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S1025

Gefitinib(Iressa)

(Synonyms

ZD-1839, Iressa

)

Technical Data:

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M.Wt: 446.90
Formula: C₂₂H₂₄ClFN₄O₃
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 184475-35-2

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Quality Control:

MSDS
Batch S102502: H-NMR COA

Biological Activity of Gefitinib(Iressa):

MCF10A cells are nontransformed breast epithelial cells that require EGF to proliferate.The monolayer growth of these EGF-driven untransformed cells is inhibited by ZD1839 with an IC50 of 20 nM, similar to its IC50 in vitro for EGFR and consistent with effective inhibition of EGFR in vivo. ^[1]Cell line characteristics and sensitivity to ZD1839 at 1uM are 59% inhibition for MDA-MB-231,74% inhibition for A431, 81% inhibition for SKBr3,60% inhibition for SKOV3, 33% inhibition for BT474,52% inhibition for MCF-7, 28% inhibition for T47D, respectively.

References on Gefitinib(Iressa):

[1] Mark M. Moasser et al. Cancer Res. 2001 October 1;61:7184-7188

[2] Neil G. Anderson et al. International Journal of Cancer.2001 Sep 23;94(6):774-782

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Customer's Feedback

Arnaud AUTRET, Trinity College

"I would like to confirm you that everything is perfectly fine with ABT and Obatoclax we got from your company. We confirmed their activity in vitro. We notably observed their impact in an apoptotic model and results are similar to those which have been published."

Dongfeng Chen, The Rausing Lab

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"I am very satisfied with your product and costumer service. Bortezomib works very well in our assay, it is comparably cheaper than other inhibitors that we tested is more reliable for our assays. We see a great effect by using 10nM concentration."

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Zhenghe John Wang Assistant Professor, Case Western Reserve University

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Yu Wang, Harvard University

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Philip Seeman, Toronto University

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