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S1025

Gefitinib(Iressa)

 (Synonyms

ZD-1839, Iressa

)

Technical Data:
Gefitinib(Iressa)
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M.Wt: 446.90
Formula: C22H24ClFN4O3
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 184475-35-2
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Price and Availability of Gefitinib(Iressa):

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Applications & Customer's Feedback of Gefitinib(Iressa):

     

Quality Control:
MSDS
Batch S102502: H-NMR  COA
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Biological Activity of Gefitinib(Iressa):

MCF10A cells are nontransformed breast epithelial cells that require EGF to proliferate.The monolayer growth of these EGF-driven untransformed cells is inhibited by ZD1839 with an IC50 of 20 nM, similar to its IC50 in vitro for EGFR and consistent with effective inhibition of EGFR in vivo. [1]
Cell line characteristics and sensitivity to ZD1839 at 1uM are 59% inhibition for MDA-MB-231,74% inhibition for A431, 81% inhibition for SKBr3,60% inhibition for SKOV3, 33% inhibition for BT474,52% inhibition for MCF-7, 28% inhibition for T47D, respectively.



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