Gefitinib (ZD1839)

Catalog No.S1025

Gefitinib (ZD1839) Chemical Structure

Molecular Weight(MW): 446.90

Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

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Cited by 91 Publications

12 Customer Reviews

  • Perturbation of EGFR by its ligand EGF and gefitinib (ZD-1839 Iressat; inhibits EGFR) produces opposite responses in the predicted EGFR target genes SOCS2 and NR2E1.

    Mol Syst Biol 2011 7, 486. Gefitinib (ZD1839) purchased from Selleck.

    Effects of shRNA-mediated RECK depletion on EGFR signaling in MEFs. (a) Immunoblotting (IB) of the indicated proteins in wild-type MEFs transduced with the indicated shRNAs and cultured for 48 h in the presence of 0.1% dimethyl sulfoxide (DMSO; vehicle) or 1 mM gefitinib (S1025, Selleck Chemicals,Houston, TX, USA). (b) Immunoprecipitation from whole lysates of cells from panel a with an anti-phosphorylated tyrosine (pTyr) antibody. Precipitates from 500 mg protein in whole cell lysates (upper) or 20 mg protein in whole cell lysates (lower) were analyzed by IB with anti-EGFR antibody.

    Oncogene 2010 30, 737-750. Gefitinib (ZD1839) purchased from Selleck.

  • (B–C) LNCaP (B) and LNCaP-AI (C) cells were transiently transfected with sPLA2-IIa(-800)-Luc (0.5 μg). The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 lM) and Bortezomib (20 μM) without or with EGF (100 ng/ml) for 24 h. Luciferase assay was performed according to a standard protocol with Renilla luciferase as an internal control. Data are presented as the mean (±SD) of duplicate values of a representative experiment that was independently repeated for five times.

    Carcinogenesis 2010 31, 1948–1955 . Gefitinib (ZD1839) purchased from Selleck.

    LNCaP-AI cells were starved in 1% stripped medium for 24 h. The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 μM) and Bortezomib (20 μM) for 24 h. Cell culture medium was collected from each sample and subjected to ELISA for sPLA2-IIa. The condition medium samples were diluted 10 times for ELISA. Average of duplicate samples was converted to nanogram per milliliter against standard curve. The data represent one of five repeated experiments.

     

     

    Carcinogenesis 2010 31, 1948–1955. Gefitinib (ZD1839) purchased from Selleck.

  • Susceptibility of lung cancer cells to cytolytic activity of NK-92 cells after treatment with EGFR inhibitors. Three lung cancer cells were untreated (open circle) or treated with 10 μM erlotinib or gefitinib (black filled square or black filled triangle) for 24 hours. The lung cancer cells were cocultured with NK-92 cells at indicated effector to target ratio (E:T ratio). To determine the specificity of NKG2D-mediated cytolysis of lung cancer cells, NK-92 cells were preincubated with blocking mAb against NKG2D before the assay (gray filled square and triangle) and correspond-ing isotype mAb (open square and triangle).

    J Immunother 2011 34(4), 372-81. Gefitinib (ZD1839) purchased from Selleck.

    Suppression of EGFR signaling by Gefitinib is dose dependent and non- toxic at millimolar concentrations.Results from plaque reduction tests of Hep2 cells infected with VACV(12.5pfu/well) treated with a serial dilution of Gefitinib (1000-0.01 m) and analyzed for (A)proliferation as indicator of cytotoxicity,(B) IC50 of plaque size inhibition, (C)dose dependent inhibition of EGFR-ERK1/2signaling and VACV proteins by Western blot analysis (pEGFR detection was obtained from a different experiment with identicals ettings) and (D)dose dependent inhibition of orthopoxvirus genome replication by real-time PCR.Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

  • A circular zone of EGFR activated but uninfected cells facilitate virus induced plaque development , efficiently blocked by Gefitinib. (A)Immun of luorescent staining of aplaque reduction tests with Hep2 cells 24,48,72 and 96 h after VACV infection (6.25pfu/chamber). VACV infected cells(green) were visualized by human IgG directed to orthopoxviruses (VIG) detected with a secondary FITC labelled antibody. Uninfected cells with activated EGFR signaling(red) are detected with a secondary Cy3labelled antibody. Positive cells for both , VACV and phosphorylated EGFR are shown in yellow(merge). Cellular nuclei are counterstained with DAPI. (B)Immunofluorescent staining of a plaque reduction test as described for (A) and treated with three different Gefitinib concentrations (1000 nM, 1 nM, and 0.01 nM) . The test was analyzed 96h afterVACV infection.Uninfected cells are shown as controls. Magnification100×.(For interpretation of the references to color in this figure legend , the reader is referred to the web version of the article.)

     

     

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

    The EGF-dependent increased association of PCM1 and AZI1 requires EGFR kinase activity. ZD1839 (Iressa)—EGFR tyrosine kinase inhibitor.

    Mol Biosyst 2011 7, 3223-33. Gefitinib (ZD1839) purchased from Selleck.

  • Reduction of GPER expression in HCC1806 cells after treatment with gefitinib. (A) Concentration dependence. HCC1806 cells were treated with 50-500 nM gefitinib for 48 h. GPER was detected by western blotting. (B) Time dependence. HCC1806 cells were treated with 200 nM gefitinib for 24-96 h. ap<0.05 vs. control; bp<0.001 vs. control. Mean values and SE of three independent experiments are shown. (C) Representative western blotting of concentration dependence. (D) Representative western blotting of time dependence

    Oncol Rep, 2017, 37(2):1212-1218. Gefitinib (ZD1839) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 215496. Gefitinib (ZD1839) purchased from Selleck.

  • Breast cancer cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of  Gefitinib for 24 hours.

     

     

    2010 Dr. Zhang of Tianjin Medical University. Gefitinib (ZD1839) purchased from Selleck.

    MTT assay result. 0-500nM Gefitinib treated with H1299, H358, H25 and HCC827 cell lines by 72h, Proliferation rate was tested.

     

     

    2010 Dr. Vicky Tin from University of Hong Kong. Gefitinib (ZD1839) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
Features A potent EGFR tyrosine kinase inhibitor.
Targets
Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
26 nM 37 nM 37 nM 57 nM
In vitro

Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhibits EGFR and ERK phosphorylation up to 72 hours after EGF stimulation in both the high- and low-EGFR-expressing cell lines. [1] Gefitinib is the monolayer growth of these EGF-driven untransformed MCF10A cells with an IC50 of 20 nM. [2] The combination of Gefitinib (0.2 μM and 0.5 μM) with irradiation lead to a significant growth inhibition in LoVo cells, compared with radiation alone.. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB NY\a[ow2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMEW0JO69VQ>? NEXSXXgyPjVzNkS3Ny=>
NIH3T3 NWm2[5lsTnWwY4Tpc44hSXO|YYm= M3LaelAvOiEQvF2= NVu0Z2w{OiCq MY\EUXNQ NXLJOIlxUW6qaXLpeIlwdiCxZjDFS2Yhe3SrbYXsZZRm\CCqdX3hckBmemKEMTDheZRweGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCxOFQh|ryP NYHycXNTOTZ2OECyPFQ>
COS7 MWLGeY5kfGmxbjDBd5NigQ>? MmCxPVYh|ryP MUDJcohq[mm2aX;uJI9nKGi3bXHuJGpCUzJiVk[xO2YhdXW2YX70JIV5eHKnc4Pl[C=> NYTMS3Z5OTdzN{i3NlI>
A549 NX[zO4M2S3m2b4TvfIlkKEG|c3H5 NF61fHE6PiCq M4fKTmROW09? NUHyZmNCUUN3ME2xN{42QSEQvF2= NH3KW5AyQDNzM{iwOy=>
K562 NYf5O5NzS3m2b4TvfIlkKEG|c3H5 NWPmfY5QQTZiaB?= M3XCPWROW09? MVzJR|UxRTlwM{[g{txO M3fsS|E5OzF|OEC3
MDA-MB-231 NELnfndEgXSxdH;4bYMhSXO|YYm= MnO2PVYhcA>? M1uycGROW09? Ml72TWM2OD1|Nj62NUDPxE1? MWixPFMyOzhyNx?=
MOLT4 NFXjVHpEgXSxdH;4bYMhSXO|YYm= MkDMPVYhcA>? MlPlSG1UVw>? MlfzTWM2OD1zNT6wNkDPxE1? M{fCdVE5OzF|OEC3
MCF7 M2DDZ2N6fG:2b4jpZ{BCe3OjeR?= NFTnTIU2OCEQvF2= NWrYVohkPzJiaB?= M4OyVGlEPTB;MUKuNFUh|ryP MofLNVg4PzF6MUm=
BT474 MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmq5O|IhcA>? MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKWNEe0JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWUQnKyJJdqfGhiRVO1NEBw\iByLkOg{txO M1LUVVE6ODJ6NEK0
HN5 MmXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUe3NkBp MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiQNTDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghTUN3MDDv[kAxNjBzIN88US=> NGf3e3EyQTB{OESyOC=>
BA/F3 M33jRmN6fG:2b4jpZ{BCe3OjeR?= M3e3XFczKGh? MoTsR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCHR1\SJGw5PTiUIH31eIFvfCC5aYToJGlEPTBib3[gNE4xOTB6IN88US=> NX3JeW9IOTl{M{myNlk>
NIH3T3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mle4O|IhcA>? M2LiS2dzd3e2aDDpcohq[mm2aX;uJI9nKG2xdYPlJG5KUC9|VEOgZ4VtdHNiZYjwdoV{e2mwZzDldmIzKGenbnWge4l1cCCLQ{WwJI9nKDBwNUSg{txO MYexPVY3PTN5Nx?=
MCF7 MX MV\GeY5kfGmxbjDBd5NigQ>? MXezNEBucW5? NXjyPYtTUW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4yKM7:TR?= MWSxPVk{Ojl4MB?=
A431 NWPnWXdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXixNEDPxE1? NFGyNFA4OiCq NEH4fGFIUTVyPUCuOVE1KM7:TR?= NFTsbGsyQTl4OUS2OS=>
A431 NHPJSFlMcW6jc3WgRZN{[Xl? MVWwMlEh|ryP NID2e2QyKGh? M1HiNmlvcGmkaYTpc44hd2ZiRVfGMYlv\HWlZXSgSWdHWiCyaH;zdIhwenmuYYTpc44> NHP6VWUyQTl4OUS2OS=>
A431 M1r2OGtqdmG|ZTDBd5NigQ>? MmnXNVAxKM7:TR?= NIW1dHEyOCCvaX6= NHzmOoVRem:ub37n[YQhcW6qaXLpeI9zgSCjY4Tpeol1gSCxZjDFS2YucW6mdXPl[EBGT0[UIIDoc5NxcG:{eXzheIlwdg>? MYKxPVk3QTR4NR?=
Sf9 MVXLbY5ie2ViQYPzZZk> MkL0NVAhdWmw NGjGVHpFVVOR MX7Jcohq[mm2aX;uJI9nKEWJRmKg[ZhxemW|c3XkJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdoVk\XC2b4KgZZV1d3Cqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wN|Mh|ryP Mo[wNlAxPTZ2MkW=
NCI-H1975 NFrJTVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\lfWozPSEQvF2= M{DyXVczKGh? M2TkVmlEPTB;OD6yOkDPxE1? NYnsbmJbOjBzNUG2O|A>
NCI-H1975 MX3LbY5ie2ViQYPzZZk> NE[3OpAyOCEQvF2= M1vzNmlvcGmkaYTpc44hd2ZiRVfGVkBifXSxcHjvd5Bpd3K7bHH0bY9v Mn;rNlAyPTF4N{C=
NCI-H1975 M3jUNWZ2dmO2aX;uJGF{e2G7 MX[xNEDPxE1? MlzYTY5pcWKrdHnvckBw\iCHUlLCNkBifXSxcHjvd5Bpd3K7bHH0bY9v MXOyNFE2OTZ5MB?=
NCI-H1975 Ml\kSpVv[3Srb36gRZN{[Xl? NXPOWIdDPSEQvF2= MV20PEBp MWHJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGG|c3Xzd4VlKGG|IHHjeIl3[XSrb36gc4Yh[2G|cHHz[U0{ MoO0NlAyPTF4N{C=
A375 MnvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInBW2c1QCCq NIXGNlJKSzVyPUKwMlU2KM7:TR?= NV25e5VbOjB|MES1N|c>
SMMC7721 NIfxS|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7adXo1QCCq NXXzToxsUUN3ME2zN{4yOiEQvF2= MlTXNlA{ODR3M{e=
DU145 MlTpR5l1d3SxeHnjJGF{e2G7 MWO1JIQ> MoTRSG1UVw>? NEPwRpRKSzVyPUSyMlE4KM7:TR?= NYe4ZYdjOjB2Nk[1OVU>
MIAPaCa2 MVHDfZRwfG:6aXOgRZN{[Xl? MlrOOUBl Mn\KSG1UVw>? NXzlSZVGUUN3ME21NE43OiEQvF2= NIOzT4MzODR4NkW1OS=>
PANC1 Mn3NR5l1d3SxeHnjJGF{e2G7 Mo\qOUBl MUjEUXNQ Mm\BTWM2OD12MD60NkDPxE1? NY\0eHBYOjB2Nk[1OVU>
PC9 NHv5UY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWi1Sm81SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBGT0[ULXTl[olkcWWwdDDoeY1idiCSQ{mgZ4VtdHNid3n0bEBGSzVyIH;mJFAvODF5IN88US=> NXz4TIlHOjF{MEi4NFI>
PC9 NFL3U2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDybIRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIdzd3e2aD3y[ZNqe3SjboSgbJVu[W5iUFO5JINmdGy|IHX4dJJme3OrbnegSWdHWiCHN{S2Y2E4PTBxVEe5NG0hdXW2YX70JJdqfGhiRVO1NEBw\iB5IN88US=> NWLoZ4VSOjF{MEi4NFI>
PC3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnFNVAh|ryP NGLXbVg4OiCq NYXqSoM3TE2VTx?= M3;vTWlEPTB;Nz60JO69VQ>? M1fQT|IyOzV|NUS2
MDA-MB-468 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGraWm8yODBizszN MmHUOFghcA>? MmfTSG1UVw>? NUDpfFY2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJk> MojONlE1Ojl4M{K=
Plasmodium falciparum Mmr0dWhVWyCycn;mbYxqdmdiZn;yJIlvcGmkaYTvdpMhd2ZiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJJBzd2yrZnXyZZRqd25? NFnuU4YzOThzN{C0OS=>
NCI-H1993 NWLZUmE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jLZ|czKGh? MVfEUXNQ MlW0TWM2OD1yLkGg{txO MnvBNlE6OTZ2M{O=
NCI-H292 M3XGUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX23NkBp NITtNGNFVVOR M2X0UWlEPTB;MD6wNkDPxE1? NHnHWpQzOTlzNkSzNy=>
A431 NUH2dXlWU2mwYYPlJGF{e2G7 M3jwd|IhcA>? NYe5XlhkTE2VTx?= MkDVTY5pcWKrdHnvckBw\iCHR1\SJJBpd3OyaH;yfYxifGmxbjDpckBGT0Zvc4TpcZVt[XSnZDDoeY1idiCDNEOxJJdqfGhiSVO1NEBw\iByLkCwNUDPxE1? NVfLUFduOjJzMEGxN|I>
MCF7 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1iwcFExOMLizsznM41N MnPaOFghcA>? NF7pcYNFVVOR M2\aVWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDveoVz\XiycnXzd4lv\yCHR1\SJIdmdmVid3n0bEBKSzVyIH;mJFEzNjB3IN88US=> NFL3fVMzOjFzOUGzNC=>
BT474 MUfDfZRwfG:6aXOgRZN{[Xl? M1\yO|ExKM7:TR?= M3jXeFQ5KGh? NEfxNodEgXSxdH;4bYNqfHliYXfhbY5{fCC|ZYL1cU1{fGG{dnXkJIh2dWGwIFLUOFc1KGOnbHzz M3PS[FIzOTN6M{C4
MCF7 M{m0SGN6fG:2b4jpZ{BCe3OjeR?= MWOxNEDPxE1? NXzEXop3PDhiaB?= M2q4dWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KHOncoXtMZN1[XK4ZXSgbJVu[W5iTVPGO{Bk\WyuczDveoVzNWW6cILld5NqdmdiRYLiRlIh[2WubIO= NYfnWW96OjJzM{izNFg>
HCC827 MYnLbY5ie2ViQYPzZZk> NInBfXcxNjF{NTFOwG0> NYDPT4VSOjRiaB?= NVPS[5VXTE2VTx?= NHPJe2xKdmirYnn0bY9vKG:oIFXHSnIh\GWuIFW3OFYuSTd3MDDteZRidnRiWUGwOlgh[XW2b4Doc5NxcG:{eXzheIlwdg>? M3LGfVIzOzN7M{Sy
HCC827 NVTiU2cxU2mwYYPlJGF{e2G7 NGHUPIoxNjF{NTFOwG0> NUjOO2RIOjRiaB?= NHjvXoRFVVOR MXPJcohq[mm2aX;uJI9nKEWJRmKg[IVtKEV5NE[tRVc2OCCvdYThcpQudWWmaXH0[YQhTXKtIIDoc5NxcG:{eXzheIlwdg>? MYGyNlM{QTN2Mh?=
HCC827 NYLP[ZNsU2mwYYPlJGF{e2G7 NIHLSYkxNjF{NTFOwG0> M17wUlI1KGh? NGOybnlFVVOR MonrTY5pcWKrdHnvckBw\iCHR1\SJIRmdCCHN{S2MWE4PTBibYX0ZY51NW2nZHnheIVlKEGtdDDwbI9{eGixconsZZRqd25? NX;RR2M6OjJ|M{mzOFI>
A431 NWqxU4JzU2mwYYPlJGF{e2G7 NU\GVG9rOTByIN88US=> Ml3aN|AhdWmw NHPBcGhKdmirYnn0bY9vKG:oIFXHSnIh\GW{aY\l[EBnem:vIHj1cYFvKEF2M{GgZ4VtdCCvZX3idoFv\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHCxbImtS4x2NVS7cjDwbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFEvODhizszN NUKyPYg5OjJ4OUi3PFI>
H460 NF3QRXREgXSxdH;4bYMhSXO|YYm= NYH2RXA1PzJiaB?= MlezTWM2OD13LkW5JO69VQ>? NHv0VJYzOjd{N{S0PS=>
HT-29 MULDfZRwfG:6aXOgRZN{[Xl? NGfPeYE4OiCq M{\mc2lEPTB;Mz6zOkDPxE1? M4LnSFIzPzJ5NES5
SGC7901 M13DTmN6fG:2b4jpZ{BCe3OjeR?= NV7FNFE2PzJiaB?= NHHQdXZKSzVyPUGwMlI3KM7:TR?= MlvyNlI4Ojd2NEm=
A498 M1LkZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDpWW1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG0PVgh[2WubIOg[ZhxemW|c3nu[{BGT0[UIHHu[EBUWkNid3n0bEBKSzVyIH;mJFgvPiEQvF2= M4fSNVIzQDF6OES4
Calu3 MoTTR5l1d3SxeHnjJGF{e2G7 MnK2NVAh|rypL33M MYW3NkBp NYHTfIFiUUN3ME2xMlYh|ryP MYGyN|EyPjF4OB?=
FADU MoXFR5l1d3SxeHnjJGF{e2G7 M3zNcFExKM7:Zz;tUC=> NUTMUZA6PzJiaB?= MYXJR|UxRTBwMEWg{txO MnX0NlMyOTZzNki=
HCC827 MU\DfZRwfG:6aXOgRZN{[Xl? M3z5NVExKM7:Zz;tUC=> NXyyN295PzJiaB?= NFHUdnpKSzVyPUCuNFAyPSEQvF2= NYrhR45jOjNzMU[xOlg>
PC9 NFXYUW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfsS3ZpOTBizsznM41N MlG2O|IhcA>? MljITWM2OD1yLkCwNVQh|ryP MVOyN|EyPjF4OB?=
Sf9 NVriVIJZU2mwYYPlJGF{e2G7 NIfVdlgyKGh? NHzVdIpFVVOR M2T0eWlvcGmkaYTpc44hd2ZiaIXtZY4hT1OWLYTh[4dm\CCHR1\SJGw5OzSUIH31eIFvfCCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFAvODF3IN88US=> M2PnWFI{PjFzNkmx
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EW-18 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfyTWM2OD1{LkO1OFcyKM7:TR?= MVvTRW5ITVJ?
KU812 MlPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofaTWM2OD1{LkO2O|c6KM7:TR?= MXrTRW5ITVJ?
NY NX7FPGg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\iTWM2OD1{LkO3Nlch|ryP MonvV2FPT0WU
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CFPAC-1 MlfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLPeXhKSzVyPUKuOFM5PjRizszN MkjhV2FPT0WU
HH MmWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfyTWM2OD1{LkS5PFU1KM7:TR?= MmPuV2FPT0WU
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TE-8 M1zC[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInaNoZKSzVyPUKuOlM3PTNizszN M{HlSXNCVkeHUh?=
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DMS-79 NX;WepJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT6TWM2OD1{Lk[5Nlg1KM7:TR?= NFvBfpVUSU6JRWK=
Detroit562 NXzoOmFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;oc3FUUUN3ME2yMlY6QDR3IN88US=> M37QNHNCVkeHUh?=
HuP-T4 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXHTWM2OD1{LkeyPFE5KM7:TR?= M37YUXNCVkeHUh?=
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BB65-RCC MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\jb4VKSzVyPUKuPFA4OTNizszN M2LwOXNCVkeHUh?=
PC-3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvMdJZNUUN3ME2yMlg{OzF5IN88US=> MUnTRW5ITVJ?
OVCAR-3 NX[yNm5vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTJwOEW1PVQh|ryP M1HDU3NCVkeHUh?=
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MN-60 MonWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\VXWlEPTB;Mz6wOFk4PCEQvF2= Mlu4V2FPT0WU
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HT-1376 M{fjbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTNwMkC1NFYh|ryP MXzTRW5ITVJ?
NCI-H1793 NV;IOnJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVK1[3FHUUN3ME2zMlIyODl6IN88US=> NWX5UnpxW0GQR1XS
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NCI-H727 M2LJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfTTWM2OD1|LkO4OVg1KM7:TR?= MoG1V2FPT0WU
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639-V M2T5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljVTWM2OD1|LkW3O|kzKM7:TR?= M2DWcnNCVkeHUh?=
TE-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTNwNUmxOlkh|ryP NF7VUYZUSU6JRWK=
OAW-28 M4qybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDvW5NKSzVyPUOuOVk1OjZizszN Mn25V2FPT0WU
SK-LU-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7FTWM2OD1|Lk[wOlQ2KM7:TR?= MVjTRW5ITVJ?
CaR-1 M4jUWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLxdHJvUUN3ME2zMlYyODR6IN88US=> MnzhV2FPT0WU
A2780 M2D1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;1bWlEPTB;Mz62OFA5QSEQvF2= MUDTRW5ITVJ?
C2BBe1 Mn\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\ONWh2UUN3ME2zMlY1PDB5IN88US=> M2L0SHNCVkeHUh?=
SK-MES-1 NGrxeHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn5TWM2OD1|Lk[0OlE1KM7:TR?= NWLufFFqW0GQR1XS
PANC-10-05 NEnVRmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrw[nBMUUN3ME2zMlczODd{IN88US=> MVnTRW5ITVJ?
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NCI-H28 MmK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTNwOEK5OlEh|ryP NV7nSpJrW0GQR1XS
NCI-H1155 M1jvNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF2zPJVKSzVyPUOuPFQyPTlizszN Ml\TV2FPT0WU
KURAMOCHI M{O4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M161NGlEPTB;Mz64OlA2PiEQvF2= MUPTRW5ITVJ?
NCI-H69 NXr6c2sxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTNwOUCxO|gh|ryP NG\Nc5lUSU6JRWK=
IST-MES1 MmTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S4Z2lEPTB;Mz65OFAzQSEQvF2= NI\RUINUSU6JRWK=
NH-12 MlTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDme3hKSzVyPUOuPVQyQDdizszN M4m0bnNCVkeHUh?=
JVM-2 MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;zWGlEPTB;Mz65OFc2OiEQvF2= MVzTRW5ITVJ?
EW-16 M3:5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoX3TWM2OD1|Lkm1OVc4KM7:TR?= NW\FNHhrW0GQR1XS
NCI-H441 M2TyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\ITWM2OD1|Lkm3NFE1KM7:TR?= MojYV2FPT0WU
RCC10RGB NETndXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m0XWlEPTB;ND6wNVI1PiEQvF2= NHX4bIlUSU6JRWK=
TCCSUP NUPnOWFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu0TWM2OD12LkGxNFUh|ryP M2X3UXNCVkeHUh?=
HL-60 NXOwUZhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkn6TWM2OD12LkGyNlQyKM7:TR?= MYfTRW5ITVJ?
EW-11 NIHafHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTRwMUOyOlEh|ryP MUTTRW5ITVJ?
KARPAS-299 NVTQ[2dXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljTTWM2OD12LkOxNFE{KM7:TR?= NYrMSoFvW0GQR1XS
SNU-C2B Moq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjLcGFKSzVyPUSuN|Q3QDZizszN NEnyUnRUSU6JRWK=
LU-139 NG\5T4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHmVJJKSzVyPUSuN|czPDdizszN NX;oc3RKW0GQR1XS
HCC1937 NFz0WJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2KzNWlEPTB;ND6zO|k6OyEQvF2= MknQV2FPT0WU
GR-ST MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVG2bmRKUUN3ME20MlQ{OThizszN MmPBV2FPT0WU
SK-OV-3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\tdGlEPTB;ND60OlA1OiEQvF2= NFnwUndUSU6JRWK=
A172 NVywSm13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1O2T2lEPTB;ND61OVUzOSEQvF2= NGe2WGVUSU6JRWK=
NB10 NE\n[JlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DWN2lEPTB;ND61PVc5OSEQvF2= NUPySIZqW0GQR1XS
P30-OHK NEDnTGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXOeHNKSzVyPUSuPFE6OjlizszN MWTTRW5ITVJ?
KYSE-520 NWj5SGtyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTRwOEiwNVgh|ryP NIex[5VUSU6JRWK=
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ES1 M1\vbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXBPJBKSzVyPUSuPVYxOzVizszN Mn;mV2FPT0WU
KOSC-2 NFHZfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTRwOUm5OVkh|ryP MlzvV2FPT0WU
TE-9 MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle5TWM2OD13LkCxOVI2KM7:TR?= M13NO3NCVkeHUh?=
NCI-H1838 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXUfIZ7UUN3ME21MlAzODd4IN88US=> MmTzV2FPT0WU
KP-N-YN MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoGzTWM2OD13LkGyOVkyKM7:TR?= MmPwV2FPT0WU
ALL-PO M4j3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTVwMkK1PFch|ryP NGHjV3BUSU6JRWK=
NOMO-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLQ[WNKSzVyPUWuNlMyPzZizszN NU\mWINoW0GQR1XS
CGTH-W-1 NUCxbVQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH3WII2UUN3ME21MlM5PTh2IN88US=> NFm0SnpUSU6JRWK=
ATN-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXTcXhKSzVyPUWuOFEyQDRizszN MlHBV2FPT0WU
AGS NIXibnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH2NIl{UUN3ME21MlQ6PjF6IN88US=> MlSxV2FPT0WU
SW13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTLTWM2OD13LkWzNlY2KM7:TR?= NFzyTndUSU6JRWK=
SW1990 NI[4XopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonzTWM2OD13Lk[yNlg2KM7:TR?= NEW3b3FUSU6JRWK=
BFTC-905 NXXEd5JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTVwNkW4O|gh|ryP NHrmVJJUSU6JRWK=
RMG-I MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL4cpJzUUN3ME21MlY2QTR{IN88US=> NYD2RVdWW0GQR1XS
HD-MY-Z MoXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vGZ2lEPTB;NT62PFU5OSEQvF2= M{HGZ3NCVkeHUh?=
HCC1187 MofnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTVwN{GwN|Ih|ryP NEm4c3lUSU6JRWK=
HCC2998 NEjIbWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTVwN{G4O|ch|ryP NHfMenVUSU6JRWK=
RT-112 MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnQOXI1UUN3ME21MlkxOjR3IN88US=> MU\TRW5ITVJ?
CAKI-1 M3LZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1r1T2lEPTB;Nj6wNFk5PSEQvF2= Mn\EV2FPT0WU
HDLM-2 M{W4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXv0fHJuUUN3ME22MlAyPDh7IN88US=> M4fEVnNCVkeHUh?=
TE-10 M2TRbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rZXGlEPTB;Nj6wOFg{OyEQvF2= M1PCZnNCVkeHUh?=
KE-37 MoLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jre2lEPTB;Nj6wO|I2QCEQvF2= NFTyNJlUSU6JRWK=
RCM-1 Mn25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmCzTWM2OD14LkC3O|E6KM7:TR?= Mlf2V2FPT0WU
Mewo M3HRbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7sOIpKSzVyPU[uNVE1QDdizszN MUHTRW5ITVJ?
L-428 NUC3XINIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfRTWM2OD14LkG4NFM4KM7:TR?= M{i3b3NCVkeHUh?=
8-MG-BA NVLFeXkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDtfFNHUUN3ME22MlE6Ozd7IN88US=> M{nOenNCVkeHUh?=
SK-MEL-28 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHBTWM2OD14LkKwPVY4KM7:TR?= NWX2S2ltW0GQR1XS
VA-ES-BJ MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPHTWM2OD14LkOwOFYzKM7:TR?= NGPReo1USU6JRWK=
CAL-120 NIXCTmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTZwNEWxOlIh|ryP Mo\iV2FPT0WU
GAMG NX;HUWp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvnOlZKSzVyPU[uOVA3OiEQvF2= NYLsT3dbW0GQR1XS
MSTO-221H NXPNdIxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTZwNUGxO{DPxE1? NF;H[I9USU6JRWK=
GCT NVvvZ5VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljUTWM2OD14LkWzN|g4KM7:TR?= MYrTRW5ITVJ?
SH-4 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLrcIFrUUN3ME22MlU5QDR2IN88US=> NUXpNIM{W0GQR1XS
Calu-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTZwNkW1Olgh|ryP MkmxV2FPT0WU
SK-HEP-1 M3fvZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTZwN{G3OVMh|ryP MXLTRW5ITVJ?
PFSK-1 NHfmZplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTZwN{O0O|gh|ryP NGPv[GdUSU6JRWK=
NB12 NVrwS4hDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi1cHBKSzVyPU[uO|g1ODRizszN MYXTRW5ITVJ?
A388 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF31XlhKSzVyPU[uPFk2OiEQvF2= MnrzV2FPT0WU
KLE MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\0TWM2OD14Lkm2OVE3KM7:TR?= MVfTRW5ITVJ?
TE-11 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTdwMES5Olch|ryP NW\qZWlMW0GQR1XS
NCI-H2405 MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTdwMEizPVMh|ryP MUTTRW5ITVJ?
OVCAR-4 M36zb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTKOnAzUUN3ME23MlE2OzVizszN M2jZNHNCVkeHUh?=
KP-N-YS NVv3UXBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jZS2lEPTB;Nz6xPFE1KM7:TR?= NVPFNph{W0GQR1XS
NOS-1 M{TlUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\TVI5FUUN3ME23MlI2QDJ6IN88US=> MXPTRW5ITVJ?
DMS-114 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTdwMkm2N|Eh|ryP MmTUV2FPT0WU
NCI-H2030 M3vPdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M32zeWlEPTB;Nz6zN|Y6QCEQvF2= MlHFV2FPT0WU
HEL NX7JdnVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\4OpN4UUN3ME23MlM4PTJzIN88US=> NFLUWYtUSU6JRWK=
CAL-62 Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33SWWlEPTB;Nz6zPVg3PiEQvF2= MYHTRW5ITVJ?
COLO-668 NUP6PY5TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\OWWlEPTB;Nz60N|k3PyEQvF2= Mn3nV2FPT0WU
SKG-IIIa NEntTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTdwNEWzPFEh|ryP NH7qeXdUSU6JRWK=
HCC1419 NHjOW4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzBTWM2OD15LkS2PFM{KM7:TR?= NHnne5BUSU6JRWK=
OS-RC-2 MojQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLDZXQ2UUN3ME23MlQ6QDl2IN88US=> MUPTRW5ITVJ?
COLO-829 NXHTO3VqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTdwNk[0OlMh|ryP MWfTRW5ITVJ?
NB13 NULMW|E2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTdwOEK2Olch|ryP NUTseZNJW0GQR1XS
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D-263MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:1O2lEPTB;MUmuNFE4OiEQvF2= Mnz5V2FPT0WU
NCI-H1437 NF\rb25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF7LkC0Olch|ryP MnrCV2FPT0WU
NCI-H1048 M2\ZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nuU2lEPTB;MUmuNlMzPiEQvF2= M2Txb3NCVkeHUh?=
NCI-H446 MnjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEP1OY9KSzVyPUG5MlM2QDlizszN MnvHV2FPT0WU
NCI-N87 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTF7LkW5PVIh|ryP M{TxWHNCVkeHUh?=
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HuH-7 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHYWmdFUUN3ME2xPU44PDJzIN88US=> NXHFSVJJW0GQR1XS
NCI-H650 M2D6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfjdGUxUUN3ME2xPU44PTB6IN88US=> MYXTRW5ITVJ?
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Becker MkLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fQXGlEPTB;MUmuPFU1PyEQvF2= NUi2Xnd3W0GQR1XS
BB49-HNC Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIftR2pKSzVyPUG5MlkzKM7:TR?= MlHNV2FPT0WU
HGC-27 MlvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHhTYhDUUN3ME2yNE4yOzl2IN88US=> MmD3V2FPT0WU
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A375 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ewc2lEPTB;MkGuNFU3PyEQvF2= MVPTRW5ITVJ?
MC116 MnTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG5TWM2OD1{MT6wO|I{KM7:TR?= NUnKXHpnW0GQR1XS
GI-1 NHn1[o5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1my[GlEPTB;MkGuNVch|ryP MXfTRW5ITVJ?
HOP-62 NEHTNHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnl[HFoUUN3ME2yNU4zPzh2IN88US=> M{\0WHNCVkeHUh?=
PA-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{j6XGlEPTB;MkGuNlc5PyEQvF2= MmDVV2FPT0WU
HT NEXzZWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJzLkSzN|Eh|ryP M{nDe3NCVkeHUh?=
HUTU-80 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvTeo5UUUN3ME2yNU41OzN4IN88US=> NV2zcHdUW0GQR1XS
NCI-H1975 NEHSNWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTJzLkS2NUDPxE1? M1HFVnNCVkeHUh?=
GAK M3fUSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXiNXBTUUN3ME2yNU41QTlizszN NWTtR|Q4W0GQR1XS
SK-N-AS M1\rZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r0V2lEPTB;MkGuOVYyQSEQvF2= NIXBOYpUSU6JRWK=
OE33 MnvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moe4TWM2OD1{MT62NFQ3KM7:TR?= M4fu[XNCVkeHUh?=
YKG-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;xTWM2OD1{MT62OVQ2KM7:TR?= NWnR[Zk{W0GQR1XS
CAL-85 Mn3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\xTWM2OD1{MT65N|A2KM7:TR?= NHnCfYFUSU6JRWK=
NCI-H2347 NIDy[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJzLkm0Nlgh|ryP NVm3[4xLW0GQR1XS
PANC-08-13 NF32WmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof5TWM2OD1{Mj6wNVE6KM7:TR?= M1;hVHNCVkeHUh?=
SK-N-FI M2XQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXW1cppnUUN3ME2yNk4{ODd2IN88US=> NGLXR3VUSU6JRWK=
NEC8 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDFenRYUUN3ME2yNk42ODd6IN88US=> NIfiWW5USU6JRWK=
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HuO9 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jRcWlEPTB;MkKuO|M6PiEQvF2= NX7y[WJsW0GQR1XS
COLO-800 MoD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjU[WQxUUN3ME2yNk44PjV|IN88US=> M3rZN3NCVkeHUh?=
HT-29 Ml;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTJ{Lki4NlMh|ryP M3XTOHNCVkeHUh?=
OC-314 NI\FS2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVv0XnVoUUN3ME2yNk45QDR3IN88US=> NEjET4NUSU6JRWK=
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Saos-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLpSFRRUUN3ME2yN{42OTh{IN88US=> M1\5TXNCVkeHUh?=
UACC-62 NUTscnZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTJ|LkW4N|Mh|ryP NGLwVGRUSU6JRWK=
D-247MG MnvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\zVmlEPTB;MkOuO|k{QSEQvF2= NX\Sc4JVW0GQR1XS
COLO-741 M1j4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPIVYRvUUN3ME2yN{46PTZ3IN88US=> M1rLbHNCVkeHUh?=
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LNCaP-Clone-FGC NV\RO3FpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHkVW9YUUN3ME2yOE4xOjFzIN88US=> NWC3OnBzW0GQR1XS
SW1710 NXH4XVNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPXWHlKSzVyPUK0MlE2ODZizszN MknmV2FPT0WU
LU-99A MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnG4TWM2OD1{ND6xPFQyKM7:TR?= M3HONnNCVkeHUh?=
HOP-92 M4Dne2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLJU|hKSzVyPUK0MlczPSEQvF2= MlHNV2FPT0WU
LS-123 MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJ2Lkm2NVQh|ryP NGfuW5pUSU6JRWK=
T84 Ml;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVz6RoFYUUN3ME2yOE46PzZ3IN88US=> MmPhV2FPT0WU
HCT-116 NESxNpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJ3LkSxPFYh|ryP NWHjU2lZW0GQR1XS
M14 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3QTWM2OD1{NT60OFQ4KM7:TR?= MlrPV2FPT0WU
OCUB-M MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD4XZZjUUN3ME2yOU41PDV4IN88US=> NV\Xb5lNW0GQR1XS
MKN45 M3XFVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHwTWM2OD1{NT62N|E2KM7:TR?= MmPYV2FPT0WU
LCLC-97TM1 MlPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjQN2pKSzVyPUK1MlczQDVizszN M3;4b3NCVkeHUh?=
RVH-421 MmrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTJ3LkixOlEh|ryP MlXHV2FPT0WU
NKS-81-FD NFnl[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX3TWM2OD1{NT65NFIyKM7:TR?= NGi3dYJUSU6JRWK=
NCI-H596 MnzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJ4LkC0PFch|ryP M2TDS3NCVkeHUh?=
GB-1 M2KweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\NT41KSzVyPUK2MlE5PzlizszN NVSycVJ4W0GQR1XS
ZR-75-30 NWnL[243T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqzWpR5UUN3ME2yOk4zOjl5IN88US=> MoL6V2FPT0WU
U-2-OS MnfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL3dm9VUUN3ME2yOk4{PzV5IN88US=> NFH1Oo9USU6JRWK=
HuP-T3 MlLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v1VmlEPTB;Mk[uOlExOiEQvF2= NX7B[2xkW0GQR1XS
MOLT-16 Mn;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYewNI43UUN3ME2yOk43OTZ4IN88US=> M1e4enNCVkeHUh?=
U-87-MG NYP3VGFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjL[ZZuUUN3ME2yOk44PDN6IN88US=> M1zhOHNCVkeHUh?=
8505C NGTmXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJ4LkmxNlYh|ryP MY\TRW5ITVJ?
SK-MEL-3 M4XlVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXQeHB2UUN3ME2yOk46QDJ6IN88US=> MWjTRW5ITVJ?
COLO-824 M2PuWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfoTWM2OD1{Nz6yNVk2KM7:TR?= M1qyVHNCVkeHUh?=
EW-1 NX6ze2ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJ5LkO1OVQh|ryP NHzsdHVUSU6JRWK=
UACC-257 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrYSHFMUUN3ME2yO{4{QDB2IN88US=> NX;3So1KW0GQR1XS
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UACC-893 NXnFdFVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1W3VmlEPTB;MkeuOlY{OSEQvF2= MXXTRW5ITVJ?
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KYSE-410 NGOwbGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJ6LkK3O|kh|ryP MYDTRW5ITVJ?
SF126 NGrmbm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHaeXlKSzVyPUK4Mlc1OzVizszN NHrSRmZUSU6JRWK=
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SW1573 NWXVOoE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn33TWM2OD1{OT6zOVA6KM7:TR?= NXjGTo95W0GQR1XS
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EW-22 NUL6TGlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTNyLkG5Olkh|ryP MYDTRW5ITVJ?
H4 MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmOxTWM2OD1|MD60OlU1KM7:TR?= M{DadXNCVkeHUh?=
CAS-1 M1vsV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITGc4xKSzVyPUOwMlc5PTlizszN MUnTRW5ITVJ?
MG-63 NInN[GpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVu3ZoxDUUN3ME2zNE45PDd6IN88US=> M3[3eHNCVkeHUh?=
MDA-MB-415 M1LEdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTNzLkG3OVMh|ryP M{HSSnNCVkeHUh?=
NCI-H1395 Mnf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPtTWM2OD1|MT6yN|I5KM7:TR?= NFXPXINUSU6JRWK=
Ca-Ski MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX76OIlMUUN3ME2zNU4{OTd5IN88US=> M1nWNnNCVkeHUh?=
BxPC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGX6RpVKSzVyPUOxMlM4OjlizszN MVHTRW5ITVJ?
A3-KAW M4OxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPhUoY4UUN3ME2zNU41PDdzIN88US=> NWTKZZgxW0GQR1XS
T-24 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVP6RnFqUUN3ME2zNU44OzZ{IN88US=> MoXUV2FPT0WU
NCI-H2029 MkHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2i3TWlEPTB;M{GuO|c3PSEQvF2= M2TNTnNCVkeHUh?=
YAPC NGfVU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYraWYh1UUN3ME2zNk4xPDB5IN88US=> NFf5[4ZUSU6JRWK=
SK-MEL-2 NWH4dG1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfHPZhKSzVyPUOyMlA2OiEQvF2= MX\TRW5ITVJ?
LS-513 M3rFcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTN{LkGxPFch|ryP M1:wZnNCVkeHUh?=
AsPC-1 MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlO0TWM2OD1|Mj6zOlA2KM7:TR?= MXfTRW5ITVJ?
KYSE-150 NYLSb|F7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTN{LkO3O|Mh|ryP MYTTRW5ITVJ?
NCI-H520 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\LTWM2OD1|Mj60OFgzKM7:TR?= MW\TRW5ITVJ?
JEG-3 NHnMNGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTN|LkC5O|Eh|ryP MVrTRW5ITVJ?
GMS-10 Mm\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vWRmlEPTB;M{OuN|AxPCEQvF2= NWTiblRPW0GQR1XS
HT-1080 NHLGVZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTN|LkO5JO69VQ>? Mn[yV2FPT0WU
NCI-H1651 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\3bJFKSzVyPUOzMlM6PiEQvF2= NUDZ[FIyW0GQR1XS
NCI-H2122 M3j5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTrOVlKSzVyPUOzMlU2PzRizszN MYPTRW5ITVJ?
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8305C NIL4UmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDtNI82UUN3ME2zN{46QTN5IN88US=> M4jnPHNCVkeHUh?=
KM12 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XkW2lEPTB;M{SuNFQ4QCEQvF2= MmDEV2FPT0WU
HCT-15 MkHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTN2LkGyO{DPxE1? NHPlcYNUSU6JRWK=
OVCAR-5 NWrRXlBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\VdGRNUUN3ME2zOE4zOTh{IN88US=> NGPPNGlUSU6JRWK=
NCI-H2291 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPLXoFKSzVyPUO0MlI1PzJizszN MUHTRW5ITVJ?
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C-33-A Mn30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTN2Lk[4OVch|ryP NGrDVXhUSU6JRWK=
NCI-H2452 NV;yO|BZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTN2Lke4PFIh|ryP MoTYV2FPT0WU
MDA-MB-157 NUDrSmI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPKZYpVUUN3ME2zOE45OTl|IN88US=> MknUV2FPT0WU
LN-405 NGr2UmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTN3LkSzNFgh|ryP NXfxPZkzW0GQR1XS
MDA-MB-231 M37idmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTN3LkWwOVQh|ryP NYW4cmYxW0GQR1XS
EW-24 MmDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LOb2lEPTB;M{WuOlM{PSEQvF2= M361RXNCVkeHUh?=
MKN28 NE[1e|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3SyZmlEPTB;M{WuPFI{PiEQvF2= NXvmcnBIW0GQR1XS
KINGS-1 NFzETm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDUOG9KSzVyPUO1Mlg1OzRizszN NX;OTYhDW0GQR1XS
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IGR-1 M1PEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLHTWM2OD1|Nj63NFc2KM7:TR?= M{Sz[HNCVkeHUh?=
SW626 NIP1S5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTN5LkC0NVch|ryP NITo[ZlUSU6JRWK=
ONS-76 Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf3TXdKSzVyPUO3MlE{ODlizszN M4LKbXNCVkeHUh?=
T98G Mn3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHUZXBKSzVyPUO3Mlg3OzVizszN NHnwVllUSU6JRWK=
NB14 MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX3elhWUUN3ME2zPE41PTR2IN88US=> M2\zSHNCVkeHUh?=
D-423MG NHG3VpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XBWWlEPTB;M{iuOFg3QSEQvF2= NVrObHBjW0GQR1XS
NCI-H510A NFq3Z4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH35enJKSzVyPUO4MlY1PTFizszN MXvTRW5ITVJ?
NMC-G1 MoDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW0TWM2OD1|OD63NlIzKM7:TR?= NV7SXHdPW0GQR1XS
SW948 NYroUoVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTN6Lki5OFkh|ryP MU\TRW5ITVJ?
MFM-223 MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TYSGlEPTB;M{iuPVQ{OSEQvF2= MmXQV2FPT0WU
PAN1 MoPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7PN|ZKSzVyPUO4Mlk6OTlizszN Mo\RV2FPT0WU
MZ7-mel MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{KzV2lEPTB;M{muNVE6QSEQvF2= NGnKXY9USU6JRWK=
COLO-679 Mn;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTN7Lkm3NFgh|ryP NEfjWVZUSU6JRWK=
SW872 NWTYW3VST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHUXHFjUUN3ME20NE4zODNzIN88US=> NYnJdFFtW0GQR1XS
HT-1197 MoXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHiw[2tKSzVyPUSwMlI5PjlizszN MojZV2FPT0WU
ES6 M2XubGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTRyLkS1OVIh|ryP MnPaV2FPT0WU
SNU-387 M1rnfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jHfWlEPTB;NECuPFI{QCEQvF2= MVfTRW5ITVJ?
T47D MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\LTZY4UUN3ME20NU4xOTl{IN88US=> Ml64V2FPT0WU
G-402 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHnW2tnUUN3ME20NU4xQDB7IN88US=> NHXMO|RUSU6JRWK=
MZ1-PC MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\WTWM2OD12MT64NUDPxE1? NELncVNUSU6JRWK=
SW1417 MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTR{LkOwN{DPxE1? MmfRV2FPT0WU
RERF-LC-MS NFzCdI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTR{LkWwPFch|ryP MoPHV2FPT0WU
SF539 NEW5bpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTR{LkW1Nlkh|ryP MlnDV2FPT0WU
ESS-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHK1VmpKSzVyPUSzMlU2PThizszN MWrTRW5ITVJ?
RO82-W-1 NVP5blhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPnNYVjUUN3ME20N{43OTV|IN88US=> NIDw[2ZUSU6JRWK=
S-117 M2LaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\iS5dKSzVyPUSzMlY6PThizszN NXPTWlZkW0GQR1XS
SW756 M3TGTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PwWGlEPTB;NEOuPFI1OiEQvF2= MnXTV2FPT0WU
CP66-MEL NV;qW3I3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi0NZBKSzVyPUS1MlcyPDNizszN M3zRT3NCVkeHUh?=
H-EMC-SS NICzfXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7CS4ZYUUN3ME20OU44Pjl|IN88US=> MUPTRW5ITVJ?
NCI-H2052 Mo\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInnZpJKSzVyPUS1MlkxOjdizszN NF62WYVUSU6JRWK=
SW684 M3PwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ETWM2OD12Nz6wNFgyKM7:TR?= NGPkZ45USU6JRWK=
HCC1569 MlLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LXNWlEPTB;NEeuNVY2QCEQvF2= NGfWR21USU6JRWK=
KGN MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjYXmJKSzVyPUS3MlM{OTFizszN M1TKe3NCVkeHUh?=
LCLC-103H MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1i4UGlEPTB;NEeuOFQxPCEQvF2= NF:zPXlUSU6JRWK=
SW780 M{LCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnhTWM2OD12Nz62N|UyKM7:TR?= M1PjOHNCVkeHUh?=
NCI-H1703 MlPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF22RllKSzVyPUS4MlM{PTJizszN MV\TRW5ITVJ?
HCC1395 NGXjdJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTR6Lke0N|Ih|ryP Mn3XV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts. [3] Gefitinib treatment of nude mice bearing established human GEO colon cancer xenografts reveals a reversible dose-dependent inhibition of tumor growth because GEO tumors resumes the growth rate of controls at the end of the treatment. [4]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: NR6, NR6M and NR6W cells
  • Concentrations: 0-2 μM
  • Incubation Time: 72 hours
  • Method: Exponentially growing cells including NR6, NR6M, NR6M and NR6W cells are seeded in sextuple in 96-well plates at a concentration of 2000 cells/well, allowed to adhere and subsequently washed in PBS and incubated overnight in medium containing 0.5% FCS. Cells are then treated with varying concentrations (0-2 μM) of Gefitinib or the solute control DMSO and EGF. The optimal EGF concentration for inducing proliferation of NR6wtEGFR and NR6W cells has previously been determined and hence NR6wtEGFR and NR6W cells are supplemented with 10 nM and 0.1 nM EGF, respectively. EGF is not added to NR6 and NR6M cells. After 72 hours the amount of cells are measured by performing a MTT proliferation assay.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female nude mice (cba nu/nu) aged 8–10 weeks are intra-dermal injected with LoVo cells.
  • Formulation: 0.5% polysorbate
  • Dosages: 100 mg/kg
  • Administration: Once daily by oral administration (0.1 mL/10 g body weight) for 14 days
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water slightly soluble or insoluble
In vivo Add solvents individually and in order:
5% DMSO+corn oil
2.5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 446.90
Formula

C22H24ClFN4O3

CAS No. 184475-35-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03050164 Completed Bioequivalence Study Hunan Kelun Pharmaceutical Co., Ltd. September 8, 2016 Phase 1
NCT02856893 Not yet recruiting NSCLC European Organisation for Research and Treatment of Cancer - EORTC|AstraZeneca March 2017 Phase 2
NCT02976116 Recruiting NSCLC Hutchison Medipharma Limited December 2016 Phase 2
NCT02951637 Not yet recruiting Lung Adenocarcinoma Shanghai Chest Hospital|Ruijin Hospital|Changhai Hospital December 2016 Phase 2
NCT02930954 Not yet recruiting Non-small-cell Lung Cancer Caicun Zhou|Tongji University November 2016 Phase 2
NCT02929693 Enrolling by invitation Cancer Shanghai University of Traditional Chinese Medicine|Shanghai Chest Hospital|Shanghai Pulmonary Hospital, Shanghai, China October 2016 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID