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Gefitinib hydrochloride

Name: Gefitinib hydrochloride
Brand: Selleck Chemicals
SKU: S5098
Rating: 5 (237 reviews)

Synonyms: ZD1839 hydrochloride

Catalog No.S5098 Purity: 99.94%

Gefitinib (ZD1839) is an EGFR inhibitor with IC50s of 15.5 nM and 823.3 nM for WT EGFR and EGFR (858R/T790M), respectively.

Gefitinib hydrochloride Chemical Structure

CAS: 184475-55-6

Selleck's Gefitinib hydrochloride has been cited by 237 publications

Purity & Quality Control

Batch: Purity: 99.94%

99.94

Gefitinib hydrochloride Related Products

Related Targets	EGFR/ErbB1 HER2/ErbB2 ErbB3 ErbB4 mutant EGFR	Click to Expand
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Signaling Pathway

EGFR Signaling Pathway

Choose Selective EGFR Inhibitors

Biological Activity

Description

Gefitinib (ZD1839) is an EGFR inhibitor with IC50s of 15.5 nM and 823.3 nM for WT EGFR and EGFR (858R/T790M), respectively.

Targets

EGFR ^[1] (Cell-free assay)	EGFR (858R/T790M) ^[1] (Cell-free assay)
15.5 nM	823.3 nM

References

[1] Li Y, et al. Molecules. 2016, 21(11), pii: E1462.

Chemical Information & Solubility

Molecular Weight	483.36	Formula	C₂₂H₂₄ClFN₄O₃.HCl
CAS No.	184475-55-6	SDF	--
Smiles	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 4 mg/mL ( (8.27 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 1 mg/mL

Ethanol : 1 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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