Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

Size Price Stock Quantity  
In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 570 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 37 Publications

4 Customer Reviews

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 MlTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLKWndMUUN3ME2wMlAxPTd{IN88US=> NEnCN5pUSU6JRWK=
KASUMI-1 Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMEC5NVEh|ryP M{H4OHNCVkeHUh?=
HCC2218 MnTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz3U3hKSzVyPUCuNFA6QDdizszN NF7pWFRUSU6JRWK=
KARPAS-45 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO2TWM2OD1yLkCxOlcyKM7:TR?= NWPR[WxKW0GQR1XS
HSC-4 NHrLdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfwTWM2OD1yLkCxO|Q5KM7:TR?= NH;DN|ZUSU6JRWK=
CHL-1 MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4KwemlEPTB;MD6wNVg{QSEQvF2= NYLhXVc1W0GQR1XS
KY821 M{jhOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorHTWM2OD1yLkCyNFYh|ryP MnjDV2FPT0WU
NCI-N87 MlTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEK3O|Mh|ryP M1LLRnNCVkeHUh?=
DOK NXXyW4t7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEOxPVQh|ryP M33XZXNCVkeHUh?=
DSH1 NH[yfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\HTWM2OD1yLkCzN|E1KM7:TR?= NIL3OmZUSU6JRWK=
MDA-MB-175-VII MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP4[phKSzVyPUCuNFM1OTZizszN NU\jSJhiW0GQR1XS
NCI-H2170 NHfzWJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rTd2lEPTB;MD6wN|czQCEQvF2= M3LoSnNCVkeHUh?=
BT-474 NX3ndoFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojGTWM2OD1yLkC0PVg3KM7:TR?= M4XBOnNCVkeHUh?=
EFO-27 M1PFfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzX[JZKSzVyPUCuNFUyQDJizszN NVvL[5p2W0GQR1XS
NCI-H720 MnXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrnbGpKSzVyPUCuNFU{OjVizszN MUTTRW5ITVJ?
PC-14 NXjrcHYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoG4TWM2OD1yLkC1OlY5KM7:TR?= MWDTRW5ITVJ?
EC-GI-10 Ml:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXHVWJKSzVyPUCuNFU6OTJizszN MmDOV2FPT0WU
KYSE-450 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\NTWM2OD1yLkC1PVc5KM7:TR?= M2LveXNCVkeHUh?=
BPH-1 NIXBT2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\5[3ZKSzVyPUCuNFU6QDhizszN M3fpSnNCVkeHUh?=
NCI-H292 NGPSXZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwME[wPUDPxE1? M4LJS3NCVkeHUh?=
H9 NVr0RZJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2f6WWlEPTB;MD6wO|E{OiEQvF2= MUHTRW5ITVJ?
NCI-H526 M4D1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMEe4NlMh|ryP MYLTRW5ITVJ?
NCI-H1623 MorMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvzeVdKSzVyPUCuNFgxOjVizszN NXzFNFdkW0GQR1XS
KYSE-140 M{nzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r5W2lEPTB;MD6wPFM{KM7:TR?= NXrlcpAxW0GQR1XS
Ca9-22 Mmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMEizOVMh|ryP Mn3UV2FPT0WU
AU565 Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\4TWM2OD1yLkC4OVA1KM7:TR?= MVnTRW5ITVJ?
ZR-75-30 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PHW2lEPTB;MD6wPVU1PSEQvF2= NF3vVXlUSU6JRWK=
NCI-H1770 NFjUR2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMUCyPEDPxE1? NFfwS3BUSU6JRWK=
LB2241-RCC NFTnXYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j6fGlEPTB;MD6xNFg5PCEQvF2= MnXTV2FPT0WU
CAL-39 NF;y[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXoRm9pUUN3ME2wMlEyPzl{IN88US=> NUnHNWx5W0GQR1XS
UACC-893 MkPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fYVWlEPTB;MD6xNVg5PSEQvF2= MWXTRW5ITVJ?
LU-65 M3HUb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMUK2N|Mh|ryP NGHSeIJUSU6JRWK=
HN MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK3Smo5UUN3ME2wMlE{ODd5IN88US=> NEHY[GRUSU6JRWK=
TI-73 NW\PV3NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jHV2lEPTB;MD6xOFcyPSEQvF2= NHrNUYZUSU6JRWK=
KU812 Mn;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMUW0OVYh|ryP MULTRW5ITVJ?
SW13 M4Ptcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTtW|EzUUN3ME2wMlE3OjF4IN88US=> M3fLdnNCVkeHUh?=
BB30-HNC Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;JXo9KSzVyPUCuNVY2PzZizszN NXSy[Zc5W0GQR1XS
HSC-2 NE\1PWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMU[4N|ch|ryP Ml\PV2FPT0WU
BV-173 M3fTNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7GN|ZoUUN3ME2wMlE4PTl4IN88US=> NGewdGZUSU6JRWK=
CAL-27 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PISmlEPTB;MD6xO|Y{PiEQvF2= NYH1c5c1W0GQR1XS
SBC-1 NFfZdlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMUi5OVkh|ryP MYjTRW5ITVJ?
CAL-33 NIXBWphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LkbGlEPTB;MD6yNFE5PCEQvF2= MULTRW5ITVJ?
NCI-H209 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXvdoNWUUN3ME2wMlIxPDZizszN MWrTRW5ITVJ?
COR-L105 M2DvPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjjW3ZKSzVyPUCuNlExQDRizszN M2O1ZnNCVkeHUh?=
HSC-3 NYq1O2w2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMkGxPVgh|ryP NUja[Zg6W0GQR1XS
NCI-H69 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMkG0OVEh|ryP M1zJO3NCVkeHUh?=
MOLT-13 NHzW[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknXTWM2OD1yLkKzPVc2KM7:TR?= MXLTRW5ITVJ?
ML-2 NWXEenJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGS3PZZKSzVyPUCuNlQ5ODJizszN NG\wS2FUSU6JRWK=
IGROV-1 Mn6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMkW5OVIh|ryP NH\rfotUSU6JRWK=
TK10 NX\L[ZJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPJZZE3UUN3ME2wMlI3PzN6IN88US=> NGTQTYpUSU6JRWK=
EoL-1-cell M1nRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7xW3ZKSzVyPUCuNlY5QTJizszN NHPQdZZUSU6JRWK=
HO-1-N-1 NX3xUZkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPmfoxuUUN3ME2wMlI4QDV|IN88US=> NHLOWZZUSU6JRWK=
BHY MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPPOpVKSzVyPUCuNlg3PTVizszN NWrwc45wW0GQR1XS
LU-139 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3QTWM2OD1yLkOwOVEh|ryP NYDiUXl{W0GQR1XS
23132-87 NF7PcWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPCUo5KSzVyPUCuN|E6OjNizszN MUPTRW5ITVJ?
ACHN MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwM{G5PVQh|ryP NIm0TVBUSU6JRWK=
DoTc2-4510 MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrFTWM2OD1yLkOyNlE6KM7:TR?= MYjTRW5ITVJ?
BB65-RCC NIn6d2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlznTWM2OD1yLkO0OVk{KM7:TR?= MXPTRW5ITVJ?
HLE MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwM{WwOFYh|ryP MnjvV2FPT0WU
HCC1419 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGni[I9KSzVyPUCuN|Y1ODhizszN NVnUb5V7W0GQR1XS
A388 NUjQXJlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXITWM2OD1yLkO2PFU4KM7:TR?= MV;TRW5ITVJ?
NUGC-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwM{izO|Mh|ryP M{\KWXNCVkeHUh?=
KYSE-180 M1r5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVq5WZR7UUN3ME2wMlM6ODh7IN88US=> NHrHbmFUSU6JRWK=
TE-6 NUjpRWlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\rTWM2OD1yLkSwNlQ3KM7:TR?= NGPSRYdUSU6JRWK=
A498 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TTbGlEPTB;MD60NFY4PCEQvF2= NYe0fpUzW0GQR1XS
NCI-H1648 MkLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwNESxPFIh|ryP MY\TRW5ITVJ?
DU-145 M1v4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ruO2lEPTB;MD60OFg{OyEQvF2= M3:4fHNCVkeHUh?=
CW-2 NGfL[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;4TmlEPTB;MD60OlkyPCEQvF2= NFi0cpBUSU6JRWK=
A431 NIOxe|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXVR3dvUUN3ME2wMlQ5OjN|IN88US=> NXPXOpd[W0GQR1XS
SAS MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDMTWM2OD1yLkS4N|k5KM7:TR?= M2fv[nNCVkeHUh?=
NCI-H2126 NFTPT45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwNUG5NlYh|ryP MWPTRW5ITVJ?
NCI-H358 M1LkVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvUcmd6UUN3ME2wMlU{OjFizszN NED3ZWxUSU6JRWK=
FADU NVXBcXFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDFO|VuUUN3ME2wMlU1PDB2IN88US=> Ml\JV2FPT0WU
ACN Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGi0[YxKSzVyPUCuOVUxQTRizszN MYfTRW5ITVJ?
HCC70 NGi1WpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwNUe2OlEh|ryP NGLtSYpUSU6JRWK=
NCI-H1838 NHPMZ|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwNkCyPVkh|ryP M{SxdXNCVkeHUh?=
CAL-54 NUflVHZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX25VpZRUUN3ME2wMlYyPjJzIN88US=> M4fZfXNCVkeHUh?=
NCI-H1975 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwNkG3Nlgh|ryP MU\TRW5ITVJ?
COR-L88 NHXu[HhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljqTWM2OD1yLk[0NVE{KM7:TR?= M1PhfnNCVkeHUh?=
CTV-1 MnPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwNkSzPVIh|ryP NWDwO|k4W0GQR1XS
EW-18 NYT4blN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HhT2lEPTB;MD62PFY6QCEQvF2= NEj1OoZUSU6JRWK=
HCC1806 M164fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1r5S2lEPTB;MD62PVY3PiEQvF2= MV7TRW5ITVJ?
HuP-T4 M3nxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfDSnZKSzVyPUCuOlk4PiEQvF2= NF25XHVUSU6JRWK=
MDA-MB-361 NH;jT4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfCTWM2OD1yLkeyOlYzKM7:TR?= MluyV2FPT0WU
NCI-H1573 NH60UGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DZUWlEPTB;MD63N|Y{KM7:TR?= MmX1V2FPT0WU
KU-19-19 NITR[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTvTWM2OD1yLke3OFY1KM7:TR?= MkjZV2FPT0WU
COLO-678 NF2yRXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HXVmlEPTB;MD64NFg{PCEQvF2= Ml64V2FPT0WU
C-33-A NYCzdFQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\EemlEPTB;MD64NVI6PyEQvF2= MX7TRW5ITVJ?
Calu-3 M3jT[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LtZWlEPTB;MD64NVQ{PCEQvF2= M2X5T3NCVkeHUh?=
AGS MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwOEO2OFgh|ryP NFWy[m5USU6JRWK=
SCC-25 NITtcIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DDPGlEPTB;MD64OFE4OSEQvF2= M{i5OHNCVkeHUh?=
JVM-2 NEK3U2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwOEiyPVkh|ryP MmDzV2FPT0WU
HCE-T M3[x[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrueW1WUUN3ME2wMlg5PDJ6IN88US=> NFHrV3pUSU6JRWK=
ES4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrrTWM2OD1yLkm3PFM3KM7:TR?= NH;1WXZUSU6JRWK=
EKVX Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jT[GlEPTB;MT6wNVA3PCEQvF2= NFWyW4VUSU6JRWK=
D-542MG M2fycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlf2TWM2OD1zLkCxNFY1KM7:TR?= Ml25V2FPT0WU
SW1116 MnyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX5UWlKSzVyPUGuNFEzQDdizszN M3TIZ3NCVkeHUh?=
5637 MoH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFwMEG1NUDPxE1? Mn\JV2FPT0WU
HT-1376 NVfRblJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PBdWlEPTB;MT6wNVUyOyEQvF2= M3zR[nNCVkeHUh?=
NB69 NXHGOJVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz5TWM2OD1zLkCyPVQ2KM7:TR?= MmD5V2FPT0WU
YKG-1 NFzldGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4KxVGlEPTB;MT6wOVQyQSEQvF2= M4PDZ3NCVkeHUh?=
EW-3 NF\qS21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTpb2RQUUN3ME2xMlA4QDh|IN88US=> NWW2[FZbW0GQR1XS
GCIY NYrOWmh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTLO2dmUUN3ME2xMlA5OTB2IN88US=> MmrjV2FPT0WU
SK-MES-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTFwMUG0PFch|ryP MVHTRW5ITVJ?
PANC-08-13 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYqzTWVPUUN3ME2xMlE3PDF4IN88US=> NWf2WXBZW0GQR1XS
SK-NEP-1 NF7hToxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjaTGNKUUN3ME2xMlE4PTF|IN88US=> MYjTRW5ITVJ?
SW954 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi4SphJUUN3ME2xMlIxOjF2IN88US=> MX;TRW5ITVJ?
NCI-SNU-5 M1TXbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzMbVZYUUN3ME2xMlI{QSEQvF2= M4[yU3NCVkeHUh?=
SW48 M4LScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;nTWM2OD1zLkK1OFMzKM7:TR?= NY\qZ5FuW0GQR1XS
HT-3 NXnyTFJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTFwMki3OVMh|ryP M17UfnNCVkeHUh?=
ETK-1 Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Wy[WlEPTB;MT6zO|Q2PiEQvF2= MmqxV2FPT0WU
SCC-15 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\FRmlEPTB;MT6zPVQ2OSEQvF2= NF3HUWlUSU6JRWK=
DU-4475 NILzeo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7rWGtKSzVyPUGuOFAyOjFizszN M33ISHNCVkeHUh?=
NB5 NFyx[JlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS1TWM2OD1zLkSxN|E4KM7:TR?= NXrwVIIxW0GQR1XS
CFPAC-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7BSJdKSzVyPUGuOFI1QTNizszN NXztfok6W0GQR1XS
NCI-H630 M4\mcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\OUGpKSzVyPUGuOFU2QDJizszN NVi0ZnM6W0GQR1XS
NCI-H82 NGKzUVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37vbWlEPTB;MT61OFAxPiEQvF2= M3jKNnNCVkeHUh?=
ECC10 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWK0XXdMUUN3ME2xMlU2OzZ7IN88US=> NGDJ[ZBUSU6JRWK=
K5 NGr0b5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LBeGlEPTB;MT61PFM2PyEQvF2= M4m5eHNCVkeHUh?=
ME-180 M4Lob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojtTWM2OD1zLk[xNFk3KM7:TR?= NHLyNVRUSU6JRWK=
KYSE-410 Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXwZmtJUUN3ME2xMlY2Pjd{IN88US=> MWXTRW5ITVJ?
G-401 Mom3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDaPVJWUUN3ME2xMlY4PDF|IN88US=> M1zvcXNCVkeHUh?=
TGBC24TKB NHrveG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO2dWlKSzVyPUGuOlgzOyEQvF2= MoTlV2FPT0WU
Detroit562 M{PQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFwN{CxOVIh|ryP M3HyZnNCVkeHUh?=
OE19 MkO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3RTWM2OD1zLkexOVEzKM7:TR?= NXj3cnptW0GQR1XS
CAKI-1 NWfVRZBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoG5TWM2OD1zLke4NlEyKM7:TR?= MYPTRW5ITVJ?
TE-12 NXrBUVN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle0TWM2OD1zLkiwOFE1KM7:TR?= MVvTRW5ITVJ?
NCI-H1666 M1;0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvSbIRLUUN3ME2xMlgxQTR6IN88US=> NYnMWGE4W0GQR1XS
TE-1 NGTIWmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnt[3FHUUN3ME2xMlgyPDd3IN88US=> M1Xze3NCVkeHUh?=
CAL-12T MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXkb|dKSzVyPUGuPFg6PDVizszN NGe1dJBUSU6JRWK=
TE-8 MnXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LtcGlEPTB;MT65NVM4PyEQvF2= NFztUodUSU6JRWK=
KYSE-270 MmG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTSeGxPUUN3ME2yMlAzPzN{IN88US=> NUTyeVk4W0GQR1XS
GMS-10 NX7jT41XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoWwTWM2OD1{LkCzOVE4KM7:TR?= MnOyV2FPT0WU
A2780 NIXmVolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7IeIFUUUN3ME2yMlA3Ojl2IN88US=> MojpV2FPT0WU
OMC-1 NUnLN2dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDQcJh6UUN3ME2yMlA5OTZ7IN88US=> NG\5folUSU6JRWK=
LoVo MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHMTWM2OD1{LkGwO|k4KM7:TR?= NHv4TnJUSU6JRWK=
PANC-03-27 Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DOO2lEPTB;Mj6xOlY{OSEQvF2= MlnqV2FPT0WU
MDA-MB-157 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJwMkG4Nlgh|ryP M1TuTXNCVkeHUh?=
CaR-1 Mor0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPqTWM2OD1{LkK4NlgyKM7:TR?= NVfmTIJzW0GQR1XS
769-P MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHURlFyUUN3ME2yMlI6ODN5IN88US=> M135TnNCVkeHUh?=
NB7 NE\xRnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJwMkm2O|Yh|ryP MlexV2FPT0WU
MKN7 MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\EenJKSzVyPUKuN|U{OzVizszN MnmwV2FPT0WU
NCI-H1048 M3j5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TFZ2lEPTB;Mj60PVE2QCEQvF2= NVH5RVRFW0GQR1XS
RCM-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rIdmlEPTB;Mj61Nlk{QCEQvF2= NHTGfI1USU6JRWK=
HT55 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHETWM2OD1{LkW3N|gh|ryP MW\TRW5ITVJ?
HCC1569 NIPkT5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj0Z4hKSzVyPUKuOVgzQTdizszN M2r6XHNCVkeHUh?=
LXF-289 NGrIPG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJwNkO1OlUh|ryP NIjFO5VUSU6JRWK=
OVCAR-3 M{DhSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDw[pMxUUN3ME2yMlY4OTZ5IN88US=> M3vreHNCVkeHUh?=
TE-10 NVHuc5BsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3SVIRKSzVyPUKuOlgxPzhizszN MnTVV2FPT0WU
SNU-C2B NUPCOnhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nWUWlEPTB;Mj62PFYyPiEQvF2= Mm\QV2FPT0WU
LB1047-RCC MlvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjMTWM2OD1{Lke0PFg5KM7:TR?= M{[3[nNCVkeHUh?=
SN12C MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;UOXVmUUN3ME2yMlkyQTZ2IN88US=> NIPDZ3ZUSU6JRWK=
786-0 Mmj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTNVZZWUUN3ME2zMlA3PDB6IN88US=> M3LWR3NCVkeHUh?=
HT-29 Mn3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGH3e3RKSzVyPUOuNFc{ODlizszN NV3OToY3W0GQR1XS
RPMI-7951 NVHqPXM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[xTWM2OD1|LkC3OVkh|ryP MlrmV2FPT0WU
NBsusSR MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTNwMUiyOVQh|ryP NV;vO|cxW0GQR1XS
NKM-1 M{nnNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTNwMUi3OFQh|ryP M2HyXXNCVkeHUh?=
Capan-2 NYfrcnBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jHW2lEPTB;Mz60Olg4PSEQvF2= MWfTRW5ITVJ?
MKN1 M1Xzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrmTWM2OD1|LkS3NVA5KM7:TR?= NHK1OVdUSU6JRWK=
OAW-42 NH\YTXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTNwNUCwNlYh|ryP MljDV2FPT0WU
SKG-IIIa M1LLO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\uTWlEPTB;Mz61NlI{PyEQvF2= MoraV2FPT0WU
no-11 NWS4XodvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULwTnh[UUN3ME2zMlU{PTZ2IN88US=> NXy0XZB{W0GQR1XS
NY NYC5TIdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITUdVRKSzVyPUOuOVM3PTVizszN MXHTRW5ITVJ?
HEC-1 NYnaVHdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TRXGlEPTB;Mz61PFk2KM7:TR?= MkL1V2FPT0WU
NCI-H441 NYTkVFl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTNwNUm4OFEh|ryP NYPufpV4W0GQR1XS
NCI-H2009 NV;mWGJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHXOYxKSzVyPUOuOlEzOTZizszN MmTUV2FPT0WU
T47D MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\CbXBZUUN3ME2zMlYzOjF5IN88US=> NYTkS2pnW0GQR1XS
SNU-449 MnvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnHZZRVUUN3ME2zMlY2QDJ4IN88US=> NXvxc4VqW0GQR1XS
NCI-SNU-1 NX3s[mJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTNwNkm3N|Uh|ryP M37pPHNCVkeHUh?=
BT-20 Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nhcmlEPTB;Mz62PVc6PSEQvF2= MkT2V2FPT0WU
LS-123 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGr4eVhKSzVyPUOuO|QzQDRizszN NWPXb|d3W0GQR1XS
8305C M3yyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDxdYFKSzVyPUOuO|U6OTFizszN M3;4dHNCVkeHUh?=
OCUB-M MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDKTWM2OD1|Lke2NVg4KM7:TR?= NYe5fHVrW0GQR1XS
KOSC-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37oVWlEPTB;Mz64N|Q2OSEQvF2= MWjTRW5ITVJ?
NCI-H1693 NVrMW|ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHyNmF{UUN3ME2zMlg1OThzIN88US=> MV7TRW5ITVJ?
TE-9 M1zDZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe4TndKSzVyPUOuPFQ{QDJizszN MknJV2FPT0WU
MV-4-11 NE\abYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTNwOEe5PVQh|ryP MXjTRW5ITVJ?
GAMG M1XFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37TfmlEPTB;Mz65NVMyPCEQvF2= NH3FdXVUSU6JRWK=
KNS-62 Ml3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX6TItvUUN3ME2zMlk1PzNzIN88US=> NGrPXWFUSU6JRWK=
MC116 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTNwOUW0PFkh|ryP MlntV2FPT0WU
647-V M4C3PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXTboRKUUN3ME2zMlk5PDV{IN88US=> M4ThXnNCVkeHUh?=
U-87-MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTRwMUC0PFEh|ryP NYrSSXA5W0GQR1XS
RPMI-8226 NGrYcXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoGyTWM2OD12LkGxOlMyKM7:TR?= M{jIeHNCVkeHUh?=
SW1417 NYqzTWZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFy1UGtKSzVyPUSuNVIyPDdizszN M1v5S3NCVkeHUh?=
LAMA-84 NG[1RlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTRwMUewNkDPxE1? NYLpR45nW0GQR1XS
LS-513 NYCwOYV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfq[FVKSzVyPUSuN|EzOTdizszN M2\wdHNCVkeHUh?=
KLE Ml7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXhcmJFUUN3ME20MlQxQDF7IN88US=> NWf2blQ5W0GQR1XS
HCT-116 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTRwNEGwNFch|ryP M4\nT3NCVkeHUh?=
EPLC-272H NVHMZYNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[5fY5OUUN3ME20MlQyPTN|IN88US=> M4S4d3NCVkeHUh?=
KS-1 M3jBZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HUfmlEPTB;ND61NFg5QSEQvF2= NWrNWYoyW0GQR1XS
HT-1197 M3;Ue2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HLOmlEPTB;ND61NlY3QSEQvF2= NYm4VpNXW0GQR1XS
LCLC-97TM1 M3Xrcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTRwNUO2PFYh|ryP NVv6boJ4W0GQR1XS
ES5 MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mke2TWM2OD12LkizO|I{KM7:TR?= MoXRV2FPT0WU
CTB-1 NXLKfHlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnK5TWM2OD12Lki0PFgh|ryP MWfTRW5ITVJ?
HL-60 MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjPNW4yUUN3ME20Mlg3PjFzIN88US=> Ml;BV2FPT0WU
VM-CUB-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTRwOE[4NVkh|ryP M2DaeHNCVkeHUh?=
MEG-01 M{LW[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXETWM2OD12Lkm5OFA{KM7:TR?= M3rCV3NCVkeHUh?=
KYSE-520 NVPmV3VRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTVwMkC4N|kh|ryP MYHTRW5ITVJ?
HuO-3N1 NF;HV|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPqTWM2OD13LkK0NFQ{KM7:TR?= NGHNeXBUSU6JRWK=
SW620 M1n3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX72PWdwUUN3ME21MlI1QTZ2IN88US=> M{TSWHNCVkeHUh?=
U031 NU\HcXBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGOyPXlKSzVyPUWuNlU1OjRizszN MYXTRW5ITVJ?
TE-5 NHvvUnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPCcmVKSzVyPUWuOFA5PSEQvF2= NWXidpN7W0GQR1XS
NCI-H747 Mny2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlX4TWM2OD13LkSyOFczKM7:TR?= NIfLWohUSU6JRWK=
MG-63 NE\B[|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTVwNEi3OlIh|ryP MlXtV2FPT0WU
HC-1 NFK0UVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC2TWM2OD13LkWxPFM6KM7:TR?= MV7TRW5ITVJ?
HCC2998 NVjCbYNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PrcGlEPTB;NT61NlYyPSEQvF2= M{G5N3NCVkeHUh?=
NTERA-S-cl-D1 NE\YS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7h[lBKSzVyPUWuOVQ2OzdizszN M3iwR3NCVkeHUh?=
KINGS-1 MnvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTD[ZBlUUN3ME21MlYxQTR2IN88US=> NXXRW5hlW0GQR1XS
D-423MG M4TjT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFK4SIJKSzVyPUWuOlE4ODVizszN NIC5[VhUSU6JRWK=
SW962 M2rSNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rNZmlEPTB;NT62NlA{OiEQvF2= MWXTRW5ITVJ?
LOXIMVI M2fJe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTVwNkO4O|Mh|ryP MXvTRW5ITVJ?
LS-411N MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTVwN{m0OFEh|ryP M1PyUHNCVkeHUh?=
NCI-H2291 NWq5[WtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTVwOUi5OFMh|ryP MoHQV2FPT0WU
A549 M1LS[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fRO2lEPTB;Nj6xNlU2OyEQvF2= M2DiXnNCVkeHUh?=
LS-1034 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTZwMkC3NFYh|ryP NF22TW1USU6JRWK=
NB14 MnLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVKyWGlxUUN3ME22MlQ{QDN4IN88US=> MUHTRW5ITVJ?
NCI-H1299 NIHqe2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fhb2lEPTB;Nj62N|E4OSEQvF2= MmXZV2FPT0WU
BT-549 MkTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XxRWlEPTB;Nj62Olg5QSEQvF2= MYjTRW5ITVJ?
J-RT3-T3-5 M{XzeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fTW2lEPTB;Nj64Olkh|ryP NX3vV|FXW0GQR1XS
SW756 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{flRmlEPTB;Nj65NVE4PiEQvF2= Mn2wV2FPT0WU
DJM-1 NX\p[3plT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYqxcWo{UUN3ME22MlkzODF{IN88US=> MojEV2FPT0WU
GP5d MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTZwOUezPVQh|ryP MmHGV2FPT0WU
MOLT-4 M2HFUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Hl[GlEPTB;Nz6wNlE{PSEQvF2= NHeyUXpUSU6JRWK=
NCI-H28 NUXVSVZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHOw[XBKSzVyPUeuNVY1ODVizszN NEfI[4pUSU6JRWK=
MN-60 MknSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PUdGlEPTB;Nz6yPFA5QSEQvF2= MorVV2FPT0WU
RMG-I NX\rbWhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTdwM{myPVYh|ryP MkTTV2FPT0WU
COLO-800 NEPJZ4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmriTWM2OD15LkSxOFQ3KM7:TR?= NV\NPFM6W0GQR1XS
DB NIPTXW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHS0ToVKSzVyPUeuOlExODVizszN MX3TRW5ITVJ?
Ca-Ski NIXRS2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq4TWM2OD15Lk[0NlU6KM7:TR?= MXXTRW5ITVJ?
HEL NFKyVGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;5fIxKUUN3ME23MlcyOjB|IN88US=> MnG2V2FPT0WU
NH-12 M2Xk[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fYSmlEPTB;Nz63NlgxQCEQvF2= MnTHV2FPT0WU
LB373-MEL-D M1yyTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{GwbWlEPTB;Nz63Olc4OSEQvF2= M3WyRnNCVkeHUh?=
SW900 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrhfXZKSzVyPUeuPFIyOjFizszN MVfTRW5ITVJ?
JVM-3 M3;XTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHlTWM2OD15Lki5OVk6KM7:TR?= NGjhWVBUSU6JRWK=
OAW-28 NEfGbIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzESYExUUN3ME23Mlk1PTd6IN88US=> NYD3ZpdtW0GQR1XS
KURAMOCHI NI\MSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTGcIpTUUN3ME23Mlk1QDFzIN88US=> M3yyb3NCVkeHUh?=
BE-13 M1PWdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rSZWlEPTB;Nz65PFEyOiEQvF2= NFqzVppUSU6JRWK=
VMRC-RCZ M1\aUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRThwMEG2PVch|ryP M1fJSXNCVkeHUh?=
NCI-H727 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\PPGlEPTB;OD6xNFQzKM7:TR?= MkLnV2FPT0WU
SW1710 MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET5R4tKSzVyPUiuNVg2OTVizszN MlLnV2FPT0WU
D-502MG M3nrXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT3TXF{UUN3ME24MlI6Ojh{IN88US=> NU\IW|VTW0GQR1XS
NCI-H1993 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfLW5RKSzVyPUiuN|M3OzFizszN MkXoV2FPT0WU
SCC-4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRThwNESwOVkh|ryP NFHZO|ZUSU6JRWK=
HAL-01 NYnifo9lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjrOmtGUUN3ME24MlUyQTFizszN MojxV2FPT0WU
GT3TKB NGDocnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jKcWlEPTB;OD62O|k3PCEQvF2= NG\EVVlUSU6JRWK=
SK-OV-3 NH\USGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;uTWM2OD16LkexN|I6KM7:TR?= NYnX[pBCW0GQR1XS
COLO-829 Ml7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfTTWM2OD16LkiwPVc3KM7:TR?= M1G3b3NCVkeHUh?=
OCI-AML2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTHTWM2OD16Lkm1OFgyKM7:TR?= MVPTRW5ITVJ?
OS-RC-2 MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofLTWM2OD17LkCyNVkh|ryP MnTqV2FPT0WU
BFTC-909 NEj6XlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTlwME[3PVkh|ryP NYXp[ZlDW0GQR1XS
EW-11 NET2SHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXWNpBKSzVyPUmuNVc3PTNizszN MYLTRW5ITVJ?
HCE-4 MkK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3tdYdKSzVyPUmuNlE2PThizszN NV7pZ3FJW0GQR1XS
BALL-1 MoK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXjXVlqUUN3ME25MlIyQTB5IN88US=> M4LOSXNCVkeHUh?=
SF539 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTlwMkO1OlIh|ryP NWHhcmVLW0GQR1XS
CAMA-1 M1[4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjhTWM2OD17LkK4NVI5KM7:TR?= M3\2XXNCVkeHUh?=
C32 M4LOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvNTWM2OD17LkOzNFY1KM7:TR?= MU\TRW5ITVJ?
NCI-H1703 NFHPeVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;YS4J1UUN3ME25MlM1Ozd3IN88US=> M3\tfHNCVkeHUh?=
NCI-H1650 M37qTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13zWGlEPTB;OT62NFk1PiEQvF2= MX\TRW5ITVJ?
NCI-H1563 Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPtdmtOUUN3ME25Mlc3ODNzIN88US=> MnfwV2FPT0WU
CAL-85-1 NWHteGxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHxTWM2OD17Lki3N|g{KM7:TR?= M1O1XHNCVkeHUh?=
UM-UC-3 MlvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3z3SGlEPTB;OT65OVA{KM7:TR?= NIPHO2xUSU6JRWK=
BxPC-3 NXizU|FVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjQTWM2OD1zMD6wPVczKM7:TR?= MmXOV2FPT0WU
MHH-PREB-1 M4fncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFyLkG5PVkh|ryP NWnsT4ZzW0GQR1XS
DEL MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LWV2lEPTB;MUCuN|k1PiEQvF2= MonhV2FPT0WU
HuCCT1 NF;TNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXziN2ZmUUN3ME2xNE43ODN|IN88US=> MUnTRW5ITVJ?
OVCAR-4 MlXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfPW3JKSzVyPUGwMlg5OzVizszN MULTRW5ITVJ?
CAL-72 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;RfWlEPTB;MUCuPVM6OSEQvF2= NULkXo5HW0GQR1XS
HCC1954 NG\qPWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHZT4JnUUN3ME2xNU4xPzV2IN88US=> M4j0NXNCVkeHUh?=
EFO-21 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD0dIJHUUN3ME2xNU4yODR3IN88US=> NFjROWhUSU6JRWK=
FTC-133 M3S4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW4UGZnUUN3ME2xNU4yPDB5IN88US=> NE\nNpRUSU6JRWK=
SK-MEL-24 NIPXVVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTFzLkKzOlYh|ryP M4TPbHNCVkeHUh?=
UACC-62 Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPITWM2OD1zMT6yN|Y5KM7:TR?= MWjTRW5ITVJ?
NCI-H650 MmO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHuxNmNKSzVyPUGxMlI1OThizszN MV;TRW5ITVJ?
ALL-PO MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHXVYpKSzVyPUGxMlI2OTJizszN MnfOV2FPT0WU
T84 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYC1O|F[UUN3ME2xNU4{QTB5IN88US=> NYHH[2dOW0GQR1XS
IST-MEL1 NEfpVGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\OTWM2OD1zMT60OVU6KM7:TR?= MnKxV2FPT0WU
SW626 NIXmUJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XzRWlEPTB;MUGuOVc2PSEQvF2= NHLSPYJUSU6JRWK=
RPMI-2650 MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTFXmgxUUN3ME2xNU42QDh3IN88US=> NW\1dlNTW0GQR1XS
MC-IXC Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfaXndKSzVyPUGxMlY4OjhizszN MoPGV2FPT0WU
HOP-62 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWm3bVR7UUN3ME2xNU43PzZ2IN88US=> NUHEeYtnW0GQR1XS
NOS-1 M3zDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1q1T2lEPTB;MUGuO|ExQSEQvF2= M4D2c3NCVkeHUh?=
SW1573 NHny[pRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnWTWM2OD1zMT63Nlk2KM7:TR?= NHzQRVBUSU6JRWK=
WM-115 NH;nUnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjGXYlKSzVyPUGxMlc2QDhizszN NUDXc40zW0GQR1XS
HuO9 NGnlcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTFzLki3O|Qh|ryP NI\hW2JUSU6JRWK=
YAPC NITjXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTFzLkmyOVkh|ryP NGrjeoNUSU6JRWK=
MDA-MB-453 M{TsPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7lXGZKSzVyPUGxMlk2OTVizszN MoXjV2FPT0WU
NCI-H596 NGHMSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTF{LkCzOlkh|ryP Mm\6V2FPT0WU
A172 M1jCXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzxXodKSzVyPUGyMlA4QThizszN M3S4[HNCVkeHUh?=
RS4-11 NHew[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTF{LkG3NlUh|ryP NUP6[JQzW0GQR1XS
HCC1937 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTF{Lke1OlQh|ryP M4nKZnNCVkeHUh?=
SW837 M37CT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3uNZJtUUN3ME2xNk46ODJ6IN88US=> NUnrUYhTW0GQR1XS
NMC-G1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jCVWlEPTB;MUKuPVI{PCEQvF2= MVHTRW5ITVJ?
PFSK-1 NXrpbpFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nESmlEPTB;MUOuNFYh|ryP MX\TRW5ITVJ?
DBTRG-05MG Ml\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTRTWM2OD1zMz6wOlMzKM7:TR?= MX;TRW5ITVJ?
SK-UT-1 NXe5OWNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF|LkGwPFMh|ryP MVrTRW5ITVJ?
OVCAR-5 NYnHU3ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTF|LkG1PVMh|ryP NF7J[ZFUSU6JRWK=
8505C MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTF|LkKwOlch|ryP MUfTRW5ITVJ?
SK-MEL-1 NVnGdGFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fmVmlEPTB;MUOuO|E{PSEQvF2= MnHtV2FPT0WU
LK-2 MnjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTF|Lke2N|kh|ryP NUXCTWl[W0GQR1XS
OE33 MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF|Lke4OkDPxE1? MmH4V2FPT0WU
Ramos-2G6-4C10 M3nxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLSTWM2OD1zND6wNlAzKM7:TR?= M3n5THNCVkeHUh?=
EW-13 NWLvfGZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\pc2pwUUN3ME2xOE4xOzV{IN88US=> MnnEV2FPT0WU
NCI-H1793 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\pTmlEPTB;MUSuNlA5PyEQvF2= M1vuPXNCVkeHUh?=
BHT-101 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrWTWM2OD1zND6yOFEh|ryP NEfI[XZUSU6JRWK=
RKO M2ri[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fYTWlEPTB;MUSuOVA4PSEQvF2= MoDOV2FPT0WU
NEC8 NYXHRmtQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXhSndKSzVyPUG0MlU1PzJizszN MYTTRW5ITVJ?
PANC-10-05 NHXxPVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHJfZFKSzVyPUG0MlYzPDdizszN MVrTRW5ITVJ?
NCI-H2030 MmnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrqN4NKSzVyPUG0MlY1PDhizszN MnHOV2FPT0WU
C2BBe1 NWjqXYJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrZVohKSzVyPUG0Mlc3PCEQvF2= MYfTRW5ITVJ?
EM-2 NYfNZoVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jQPGlEPTB;MUSuPFU4PiEQvF2= NEH3NZFUSU6JRWK=
HCC1395 MofVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1i5dGlEPTB;MUSuPVM{QCEQvF2= NUD4UVk{W0GQR1XS
A2058 M3z3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzRNXpKSzVyPUG1MlA1ODlizszN M2j1THNCVkeHUh?=
SW1463 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLHTWM2OD1zNT6wOFg2KM7:TR?= M1vzTHNCVkeHUh?=
J82 NHHZfVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPXNmhzUUN3ME2xOU4xPTdizszN M1G1O3NCVkeHUh?=
CAL-120 M3;U[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fpbWlEPTB;MUWuNVQ1PyEQvF2= MV;TRW5ITVJ?
COLO-824 MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTF3LkG1O|kh|ryP M{mwSnNCVkeHUh?=
LNCaP-Clone-FGC NGHZRpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnwe3RvUUN3ME2xOU41OjR6IN88US=> M17jbXNCVkeHUh?=
CP66-MEL MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzZdYlKSzVyPUG1MlQ3QDhizszN M4PtO3NCVkeHUh?=
OC-314 M3y0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj5cnZKSzVyPUG1MlQ4OTRizszN NX61fmsxW0GQR1XS
OVCAR-8 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzPRY5UUUN3ME2xOU45QDZzIN88US=> MkPEV2FPT0WU
MFE-280 MmrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf2dVRKSzVyPUG2MlA1QDhizszN MUDTRW5ITVJ?
MHH-NB-11 MoTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTF4LkC4N|kh|ryP M4LXZnNCVkeHUh?=
SW1990 NYDTeVdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTF4LkG3OVUh|ryP MUHTRW5ITVJ?
U-266 MoDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHNZnR{UUN3ME2xOk4zOjl7IN88US=> MnzGV2FPT0WU
MFM-223 NVHzeZFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXwTWM2OD1zNj6zPVY2KM7:TR?= NH3kU2xUSU6JRWK=
L-363 M1S5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[2VXJKSzVyPUG2MlQ2PzdizszN NGr4XYFUSU6JRWK=
MCF7 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXETWM2OD1zNj60O|I{KM7:TR?= M1vkZ3NCVkeHUh?=
SK-MEL-3 Mm\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTF4LkS3PFch|ryP NVXOS3VFW0GQR1XS
HH NGrFVnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nsRWlEPTB;MU[uOVE3OiEQvF2= MmXOV2FPT0WU
no-10 NIXvPIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy3XYlWUUN3ME2xOk43OzR|IN88US=> M1n1NXNCVkeHUh?=
HuP-T3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7MfXQzUUN3ME2xOk43PTd4IN88US=> NGLGb4xUSU6JRWK=
QIMR-WIL M{S1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\RWYY2UUN3ME2xOk44OTB3IN88US=> NH7n[FRUSU6JRWK=
NCI-H1092 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF4LkizNVYh|ryP MVfTRW5ITVJ?
MZ2-MEL MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF4Lki0NFMh|ryP MX7TRW5ITVJ?
ES3 M3Pl[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\rUmlEPTB;MU[uPVE{PCEQvF2= MWnTRW5ITVJ?
COLO-684 MoTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrwTWM2OD1zNj65OFc4KM7:TR?= MkjnV2FPT0WU
NCI-H661 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrCNI5KSzVyPUG2Mlk3QTRizszN NUi2VZE{W0GQR1XS
CP50-MEL-B MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkL0TWM2OD1zNz6wN|Q{KM7:TR?= MXvTRW5ITVJ?
NCI-H2405 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTF5LkG5O|Qh|ryP MoX3V2FPT0WU
U-2-OS MoDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr6TWM2OD1zNz61N|A4KM7:TR?= NXKwOJlxW0GQR1XS
RERF-LC-MS NVTFUoczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTF5LkW1NFgh|ryP NVXoSYhWW0GQR1XS
NCI-H2342 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfvTnVHUUN3ME2xO{42PTdizszN MkH0V2FPT0WU
ES8 NILuWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnibGlKSzVyPUG3MlYxQDdizszN NFLVeZZUSU6JRWK=
MOLT-16 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHwTWM2OD1zNz64PVM1KM7:TR?= M3S5OnNCVkeHUh?=
RH-18 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{O4[mlEPTB;MUiuNFA{PSEQvF2= M1;yTHNCVkeHUh?=
D-283MED Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTF6LkCwPFgh|ryP M{jLTXNCVkeHUh?=
RCC10RGB M2LZ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\tTWM2OD1zOD6wOVU6KM7:TR?= NFX6[lVUSU6JRWK=
NCI-H1437 M1TJcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7RbZptUUN3ME2xPE4yPjRzIN88US=> NFPrXJNUSU6JRWK=
SW982 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX21[ZJrUUN3ME2xPE4zPjdzIN88US=> M2rmRnNCVkeHUh?=
IST-MES1 M{DmPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmO3TWM2OD1zOD60OFI5KM7:TR?= Mlm3V2FPT0WU
A704 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTOTWM2OD1zOD60O|U{KM7:TR?= NUCxVmtbW0GQR1XS
ESS-1 M{fNUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXaUphKSzVyPUG4MlUzODVizszN MXPTRW5ITVJ?
SCH M373cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XmO2lEPTB;MUiuOlQ2PiEQvF2= MoTiV2FPT0WU
COLO-320-HSR NG\VNYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTF6Lke0OkDPxE1? NWXBVpROW0GQR1XS
Mo-T MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjKXI1KSzVyPUG4MlgzODRizszN MnHGV2FPT0WU
Saos-2 NFOzb|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonFTWM2OD1zOT6xNVYzKM7:TR?= M2HmPHNCVkeHUh?=
SW684 M{fReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPjTWM2OD1zOT6xN|I3KM7:TR?= MVzTRW5ITVJ?
KMOE-2 M13vRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUK0eWN4UUN3ME2xPU4zOjR{IN88US=> NVzRfHRXW0GQR1XS
MMAC-SF M2rQUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTF7LkK2NFch|ryP MnXXV2FPT0WU
JAR M1zFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTF7LkK5PUDPxE1? M1Xxb3NCVkeHUh?=
SK-MEL-28 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfBO5ZRUUN3ME2xPU4{OzZ|IN88US=> MYfTRW5ITVJ?
KNS-81-FD M4OyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[4dnV5UUN3ME2xPU42PDZ6IN88US=> NWTjN4xDW0GQR1XS
ES7 Mlz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7rTWM2OD1zOT62NlkzKM7:TR?= MWjTRW5ITVJ?
AsPC-1 NFTldmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LJSmlEPTB;MUmuOlQ4OSEQvF2= MXTTRW5ITVJ?
NCI-H1155 MmL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTF7LkeyN|gh|ryP NFPrWnVUSU6JRWK=
KYSE-510 NGPJWFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWye49KSzVyPUG5Mlg4PDhizszN MYfTRW5ITVJ?
ES1 NHi0VGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkewTWM2OD1zOT65NlE{KM7:TR?= MmDxV2FPT0WU
PC-3 NYTUSW1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDZTWM2OD1zOT65OlA1KM7:TR?= MmjmV2FPT0WU
GCT MmD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPNVlFKSzVyPUKwMlMxOjZizszN M4f1PXNCVkeHUh?=
KARPAS-299 Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjaT3dKSzVyPUKwMlM1OjJizszN MUfTRW5ITVJ?
DOHH-2 Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrIXXpKSzVyPUKwMlU1PjNizszN NH7EeJNUSU6JRWK=
COLO-741 NGDxeYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzKTWM2OD1{MD62OkDPxE1? MWLTRW5ITVJ?
NCI-H1395 Mn24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHEcVNKSzVyPUKwMlY3QTdizszN M3z0OHNCVkeHUh?=
HCC1187 NVHweJhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUH4VG5vUUN3ME2yNE43PzN2IN88US=> MkTNV2FPT0WU
Becker NUnmNJR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDYW4hKSzVyPUKwMlczODFizszN M3LsR3NCVkeHUh?=
LU-134-A MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TNN2lEPTB;MkGuNVAzPiEQvF2= NXvaUHlYW0GQR1XS
MKN45 NGD2b|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1GxfmlEPTB;MkGuNVU2OSEQvF2= MX3TRW5ITVJ?
LC-2-ad NUfiSIFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJzLkK3Nlkh|ryP MlL6V2FPT0WU
EW-24 NV3hcWN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkToTWM2OD1{MT6zPVQ2KM7:TR?= Mnf3V2FPT0WU
SK-N-AS NYLBXYZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLQTWM2OD1{MT64Nlc3KM7:TR?= MmDzV2FPT0WU
NCI-H2052 MlPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTJzLki5OlMh|ryP M1nOVXNCVkeHUh?=
A4-Fuk MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXey[oU1UUN3ME2yNk4yPDF7IN88US=> NYK2d5RqW0GQR1XS
NB10 M2W2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3iZ4RtUUN3ME2yNk4zOzdzIN88US=> M4TLeXNCVkeHUh?=
CHP-212 MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXITWM2OD1{Mj6zNlIzKM7:TR?= NFi4W|hUSU6JRWK=
KM12 Mo\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJ{LkO1OkDPxE1? NWf1fJdWW0GQR1XS
JEG-3 M1nN[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDKTWM2OD1{Mj6zO|gh|ryP NHPwcIxUSU6JRWK=
LN-405 MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmH5TWM2OD1{Mj61PVE{KM7:TR?= MWjTRW5ITVJ?
HCT-15 NEXrUmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO4cFgyUUN3ME2yNk44PDRzIN88US=> MmHMV2FPT0WU
MLMA M4DDPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJ{Lke0O{DPxE1? MXHTRW5ITVJ?
GI-1 M3\EU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJ{Lke2OVgh|ryP M{fK[HNCVkeHUh?=
RT-112 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7DTWM2OD1{Mj64OlE3KM7:TR?= MlrIV2FPT0WU
MPP-89 NVvFTWp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHuSlRKSzVyPUKyMlg3PjFizszN MlPQV2FPT0WU
A3-KAW NYT3[5VqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjP[YFKSzVyPUKzMlExODNizszN M2HCUXNCVkeHUh?=
KALS-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T1PGlEPTB;MkOuNVQyPCEQvF2= NGmydnVUSU6JRWK=
SF126 NVPi[opbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLBdZc4UUN3ME2yN{43QTJ2IN88US=> NX;xVJRRW0GQR1XS
SiHa MorzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;uWWZKSzVyPUKzMlk{OjdizszN MojhV2FPT0WU
MDA-MB-415 NUP6c|Q2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTJ|Lkm0PVkh|ryP M3vOb3NCVkeHUh?=
Daoy M{PSbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTR[IdKUUN3ME2yOE4yOjZizszN MkPlV2FPT0WU
COR-L23 Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[0bGlEPTB;MkSuNVc3PyEQvF2= M3TFNnNCVkeHUh?=
KG-1 NX\E[WRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTJ2LkG5Nlgh|ryP NFe5UG5USU6JRWK=
L-428 MnO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rRW2lEPTB;MkSuOVc6OSEQvF2= NI[4OZhUSU6JRWK=
NCI-H520 M1zKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\wWpVQUUN3ME2yOE45QDZzIN88US=> NEDSOGZUSU6JRWK=
COLO-792 NVqyVW9sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\uW2lEPTB;MkWuNlc{OiEQvF2= MUjTRW5ITVJ?
NB12 NGTvPG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIOyU3hKSzVyPUK1MlI6PDdizszN M3r1RXNCVkeHUh?=
GAK MknTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfW[pBKSzVyPUK1MlI6PjNizszN Mnz6V2FPT0WU
SW780 NETS[HBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLmZoVDUUN3ME2yOU4{OjZ2IN88US=> M4nFOHNCVkeHUh?=
GB-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTJ3LkSwOlkh|ryP MYfTRW5ITVJ?
P12-ICHIKAWA NIrHXFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rNbWlEPTB;MkWuOFc5PSEQvF2= M4DHNXNCVkeHUh?=
NCI-H1651 NGXNflRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Pqb2lEPTB;MkWuOVk4KM7:TR?= M4KwcHNCVkeHUh?=
KE-37 NXOxWFJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\1TWM2OD1{NT63N|E2KM7:TR?= M1TwRnNCVkeHUh?=
CCRF-CEM MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJ3Lkm2O{DPxE1? NV34SHlEW0GQR1XS
SF295 M4ezWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moj5TWM2OD1{Nj6wOFI2KM7:TR?= MYTTRW5ITVJ?
G-361 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJ4LkGwNlch|ryP MlnXV2FPT0WU
HOP-92 M4jOT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;Cd5Z[UUN3ME2yOk4yOjJ4IN88US=> Mom0V2FPT0WU
UMC-11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTJ4LkS1NVQh|ryP MoTiV2FPT0WU
IST-SL1 NWDtZnplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DycGlEPTB;Mk[uOlU6OSEQvF2= MmPLV2FPT0WU
TE-11 MoK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzkXmlSUUN3ME2yOk44PzV{IN88US=> NIfYPXNUSU6JRWK=
NCI-H1304 NIrTb21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr4TWM2OD1{Nj65NVA5KM7:TR?= NGTBS|JUSU6JRWK=
SJSA-1 Mn24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPh[2NKSzVyPUK3MlAyPzZizszN NEe0SIVUSU6JRWK=
BCPAP NHn1cnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJ5LkGzO{DPxE1? MWPTRW5ITVJ?
HTC-C3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrlVXFKUUN3ME2yO{4zPTZzIN88US=> MXjTRW5ITVJ?
EW-16 M3fDdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rCS2lEPTB;MkeuNlk1PyEQvF2= MXzTRW5ITVJ?
HT-144 NFG0doZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJ5LkSwN|Ih|ryP MX3TRW5ITVJ?
MHH-ES-1 MmDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3hZnpKSzVyPUK3MlQ1PDdizszN M3\RU3NCVkeHUh?=
T98G M3fCXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fFVGlEPTB;MkeuOVg1PiEQvF2= MYHTRW5ITVJ?
RPMI-8866 M2LFd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTJ5Lke1OlIh|ryP NVzCN4tCW0GQR1XS
BEN NFzVTmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTSTWM2OD1{Nz64OVE4KM7:TR?= MVjTRW5ITVJ?
MDA-MB-231 NH3YXJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3WSIZPUUN3ME2yPE4zPzl3IN88US=> MXzTRW5ITVJ?
HuH-7 M2nWR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJ6LkSwNlgh|ryP MVrTRW5ITVJ?
SK-N-FI Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDxTWM2OD1{OD60N|Mh|ryP NX;v[ZVGW0GQR1XS
AN3-CA MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjZbFJ[UUN3ME2yPE41Ozl3IN88US=> M3fvZ3NCVkeHUh?=
EGI-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfqTWM2OD1{OD61PVI5KM7:TR?= M4DNdXNCVkeHUh?=
697 NFixbo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\TfmlEPTB;MkiuOlM{OSEQvF2= NWTxOVFkW0GQR1XS
TCCSUP NGTLNmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjJOlRDUUN3ME2yPE43PDF6IN88US=> MnPHV2FPT0WU
GR-ST MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJ6Lk[2PVYh|ryP MWnTRW5ITVJ?
SK-N-DZ NULvcGJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLETWM2OD1{OD62PFg2KM7:TR?= MXLTRW5ITVJ?
MIA-PaCa-2 Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:wTWM2OD1{OD63PVU6KM7:TR?= NUm2PI8zW0GQR1XS
IGR-1 NYrhc3JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3VfI5KSzVyPUK4Mlg5PzRizszN MUnTRW5ITVJ?
BFTC-905 NVnXTIZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXLTWM2OD1{OT6yO|A2KM7:TR?= MkCyV2FPT0WU
NCI-H1581 M4WxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTJ7LkOxOFUh|ryP NFq1TZhUSU6JRWK=
RD MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT5UWg5UUN3ME2yPU42OjN|IN88US=> M{XwNHNCVkeHUh?=
SF268 M{n5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDsWZJ5UUN3ME2yPU42QTNzIN88US=> MYLTRW5ITVJ?
SHP-77 M3PSO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jSNGlEPTB;MkmuOlE5OiEQvF2= NVXUfI9RW0GQR1XS
D-566MG MnHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj0TWM2OD1{OT65N|k{KM7:TR?= NXHJdFNTW0GQR1XS
TGBC1TKB NFvsS2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTNyLkGyN|gh|ryP NVPwelFqW0GQR1XS
MEL-HO NGPzSGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPTTWM2OD1|MD6xOFI{KM7:TR?= M3HQZXNCVkeHUh?=
SJRH30 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTNyLkKxNFgh|ryP NI\GXXJUSU6JRWK=
D-336MG MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[0e3JKSzVyPUOwMlI5QTJizszN MY\TRW5ITVJ?
C3A NIPOeohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTNyLkK5Nlch|ryP NXrROFJWW0GQR1XS
Calu-6 NVrLTmVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTNyLkK5OlMh|ryP NGjM[olUSU6JRWK=
MZ1-PC MnnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\aTWM2OD1|MD6zPVMh|ryP Mn;TV2FPT0WU
KYSE-70 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7TTWM2OD1|MD61NVE1KM7:TR?= NWnqbZlPW0GQR1XS
CAPAN-1 MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v1U2lEPTB;M{CuOVE5OSEQvF2= Mo\OV2FPT0WU
DK-MG M4\2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPZS4I5UUN3ME2zNE42PDV4IN88US=> NUDzUm56W0GQR1XS
SK-HEP-1 NULkbYxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTNyLk[zNlYh|ryP NITPVYtUSU6JRWK=
MS-1 M1zQW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LaPGlEPTB;M{CuPFg5QSEQvF2= Mn71V2FPT0WU
GI-ME-N NYLuboFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLHTWM2OD1|MT6wOVcyKM7:TR?= NHjGN2xUSU6JRWK=
NCI-H510A NUXKdGc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvETWM2OD1|MT60NFA3KM7:TR?= MWPTRW5ITVJ?
NB17 M1TEO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nqWGlEPTB;M{GuOVE5PSEQvF2= MUPTRW5ITVJ?
639-V MkXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPyNVRpUUN3ME2zNU42OjR|IN88US=> Mlz1V2FPT0WU
CAL-51 M33lPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\RT4FKSzVyPUOxMlU3PjdizszN MoPuV2FPT0WU
HGC-27 M3T6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTNzLkW4O|Mh|ryP NGT3Z49USU6JRWK=
GOTO M1[0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPtWHpKSzVyPUOxMlg2ODZizszN MVnTRW5ITVJ?
ChaGo-K-1 NFf5TW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj2NIlKSzVyPUOyMlAxPyEQvF2= MlTyV2FPT0WU
RO82-W-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjBTWM2OD1|Mj6xOlA1KM7:TR?= NGHnOopUSU6JRWK=
SH-4 M3PVOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTN{LkG4OVgh|ryP MYnTRW5ITVJ?
A204 M1zOXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXGfHV2UUN3ME2zNk42ODZ7IN88US=> NH3UTmxUSU6JRWK=
DMS-273 NUHqZoh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVmzfpl7UUN3ME2zNk42OzJ{IN88US=> NYjDUFA4W0GQR1XS
KGN Mn76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnkU2VjUUN3ME2zNk43OzNizszN MVvTRW5ITVJ?
SK-MEL-2 Mm\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTN{Lk[1Nlch|ryP NEjIVFFUSU6JRWK=
NCI-H2228 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC0TWM2OD1|Mj62OlAzKM7:TR?= MWXTRW5ITVJ?
MKN28 Mn3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\kPGlEPTB;M{KuO|g{QCEQvF2= M2LzNnNCVkeHUh?=
H-EMC-SS NIiyW4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn4VIRKSzVyPUOyMlk3PzhizszN MknQV2FPT0WU
ATN-1 MkLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPCcohKSzVyPUOzMlE1OTZizszN NYO0[GhzW0GQR1XS
D-263MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjGdHBHUUN3ME2zN{45Ozd6IN88US=> NGnMUHFUSU6JRWK=
LU-135 NITJeYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\jTWM2OD1|Mz64PFI6KM7:TR?= NXnmRVRmW0GQR1XS
C8166 NWDIN|k5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37TRWlEPTB;M{OuPFg2PCEQvF2= NWW5Wm9VW0GQR1XS
T-24 MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfCTWM2OD1|ND6wNlA2KM7:TR?= NV;BZ5h5W0GQR1XS
Mewo NEf1bHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXCSJdKSzVyPUO0MlE{PDlizszN NE\tO5lUSU6JRWK=
22RV1 NF7HcGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlmxTWM2OD1|ND6xO|U1KM7:TR?= MXPTRW5ITVJ?
KM-H2 MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTN2LkG3O|kh|ryP MWHTRW5ITVJ?
NCI-H2122 NEnZfHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[5N2ZuUUN3ME2zOE4{PDdzIN88US=> MkDmV2FPT0WU
ABC-1 NH3XVWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LXb2lEPTB;M{SuN|Y6OyEQvF2= NWKwV5EyW0GQR1XS
NCI-H1355 M1Kxbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkO3TWM2OD1|ND6zPFg6KM7:TR?= NXLMTmRUW0GQR1XS
NOMO-1 MlfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnOTWM2OD1|ND61O|A{KM7:TR?= NYrwNlNDW0GQR1XS
MZ7-mel MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:wXGlEPTB;M{SuOlQ5PyEQvF2= NETTb5ZUSU6JRWK=
NCI-H810 M3L4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTN2LkeyO|gh|ryP M{HzenNCVkeHUh?=
D-392MG M4L4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuzUGZ7UUN3ME2zOU4xPTZ3IN88US=> M2Dqb3NCVkeHUh?=
LB771-HNC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrzTWM2OD1|NT6xOlU5KM7:TR?= M1vtPHNCVkeHUh?=
COLO-679 M1\oc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzxdnpbUUN3ME2zOU4{QDhizszN MYHTRW5ITVJ?
SK-PN-DW NEO2[ldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfhN2pTUUN3ME2zOU41OzZ7IN88US=> M1TScnNCVkeHUh?=
VA-ES-BJ M2PhSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLSTWM2OD1|NT60OlQ6KM7:TR?= M4HCWnNCVkeHUh?=
KNS-42 M4fVOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTzd2xkUUN3ME2zOU42QDJ4IN88US=> NXPSO2d7W0GQR1XS
RVH-421 NHPoNpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLLfVlQUUN3ME2zOU44PjR3IN88US=> NWX1clZZW0GQR1XS
P30-OHK MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PtRmlEPTB;M{WuPFc2OiEQvF2= NWnkdHhkW0GQR1XS
G-402 NGXWNFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fMZ2lEPTB;M{WuPVg3PyEQvF2= NWjkeIpxW0GQR1XS
S-117 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITwd3ZKSzVyPUO2MlMxODhizszN NIf0fHZUSU6JRWK=
RXF393 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTN4LkO3PFUh|ryP MVjTRW5ITVJ?
LCLC-103H M33DXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;aTWM2OD1|Nj63PFA{KM7:TR?= NVn6SJZtW0GQR1XS
U-118-MG M3v5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvSTWM2OD1|Nj64PFQ4KM7:TR?= NVLweI5sW0GQR1XS
8-MG-BA MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jTcmlEPTB;M{[uPVQ5OyEQvF2= NHXOUG1USU6JRWK=
MFH-ino NWjTN4t3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;KNmN7UUN3ME2zO{4{OzdzIN88US=> NVH3VYxNW0GQR1XS
NCI-H23 M4DDXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTqTWM2OD1|Nz60NVk3KM7:TR?= MlfoV2FPT0WU
NCI-H446 M1nJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPKcFF7UUN3ME2zO{41QDZ{IN88US=> NHPCbVlUSU6JRWK=
LU-99A MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjuemtKSzVyPUO3MlU4OzFizszN NX;VZ41WW0GQR1XS
KP-N-YN MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjBTWM2OD1|Nz62NVk2KM7:TR?= M{XFWXNCVkeHUh?=
SCC-9 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDlRot4UUN3ME2zO{44QDN6IN88US=> NIHvN2lUSU6JRWK=
EFM-19 NYLGdWtPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILy[VZKSzVyPUO3Mlc6PjdizszN NY\oc|FPW0GQR1XS
A427 NXnzTVJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTN5LkmxNFch|ryP NUPkUG9{W0GQR1XS
LB831-BLC NEThWmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEH2d29KSzVyPUO4MlYxOzlizszN Mn[yV2FPT0WU
HOS MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjIN4JuUUN3ME2zPU43Ojd|IN88US=> MXfTRW5ITVJ?
LAN-6 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTRyLkCxNVIh|ryP MXfTRW5ITVJ?
U251 NVnzSmZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTRyLkSwOVQh|ryP NXK2[FkyW0GQR1XS
SNU-387 NHHPU|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTRyLkS1OVMh|ryP NHfHW41USU6JRWK=
DMS-79 NYD3TGVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPPZ|k2UUN3ME20NE42QDh7IN88US=> M2rlRnNCVkeHUh?=
SK-LU-1 MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInBXlJKSzVyPUSwMlY2PjhizszN NWHMZ2FVW0GQR1XS
HT NIWyb4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfjVYNKSzVyPUSwMlY3OzlizszN NY\VSFB3W0GQR1XS
KP-N-YS MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPwVGJGUUN3ME20NE43PzZ6IN88US=> Mnf1V2FPT0WU
DMS-114 MnHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17nfmlEPTB;NECuPFM4PCEQvF2= MXrTRW5ITVJ?
HUTU-80 NHrHV|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\1XHJKSzVyPUSxMlA2PjlizszN MVjTRW5ITVJ?
ONS-76 M{DpVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTRzLkS3NFkh|ryP MU\TRW5ITVJ?
A673 MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPyVm5KSzVyPUSxMlUyPTdizszN NUHyfZZlW0GQR1XS
HPAF-II M4DhZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;WXY44UUN3ME20NU43PzB7IN88US=> NYTpTXI1W0GQR1XS
UACC-257 Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO0TWM2OD12MT63N|Y6KM7:TR?= MUDTRW5ITVJ?
EW-22 NGDpZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHjNmpKSzVyPUSxMlg3QTdizszN NVnkNJQ{W0GQR1XS
NCI-H1755 NWP3UZhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXCTWM2OD12MT64O|I2KM7:TR?= MUfTRW5ITVJ?
KYSE-150 MnLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDYfVZsUUN3ME20Nk4yPzh{IN88US=> NFXoR2RUSU6JRWK=
CGTH-W-1 NHmzZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NED2blVKSzVyPUSyMlQ6PTVizszN MkHNV2FPT0WU
NB13 MoTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTR{Lk[yNVch|ryP M37ibnNCVkeHUh?=
SW872 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\kW4FJUUN3ME20Nk43OzNzIN88US=> M1rvXXNCVkeHUh?=
KP-4 M{Tn[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXL5dZB2UUN3ME20Nk45QDN{IN88US=> MVPTRW5ITVJ?
HCC38 NYizTWtLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MluzTWM2OD12Mj65OlE5KM7:TR?= NV2xRlFxW0GQR1XS
BB49-HNC NIHxS5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTR|LkKzOVYh|ryP NFq2W3hUSU6JRWK=
CAL-62 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXWWnVKSzVyPUSzMlQxOjhizszN M3nSTHNCVkeHUh?=
NCI-H2029 M2jDUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTR|LkW1PFEh|ryP M4DWSHNCVkeHUh?=
M14 MmW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TtS2lEPTB;NESuNVM{OiEQvF2= MVTTRW5ITVJ?
COLO-680N M1HGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrZdo9OUUN3ME20OE4{OzlizszN MWLTRW5ITVJ?
Hs-578-T MnLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLicXBrUUN3ME20OU4xOjl2IN88US=> MnThV2FPT0WU
MSTO-211H MkjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1SxbWlEPTB;NEWuPVQ5OiEQvF2= NUP6OI5FW0GQR1XS
EW-1 NXjyRlFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojiTWM2OD12NT65Olg6KM7:TR?= NF3IU3ZUSU6JRWK=
SW948 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInqe4tKSzVyPUS2MlQ1PjJizszN M3:y[3NCVkeHUh?=
NCI-H460 NV31W3ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;EO4xKSzVyPUS2MlUzOyEQvF2= MVHTRW5ITVJ?
CAS-1 MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ru[GlEPTB;NE[uO|cxOSEQvF2= NYTpU2lNW0GQR1XS
TGBC11TKB MmnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK0bXViUUN3ME20O{4yPzd5IN88US=> MUTTRW5ITVJ?
HD-MY-Z MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTR6Lke4OkDPxE1? MVXTRW5ITVJ?
NCI-H226 NGXWNZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVflUGpjUUN3ME20PU44Pzh3IN88US=> NVyxNmk4W0GQR1XS
PA-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTR7LkizN|Uh|ryP MlXYV2FPT0WU
LB2518-MEL NIHiVJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGW2eZRKSzVyPUS5Mlg4OjNizszN M3\jW3NCVkeHUh?=
A101D Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTR7Lkm0NlUh|ryP MkfjV2FPT0WU
NCI-H2087 NGnPVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHTR3dzUUN3ME20PU46Pjh{IN88US=> NIe4SotUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water slightly soluble or insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

EGFR Signaling Pathway Map

EGFR Inhibitors with Unique Features

Related EGFR Products

Tags: buy Afatinib (BIBW2992) | Afatinib (BIBW2992) supplier | purchase Afatinib (BIBW2992) | Afatinib (BIBW2992) cost | Afatinib (BIBW2992) manufacturer | order Afatinib (BIBW2992) | Afatinib (BIBW2992) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID