Gefitinib (ZD1839)

Catalog No.S1025

Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

Price Stock Quantity  
USD 191 In stock
USD 147 In stock
USD 270 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Gefitinib (ZD1839) Chemical Structure

Gefitinib (ZD1839) Chemical Structure
Molecular Weight: 446.90

Validation & Quality Control

Cited by 90 publications:

11 customer reviews :

Quality Control & MSDS

Related Compound Libraries

EGFR Inhibitors with Unique Features

  • Pan EGFR Inhibitor

    AZD8931 (Sapitinib) Pan-ErbB inhibitor, EGFR/ErbB2/ErbB3, IC50=4 nM/3 nM/4 nM.

  • Most Potent EGFR Inhibitor

    Afatinib (BIBW2992) EGFR(wt), IC50=0.5 nM; EGFR(L858R), IC50=0.4 nM; EGFR(L858R/T790M), IC50=10 nM; HER2, IC50=14 nM.

  • FDA-approved EGFR Inhibitor

    Lapatinib Approved by FDA for breast cancer.

  • Newest EGFR Inhibitor

    CO-1686 (AVL-301) Irreversible, mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT, respectively.

Product Information

  • Compare EGFR Inhibitors
    Compare EGFR Products
  • Research Area
  • Combination Therapy
    Combination Therapy

Product Description

Biological Activity

Description Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
Targets Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
IC50 26 nM 37 nM 37 nM 57 nM
In vitro Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhibits EGFR and ERK phosphorylation up to 72 hours after EGF stimulation in both the high- and low-EGFR-expressing cell lines. [1] Gefitinib is the monolayer growth of these EGF-driven untransformed MCF10A cells with an IC50 of 20 nM. [2] The combination of Gefitinib (0.2 μM and 0.5 μM) with irradiation lead to a significant growth inhibition in LoVo cells, compared with radiation alone.. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
KBMnu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml3RTWM2OD1yLkC1OEDPxE1?M3ezdVE3PTF4NEez
NIH3T3NFfTSYNHfW6ldHnvckBCe3OjeR?=NGLwXXMxNjJizszNM2\TdFIhcA>?NYXSbotRTE2VTx?=MYnJcohq[mm2aX;uJI9nKEWJRjDzeIlufWyjdHXkJIh2dWGwIHXyZmIyKGG3dH;wbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvODF2NDFOwG0>MUWxOlQ5ODJ6NB?=
COS7MX3GeY5kfGmxbjDBd5NigQ>?NHftbIE6PiEQvF2=MVHJcohq[mm2aX;uJI9nKGi3bXHuJGpCUzJiVk[xO2YhdXW2YX70JIV5eHKnc4Pl[C=>NGrifI4yPzF5OEeyNi=>
A549M{ThXGN6fG:2b4jpZ{BCe3OjeR?=MYS5OkBpNVuy[ppCTE2VTx?=MmnOTWM2OD1zMz61PUDPxE1?M1HTXFE5OzF|OEC3
K562NVXENWJFS3m2b4TvfIlkKEG|c3H5MYK5OkBpMXXEUXNQM{flfmlEPTB;OT6zOkDPxE1?NVzUUYRQOTh|MUO4NFc>
MDA-MB-231M1zsOWN6fG:2b4jpZ{BCe3OjeR?=NFXSTFM6PiCqM{LUbmROW09?NXPkdmZJUUN3ME2zOk43OSEQvF2=NEfzeHgyQDNzM{iwOy=>
MOLT4NVntdWtXS3m2b4TvfIlkKEG|c3H5MXK5OkBpMkT4SG1UVw>?NFjKeYxKSzVyPUG1MlAzKM7:TR?=NGraTI4yQDNzM{iwOy=>
MCF7NUHk[ZpoS3m2b4TvfIlkKEG|c3H5MUK1NEDPxE1?Ml;yO|IhcA>?NGXSOo9KSzVyPUGyMlA2KM7:TR?=M4Xad|E5PzdzOEG5
BT474NEG0OFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV\wUlF7PzJiaB?=Mmj3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEVES3OEBk\WyuczDveoVz\XiycnXzd4lv\yCHUlLiNkB4cXSqIFXDOVAhd2ZiMD6zJO69VQ>?NG[1Z|cyQTB{OESyOC=>
HN5MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVy3NkBpM1\jcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSF61JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWJRmKge4l1cCCHQ{WwJI9nKDBwMEGg{txOMkTQNVkxOjh2MkS=
BA/F3NVHPOXFFS3m2b4TvfIlkKEG|c3H5NFvIUWg4OiCqMmTKR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCHR1\SJGw5PTiUIH31eIFvfCC5aYToJGlEPTBib3[gNE4xOTB6IN88US=>NYrSU25EOTl{M{myNlk>
NIH3T3MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFS2N3U4OiCqM3HGb2dzd3e2aDDpcohq[mm2aX;uJI9nKG2xdYPlJG5KUC9|VEOgZ4VtdHNiZYjwdoV{e2mwZzDldmIzKGenbnWge4l1cCCLQ{WwJI9nKDBwNUSg{txONWrjRVZHOTl4NkWzO|c>
MCF7 MXMXTGeY5kfGmxbjDBd5NigQ>?MWqzNEBucW5?NUjmUpNwUW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4yKM7:TR?=MUmxPVk{Ojl4MB?=
A431NV7leIp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVWxNEDPxE1?NVrrfnV5PzJiaB?=MoDPS2k2OD1yLkWxOEDPxE1?NW\OWJVmOTl7Nkm0OlU>
A431Mly0T4lv[XOnIFHzd4F6NWP6RoxROC5zIN88US=>MkjYNUBpNXTNdo1NUW6qaXLpeIlwdiCxZjDFS2YucW6mdXPl[EBGT0[UIIDoc5NxcG:{eXzheIlwdg>?MlrtNVk6Pjl2NkW=
A431MVzLbY5ie2ViQYPzZZk>M3W1b|ExOCEQvF2=NHK0O3kyOCCvaX6=NWH2TJBGWHKxbH;u[4VlKGmwaHnibZRwenliYXP0bZZqfHlib3[gSWdHNWmwZIXj[YQhTUeIUjDwbI9{eGixconsZZRqd25?Mn\xNVk6Pjl2NkW=
Sf9M4rYemtqdmG|ZTDBd5NigQ>?MUCxNEBucW5?NXfubJpuTE2VTx?=MnfMTY5pcWKrdHnvckBw\iCHR1\SJIV5eHKnc4Pl[EBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJJm[2WydH;yJIF2fG:yaH;zdIhwenmuYYTpc44hf2m2aDDJR|UxKG:oIECuNFM{KM7:TR?=MkjnNlAxPTZ2MkW=
NCI-H1975M4fiR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYTKd|hEPSEQvF2=NFfjfYM4OiCqNFrYfGNKSzVyPUiuNlYh|ryPMV:yNFE2OTZ5MB?=
NCI-H1975NYnkfJpJU2mwYYPlJGF{e2G7MVmxNEDPxE1?MYTJcohq[mm2aX;uJI9nKEWJRmKgZZV1d3Cqb4PwbI9zgWyjdHnvci=>Mnf0NlAyPTF4N{C=
NCI-H1975MXjGeY5kfGmxbjDBd5NigQ>?M{fvOlExKM7:TR?=NYfjfZdlUW6qaXLpeIlwdiCxZjDFVmJDOiCjdYTvdIhwe3Cqb4L5cIF1cW:wNHzFZ3IzODF3MU[3NC=>
NCI-H1975NH;WZ4RHfW6ldHnvckBCe3OjeR?=NHfVbYc2KM7:TR?=MlzzOFghcA>?NXX4WVR2UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDhd5Nme3OnZDDhd{Bi[3SrdnH0bY9vKG:oIHPhd5Bie2VvMx?=M3zLeFIxOTVzNkew
A375MlXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXu0PEBpM4Xwd2lEPTB;MkCuOVUh|ryPMY[yNFMxPDV|Nx?=
SMMC7721MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFrzNXo1QCCqM2S1cWlEPTB;M{OuNVIh|ryPMWCyNFMxPDV|Nx?=
DU145NIjYe3ZEgXSxdH;4bYMhSXO|YYm=MnHoOUBlM13sbWROW09?Mn\uTWM2OD12Mj6xO{DPxE1?NIjt[|kzODR4NkW1OS=>
MIAPaCa2MULDfZRwfG:6aXOgRZN{[Xl?NXK2XWRMPSCmMoDzSG1UVw>?NWnOUZZlUUN3ME21NE43OiEQvF2=MUCyNFQ3PjV3NR?=
PANC1M{fYSmN6fG:2b4jpZ{BCe3OjeR?=NUP0VHVqPSCmMoHiSG1UVw>?MVLJR|UxRTRyLkSyJO69VQ>?NWjqc5lQOjB2Nk[1OVU>
PC9M4i4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHXJcJpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGVITlJvZHXmbYNq\W62IHj1cYFvKFCFOTDj[YxteyC5aYToJGVEPTBib3[gNE4xOTdizszNM13zNlIyOjB6OECy
PC9NIDmVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3XzeGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[5Jwf3SqLYLld4l{fGGwdDDoeY1idiCSQ{mgZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKEV5NE\fRVc2OC:WN{mwUUBufXSjboSge4l1cCCHQ{WwJI9nKDdizszNNYi1U4xWOjF{MEi4NFI>
PC3NIXwfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2fFRVExKM7:TR?=NX6zOmt5PzJiaB?=NYn5XIxbTE2VTx?=NInMTlRKSzVyPUeuOEDPxE1?MlzZNlE{PTN3NE[=
MDA-MB-468NWLKc5B6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWGxNFAh|ryPMUO0PEBpMX3EUXNQM4LkSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5NFTL[IYzOTR{OU[zNi=>
Plasmodium falciparumMnv0dWhVWyCycn;mbYxqdmdiZn;yJIlvcGmkaYTvdpMhd2ZiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJJBzd2yrZnXyZZRqd25?NHzt[YMzOThzN{C0OS=>
NCI-H1993M1nBXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmG4O|IhcA>?Mlm1SG1UVw>?MWTJR|UxRTBwMTFOwG0>M1TqeVIyQTF4NEOz
NCI-H292NFrhRYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHvDVWg4OiCqMUTEUXNQNXzxT21LUUN3ME2wMlAzKM7:TR?=MXKyNVkyPjR|Mx?=
A431MV\LbY5ie2ViQYPzZZk>Ml7LNkBpNHzXW4NFVVORMXHJcohq[mm2aX;uJI9nKEWJRmKgdIhwe3Cqb4L5cIF1cW:wIHnuJGVITi2|dHnteYxifGWmIHj1cYFvKEF2M{Gge4l1cCCLQ{WwJI9nKDBwMECxJO69VQ>?MmqyNlIyODFzM{K=
MCF7M3XVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWjLdoRHOTBywrFOwIcwdUx?MVu0PEBpNHz4UllFVVORNXrmd2t[SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJI93\XKneIDy[ZN{cW6pIFXHSnIh\2WwZTD3bZRpKEmFNUCgc4YhOTJwMEWg{txONH72XYEzOjFzOUGzNC=>
BT474MYLDfZRwfG:6aXOgRZN{[Xl?MVOxNEDPxE1?Ml:0OFghcA>?M1;mSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KHOncoXtMZN1[XK4ZXSgbJVu[W5iQmS0O|Qh[2WubIO=NFi0UXgzOjF|OEOwPC=>
MCF7MV7DfZRwfG:6aXOgRZN{[Xl?M1rQVFExKM7:TR?=MmfaOFghcA>?M1LCXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KHOncoXtMZN1[XK4ZXSgbJVu[W5iTVPGO{Bk\WyuczDveoVzNWW6cILld5NqdmdiRYLiRlIh[2WubIO=NXLsZpExOjJzM{izNFg>
HCC827MoK5T4lv[XOnIFHzd4F6NYDm[ZlZOC5zMkWg{txOM2[4fVI1KGh?M2\QdmROW09?MUPJcohq[mm2aX;uJI9nKEWJRmKg[IVtKEV5NE[tRVc2OCCvdYThcpQhYTFyNkigZZV1d3Cqb4PwbI9zgWyjdHnvci=>MUWyNlM{QTN2Mh?=
HCC827MVzLbY5ie2ViQYPzZZk>MnHWNE4yOjVizszNMnz0NlQhcA>?NFH5SmdFVVORNV;FVmdtUW6qaXLpeIlwdiCxZjDFS2ZTKGSnbDDFO|Q3NUF5NUCgcZV1[W62LX3l[IlifGWmIFXyb{BxcG:|cHjvdplt[XSrb36=Mlq5NlI{Ozl|NEK=
HCC827NUX4U|BzU2mwYYPlJGF{e2G7M3PLWlAvOTJ3IN88US=>M4DmeVI1KGh?NVS0UWlSTE2VTx?=M1PtbGlvcGmkaYTpc44hd2ZiRVfGVkBl\WxiRUe0Ok1CPzVyIH31eIFvfC2vZXTpZZRm\CCDa4SgdIhwe3Cqb4L5cIF1cW:wMUmyNlM{QTN2Mh?=
A431NHfWbphMcW6jc3WgRZN{[Xl?NHi5[WUyODBizszNMUOzNEBucW5?NUDwdppbUW6qaXLpeIlwdiCxZjDFS2ZTKGSncnn2[YQh\nKxbTDoeY1idiCDNEOxJINmdGxibXXtZpJidmViYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCyb3z5MWdtfS2WeYKgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAyNjB6IN88US=>M3XwZVIzPjl6N{iy
H460MmC2R5l1d3SxeHnjJGF{e2G7NUTU[4syPzJiaB?=MULJR|UxRTVwNUmg{txOMl:wNlI4Ojd2NEm=
HT-29NVq3NG5YS3m2b4TvfIlkKEG|c3H5NEX0SW04OiCqM4jVfmlEPTB;Mz6zOkDPxE1?NHjtOZYzOjd{N{S0PS=>
SGC7901MYjDfZRwfG:6aXOgRZN{[Xl?Mn\6O|IhcA>?MVXJR|UxRTFyLkK2JO69VQ>?NVHSeoM3OjJ5Mke0OFk>
A498MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIf1OIVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG0PVgh[2WubIOg[ZhxemW|c3nu[{BGT0[UIHHu[EBUWkNid3n0bEBKSzVyIH;mJFgvPiEQvF2=MVOyNlgyQDh2OB?=
Calu3Mki0R5l1d3SxeHnjJGF{e2G7NELr[VkyOCEQvHevcWw>M3zLcFczKGh?NHX6TWpKSzVyPUGuOkDPxE1?M17wUVI{OTF4MU[4
FADUMU\DfZRwfG:6aXOgRZN{[Xl?M1i0eVExKM7:Zz;tUC=>MorkO|IhcA>?MY\JR|UxRTBwMEWg{txOMkXCNlMyOTZzNki=
HCC827MWLDfZRwfG:6aXOgRZN{[Xl?Mn3kNVAh|rypL33MMl;SO|IhcA>?NYLG[IpyUUN3ME2wMlAxOTVizszNM2T0SlI{OTF4MU[4
PC9NE\jOW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXzONohnOTBizsznM41NNXfjSpplPzJiaB?=Mmq1TWM2OD1yLkCwNVQh|ryPM2PaTlI{OTF4MU[4
Sf9NInNSZJMcW6jc3WgRZN{[Xl?MmHHNUBpMXHEUXNQMXvJcohq[mm2aX;uJI9nKGi3bXHuJGdUXC22YXfn[YQhTUeIUjDMPFM1WiCvdYThcpQh\XiycnXzd4VlKHerdHigTWM2OCCxZjCwMlAyPSEQvF2=M{HwSFI{PjFzNkmx
16HBE14o-NIrMdWlEgXSxdH;4bYMhSXO|YYm=NVfJPJdUOTBizszNM{nB[VczKGh?NGrZOpFFVVORMlPDR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNVZJSkVzNH:tJINmdGy|IHjhdoJwemmwZzD3bYxlKHS7cHWgSWdHWiCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjD3bZRpKEmFNUCgc4YhOTJwN{Gg{txOM1Hqc|I{PjZ6NESx
NCI-H1975NXXyZXdkS3m2b4TvfIlkKEG|c3H5M{fMZVExKM7:TR?=M1i2eVczKGh?NYftcoV2TE2VTx?=NUGwcYt7S3m2b4TvfIlkcXS7IHHnZYlve3RiZ3XmbZRqdmmkLYLld4l{fGGwdDDoeY1idiCQQ1mtTFE6PzViY3XscJMhcGG{Yn;ybY5oKEWJRmKgUFg2QFJxVEe5NG0h\G:3YnzlJI12fGGwdDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckB4cXSqIFnDOVAhd2ZiNj65NVch|ryPMlnuNlM3Pjh2NEG=
16HBENEfiOXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVv6cWhCPzJiaB?=MojMSG1UVw>?MoHTRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiBzNljCSUBk\WyuczDlfJBz\XO|aX7nJJdqdGRidInw[UBGT0[UIIfpeIghUUN3MDDv[kAyNjZyMTFOwG0>NHX5cWkzOzd7MkOxPC=>
16HBENWXtPGxMTnWwY4Tpc44hSXO|YYm=MnjQNVAxKM7:TR?=MX6xOVAhdWmwNFTpS|JFVVORM{H4dGlv\HWldHnvckBw\iCwaYTybYMhd3irZHWgdJJw\HWldHnvckBqdiCqdX3hckAyPkiERTDj[YxteyCneIDy[ZN{cW6pIIfpcIQhfHmyZTDFS2ZTNUf4bm9tOjN5OUKzNVg>
A549NV\CUWh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2LjcFczKGh?NFixVpNFVVORNFzhUGlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBGT0[UL3utVoF{KGSncHXu[IVvfCCqdX3hckBCPTR7IHPlcIx{KHerdHigTWM2OCCxZjC0MlYzPiEQvF2=NWnrXoFXOjN5OUKzNVg>
SH-SY5YNXXvW5RxS3m2b4TvfIlkKEG|c3H5NF7YR|g4OiCqMlvmTWM2OD1zOD6yNUDPxE1?NVe2dWVxOjN6N{G5NFk>
LoVoNYXYepdoU2mwYYPlJGF{e2G7MVqyJEBpNGTvfIRFVVORM2\r[2lvcGmkaYTpc44hd2ZiRVfGVkBxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwME[yJO69VQ>?NFTue3QzOzl|MEm5OC=>
PC9MmTDT4lv[XOnIFHzd4F6MYqyJIg>MmLNSG1UVw>?MkiwTY5pcWKrdHnvckBw\iCHR1\SJIV5d25iMUmg[IVt\XSrb36gZYN1cX[jdHnu[{BufXSjboSgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIGDDPUBk\WyuczD3bZRpKEmFNUCgc4YhOC5yMEi3JO69VQ>?NEXq[28zOzl|MEm5OC=>
HCC827NIrKUIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn\OO|IhcA>?MX;JR|UxRTBwMEGyJO69VQ>?MmC0NlM6PzNzNki=
A549MUDLbY5ie2ViQYPzZZk>NIr1W2MyKM7:TR?=NGPpfHkyKGh?MnThSG1UVw>?NYn2WIluUW6qaXLpeIlwdiCxZjDFS2ZTKGG3dH;wbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvODN7OTFOwG0>MYqyN|k5QDN3NB?=
A549NH33e4JHfW6ldHnvckBCe3OjeR?=MUWxJO69VQ>?NEnqbGsyKGh?MoLqSG1UVw>?NYrhRpRmS2WubIXsZZIhfXC2YXvlNH\mT2EzOzl6OEO1OC=>
HCC827NFjt[VVMcW6jc3WgRZN{[Xl?MnGxNE42KM7:TR?=NFnvToczKGh?MomySG1UVw>?NH;jcW5KdmirYnn0bY9vKG:oIFXHSnIheGixc4Doc5J6dGG2aX;uJIlvKGenZnn0bY5q[i2{ZYPpd5RidnRiaIXtZY4hUEOFOEK3JINmdGy|MmXoNlM6QTN|Mki=
HCC827Mn\OSpVv[3Srb36gRZN{[Xl?NFLsOnUxNjVizszNM2HPc|IhcA>?MoLJSG1UVw>?MkPuTY5pcWKrdHnvckBw\iClLV3leEBxcG:|cHjvdplt[XSrb36gbY4h\2WoaYTpcoljNXKnc3nzeIFvfCCqdX3hckBJS0N6MkegZ4VtdHN?NH3uV2MzOzl7M{OyPC=>
HCC827MoHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYHSc5k4OTBizszNM1nhVFczKGh?MnzZSG1UVw>?MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHfl[ol1cW6rYj3z[Y5{cXSrdnWgbJVu[W5iSFPDPFI4KGOnbHzzJIhiemKxcnnu[{BGT0[UIFW3OFYhfG9iQUe1NEBl\WyndHnvckB4cXSqIFnDOVAhd2ZiMD6wNFU5OSEQvF2=M{DPSVI1ODV|Nke0
A431MlXUT4lv[XOnIFHzd4F6Mn3aNVAxKM7:TR?=NG\EVHQ{OCCvaX6=MX7Jcohq[mm2aX;uJI9nKEWJRmKgbY4he2inZDDt[Y1jemGwZTD2[ZNq[2ynczD3bZRpKEmFNUCgc4YhOS5zIN88US=>Mn3GNlQxQTR2M{K=
BCRP-MDCK2MkDySpVv[3Srb36gRZN{[Xl?M{DtcFEvQCEQvF2=MVu3NkBpM{nmZ2ROW09?NFLnfFBKdmO{ZXHz[UBw\iCybHHzcYEhdWWvYoLhcoUh\XiycnXzd4lwdiCxZjDCR3JRKGW6cILld5NqdmdicnXwc5J1\XJiZ3Xu[UBITlB?NWfZN2tJOjRzOESyNVM>
BCRP-MDCK2M4XCVGZ2dmO2aX;uJGF{e2G7NF;WWIkyNjhizszNMXy3NkBpMW\EUXNQNEfXZpBT\WS3Y4Tpc44hd2ZicHzhd41iKG2nbXLyZY5mKGW6cILld5Nqd25ib3[gRmNTWCCneIDy[ZN{cW6pIILldI9zfGW{IHflcoUhT0[SMnOwNlQyQDR{MUO=
MDCKMmjFR5l1d3SxeHnjJGF{e2G7M1HIblczKGh?NYrWbmhTTE2VTx?=NUj2[2tWT0l3ME2xMlQ2KM7:TR?=NWjtdpUyOjRzOESyNVM>
MDCK2NHjSWY1HfW6ldHnvckBCe3OjeR?=M3L3clEvQCEQvF2=NGfJSYE4OiCqMoLkSG1UVw>?NYnoNllbUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2LQJIV5eHKnc4Pl[EBie3Onc4Pl[EBieyCKb3XjbJN1KDN|M{SyJIFk[3WvdXzheIlwdiC5aYToJGlEPTBib3[gN{4yQSEQvF2=MmXmNlQyQDR{MUO=
A431MnHKR5l1d3SxeHnjJGF{e2G7MYC3NkBpM3\3SmROW09?NWHjWmZyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR|MTDj[YxteyCneIDy[ZN{cW6pIFXHSnIhf2m2aDDJR|UxKG:oIECuOVUh|ryPMnfyNlQ1OTFzMkO=
Calu3MXTDfZRwfG:6aXOgRZN{[Xl?MoWzO|IhcA>?MXnEUXNQNXz2Xm81S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS2GudUOgZ4VtdHNiZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCwMlk6KM7:TR?=MonINlQ1OTFzMkO=
KBMVzLbY5ie2ViQYPzZZk>NXLC[Hh3OTBizszNM{LpcVEhcA>?MWXEUXNQM4H3ZWlvcGmkaYTpc44hd2ZiRVfGMZN1cW23bHH0[YQh[XW2b4Doc5NxcG:{eXzheIlwdiCxZjDFS2ZTKHerdHigTWM2OCCxZjCwMlAzPSEQvF2=MWqyOFQyOTF{Mx?=
BEAS2BM4rJS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGDQOpg2OCEQvF2=NG\oO284OiCqM2LDemROW09?NEDlVGlKSzVyPUGzMlk1KM7:TR?=NH;FZnMzPDZyN{W5NS=>
NCI-H1975Mn\nSpVv[3Srb36gRZN{[Xl?MU[xNFAh|ryPNHXpTG0yPTBibXnuNIX4e3hFVVORMUTJcoR2[3Srb36gc4YhVk9icILv[JVkfGmxbjDpckBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiaHHyZo9zcW6pIFXHSnIhVDh3OGKvWFc6OE1ibYX0ZY51NFrGcXEzPDZyN{W5NS=>
HelaMWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MW[yOEBpNELzdFBFVVORMnrMTWM2OD1{Lk[3JO69VQ>?MojVNlQ4OzF{OEG=
HepG2NXHGW4ZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkjyNlQhcA>?MYHEUXNQMoG2TWM2OD14LkSyJO69VQ>?Moj2NlQ4OzF{OEG=
Sf9M1;sUGtqdmG|ZTDBd5NigQ>?MXexNEBucW5?NGr4V3BFVVORM1XZWGlvcGmkaYTpc44hd2ZiYYX0c5Bpd3OyaH;yfYxifGmxbjDv[kBz\WOxbXLpcoFvfCCqaYOteIFo\2WmIFXHSnIhMGGvaX7vJIFkcWRiNkS1MVEyQDZrIHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOC5yMjFOwG0>M1TqW|I1PzNzMkix
SW620M4rF[mN6fG:2b4jpZ{BCe3OjeR?=M1XMR|Q5KGh?MWPEUXNQMmfGTWM2OD1{OD6yJO69VQ>?M3L4VVI1QTByNUm0
HCC827NISxS3FHfW6ldHnvckBCe3OjeR?=NYrV[XlLOC53IN88US=>NEHNOHIzKGh?NIqxb3FFVVORNHfyWWZld2W|IH7veEBqdmirYnn0JIMuVWW2IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiQVvUJJBpd3OyaH;yfYxifGmxbh?=MmPRNlM6QTN|Mki=
HCC827M3jzb2Z2dmO2aX;uJGF{e2G7NHvET24xNjVizszNM1\BU|IhcA>?MYDEUXNQM2LNXIRw\XNibn;0JIlvcGmkaYSgZ{1O\XRiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCyNESvOFIheGixc4Doc5J6dGG2aX;uMkLHNlM6QTN|Mki=
HCC827MX7DfZRwfG:6aXOgRZN{[Xl?MVmwMlUh|ryPMoXOO|IhcA>?M4nLXmROW09?MoeybIF{KG6xIHP5eI91d3irY3n0fS=>Moe3NlM6QTN|Mki=
NCI-H1975Mn\vSpVv[3Srb36gRZN{[Xl?NIfVRoYyOCEQvF2=NF3oVpU5KGh?MXXEUXNQM2PHSoRw\XNibn;0JIlvcGmkaYTpJGVITlJiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKEWUSzDwbI9{eGixconsZZRqd25?NYC1bnZvOjNzMU[xOlg>
A431NFPHV4pMcW6jc3WgRZN{[Xl?NFK1ZYEyKM7:TR?=MoPINUBpNWHQWGNZTE2VTx?=NV\icpFmcGG|IH7vJIlzemW4ZYLzbYJt\SCrbnjpZol1cW:wIH;mJGVITlJiYYX0c5Bpd3OyaH;yfYxifGmxbh?=MkHUNlQ6ODB3OUS=
LNCaPM4myT2Z2dmO2aX;uJGF{e2G7NG\h[GsyOCEQvF2=NVv6Z4RvOmhib4KgOEBpMofYSG1UVw>?NU\H[4I3\G:nczDuc5QhcW6qaXLpeEBifXSxcHjvd5Bpd3K7bHH0bY9vKG:oIHntcZVvd3C3cnnmbYVlKG[uYXeteIFo\2WmIFLtfEBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|MmDdRXRRMmflNVg3Pjd|MUK=
H1975NXH6cnA{U2mwYYPlJGF{e2G7NIfLTHEyKM7:TR?=MX[yOEBpM{DHe2ROW09?MV3kc4V{KG6xdDDpcohq[mm2IFXHSnIheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGgyQTd3IHPlcIx{KGijcnLvdolv\yCHR1\SJGw5PTiUL2S3PVBOKG23dHHueC=>M3nHdVI1PjB5NUmx
H1975M4XXZmZ2dmO2aX;uJGF{e2G7MVmxJO69VQ>?NFq1TnozPCCqNV3qNIRUTE2VTx?=NHvv[Zlld2W|IH7veEBqdmirYnn0JGVTUyCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hUDF7N{WgZ4VtdHNiaHHyZo9zcW6pIFXHSnIhVDh3OGKvWFc6OE1?NUL0b5JGOjR4MEe1PVE>
HCC827NVPUN4xNU2mwYYPlJGF{e2G7MWGwMlEyKM7:TR?=M1roWlEhcA>?Mlv0SG1UVw>?MX7oZZMhdm9iaYLy[ZZmenOrYnzlJIlvcGmkaYTpc44hd2ZiRVfGVkBie3Onc4Pl[EBieyC{ZXPveoVzgSCxZjDFS2ZTKGG3dH;wbI9{eGixconsZZRqd25?NGr2bXEzPDF{NEi5PC=>
H1975MYPLbY5ie2ViQYPzZZk>M3PxNFAvOzNizszNM{K3N|IhcA>?NWPxcoRpTE2VTx?=NFiycFhld2W|IH7veEBqdmirYnn0JGVITlJiTEi1PHIwXDd7MF2g[I92[mynIH31eIFvfCCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hSUuWIIDoc5NxcG:{eXzheIlwdg>?M3vTNFI1OTJ2OEm4
H1975M3z2emtqdmG|ZTDBd5NigQ>?NFXufoIxNjN|IN88US=>MljiNkBpNHzPOYNFVVORMYjkc4V{KG6xdDDpcohq[mm2IFXHSnIhVDh3OGKvWFc6OE1iZH;1ZoxmKG23dHHueEBie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gSXJMKHCqb4PwbI9zgWyjdHnvci=>MX6yOFEzPDh7OB?=
H1975NWDGV|lnU2mwYYPlJGF{e2G7NW\XXYpWOC5|MzFOwG0>Mlm0NkBpNY[wN|hqTE2VTx?=M{TEeoRw\XNibn;0JIlvcGmkaYSgSWdHWiCOOEW4Vk9VPzlyTTDkc5VjdGVibYX0ZY51KHCqb4PwbI9zgWyjdHnvci=>MVyyOFEzPDh7OB?=
H1975NHfTZVBMcW6jc3WgRZN{[Xl?MmPLNE4yOjVizszNM1zRflI1KGh?M2DrTmROW09?M17JNIRw\XNibn;0JIlvcGmkaYSgSWdHWiCOOEW4Vk9VPzlyTTDteZRidnRiWUGwOlgh[XW2b4Doc5NxcG:{eXzheIlwdg>?MYWyNlM{QTN2Mh?=
H1975M4Pm[WtqdmG|ZTDBd5NigQ>?Ml65NE42KM7:TR?=NGjadVkzPCCqNGnBflFFVVORM2XBeYRw\XNibn;0JIlvcGmkaYSgSWdHWiCOOEW4Vk9VPzlyTTDteZRidnRvbXXkbYF1\WRiRYLrJJBpd3OyaH;yfYxifGmxbh?=M3Lnc|IzOzN7M{Sy
H1975M{\j[WtqdmG|ZTDBd5NigQ>?MmjRNE42KM7:TR?=MnX2NlQhcA>?MXrEUXNQMYjkc4V{KG6xdDDpcohq[mm2IFXHSnIhVDh3OGKvWFc6OE1ibYX0ZY51NW2nZHnheIVlKEGtdDDwbI9{eGixconsZZRqd25?MkXzNlI{Ozl|NEK=
MIAPaCa2M3zFfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXGyMlUh|ryPNEjDOlQ4OiCqM3e3UGROW09?M1\vbYhieyCwbzDndo94fGhiaX7obYJqfGmxbh?=MVSyNFQ3PjV3NR?=
MIAPaCa2M3zJTmN6fG:2b4jpZ{BCe3OjeR?=NFXrd40yKM7:TR?=M4ew[FExKGR?NVT1blNNTE2VTx?=NH;6cJRp[XNibn:gZ5l1d3SxeHnjbZR6KGG|c3Xzd4VlKGG|IIP1dJBz\XO|aX;uJI9nKGOxbH;ufUBnd3KvYYTpc44>M3H6d|IxPDZ4NUW1
MIAPaCa2MUDBdI9xfG:|aYOgRZN{[Xl?NH;SSWMyOCEQvF2=M2\mclI1cCCxcjC0PEBpM1nrU2ROW09?MorJ[I9meyCwb4SgbY5lfWOnIHHwc5B1d3Orcx?=NYLNN3RwOjB2Nk[1OVU>
MIAPaCa2MnnhRZBweHSxc3nzJGF{e2G7NYftXFJ{OjBizszNMoe4NlQhcA>?MWfEUXNQNWXDV|Nb\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyClYYPwZZNmKDNiYXP0bZZifGmxbh?=MWOyNFQ3PjV3NR?=
EoL-1M1HFW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUjRRZRmUUN3ME21MlE4KG6PMlToV2FPT0WU
NCI-H720NFPzV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIjQXopKSzVyPUK2MlkzKG6PMVzTRW5ITVJ?
NCI-SNU-5M3vxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1\wbmlEPTB;MkiuNVkhdk1?MWHTRW5ITVJ?
EW-3NGnIcVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3zYfmlEPTB;NE[uNFQhdk1?NU\xOI1HW0GQR1XS
HCC2218M2Pnfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXTvbJc3UUN3ME21NE42QSCwTR?=NEDvXIhUSU6JRWK=
HuO-3N1M{fzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnPtTWM2OD13Nj6wPUBvVQ>?NXviZnM3W0GQR1XS
DBMW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4\PUGlEPTB;NkCuPVYhdk1?NGjzTXpUSU6JRWK=
HSC-4NHG4TYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVvZXGRpUUN3ME22NU42OyCwTR?=NG\GcJpUSU6JRWK=
DOKM2j4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUXJR|UxRTl|Lk[yJI5ONFXCSoNUSU6JRWK=
H9NFTUfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkjxTWM2OD1zM{euNkBvVQ>?NVP2R5pzW0GQR1XS
NCI-H292NYTZSotGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVTZWIVuUUN3ME2xOlIvPjZibl2=MUnTRW5ITVJ?
HSC-2MljHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYXafnFnUUN3ME2xOlUvPTdibl2=NG\LeZBUSU6JRWK=
LU-65NEnKdHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHO4fHhKSzVyPUG2Ok43OSCwTR?=M3XpO3NCVkeHUh?=
BV-173MlTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHT5b3lKSzVyPUG4Ok42PSCwTR?=M{DYfXNCVkeHUh?=
LB2241-RCCNFjsXndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVjJR|UxRTF7ND65N{BvVQ>?NV;OeG5oW0GQR1XS
KG-1NVj5fYw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF3LVGxKSzVyPUKwOE4{PCCwTR?=Mny0V2FPT0WU
CHL-1NHvi[4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYDCdmI2UUN3ME2yNFgvPTFibl2=MX7TRW5ITVJ?
KYSE-140MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFvlb4JKSzVyPUKwPU46PiCwTR?=MX3TRW5ITVJ?
DU-145M{HndWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3nkT2lEPTB;MkG5MlA1KG6PMoTvV2FPT0WU
EW-13Ml\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnTqTWM2OD1{MkWuNUBvVQ>?NWTKdoJzW0GQR1XS
KYSE-450NIPVeHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mkn3TWM2OD1{NEeuPVIhdk1?NUT3WHhPW0GQR1XS
CAL-72NIG4PYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlzyTWM2OD1{NkiuO|Mhdk1?NIrDb4JUSU6JRWK=
MEG-01M3fTXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYTvS2JYUUN3ME2yO|YvPzZibl2=MW\TRW5ITVJ?
HCE-TNIXmbmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX3JR|UxRTJ5OT63PUBvVQ>?M{jGO3NCVkeHUh?=
NCI-SNU-1MnvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M17vZmlEPTB;MkizMlMzKG6PMlTKV2FPT0WU
CAL-27MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVTxcHZ7UUN3ME2yPFkvODhibl2=NH;KTJdUSU6JRWK=
BALL-1M{nJVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MojpTWM2OD1{OUeuOFIhdk1?NE[w[oRUSU6JRWK=
SBC-1NFXjUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFHzTI5KSzVyPUOwO{44QSCwTR?=NEjRZ5NUSU6JRWK=
CAL-54MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVTJR|UxRTNzMT6yN{BvVQ>?NWHWSYY4W0GQR1XS
TI-73MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4LoZ2lEPTB;M{GyMlc2KG6PMmXFV2FPT0WU
P12-ICHIKAWAMnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3;xOWlEPTB;M{K4MlA3KG6PM{fae3NCVkeHUh?=
ACHNNF3vO3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnnnTWM2OD1|M{GuOEBvVQ>?MlXTV2FPT0WU
PC-14MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoDJTWM2OD1|M{OuOFEhdk1?NUPSbFdpW0GQR1XS
HCC1806M4T3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWfJR|UxRTN|Nz61NUBvVQ>?NV\RV4FvW0GQR1XS
SK-MEL-24MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1npRWlEPTB;M{O3Mlg4KG6PNVjUT5BnW0GQR1XS
A4-FukMU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoHETWM2OD1|NUCuNFIhdk1?MUHTRW5ITVJ?
ECC10MmO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NETab2pKSzVyPUO1Nk46PiCwTR?=NGnab4hUSU6JRWK=
KASUMI-1NGm1bYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF\Sb4dKSzVyPUO2Ok44OyCwTR?=M3rSfXNCVkeHUh?=
CAL-33MoPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGfhTFhKSzVyPUO3NE46KG6PMofQV2FPT0WU
MDA-MB-175-VIINFT2dJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2f2RWlEPTB;M{e4Mlg5KG6PM4nK[XNCVkeHUh?=
NUGC-3NYfrUotCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVzFNppTUUN3ME20NFEvQDFibl2=M3K2OXNCVkeHUh?=
KY821NVrUOFFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYPXcnk{UUN3ME20NFgvPTdibl2=NGm1OldUSU6JRWK=
CTB-1NYT2TotPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXTJR|UxRTR{ND60JI5OMYHTRW5ITVJ?
DoTc2-4510M2HFd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnqyTWM2OD12NEKuNVIhdk1?M2Tk[XNCVkeHUh?=
EFO-27NGX2O4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1fXfGlEPTB;NEW0Mlc1KG6PMm\ZV2FPT0WU
BPH-1MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX;kNnFQUUN3ME20PVEvOTZibl2=Mkn5V2FPT0WU
KYSE-270MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWTJR|UxRTR7OD62OUBvVQ>?MUfTRW5ITVJ?
HO-1-N-1M{XxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml3STWM2OD13MEmuNlUhdk1?MorlV2FPT0WU
SK-MEL-1NYf4SGpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYfJSWxDUUN3ME21NVAvQTlibl2=M4XSTHNCVkeHUh?=
MOLT-13NYG3VWtTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVHJR|UxRTVzND64NkBvVQ>?NGPpSndUSU6JRWK=
TK10NG\0OZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoLCTWM2OD13MUWuNVEhdk1?MWLTRW5ITVJ?
HNNGjydVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3v2R2lEPTB;NUG3MlM5KG6PNWTycG15W0GQR1XS
SCC-15MkTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVnGSZJwUUN3ME21NlUvPjhibl2=Ml7ZV2FPT0WU
NCI-H358M4\hd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml7sTWM2OD13MkeuOlYhdk1?NHHzZZJUSU6JRWK=
KYSE-180NEe3fmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHzxNGtKSzVyPUWzNE43OiCwTR?=NVjpboRPW0GQR1XS
NCI-H82M1fuZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWfCZ4tWUUN3ME21OFAvPSCwTR?=NW\0NVdRW0GQR1XS
NB7NH7xNFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml7XTWM2OD13NE[uN|Ihdk1?M1HwWHNCVkeHUh?=
DSH1MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1v4V2lEPTB;NU[2Mlg5KG6PNWXi[G1MW0GQR1XS
RS4-11M3\6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWTJR|UxRTV4OD61PUBvVQ>?Ml\CV2FPT0WU
CANNEjIO4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnrwTWM2OD13OECuO|Yhdk1?MYTTRW5ITVJ?
Ca9-22Mk\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3HtW2lEPTB;NUi4MlY1KG6PMny3V2FPT0WU
CAL-39Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWHJR|UxRTV7Nj6zJI5OMnXKV2FPT0WU
NCI-H1623M136Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mk[yTWM2OD13OUmuN|Yhdk1?M4rOWHNCVkeHUh?=
FADUNEPh[Y5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYnJR|UxRTZyND62PUBvVQ>?NWSwfW97W0GQR1XS
NB69MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3LXRWlEPTB;NkG0MlM2KG6PMmjMV2FPT0WU
Ramos-2G6-4C10M4niVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NULadlFqUUN3ME22NlEvPDZibl2=NIHCVVFUSU6JRWK=
LB1047-RCCMVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVfJR|UxRTZ{NT6yPUBvVQ>?MWnTRW5ITVJ?
MV-4-11MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVXwcFBCUUN3ME22NlcvPyCwTR?=NWDnXWM5W0GQR1XS
DBTRG-05MGM3O0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{fjW2lEPTB;NkOyMlI5KG6PNWrpfJVIW0GQR1XS
ME-180NV7OfoZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEDGNXpKSzVyPU[zNk46KG6PMnP0V2FPT0WU
NBsusSRNVnSUWk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3jSO2lEPTB;NkS2MlUzKG6PNXOzPHp3W0GQR1XS
COR-L105MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVLJR|UxRTZ4Mj61N{BvVQ>?MnTDV2FPT0WU
ETK-1NFPkUG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUPJR|UxRTZ4Mj61PUBvVQ>?MUjTRW5ITVJ?
L-363Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mm[3TWM2OD14N{GuPVQhdk1?Mm\IV2FPT0WU
LU-134-AMXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4WwTmlEPTB;N{G5MlA6KG6PNE[zXmtUSU6JRWK=
NCI-H1770NEK5NJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVH2PWVjUUN3ME23NlIvPCCwTR?=NFrkRoFUSU6JRWK=
HAL-01M4HuZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{n2U2lEPTB;N{O0MlcyKG6PMl\ZV2FPT0WU
COLO-684MmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXzpc2VwUUN3ME23OVMvODFibl2=M1fVSnNCVkeHUh?=
TE-6M2foZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX3JR|UxRTd4ND6zNUBvVQ>?NU\IfGhIW0GQR1XS
A431NX7jXoN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NITxZmhKSzVyPUe4NE4xPCCwTR?=NFS3XVZUSU6JRWK=
LU-135MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYjv[ZJ{UUN3ME23PFMvODNibl2=NWroXlA{W0GQR1XS
EC-GI-10NFrpc|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mlz3TWM2OD15OEiuOVIhdk1?Mo[0V2FPT0WU
TE-12M17ySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mo\BTWM2OD16MkGuNVEhdk1?MX7TRW5ITVJ?
LoVoMkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1T2cGlEPTB;OEW5MlA3KG6PM{XsTHNCVkeHUh?=
23132-87MkDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEjnPXRKSzVyPUi2OE4zQCCwTR?=NXTNdmNDW0GQR1XS
AU565M331fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVLVdZVlUUN3ME24OlkvPiCwTR?=NEfUZ4lUSU6JRWK=
DELMXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWjJR|UxRTh5Nz62OUBvVQ>?NUDobWE2W0GQR1XS
COR-L88MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2PxWGlEPTB;OEiyMlI3KG6PMULTRW5ITVJ?
NCI-H2126MoDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1GxVWlEPTB;OEiyMlg{KG6PNYrzXXlXW0GQR1XS
CAPAN-1NXz2U|RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MknSTWM2OD16OEOuNlkhdk1?NFjyd2pUSU6JRWK=
BT-474MkPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmnwTWM2OD17M{iuNVQhdk1?NFv0U2dUSU6JRWK=
BHYMl\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX7JR|UxRTl5NT60PEBvVQ>?MoTqV2FPT0WU
HT-3NF3LT4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVTGSGdSUUN3ME25PFIvPDFibl2=NXjRNXV6W0GQR1XS
SK-NEP-1Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUDJR|UxRTl6OT60OEBvVQ>?MnzWV2FPT0WU
MS-1M4f6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1zMRWlEPTB;OUm0MlY6KG6PM2HxOXNCVkeHUh?=
DOHH-2M{DjNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mki2TWM2OD1zLkCwNFIyKM7:TR?=NIjoTlFUSU6JRWK=
NCI-H1304M2PRNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlLDTWM2OD1zLkCxOlQ{KM7:TR?=MnLwV2FPT0WU
EM-2NXfhdXd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV3LW4t4UUN3ME2xMlA{ODF4IN88US=>M1q4T3NCVkeHUh?=
MHH-PREB-1MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkjXTWM2OD1zLkC4OFUyKM7:TR?=NV2zTFZiW0GQR1XS
KU-19-19NYLFeFB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1XO[mlEPTB;MT6wPFU1OSEQvF2=M3nUcnNCVkeHUh?=
NCI-H1648Mlf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2i0VmlEPTB;MT6xNFYyPiEQvF2=NIfVVZNUSU6JRWK=
MKN1M2HNUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXTEZ3Y4UUN3ME2xMlIyQTh5IN88US=>M{fNdnNCVkeHUh?=
SNU-449NXXh[Jo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFrqbYpKSzVyPUGuNlIzODhizszNMYPTRW5ITVJ?
OAW-42MlzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4r5UmlEPTB;MT6yO|gzPSEQvF2=M3rS[nNCVkeHUh?=
769-PNUTtVY5MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVfJR|UxRTFwMke5NVgh|ryPM2[5PXNCVkeHUh?=
SW1088M{\tWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M33JTmlEPTB;MT6yPVYxPyEQvF2=Mn3pV2FPT0WU
GCIYMVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEDweGVKSzVyPUGuN|AyOzJizszNNV3Oepd7W0GQR1XS
CTV-1M4Poc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUXJR|UxRTFwM{C4JO69VQ>?NWjBVHlLW0GQR1XS
NCI-H1092NFnmemlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnjzTWM2OD1zLkOwPFUh|ryPMWfTRW5ITVJ?
NKM-1NF3LcoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHKwNGpKSzVyPUGuN|I2QTdizszNM4fxU3NCVkeHUh?=
NCI-H1650MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFzYWHNKSzVyPUGuN|M1QDJizszNNUnrNY1IW0GQR1XS
SW954MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoDHTWM2OD1zLkO0NFQ5KM7:TR?=MVPTRW5ITVJ?
SW48Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWPjOlV7UUN3ME2xMlM3PjF6IN88US=>NF\6RWtUSU6JRWK=
SK-N-DZNVTuT|luT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1;HdmlEPTB;MT6zOlk1PyEQvF2=MYXTRW5ITVJ?
KMOE-2M{PweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkPzTWM2OD1zLkO5PFE2KM7:TR?=NVTmS4c2W0GQR1XS
NB5MoT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlfJTWM2OD1zLkSwPFk1KM7:TR?=MVTTRW5ITVJ?
CCRF-CEMNH:x[lZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX7JR|UxRTFwNEGxNUDPxE1?Mlq3V2FPT0WU
RH-1MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mnj4TWM2OD1zLkSxNVM3KM7:TR?=NF70NHlUSU6JRWK=
NCI-H526Ml;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3TNZmlEPTB;MT60N|gzPiEQvF2=MVfTRW5ITVJ?
697NX;vTJBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF;PfpZKSzVyPUGuOFQyODRizszNMVPTRW5ITVJ?
J82NEHDfJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGD0elZKSzVyPUGuOFU4PjZizszNNGn2fmtUSU6JRWK=
BE-13M17ZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWPTR3d1UUN3ME2xMlUxPjdzIN88US=>M{n3PXNCVkeHUh?=
SASMV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEjZPHhKSzVyPUGuOVE3OjJizszNMkfqV2FPT0WU
SCC-25MmHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUPJR|UxRTFwNUKzNlIh|ryPNWfVe5dzW0GQR1XS
LAMA-84NIW5NG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn7STWM2OD1zLkWzPFE2KM7:TR?=M{fRR3NCVkeHUh?=
HSC-3M4jYZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkjpTWM2OD1zLkW0N|gh|ryPMnXEV2FPT0WU
BT-549MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{HjUmlEPTB;MT61PFc1PyEQvF2=NWHWeIJqW0GQR1XS
ML-2NU\DcItIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkD6TWM2OD1zLk[0NFI6KM7:TR?=Mke1V2FPT0WU
BB30-HNCMWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX\aelRRUUN3ME2xMlY5QTd{IN88US=>M2H0SXNCVkeHUh?=
PANC-03-27MoLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnvhTWM2OD1zLkewNVM6KM7:TR?=NEDBZVFUSU6JRWK=
COLO-678NYrsXJZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml64TWM2OD1zLkezOFQ1KM7:TR?=NFTyXYRUSU6JRWK=
NCI-H1666MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2LlRmlEPTB;MT63OFcxPCEQvF2=MYPTRW5ITVJ?
NCI-H209M2nZSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1PtdmlEPTB;MT63O|I3QSEQvF2=MYnTRW5ITVJ?
EPLC-272HNGHWU4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnfBTWM2OD1zLki1OVQ6KM7:TR?=NGXjeXJUSU6JRWK=
OMC-1M{HLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1LnW2lEPTB;MT65PVg5QCEQvF2=MVXTRW5ITVJ?
HCC70M4HsNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1racGlEPTB;Mj6wNFgyPSEQvF2=NVrFNllJW0GQR1XS
CAL-12TNYXub5ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYjJR|UxRTJwMEG4OlEh|ryPNHLKZ41USU6JRWK=
TGBC24TKBNGnueotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NU\xS3V5UUN3ME2yMlAzQTZzIN88US=>MojaV2FPT0WU
EKVXNYjBRXh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MonoTWM2OD1{LkC0PVM6KM7:TR?=MVvTRW5ITVJ?
SW1116MofpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWLJR|UxRTJwME[wNFkh|ryPMkDuV2FPT0WU
NCI-H2009NUjubFVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlvvTWM2OD1{LkC2NlE1KM7:TR?=M{PhO3NCVkeHUh?=
RPMI-8866M4rWcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHjadHRKSzVyPUKuNFg1QDFizszNNHLs[YtUSU6JRWK=
KARPAS-45NVvKdphQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2XBWmlEPTB;Mj6xNlQ4QSEQvF2=MkLZV2FPT0WU
RXF393MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M12w[WlEPTB;Mj6xN|A{PiEQvF2=NETxcWlUSU6JRWK=
786-0MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4jKVmlEPTB;Mj6xPFQxPiEQvF2=M1PNVHNCVkeHUh?=
SCC-4MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2e4fWlEPTB;Mj6yNVc4PiEQvF2=NUTCPHVTW0GQR1XS
BT-20M4DCUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn6wTWM2OD1{LkK2O|Q1KM7:TR?=NY\2TnRxW0GQR1XS
A498NWfj[nJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEniVFJKSzVyPUKuNlk1OTVizszNNHjFWJZUSU6JRWK=
IGROV-1MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFrEenlKSzVyPUKuN|EzOzdizszNNVXBUZNDW0GQR1XS
JVM-3NGDmNYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGTOWIdKSzVyPUKuN|Q3PDNizszNNV6xS406W0GQR1XS
NCI-H2170Mnm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWW3dFVEUUN3ME2yMlM1Pzh|IN88US=>Ml;EV2FPT0WU
EW-18M1:1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVnJR|UxRTJwM{W0O|Eh|ryPMmDxV2FPT0WU
KU812M2rx[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV\JR|UxRTJwM{[3O|kh|ryPNEfYcmNUSU6JRWK=
NYNHfydJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWnJR|UxRTJwM{eyO{DPxE1?Ml;qV2FPT0WU
HTC-C3MnnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV[4OWR5UUN3ME2yMlQzOjZ5IN88US=>M3vxc3NCVkeHUh?=
CFPAC-1NV\qZnF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUfJR|UxRTJwNEO4OlQh|ryPNEDr[G1USU6JRWK=
HHM{jJ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXTDWpU1UUN3ME2yMlQ6QDV2IN88US=>M3LneHNCVkeHUh?=
MKN7NHvYcGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUf6THRxUUN3ME2yMlYzPzR6IN88US=>Mk\FV2FPT0WU
TE-8MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1XhWWlEPTB;Mj62N|Y2OyEQvF2=M2m4eXNCVkeHUh?=
MC-IXCM13adWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NI[1fWZKSzVyPUKuOlQ1PTNizszNMVLTRW5ITVJ?
DMS-79MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3fmTGlEPTB;Mj62PVI5PCEQvF2=M2DYPHNCVkeHUh?=
Detroit562NHTGRpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXSxTm15UUN3ME2yMlY6QDR3IN88US=>Mn:1V2FPT0WU
HuP-T4MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYnJR|UxRTJwN{K4NVgh|ryPNG[5dYVUSU6JRWK=
QIMR-WILMV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mkm5TWM2OD1{Lke1PVUzKM7:TR?=NWf0OXRRW0GQR1XS
BB65-RCCMUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnXFTWM2OD1{LkiwO|E{KM7:TR?=NIPrOoFUSU6JRWK=
PC-3NWjXR3YxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1ToOGlEPTB;Mj64N|MyPyEQvF2=MYjTRW5ITVJ?
OVCAR-3NXjFVVRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1nZRmlEPTB;Mj64OVU6PCEQvF2=M3nvRnNCVkeHUh?=
KYSE-510NE\UUW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXXJR|UxRTJwOE[3PFYh|ryPMXTTRW5ITVJ?
HC-1M4j5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkDmTWM2OD1{Lkm0NFEzKM7:TR?=NXvyTVBkW0GQR1XS
NCI-H1693NGPzVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2PpfGlEPTB;Mj65OVg6PyEQvF2=MkXMV2FPT0WU
DU-4475NHvYUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYrJR|UxRTJwOUmwOVIh|ryPM3e3TnNCVkeHUh?=
COLO-680NMojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEjFbllKSzVyPUOuNFA1QTVizszNMl3oV2FPT0WU
MN-60MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3rMTWlEPTB;Mz6wOFk4PCEQvF2=NInaNGhUSU6JRWK=
BCPAPMn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Moj6TWM2OD1|LkC4Nlk2KM7:TR?=NYTPW|BsW0GQR1XS
647-VNVLRdoxMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{HhNGlEPTB;Mz6xOlIzKM7:TR?=MW\TRW5ITVJ?
HT-1376M4jsd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWDJR|UxRTNwMkC1NFYh|ryPMnz0V2FPT0WU
NCI-H1793NInXVm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH2wV|FKSzVyPUOuNlExQThizszNNWHIRm5oW0GQR1XS
SW1463M1PK[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M33hcmlEPTB;Mz6yOlE6OiEQvF2=M3TrbXNCVkeHUh?=
NCI-H727M3S4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2X3Z2lEPTB;Mz6zPFU5PCEQvF2=MYPTRW5ITVJ?
LB771-HNCM3T1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVnGV41GUUN3ME2zMlM6OTJ4IN88US=>NVqyWHFzW0GQR1XS
D-542MGNGD0RlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV;JR|UxRTNwNESyNlIh|ryPNGXsepRUSU6JRWK=
NTERA-S-cl-D1M{fWS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUXhZmNOUUN3ME2zMlQ1QTV5IN88US=>MWLTRW5ITVJ?
C8166NYrFU3kxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mo\xTWM2OD1|LkS2OVIyKM7:TR?=M1v2e3NCVkeHUh?=
639-VMUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NG\GOmdKSzVyPUOuOVc4QTJizszNMWfTRW5ITVJ?
TE-1Mny1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn7uTWM2OD1|LkW5NVY6KM7:TR?=NEn3dYtUSU6JRWK=
OAW-28MoXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnPXTWM2OD1|LkW5OFI3KM7:TR?=NVuyO4l1W0GQR1XS
SK-LU-1Mn3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWHJR|UxRTNwNkC2OFUh|ryPMlnKV2FPT0WU
CaR-1Mm\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVzJR|UxRTNwNkGwOFgh|ryPMX3TRW5ITVJ?
A2780M3rrSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF[5OpFKSzVyPUOuOlQxQDlizszNMUTTRW5ITVJ?
C2BBe1NFLYW5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIq4bW9KSzVyPUOuOlQ1ODdizszNMULTRW5ITVJ?
SK-MES-1M3;oNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkXzTWM2OD1|Lk[0OlE1KM7:TR?=MnHNV2FPT0WU
PANC-10-05MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn;xTWM2OD1|LkeyNFczKM7:TR?=MlezV2FPT0WU
J-RT3-T3-5NIf4fHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX7JR|UxRTNwN{W0NFYh|ryPNFL1e2pUSU6JRWK=
ES4MkDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1raeGlEPTB;Mz64NlI5PiEQvF2=M4rXTHNCVkeHUh?=
NCI-H28M2T0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlHhTWM2OD1|LkiyPVYyKM7:TR?=MkDpV2FPT0WU
NCI-H1155NF;Cb2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYDJR|UxRTNwOESxOVkh|ryPM{ixWHNCVkeHUh?=
KURAMOCHIM2jKZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIjwTHVKSzVyPUOuPFYxPTZizszNNWXRb3lXW0GQR1XS
NCI-H69Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVuyWWJxUUN3ME2zMlkxOTd6IN88US=>MW\TRW5ITVJ?
IST-MES1NG\rSlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX7JR|UxRTNwOUSwNlkh|ryPNV\BOnVXW0GQR1XS
NH-12M4nOfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{L1TmlEPTB;Mz65OFE5PyEQvF2=NEKz[5hUSU6JRWK=
JVM-2NV;nOYFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1fjbGlEPTB;Mz65OFc2OiEQvF2=NVK5[JV{W0GQR1XS
EW-16NVHBfYFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3jxc2lEPTB;Mz65OVU4PyEQvF2=NWfYe4FwW0GQR1XS
NCI-H441MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mki5TWM2OD1|Lkm3NFE1KM7:TR?=MmTmV2FPT0WU
RCC10RGBMojtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYnJR|UxRTRwMEGyOFYh|ryPM4rMbnNCVkeHUh?=
TCCSUPMVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4DRWGlEPTB;ND6xNVA2KM7:TR?=NGL4eVFUSU6JRWK=
HL-60NH3JXpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVLxNG9ZUUN3ME20MlEzOjRzIN88US=>NU[5cpdEW0GQR1XS
EW-11MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{DCUGlEPTB;ND6xN|I3OSEQvF2=M{TUbHNCVkeHUh?=
KARPAS-299NU\zPVlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXjJR|UxRTRwM{GwNVMh|ryPMoS0V2FPT0WU
SNU-C2BNH\OZ5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWTJR|UxRTRwM{S2PFYh|ryPMVHTRW5ITVJ?
LU-139MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIPrS2NKSzVyPUSuN|czPDdizszNMUfTRW5ITVJ?
HCC1937MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEj3bIlKSzVyPUSuN|c6QTNizszNNYjNdoVUW0GQR1XS
GR-STNXHPWXhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1\GeGlEPTB;ND60N|E5KM7:TR?=NUj6bXZ3W0GQR1XS
SK-OV-3MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnnKTWM2OD12LkS2NFQzKM7:TR?=M1jXPHNCVkeHUh?=
A172MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV\JR|UxRTRwNUW1NlEh|ryPM2XNW3NCVkeHUh?=
NB10NVfVR4tnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3z6bGlEPTB;ND61PVc5OSEQvF2=MXnTRW5ITVJ?
P30-OHKMVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NW[4O2t7UUN3ME20MlgyQTJ7IN88US=>NVu1cFl7W0GQR1XS
KYSE-520MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnmxTWM2OD12Lki4NFE5KM7:TR?=NWmwTZFuW0GQR1XS
KNS-62M3z6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MofGTWM2OD12LkmwPFA4KM7:TR?=NFfzfGZUSU6JRWK=
ES1NWq4bWF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mo\ITWM2OD12Lkm2NFM2KM7:TR?=NISxUm9USU6JRWK=
KOSC-2MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH;aV|VKSzVyPUSuPVk6PTlizszNNHO1NpRUSU6JRWK=
TE-9NG\oR4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYjR[4tVUUN3ME21MlAyPTJ3IN88US=>NXLuXWRGW0GQR1XS
NCI-H1838NFjmb3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFrxfXFKSzVyPUWuNFIxPzZizszNMWHTRW5ITVJ?
KP-N-YNNFH5UVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWLJR|UxRTVwMUK1PVEh|ryPNHLtPHVUSU6JRWK=
ALL-POMorvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFLFRVlKSzVyPUWuNlI2QDdizszNNIS5OXVUSU6JRWK=
NOMO-1MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2XBdWlEPTB;NT6yN|E4PiEQvF2=MnXFV2FPT0WU
CGTH-W-1MmrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3PXXWlEPTB;NT6zPFU5PCEQvF2=NWDyeJRZW0GQR1XS
ATN-1M2[5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXrJR|UxRTVwNEGxPFQh|ryPMVLTRW5ITVJ?
AGSMkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUX6XZVmUUN3ME21MlQ6PjF6IN88US=>MULTRW5ITVJ?
SW13NULBflRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M17nWWlEPTB;NT61N|I3PSEQvF2=M2TqRXNCVkeHUh?=
SW1990MlPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkP0TWM2OD13Lk[yNlg2KM7:TR?=MmL2V2FPT0WU
BFTC-905M3jZdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NITv[Y5KSzVyPUWuOlU5PzhizszNMW\TRW5ITVJ?
RMG-IMkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoTOTWM2OD13Lk[1PVQzKM7:TR?=NFOweXVUSU6JRWK=
HD-MY-ZMoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlzJTWM2OD13Lk[4OVgyKM7:TR?=NWPTO4NNW0GQR1XS
HCC1187MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnnPTWM2OD13LkexNFMzKM7:TR?=MVfTRW5ITVJ?
HCC2998NFLRSopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1XnUWlEPTB;NT63NVg4PyEQvF2=NFr4NGtUSU6JRWK=
RT-112MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX3WRZJbUUN3ME21MlkxOjR3IN88US=>Ml7nV2FPT0WU
CAKI-1NUnYc3ZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlXqTWM2OD14LkCwPVg2KM7:TR?=MU\TRW5ITVJ?
HDLM-2NULaTFZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX7JR|UxRTZwMEG0PFkh|ryPMWLTRW5ITVJ?
TE-10MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVzJR|UxRTZwMES4N|Mh|ryPMV7TRW5ITVJ?
KE-37NIO1Sm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGPCfJVKSzVyPU[uNFczPThizszNMkfmV2FPT0WU
RCM-1Ml3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHjpZm5KSzVyPU[uNFc4OTlizszNNG\Je4hUSU6JRWK=
MewoNXLQfI9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2fQbWlEPTB;Nj6xNVQ5PyEQvF2=M{XoeHNCVkeHUh?=
L-428M1XSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIjYO5NKSzVyPU[uNVgxOzdizszNMnzEV2FPT0WU
8-MG-BAM1fuVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWSyfXlRUUN3ME22MlE6Ozd7IN88US=>NVTzc25iW0GQR1XS
SK-MEL-28NV;3VZhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4rSd2lEPTB;Nj6yNFk3PyEQvF2=MlrtV2FPT0WU
VA-ES-BJM{D3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlOxTWM2OD14LkOwOFYzKM7:TR?=NHK5bINUSU6JRWK=
CAL-120MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIj0bWRKSzVyPU[uOFUyPjJizszNM3TKdnNCVkeHUh?=
GAMGMX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXTLb3N6UUN3ME22MlUxPjJizszNNF:1e4hUSU6JRWK=
MSTO-221HNGPK[YNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVfVe|Z{UUN3ME22MlUyOTdizszNMUPTRW5ITVJ?
GCTNFTKbHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn7xTWM2OD14LkWzN|g4KM7:TR?=NGHvXHJUSU6JRWK=
SH-4MkPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWDKXlhkUUN3ME22MlU5QDR2IN88US=>M{fIW3NCVkeHUh?=
Calu-3MkW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnfITWM2OD14Lk[1OVY5KM7:TR?=MofSV2FPT0WU
SK-HEP-1MlXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX7JR|UxRTZwN{G3OVMh|ryPM1TzTHNCVkeHUh?=
PFSK-1M4\wW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUHJR|UxRTZwN{O0O|gh|ryPNVTSNGtyW0GQR1XS
NB12MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkTFTWM2OD14Lke4OFA1KM7:TR?=M4ThTHNCVkeHUh?=
A388MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWLYNlJ3UUN3ME22Mlg6PTJizszNNWXIfJpWW0GQR1XS
KLEMYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWi3VWpFUUN3ME22Mlk3PTF4IN88US=>MmH5V2FPT0WU
TE-11NFq5TFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUPaToJRUUN3ME23MlA1QTZ5IN88US=>M4jpO3NCVkeHUh?=
NCI-H2405NHjSfYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFHrWGpKSzVyPUeuNFg{QTNizszNNFq2WXdUSU6JRWK=
OVCAR-4M1PpXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGPLVo1KSzVyPUeuNVU{PSEQvF2=NIfpVJNUSU6JRWK=
KP-N-YSMUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmfmTWM2OD15LkG4NVQh|ryPNWfIU5RNW0GQR1XS
NOS-1NVnkNm1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkDHTWM2OD15LkK1PFI5KM7:TR?=NHO5TnNUSU6JRWK=
DMS-114NHnzd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MU\JR|UxRTdwMkm2N|Eh|ryPMX;TRW5ITVJ?
NCI-H2030M4nZTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVnJR|UxRTdwM{O2PVgh|ryPNI\LfoxUSU6JRWK=
HELNITVRVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVXJR|UxRTdwM{e1NlEh|ryPMnnEV2FPT0WU
CAL-62MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWXJR|UxRTdwM{m4OlYh|ryPNVLMOFJLW0GQR1XS
COLO-668NYfp[nU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mnu1TWM2OD15LkSzPVY4KM7:TR?=MmjaV2FPT0WU
SKG-IIIaNHnJ[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3LKbmlEPTB;Nz60OVM5OSEQvF2=MUTTRW5ITVJ?
HCC1419NFq1T4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUfJR|UxRTdwNE[4N|Mh|ryPMXjTRW5ITVJ?
OS-RC-2Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWLJR|UxRTdwNEm4PVQh|ryPMUHTRW5ITVJ?
COLO-829MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{D5SGlEPTB;Nz62OlQ3OyEQvF2=NFXaSFRUSU6JRWK=
NB13M1f4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M37NdWlEPTB;Nz64NlY3PyEQvF2=NEjJOpFUSU6JRWK=
DK-MGMmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUf2cFJrUUN3ME23Mlg{OjBzIN88US=>MWLTRW5ITVJ?
SHP-77M4G5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkSxTWM2OD15Lki2OlU{KM7:TR?=M2\6WnNCVkeHUh?=
NCI-H661M{jsemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1Xs[WlEPTB;OD6wOVg3PyEQvF2=MU\TRW5ITVJ?
AM-38NXzLZYRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWfLN3V4UUN3ME24MlE3OjhizszNMWrTRW5ITVJ?
VM-CUB-1MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmT5TWM2OD16LkG3NFI6KM7:TR?=Mo\0V2FPT0WU
KYSE-70NXnyXWRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWfJR|UxRThwMUm3OlEh|ryPMojKV2FPT0WU
5637MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVzse2Z7UUN3ME24MlMyODV3IN88US=>MV3TRW5ITVJ?
TGBC11TKBMkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3;rUGlEPTB;OD60OlE3PCEQvF2=MmfGV2FPT0WU
EGI-1NHHnOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{m1bmlEPTB;OD62NFA5QCEQvF2=MWjTRW5ITVJ?
D-392MGMkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWnJcYdoUUN3ME24MlY3OjF2IN88US=>NXvPUFJNW0GQR1XS
A673Ml2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlfBTWM2OD16Lk[3OlEyKM7:TR?=MWHTRW5ITVJ?
COLO-792MoOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEPHNYNKSzVyPUiuO|Q6PDZizszNNIm1[25USU6JRWK=
NCI-H1792NWfQbnlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXXJR|UxRThwOEi5NFMh|ryPM1nvWXNCVkeHUh?=
LS-1034NVfkNIp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFf2Xo1KSzVyPUiuPVQ3PTJizszNNFHoSG5USU6JRWK=
D-566MGNFfxOVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M33sRWlEPTB;OT6wNVgyKM7:TR?=NGr1XWVUSU6JRWK=
NCI-H226MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXXJR|UxRTlwMEmg{txONHLSN|FUSU6JRWK=
ChaGo-K-1NVfLSmVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MljsTWM2OD17LkGwOVc6KM7:TR?=NWHmWHBGW0GQR1XS
NCI-H2228MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{DkWWlEPTB;OT6xNVA5OSEQvF2=MnG5V2FPT0WU
RPMI-8226M1HmbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NI[ybIxKSzVyPUmuNVE{ODRizszNM4DYeXNCVkeHUh?=
BFTC-909NUnjeFN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnfPTWM2OD17LkG4Nlk4KM7:TR?=Mo\YV2FPT0WU
HPAF-IIMnP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYXJR|UxRTlwMkK1NVgh|ryPMVTTRW5ITVJ?
Capan-2NY\yU4hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3ewfWlEPTB;OT60NFExQSEQvF2=NVrHcI1jW0GQR1XS
IA-LMMkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{jFOmlEPTB;OT60NVk3PiEQvF2=MUjTRW5ITVJ?
KP-4NF7NN5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEHsTFlKSzVyPUmuOFg5OzhizszNM1jhZ3NCVkeHUh?=
A101DMU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEDMcZBKSzVyPUmuOVE4OTlizszNNXrXNYpwW0GQR1XS
EFO-21M2[0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGXNTm5KSzVyPUmuOVg4OzVizszNM3T0b3NCVkeHUh?=
C32NG\xTW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXfkO|Q2UUN3ME25MlY{OzRizszNMmPzV2FPT0WU
SW837M{nDN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{nYNGlEPTB;OT64OFgzKM7:TR?=MoDoV2FPT0WU
OCI-AML2NUSyT|hyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXe3flZ1UUN3ME25Mlg3QTZizszNNVvkc4ZMW0GQR1XS
NCI-H1355NXXFZYt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlzETWM2OD17Lkm0NFg5KM7:TR?=MmDOV2FPT0WU
NCI-H2342M4nDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlnrTWM2OD1zMD6wNVU2KM7:TR?=NGfFOmdUSU6JRWK=
A204NI\BU5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlfkTWM2OD1zMD6wOFY3KM7:TR?=MX;TRW5ITVJ?
CAL-51NVj0colRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWPJR|UxRTFyLkC4O|ch|ryPMUPTRW5ITVJ?
HCE-4M2TmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWPRWYkyUUN3ME2xNE4yOTJ{IN88US=>MmLGV2FPT0WU
NCI-H810M2nxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXnJR|UxRTFyLkG1PVch|ryPNXjybYNOW0GQR1XS
DJM-1MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4rONmlEPTB;MUCuNVc{OiEQvF2=MV3TRW5ITVJ?
SK-UT-1NF3vXFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NInGb4dKSzVyPUGwMlI2PzRizszNMmDLV2FPT0WU
U031MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUPJR|UxRTFyLkK2PFYh|ryPNHHE[3JUSU6JRWK=
YH-13MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWfWNoY1UUN3ME2xNE4{ODV5IN88US=>NEfm[ZpUSU6JRWK=
K5MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mo\TTWM2OD1zMD6zN|k2KM7:TR?=Mkj5V2FPT0WU
HEC-1NGfQfmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXnJR|UxRTFyLkSwPFEh|ryPNYHaPXZvW0GQR1XS
A2058NF7sUGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2HnSGlEPTB;MUCuOVQ6OSEQvF2=Ml\kV2FPT0WU
SW962M1z1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnPJTWM2OD1zMD62NlA1KM7:TR?=M4XhdXNCVkeHUh?=
VMRC-RCZMWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX;FfHA3UUN3ME2xNE43PzR7IN88US=>MkH1V2FPT0WU
D-336MGNVHHN2dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1TMe2lEPTB;MUCuO|AxPSEQvF2=NIfkTmtUSU6JRWK=
LXF-289MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXTLW29UUUN3ME2xNE44QTZ5IN88US=>NYHZZ5NlW0GQR1XS
SW900Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mo\oTWM2OD1zMD64NlI5KM7:TR?=MVjTRW5ITVJ?
K-562NV64SJZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4[4V2lEPTB;MUCuPFM6PSEQvF2=M{j5dHNCVkeHUh?=
HCC38M1ftVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3vRb2lEPTB;MUCuPVcyPiEQvF2=MlLDV2FPT0WU
SF-295M2Gwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV\JR|UxRTFyLkm5NFIh|ryPMlPlV2FPT0WU
LB831-BLCMmPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M17DNGlEPTB;MUGuNlU2PiEQvF2=M2XidnNCVkeHUh?=
FTC-133MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYjJU5FTUUN3ME2xNU4{ODhzIN88US=>NV\1S4pLW0GQR1XS
HCC1954MoP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXzDPFhRUUN3ME2xNU41OzZizszNMYLTRW5ITVJ?
GOTONWTHbm5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmnXTWM2OD1zMT61NlA3KM7:TR?=NWGwUpBxW0GQR1XS
LS-411NM3zVTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2XBRmlEPTB;MUGuOlExOSEQvF2=MVPTRW5ITVJ?
RPMI-7951NEPzd|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHX0Z4ZKSzVyPUGxMlY{PDhizszNNIHvNoVUSU6JRWK=
NCI-H1299M4Hy[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkDJTWM2OD1zMT62OlQ4KM7:TR?=NW\JUmRPW0GQR1XS
MLMAM3TLcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXfpXW12UUN3ME2xNU43QTl5IN88US=>M{nCcXNCVkeHUh?=
MMAC-SFNFrBSXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEjLUXlKSzVyPUGxMlczPTJizszNM36wfnNCVkeHUh?=
UM-UC-3NH7xOmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4LBS2lEPTB;MUGuO|QzOSEQvF2=NVz3No1mW0GQR1XS
SCC-9Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1e0eWlEPTB;MUGuPFE2OSEQvF2=NHjUW41USU6JRWK=
HOSM2PIbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXfTbmROUUN3ME2xNU45Pjh|IN88US=>NIr6SHdUSU6JRWK=
OE19MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1jwfGlEPTB;MUGuPVM3PyEQvF2=NWf0OpNQW0GQR1XS
Mo-TM1nGemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYjJR|UxRTFzLkm1OFEh|ryPNH\HU4ZUSU6JRWK=
CAMA-1MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NU\a[2xrUUN3ME2xNk4yPjN|IN88US=>MWjTRW5ITVJ?
U-118-MGM1rFUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1LXTWlEPTB;MUKuNlQ1OSEQvF2=M{Dlc3NCVkeHUh?=
KS-1NFjqO21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUDLUpBkUUN3ME2xNk4zQDN{IN88US=>NGiwcmJUSU6JRWK=
JARNH7NZmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NW\kRnFEUUN3ME2xNk4{OzZ7IN88US=>NYjpSGRFW0GQR1XS
ABC-1Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmTzTWM2OD1zMj6zOFEh|ryPMl3NV2FPT0WU
DaoyNIOwbm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYP5eXpQUUN3ME2xNk41PTR{IN88US=>M1LjTnNCVkeHUh?=
C3AMoPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVHUcWJwUUN3ME2xNk42Pzh3IN88US=>M3XjUHNCVkeHUh?=
GT3TKBMVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFToT41KSzVyPUGyMlY{OjdizszNMYPTRW5ITVJ?
DMS-273NUDOOo85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn:wTWM2OD1zMj64OlM{KM7:TR?=M3LtcnNCVkeHUh?=
G-361MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2TLW2lEPTB;MUKuPVEzQSEQvF2=MVzTRW5ITVJ?
RH-18M4D1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnKzTWM2OD1zMz6yPVYzKM7:TR?=NETQSoJUSU6JRWK=
SN12CMkXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVrJR|UxRTF|LkO4NFgh|ryPMVPTRW5ITVJ?
NCI-H1993NUPB[FRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn3kTWM2OD1zMz60Nlg2KM7:TR?=M3ruW3NCVkeHUh?=
LOXIMVIMl3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYDLb4dbUUN3ME2xN{43OTVzIN88US=>M3viV3NCVkeHUh?=
SK-PN-DWMn3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXvk[IhjUUN3ME2xN{45PDJ5IN88US=>MnT0V2FPT0WU
KALS-1M1rES2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXq4emNoUUN3ME2xN{45PTJ3IN88US=>NUC1cFhOW0GQR1XS
LAN-6M2jmdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHXIWnNKSzVyPUG0MlI2OyEQvF2=MoDEV2FPT0WU
A549NFW3S2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXzRSXBrUUN3ME2xOE41PzF{IN88US=>NGPGWWRUSU6JRWK=
RDMnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWjJR|UxRTF2LkS4NVMh|ryPNGSxb5JUSU6JRWK=
TGBC1TKBNYXTenZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXvJTWNWUUN3ME2xOE43PjF3IN88US=>MUnTRW5ITVJ?
NCI-H630MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF3aTZVKSzVyPUG0Mlk1PjdizszNMmHqV2FPT0WU
MIA-PaCa-2NI\6cGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWHJR|UxRTF2Lkm2PUDPxE1?NYLueJRjW0GQR1XS
NCI-H1755M{[3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NE\kSJlKSzVyPUG0Mlk6PTNizszNM3zic3NCVkeHUh?=
MOLT-4MlLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEn3W5RKSzVyPUG1MlA1QTdizszNMYfTRW5ITVJ?
CW-2NHnYSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIq0d41KSzVyPUG1MlE1OjFizszNNHvwXlZUSU6JRWK=
COLO-320-HSRMnL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml7wTWM2OD1zNT61N|A4KM7:TR?=M2jIRnNCVkeHUh?=
UMC-11Mln3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWDJR|UxRTF3Lke1NlMh|ryPM4PvZ3NCVkeHUh?=
MCF7NVrLcY04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIjXd4FKSzVyPUG1MlgyPDVizszNNWPpPYU5W0GQR1XS
NCI-H23M1jVOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2m3fWlEPTB;MUWuPFQ{QCEQvF2=NVy5NJFrW0GQR1XS
HuCCT1M1LJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWPJR|UxRTF3Lki3OEDPxE1?NV;Fb4lHW0GQR1XS
MPP-89MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{HJd2lEPTB;MUWuPVQyPyEQvF2=NYj2[|JzW0GQR1XS
HT55NI\tTFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmnFTWM2OD1zNT65OFc5KM7:TR?=MYnTRW5ITVJ?
no-11MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{T4[WlEPTB;MUWuPVY3OyEQvF2=MmjiV2FPT0WU
GP5dMWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHjiNnFKSzVyPUG2MlIyQDdizszNMVrTRW5ITVJ?
BHT-101NGnKNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1fCZ2lEPTB;MU[uNlQ{QSEQvF2=NIS0TohUSU6JRWK=
M059JM2HFVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVvJR|UxRTF4LkK4OEDPxE1?NHHTSmNUSU6JRWK=
D-283MEDNFjwbJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGPmW2ZKSzVyPUG2MlQzODlizszNNUf4XIRsW0GQR1XS
BENMYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NI\TOnJKSzVyPUG2MlUyPTVizszNMn3KV2FPT0WU
LB373-MEL-DNX\XcI5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH3YXmpKSzVyPUG2MlczOzJizszNMoO0V2FPT0WU
MEL-HOMmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmPBTWM2OD1zNj64PFU1KM7:TR?=Ml3TV2FPT0WU
GI-ME-NMnjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1;HfmlEPTB;MU[uPVA{OiEQvF2=M3jBXHNCVkeHUh?=
RKOM2j4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV7JR|UxRTF5LkC3OFgh|ryPNVzvb|EyW0GQR1XS
MZ2-MELMkDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGHHVnpKSzVyPUG3MlE{OyEQvF2=NIDLdYVUSU6JRWK=
NCI-H1573NGf6cJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MofNTWM2OD1zNz6yPFI3KM7:TR?=M1fZbXNCVkeHUh?=
NCI-H1581NYH0UlI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYnJR|UxRTF5LkS0NVEh|ryPM1PzbHNCVkeHUh?=
NCI-H747MnLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWLCSXVrUUN3ME2xO{42Ojl5IN88US=>MniyV2FPT0WU
SW1783NFjRNFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlXlTWM2OD1zNz62OFE2KM7:TR?=MlnIV2FPT0WU
Calu-6MkLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVrPemptUUN3ME2xO{43Pzh{IN88US=>NVHmZ|JUW0GQR1XS
SF268MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYLJR|UxRTF5Lk[5Olkh|ryPNXj6cnY3W0GQR1XS
ES8NWi2foJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWLxNIpqUUN3ME2xO{45PTl|IN88US=>M3HpUXNCVkeHUh?=
KM-H2NFPIdZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3OxO2lEPTB;MUeuPVQyOSEQvF2=MWHTRW5ITVJ?
D-502MGNXjCOo9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWfOO|BFUUN3ME2xO{46QDB6IN88US=>MUXTRW5ITVJ?
HLEMn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn;wTWM2OD1zOD6zNVQ5KM7:TR?=NHfF[IVUSU6JRWK=
SW982NY\LZWZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVrJR|UxRTF6LkSwO|Uh|ryPMlWyV2FPT0WU
MDA-MB-361M1H1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NULFbohXUUN3ME2xPE42PTh6IN88US=>MkPWV2FPT0WU
NCI-H1563NX;pVFdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{Dhd2lEPTB;MUiuO|EzPCEQvF2=MVfTRW5ITVJ?
MFE-280NUnjS|NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXjLNlRZUUN3ME2xPE44Ojl|IN88US=>MUXTRW5ITVJ?
U251MmPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUjF[GVDUUN3ME2xPE44OzR5IN88US=>NV\jWoZiW0GQR1XS
KNS-42Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NG\pd2NKSzVyPUG4MlgxOTVizszNM3[1dnNCVkeHUh?=
U-266NYXsUVlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWTJR|UxRTF6Lki2OFkh|ryPMnrxV2FPT0WU
OVCAR-8MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYDJR|UxRTF6LkmyO|Yh|ryPMUPTRW5ITVJ?
MFH-inoM3zLemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYPJR|UxRTF6Lkm2Olkh|ryPNYq2R|lKW0GQR1XS
D-263MGNGi4WGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHTucIJKSzVyPUG5MlAyPzJizszNMljXV2FPT0WU
NCI-H1437MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlXoTWM2OD1zOT6wOFY4KM7:TR?=MYjTRW5ITVJ?
NCI-H1048M4fybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWHJR|UxRTF7LkKzNlYh|ryPNV;MUoE{W0GQR1XS
NCI-H446NEe5WmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYC1WGdvUUN3ME2xPU4{PTh7IN88US=>NHjie5lUSU6JRWK=
NCI-N87MoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWHEWFZKUUN3ME2xPU42QTl{IN88US=>NW\IUph5W0GQR1XS
WM-115NHjIUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmDtTWM2OD1zOT62O|c1KM7:TR?=MXPTRW5ITVJ?
HuH-7NVnIeYxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHLFWFhKSzVyPUG5Mlc1OjFizszNMYTTRW5ITVJ?
NCI-H650NVzkXo9tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV7JR|UxRTF7Lke1NFgh|ryPMUHTRW5ITVJ?
TYK-nuNFXpcGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGSxSVFKSzVyPUG5Mlg{PzhizszNNXLD[5V[W0GQR1XS
BeckerMnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoSzTWM2OD1zOT64OVQ4KM7:TR?=MVvTRW5ITVJ?
BB49-HNCNHf5bmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmfkTWM2OD1zOT65NkDPxE1?NH;pZ4xUSU6JRWK=
HGC-27MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVLJR|UxRTJyLkGzPVQh|ryPMXPTRW5ITVJ?
SiHaNGHYN25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV7wSW5HUUN3ME2yNE4{PzF{IN88US=>NHTPXJRUSU6JRWK=
LB2518-MELMoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWLJR|UxRTJyLkO3N|kh|ryPNVLlepBnW0GQR1XS
TE-5NXWzdY9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXLJR|UxRTJyLke0PFIh|ryPNWG2[odHW0GQR1XS
IST-SL1MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUPJR|UxRTJyLke4O|kh|ryPMoLQV2FPT0WU
A375MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlzqTWM2OD1{MT6wOVY4KM7:TR?=NGrjVFVUSU6JRWK=
MC116M3;Ee2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVK5U49DUUN3ME2yNU4xPzJ|IN88US=>M3XQVHNCVkeHUh?=
GI-1NHH0VpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXjZSIFsUUN3ME2yNU4yPyEQvF2=NXW1VI1IW0GQR1XS
HOP-62NUm1[md2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkL5TWM2OD1{MT6yO|g1KM7:TR?=MYrTRW5ITVJ?
PA-1MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4PrfWlEPTB;MkGuNlc5PyEQvF2=NEG3fpJUSU6JRWK=
HTNFHo[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2LNemlEPTB;MkGuOFM{OSEQvF2=MmnLV2FPT0WU
HUTU-80M2TTSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIrTeFNKSzVyPUKxMlQ{OzZizszNM{PYenNCVkeHUh?=
NCI-H1975M{Dkdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlLBTWM2OD1{MT60OlEh|ryPMWDTRW5ITVJ?
GAKNWLBbW92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4DINGlEPTB;MkGuOFk6KM7:TR?=NVG1O5lQW0GQR1XS
SK-N-ASNITQRZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFP6T|dKSzVyPUKxMlU3OTlizszNMkPhV2FPT0WU
OE33M4DIdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlnSTWM2OD1{MT62NFQ3KM7:TR?=NXHyeJlUW0GQR1XS
YKG-1NIXrc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGHicoFKSzVyPUKxMlY2PDVizszNNEjY[5NUSU6JRWK=
CAL-85MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIroTVJKSzVyPUKxMlk{ODVizszNNFrWdXZUSU6JRWK=
NCI-H2347MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUHtT4x2UUN3ME2yNU46PDJ6IN88US=>NYfoNJhbW0GQR1XS
PANC-08-13NIq2bYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX7JR|UxRTJ{LkCxNVkh|ryPMWHTRW5ITVJ?
SK-N-FIMUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVzJR|UxRTJ{LkOwO|Qh|ryPMkDuV2FPT0WU
NEC8NUKwdItET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYD1XXV2UUN3ME2yNk42ODd6IN88US=>Mn3nV2FPT0WU
AN3-CANGK3emtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYDJR|UxRTJ{Lk[wPFQh|ryPMlTaV2FPT0WU
HuO9MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWXiWIQ3UUN3ME2yNk44Ozl4IN88US=>MX7TRW5ITVJ?
COLO-800MmG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkfwTWM2OD1{Mj63OlU{KM7:TR?=MmDaV2FPT0WU
HT-29Mlf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWjBSoRkUUN3ME2yNk45QDJ|IN88US=>Mn;5V2FPT0WU
OC-314NHHsVndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVLJR|UxRTJ{Lki4OFUh|ryPMXjTRW5ITVJ?
G-401MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHHpdFhKSzVyPUKzMlA1PjJizszNM37iVHNCVkeHUh?=
Saos-2NGfYV|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH:1S5dKSzVyPUKzMlUyQDJizszNMnfEV2FPT0WU
UACC-62NF73dIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlT1TWM2OD1{Mz61PFM{KM7:TR?=Mn3RV2FPT0WU
D-247MGMn31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXvJR|UxRTJ|Lke5N|kh|ryPNX\VR3Q6W0GQR1XS
COLO-741M4n2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGL1bI1KSzVyPUKzMlk2PjVizszNMVnTRW5ITVJ?
ES3NXLqXnJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnnyTWM2OD1{ND6wNFI{KM7:TR?=MXXTRW5ITVJ?
LNCaP-Clone-FGCMV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEfYdZBKSzVyPUK0MlAzOTFizszNMYHTRW5ITVJ?
SW1710NYnyepA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHvhO|ZKSzVyPUK0MlE2ODZizszNNHrlcWxUSU6JRWK=
LU-99AMl3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUTJR|UxRTJ2LkG4OFEh|ryPNFe0WpVUSU6JRWK=
HOP-92MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV34XlZRUUN3ME2yOE44OjVizszNM1vjSHNCVkeHUh?=
LS-123M1WwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGq4XW5KSzVyPUK0Mlk3OTRizszNM2KxSHNCVkeHUh?=
T84MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWHIZXVZUUN3ME2yOE46PzZ3IN88US=>NYrLTG9CW0GQR1XS
HCT-116M3HZ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4rxT2lEPTB;MkWuOFE5PiEQvF2=NX:0fYh[W0GQR1XS
M14M3HBWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MonaTWM2OD1{NT60OFQ4KM7:TR?=NHzwdXNUSU6JRWK=
OCUB-MM1rNZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUDJR|UxRTJ3LkS0OVYh|ryPMVXTRW5ITVJ?
MKN45NWnSXmRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1jUPWlEPTB;MkWuOlMyPSEQvF2=NGH6WmhUSU6JRWK=
LCLC-97TM1MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4XLN2lEPTB;MkWuO|I5PSEQvF2=MW\TRW5ITVJ?
RVH-421M1rPPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MW\JR|UxRTJ3LkixOlEh|ryPM{DIbXNCVkeHUh?=
NKS-81-FDMVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NI\0VIFKSzVyPUK1MlkxOjFizszNMUfTRW5ITVJ?
NCI-H596MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHe0VItKSzVyPUK2MlA1QDdizszNMmXYV2FPT0WU
GB-1NIO4Wo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{f4XmlEPTB;Mk[uNVg4QSEQvF2=NGLvRlRUSU6JRWK=
ZR-75-30NXWxWGwzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXH5fJVkUUN3ME2yOk4zOjl5IN88US=>M362XXNCVkeHUh?=
U-2-OSMV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkCxTWM2OD1{Nj6zO|U4KM7:TR?=MU\TRW5ITVJ?
HuP-T3NW[3cHJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{PwdmlEPTB;Mk[uOlExOiEQvF2=NXj6Rpl{W0GQR1XS
MOLT-16M1fBS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHrKfm5KSzVyPUK2MlYyPjZizszNNYO1OYVtW0GQR1XS
U-87-MGMofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHPBbnpKSzVyPUK2Mlc1OzhizszNM2XUPHNCVkeHUh?=
8505CM1zpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MljtTWM2OD1{Nj65NVI3KM7:TR?=MkPsV2FPT0WU
SK-MEL-3M1PBOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX;qRlNRUUN3ME2yOk46QDJ6IN88US=>M1rhcnNCVkeHUh?=
COLO-824MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYjJR|UxRTJ5LkKxPVUh|ryPNXfwSFI1W0GQR1XS
EW-1M1XOeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoXHTWM2OD1{Nz6zOVU1KM7:TR?=MX\TRW5ITVJ?
UACC-257MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGWxNlhKSzVyPUK3MlM5ODRizszNNWWzdoZYW0GQR1XS
Hs-578-TMmHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3vj[2lEPTB;MkeuOVI6QSEQvF2=MluwV2FPT0WU
UACC-893MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlPzTWM2OD1{Nz62OlMyKM7:TR?=Ml\NV2FPT0WU
MHH-NB-11NGjlTVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYXmR2NHUUN3ME2yO{45ODB5IN88US=>M3fUfXNCVkeHUh?=
KYSE-410NXzOT2luT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoTDTWM2OD1{OD6yO|c6KM7:TR?=NHjWR3FUSU6JRWK=
SF126NVfyfWlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mlf1TWM2OD1{OD63OFM2KM7:TR?=MoTWV2FPT0WU
HT-144NWDMeZFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{HyNWlEPTB;MkmuN|M3OiEQvF2=M1L0cHNCVkeHUh?=
SW1573NWHaO29CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGnWdW5KSzVyPUK5MlM2ODlizszNM1n5cHNCVkeHUh?=
SW620NU\0O|NmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEPnNoZKSzVyPUK5MlM3PDFizszNMVnTRW5ITVJ?
SCHMl3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXXWR5MzUUN3ME2yPU45QDNzIN88US=>NIDh[G9USU6JRWK=
EW-22NF[4XHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXPJR|UxRTNyLkG5Olkh|ryPM1HV[3NCVkeHUh?=
H4MlvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUHubVdSUUN3ME2zNE41PjV2IN88US=>NVLVWmwzW0GQR1XS
CAS-1M3m5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkTsTWM2OD1|MD63PFU6KM7:TR?=NGnOdlVUSU6JRWK=
MG-63MnWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF;yXIVKSzVyPUOwMlg1PzhizszNNEPZUJdUSU6JRWK=
MDA-MB-415M2fWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX\JR|UxRTNzLkG3OVMh|ryPMUnTRW5ITVJ?
NCI-H1395NUHiXJl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWrJR|UxRTNzLkKzNlgh|ryPM1vmPHNCVkeHUh?=
Ca-SkiMX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{nTcGlEPTB;M{GuN|E4PyEQvF2=MVLTRW5ITVJ?
BxPC-3M{jJfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MljFTWM2OD1|MT6zO|I6KM7:TR?=MXvTRW5ITVJ?
A3-KAWNUi2PZV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF3FXWxKSzVyPUOxMlQ1PzFizszNNVvyXppDW0GQR1XS
T-24NVWxbHZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXzJR|UxRTNzLkezOlIh|ryPNXjSOlZDW0GQR1XS
NCI-H2029MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYHlUHFEUUN3ME2zNU44PzZ3IN88US=>MkDXV2FPT0WU
YAPCM3fwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHf5ZnRKSzVyPUOyMlA1ODdizszNMVTTRW5ITVJ?
SK-MEL-2Mlm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEnDVnRKSzVyPUOyMlA2OiEQvF2=M{KweHNCVkeHUh?=
LS-513NF:4SGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXnJR|UxRTN{LkGxPFch|ryPMnLuV2FPT0WU
AsPC-1MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGjsW21KSzVyPUOyMlM3ODVizszNMmroV2FPT0WU
KYSE-150MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH\OeY5KSzVyPUOyMlM4PzNizszNNYTaTHl5W0GQR1XS
NCI-H520M2rZdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4j3eGlEPTB;M{KuOFQ5OiEQvF2=MVXTRW5ITVJ?
JEG-3MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{jSSGlEPTB;M{OuNFk4OSEQvF2=NGm0PZlUSU6JRWK=
GMS-10NIfRUWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2X2UGlEPTB;M{OuN|AxPCEQvF2=NY\WfJlSW0GQR1XS
HT-1080MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NU\XV5A2UUN3ME2zN{4{QSEQvF2=M{LZdXNCVkeHUh?=
NCI-H1651MoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYr2cW9sUUN3ME2zN{4{QTZizszNNUfPOo5ZW0GQR1XS
NCI-H2122NEDRVldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1z4NmlEPTB;M{OuOVU4PCEQvF2=MXLTRW5ITVJ?
ES5NGjBO3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVTJR|UxRTN|LkeyPVIh|ryPM2n0XnNCVkeHUh?=
8305CMVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXHaZ|dwUUN3ME2zN{46QTN5IN88US=>MVjTRW5ITVJ?
KM12MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M37CbGlEPTB;M{SuNFQ4QCEQvF2=M{jkbnNCVkeHUh?=
HCT-15NIOyeZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmfUTWM2OD1|ND6xNlch|ryPMV7TRW5ITVJ?
OVCAR-5NX7oU4pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHXyfW9KSzVyPUO0MlIyQDJizszNM4\RNHNCVkeHUh?=
NCI-H2291MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYLJR|UxRTN2LkK0O|Ih|ryPMkXJV2FPT0WU
CP50-MEL-BNXzvSXUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlTPTWM2OD1|ND62OVkzKM7:TR?=NWq2TmNWW0GQR1XS
C-33-AMV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYr3dZRMUUN3ME2zOE43QDV5IN88US=>M1z6fHNCVkeHUh?=
NCI-H2452NXP6V|R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVHYNHhvUUN3ME2zOE44QDh{IN88US=>M{DkWnNCVkeHUh?=
MDA-MB-157NVTEUXRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV32VZE6UUN3ME2zOE45OTl|IN88US=>NXmxb|dHW0GQR1XS
LN-405MnnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYrJR|UxRTN3LkSzNFgh|ryPNYPrNoxGW0GQR1XS
MDA-MB-231MnTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHv5elRKSzVyPUO1MlUxPTRizszNMV7TRW5ITVJ?
EW-24MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml:5TWM2OD1|NT62N|M2KM7:TR?=MoLwV2FPT0WU
MKN28NX7GRmg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGrxXJRKSzVyPUO1MlgzOzZizszNNWLwTXN3W0GQR1XS
KINGS-1MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnnTTWM2OD1|NT64OFM1KM7:TR?=Ml:zV2FPT0WU
LC-2-adNFnoOZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2DJOGlEPTB;M{[uOlk6KM7:TR?=MVPTRW5ITVJ?
IGR-1NFrJTmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXvJR|UxRTN4LkewO|Uh|ryPMoq1V2FPT0WU
SW626M1Gxbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXfJR|UxRTN5LkC0NVch|ryPM1ruXHNCVkeHUh?=
ONS-76NH7WRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn7ETWM2OD1|Nz6xN|A6KM7:TR?=NVvrUpFuW0GQR1XS
T98GNY\C[21oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWrJR|UxRTN5Lki2N|Uh|ryPM{DVOHNCVkeHUh?=
NB14NIHmRpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFnSW|VKSzVyPUO4MlQ2PDRizszNMnLBV2FPT0WU
D-423MGMWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGfDcZZKSzVyPUO4MlQ5PjlizszNMYHTRW5ITVJ?
NCI-H510AM1K2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF;vZ29KSzVyPUO4MlY1PTFizszNM2LKd3NCVkeHUh?=
NMC-G1MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml3STWM2OD1|OD63NlIzKM7:TR?=MWjTRW5ITVJ?
SW948NHrtXmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1u2TmlEPTB;M{iuPFk1QSEQvF2=MUjTRW5ITVJ?
MFM-223MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHfseFNKSzVyPUO4Mlk1OzFizszNM33YfXNCVkeHUh?=
PAN1NXzFNGVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXnJR|UxRTN6Lkm5NVkh|ryPNFzHS|RUSU6JRWK=
MZ7-melMWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUfJR|UxRTN7LkGxPVkh|ryPNULvTplGW0GQR1XS
COLO-679NIPQZo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEG4cJhKSzVyPUO5Mlk4ODhizszNM4\1XXNCVkeHUh?=
SW872Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGLncWpKSzVyPUSwMlIxOzFizszNNVPv[mgyW0GQR1XS
HT-1197MlvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUnJR|UxRTRyLkK4Olkh|ryPM4DuUXNCVkeHUh?=
ES6Mn3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUfz[Vc6UUN3ME20NE41PTV{IN88US=>NXTWSY46W0GQR1XS
SNU-387MmrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1jDbmlEPTB;NECuPFI{QCEQvF2=MXzTRW5ITVJ?
T47DMmHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFK0XVZKSzVyPUSxMlAyQTJizszNM1LKeXNCVkeHUh?=
G-402Mk\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUT4WXZPUUN3ME20NU4xQDB7IN88US=>M1jTdXNCVkeHUh?=
MZ1-PCMm\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXXZdXVvUUN3ME20NU45OSEQvF2=MnLYV2FPT0WU
SW1417MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEXqT49KSzVyPUSyMlMxOyEQvF2=NHPpboRUSU6JRWK=
RERF-LC-MSM1u4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4TMdmlEPTB;NEKuOVA5PyEQvF2=NH;UXllUSU6JRWK=
SF539NHTVWphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2HBOmlEPTB;NEKuOVUzQSEQvF2=M170SnNCVkeHUh?=
ESS-1NH34WZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MW\JR|UxRTR|LkW1OVgh|ryPMn\MV2FPT0WU
RO82-W-1MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFjh[nFKSzVyPUSzMlYyPTNizszNNH3mUZBUSU6JRWK=
S-117NV3vZnJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2rNWmlEPTB;NEOuOlk2QCEQvF2=MlPCV2FPT0WU
SW756M3KxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmjOTWM2OD12Mz64NlQzKM7:TR?=NELhd3pUSU6JRWK=
CP66-MELNWXYdnJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVLJR|UxRTR3LkexOFMh|ryPMnzaV2FPT0WU
H-EMC-SSNHnyNppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUDJR|UxRTR3Lke2PVMh|ryPMUnTRW5ITVJ?
NCI-H2052NVLiW2t4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUPJR|UxRTR3LkmwNlch|ryPM4PSfXNCVkeHUh?=
SW684Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYHJR|UxRTR5LkCwPFEh|ryPMXXTRW5ITVJ?
HCC1569M3nJbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3rz[2lEPTB;NEeuNVY2QCEQvF2=M3zhfnNCVkeHUh?=
KGNNYrNb|J1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnjTTWM2OD12Nz6zN|EyKM7:TR?=NXntW4dyW0GQR1XS
LCLC-103HMoXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnjJTWM2OD12Nz60OFA1KM7:TR?=NIHzRXFUSU6JRWK=
SW780MmX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmTtTWM2OD12Nz62N|UyKM7:TR?=MYTTRW5ITVJ?
NCI-H1703NUjMXHpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX\lVWRtUUN3ME20PE4{OzV{IN88US=>M4[zSXNCVkeHUh?=
HCC1395NWW5VYp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoDiTWM2OD12OD63OFMzKM7:TR?=MVjTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts. [3] Gefitinib treatment of nude mice bearing established human GEO colon cancer xenografts reveals a reversible dose-dependent inhibition of tumor growth because GEO tumors resumes the growth rate of controls at the end of the treatment. [4]
Features A potent EGFR tyrosine kinase inhibitor.

Protocol(Only for Reference)

Cell Assay: [1]

Cell lines NR6, NR6M and NR6W cells
Concentrations 0-2 μM
Incubation Time 72 hours
Method Exponentially growing cells including NR6, NR6M, NR6M and NR6W cells are seeded in sextuple in 96-well plates at a concentration of 2000 cells/well, allowed to adhere and subsequently washed in PBS and incubated overnight in medium containing 0.5% FCS. Cells are then treated with varying concentrations (0-2 μM) of Gefitinib or the solute control DMSO and EGF. The optimal EGF concentration for inducing proliferation of NR6wtEGFR and NR6W cells has previously been determined and hence NR6wtEGFR and NR6W cells are supplemented with 10 nM and 0.1 nM EGF, respectively. EGF is not added to NR6 and NR6M cells. After 72 hours the amount of cells are measured by performing a MTT proliferation assay.

Animal Study: [3]

Animal Models Female nude mice (cba nu/nu) aged 8–10 weeks are intra-dermal injected with LoVo cells.
Formulation 0.5% polysorbate
Dosages 100 mg/kg
Administration Once daily by oral administration (0.1 mL/10 g body weight) for 14 days

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Pedersen MW, et al. Br J Cancer. 2005, 93(8), 915-923.

[2] Moasser MM, et al. Cancer Res. 2001, 61(19), 7184-7188.

view more

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02836847 Recruiting Cholangiocarcinoma of the Extrahepatic Bile Duct|Gallbladder Cancer Shanghai Jiao Tong University School of Medicine|Xinhua H  ...more Shanghai Jiao Tong University School of Medicine|Xinhua Hospital, Shanghai Jiao Tong University School of Medicine|Ruijin Hospital|RenJi Hospital|Eastern Hepatobiliary Surgery Hospital|Huashan Hospital July 2016 Phase 2
NCT02824458 Recruiting EGFR Tyrosine Kinase Inhibitors Plus VEGFR Inhibitors Sun Yat-sen University June 2016 Phase 3
NCT02740894 Completed Is Targeted Therapy Increasing Survival Inoperable Nonsmall Cell Lung Cancer With Spinal Metastasis ? Taipei Veterans General Hospital, Taiwan February 2016 --
NCT02347839 Recruiting Lung Cancer Sun Yat-sen University January 2016 Phase 2
NCT02588261 Recruiting Non-small Cell Lung Cancer (NSCLC) Astellas Pharma Global Development, Inc.|Astellas Pharma Inc November 2015 Phase 3

view more

Chemical Information

Download Gefitinib (ZD1839) SDF
Molecular Weight (MW) 446.90
Formula

C22H24ClFN4O3

CAS No. 184475-35-2
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water <1 mg/mL (<1 mM)
In vivo 5% DMSO+corn oil 2.5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related EGFR Products

  • Erlotinib

    Erlotinib is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.

  • Afatinib (BIBW2992) Dimaleate

    Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.

  • Poziotinib (HM781-36B)

    Poziotinib (HM781-36B) is an irreversible pan-HER inhibitor with IC50 of 3.2 nM, 5.3 nM and 23.5 nM for HER1, HER2, and HER4, respectively. Phase 2.

  • Erlotinib HCl (OSI-744)

    Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.

  • Afatinib (BIBW2992)

    Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.

  • Osimertinib (AZD9291)

    Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively. Phase 3.

  • Lapatinib

    Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.

  • AG-490 (Tyrphostin B42)

    AG-490 (Tyrphostin B42) is an inhibitor of EGFR with IC50 of 0.1 μM in cell-free assays, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.

  • Rociletinib (CO-1686, AVL-301)

    Rociletinib (CO-1686, AVL-301) is an irreversible, mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT in cell-free assays, respectively. Phase 2.

  • AG-1478 (Tyrphostin AG-1478)

    AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.

Recently Viewed Items

Tags: buy Gefitinib (ZD1839) | Gefitinib (ZD1839) ic50 | Gefitinib (ZD1839) price | Gefitinib (ZD1839) cost | Gefitinib (ZD1839) solubility dmso | Gefitinib (ZD1839) purchase | Gefitinib (ZD1839) manufacturer | Gefitinib (ZD1839) research buy | Gefitinib (ZD1839) order | Gefitinib (ZD1839) mouse | Gefitinib (ZD1839) chemical structure | Gefitinib (ZD1839) mw | Gefitinib (ZD1839) molecular weight | Gefitinib (ZD1839) datasheet | Gefitinib (ZD1839) supplier | Gefitinib (ZD1839) in vitro | Gefitinib (ZD1839) cell line | Gefitinib (ZD1839) concentration | Gefitinib (ZD1839) nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us