatory effect on DNA synthesis of fetal lung cells.  SF 6847 (1 μM) causes increased exon inclusion of MAPT exon 10. SF 6847 does not affect the translation or stability of the two mRNAs. SF 6847 (1.6 μM) increases the inclusion of MAPT exon 10 by 2-fold in SHSY-5Y cells. 
-  Gazit A, et al. J Med Chem, 1989, 32(10), 2344-2352.
-  Yura Y, et al. Arch Virol, 1995, 140(7), 1181-1194.
-  Boucher P, et al. J Biol Chem, 2002, 277(18), 15507-15513.
|In vitro||DMSO||56 mg/mL (198.31 mM)|
|Ethanol||56 mg/mL (198.31 mM)|
|Water||slightly soluble or insoluble|
* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||SF 6847, RG-50872|
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