Research Area
Product Type
United States ( Change Country )
Pelitinib (EKB-569) Chemical Structure
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Biological Activity
Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors. Pelitinib inhibits EGF-induced phosphorylation of EGF-R and the growth of tumors that overexpress EGF-R in animal models.[1][2]
References on Pelitinib (EKB-569)
- [1] Clin Cancer Res 2008;14:215-223
- [2] J. Med. Chem. 2003;46, 49-63
Chemical Information
| Molecular Weight (WM): | 467.92 |
|---|---|
| Formula: | C24H23ClFN5O2 |
| CAS No.: | 257933-82-7 |
| Synonyms: |
WAY-EKB 569
|
| Dissolve in (25°C): | DMSO ≥13mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Receptor Tyrosine Kinase >> EGFR >> EGFR Inhibitors
Angiogenesis >> EGFR >> EGFR Inhibitors
JAK / STAT >> EGFR >> EGFR Inhibitors
Angiogenesis >> EGFR >> EGFR Inhibitors
JAK / STAT >> EGFR >> EGFR Inhibitors
Notes:
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