Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

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In DMSO USD 240 In stock
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USD 210 In stock
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Cited by 37 Publications

4 Customer Reviews

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 Mn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPHUVFRUUN3ME2wMlAxPTd{IN88US=> M1HIXXNCVkeHUh?=
KASUMI-1 NFrEUHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4i3bmlEPTB;MD6wNFkyOSEQvF2= Moi3V2FPT0WU
HCC2218 NW\QSXROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXu5ZYhSUUN3ME2wMlAxQTh5IN88US=> NHLnTmtUSU6JRWK=
KARPAS-45 MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Czd2lEPTB;MD6wNVY4OSEQvF2= M3zjeHNCVkeHUh?=
HSC-4 NEjWSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\1NYZKSzVyPUCuNFE4PDhizszN M3qyTHNCVkeHUh?=
CHL-1 NF6xTmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;xdWlEPTB;MD6wNVg{QSEQvF2= MUDTRW5ITVJ?
KY821 MoXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMEKwOkDPxE1? M{\2UXNCVkeHUh?=
NCI-N87 NXXYNpd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEK3O|Mh|ryP MojRV2FPT0WU
DOK NVTJWmp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjE[XBsUUN3ME2wMlA{OTl2IN88US=> M{jieHNCVkeHUh?=
DSH1 NHzrUlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rNbWlEPTB;MD6wN|MyPCEQvF2= MYjTRW5ITVJ?
MDA-MB-175-VII MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\ydGlEPTB;MD6wN|QyPiEQvF2= Mnj4V2FPT0WU
NCI-H2170 MnnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXLTWM2OD1yLkCzO|I5KM7:TR?= M1vhVHNCVkeHUh?=
BT-474 M2jid2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMES5PFYh|ryP NEjKTVVUSU6JRWK=
EFO-27 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMEWxPFIh|ryP M1TadnNCVkeHUh?=
NCI-H720 MnnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEWzNlUh|ryP M2XzPXNCVkeHUh?=
PC-14 NXnSN5RlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMEW2Olgh|ryP NIrBUllUSU6JRWK=
EC-GI-10 NUPJdphMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDw[Hk2UUN3ME2wMlA2QTF{IN88US=> M4DJXHNCVkeHUh?=
KYSE-450 NVzRSlA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEW5O|gh|ryP NW\YdYFSW0GQR1XS
BPH-1 NFXGfnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfFb|hOUUN3ME2wMlA2QTh6IN88US=> M4jad3NCVkeHUh?=
NCI-H292 NXq3N2pkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7uTWM2OD1yLkC2NFkh|ryP NYTTfIZIW0GQR1XS
H9 M2q0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH4TWM2OD1yLkC3NVMzKM7:TR?= MXrTRW5ITVJ?
NCI-H526 NF\4TVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfKTWM2OD1yLkC3PFI{KM7:TR?= M4j5dXNCVkeHUh?=
NCI-H1623 NF\WdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnyT4lKSzVyPUCuNFgxOjVizszN M4njXXNCVkeHUh?=
KYSE-140 NXPRUHNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEizN{DPxE1? MYHTRW5ITVJ?
Ca9-22 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMEizOVMh|ryP NX\CdWJkW0GQR1XS
AU565 M1fVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M334UWlEPTB;MD6wPFUxPCEQvF2= MkfuV2FPT0WU
ZR-75-30 MlvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHaTWM2OD1yLkC5OVQ2KM7:TR?= MY\TRW5ITVJ?
NCI-H1770 NEPjNVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXTd2JKSzVyPUCuNVAzQCEQvF2= Ml[0V2FPT0WU
LB2241-RCC NVvpV5JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL1[4JKSzVyPUCuNVA5QDRizszN M3v2ZXNCVkeHUh?=
CAL-39 MlzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2G2dWlEPTB;MD6xNVc6OiEQvF2= NVT6UGtlW0GQR1XS
UACC-893 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnH2TWM2OD1yLkGxPFg2KM7:TR?= MVrTRW5ITVJ?
LU-65 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVThUFhHUUN3ME2wMlEzPjN|IN88US=> NV\ON5BNW0GQR1XS
HN NHfTTm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HqemlEPTB;MD6xN|A4PyEQvF2= MXvTRW5ITVJ?
TI-73 MkLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMUS3NVUh|ryP MWDTRW5ITVJ?
KU812 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMUW0OVYh|ryP MWDTRW5ITVJ?
SW13 MoO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[1NGlEPTB;MD6xOlIyPiEQvF2= MWfTRW5ITVJ?
BB30-HNC NVfZZZZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;oRmlEPTB;MD6xOlU4PiEQvF2= MVvTRW5ITVJ?
HSC-2 MlHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjPTWM2OD1yLkG2PFM4KM7:TR?= M1qzcXNCVkeHUh?=
BV-173 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jY[GlEPTB;MD6xO|U6PiEQvF2= MmPVV2FPT0WU
CAL-27 MoLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLWTWM2OD1yLkG3OlM3KM7:TR?= NGrvcW9USU6JRWK=
SBC-1 M2CwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[4TWM2OD1yLkG4PVU6KM7:TR?= MULTRW5ITVJ?
CAL-33 NFLnNJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMkCxPFQh|ryP M{L5eXNCVkeHUh?=
NCI-H209 NIW1eIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMkC0OkDPxE1? MoTOV2FPT0WU
COR-L105 NEfsOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S4fmlEPTB;MD6yNVA5PCEQvF2= NFXMeXFUSU6JRWK=
HSC-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHKyWo1KSzVyPUCuNlEyQThizszN MlHDV2FPT0WU
NCI-H69 M3rRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMkG0OVEh|ryP NFrmXWVUSU6JRWK=
MOLT-13 NVPBVodKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfsfolKSzVyPUCuNlM6PzVizszN NFf4fZBUSU6JRWK=
ML-2 M3\vWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDOTWM2OD1yLkK0PFAzKM7:TR?= MVjTRW5ITVJ?
IGROV-1 MnPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDDTWM2OD1yLkK1PVUzKM7:TR?= MXLTRW5ITVJ?
TK10 M4SzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMk[3N|gh|ryP MmTBV2FPT0WU
EoL-1-cell MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULjXGhZUUN3ME2wMlI3QDl{IN88US=> NHXWZZRUSU6JRWK=
HO-1-N-1 NI\HN2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMke4OVMh|ryP NHf4ZlhUSU6JRWK=
BHY M1Gxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoT4TWM2OD1yLkK4OlU2KM7:TR?= NXL3V3lGW0GQR1XS
LU-139 NVjHT5F2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwM{C1NUDPxE1? NEf0VlBUSU6JRWK=
23132-87 NFLrPFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\Xb2R4UUN3ME2wMlMyQTJ|IN88US=> NXnhfJIzW0GQR1XS
ACHN NXjHPJF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\hOmlEPTB;MD6zNVk6PCEQvF2= MlH5V2FPT0WU
DoTc2-4510 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33MUWlEPTB;MD6zNlIyQSEQvF2= NFHMbVFUSU6JRWK=
BB65-RCC MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWH1U4ZnUUN3ME2wMlM1PTl|IN88US=> M{S2S3NCVkeHUh?=
HLE M123S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mli5TWM2OD1yLkO1NFQ3KM7:TR?= NGrWS3dUSU6JRWK=
HCC1419 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjocJhKSzVyPUCuN|Y1ODhizszN NVT6XHFNW0GQR1XS
A388 M{X0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrkbGZKSzVyPUCuN|Y5PTdizszN M2fBT3NCVkeHUh?=
NUGC-3 NX3OdWdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfUTWM2OD1yLkO4N|c{KM7:TR?= M3TCeHNCVkeHUh?=
KYSE-180 NF6zOHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwM{mwPFkh|ryP NF3Ue2pUSU6JRWK=
TE-6 MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwNECyOFYh|ryP MVHTRW5ITVJ?
A498 NUPFc4tiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;4O|RKSzVyPUCuOFA3PzRizszN NYXNO4V1W0GQR1XS
NCI-H1648 M{PqWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rVVGlEPTB;MD60OFE5OiEQvF2= NGX6Z4FUSU6JRWK=
DU-145 NYHiVndET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrwNY1KSzVyPUCuOFQ5OzNizszN NEPj[JBUSU6JRWK=
CW-2 NV;Fd2pYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwNE[5NVQh|ryP MkDTV2FPT0WU
A431 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{j1OGlEPTB;MD60PFI{OyEQvF2= MX7TRW5ITVJ?
SAS MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1u3bGlEPTB;MD60PFM6QCEQvF2= NVy0enJtW0GQR1XS
NCI-H2126 M2jsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3[2bmlEPTB;MD61NVkzPiEQvF2= NX3pS2FHW0GQR1XS
NCI-H358 M1nicGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHjTWM2OD1yLkWzNlEh|ryP M{S1eHNCVkeHUh?=
FADU MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvGN4lOUUN3ME2wMlU1PDB2IN88US=> NXS3SI9lW0GQR1XS
ACN M4XQNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDVSJdwUUN3ME2wMlU2ODl2IN88US=> NF[3N|lUSU6JRWK=
HCC70 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjZUYlIUUN3ME2wMlU4PjZzIN88US=> NEDPW2NUSU6JRWK=
NCI-H1838 NGfSWnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwNkCyPVkh|ryP MWTTRW5ITVJ?
CAL-54 M3HzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nzOmlEPTB;MD62NVYzOSEQvF2= MV3TRW5ITVJ?
NCI-H1975 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfuemNsUUN3ME2wMlYyPzJ6IN88US=> M3LQdXNCVkeHUh?=
COR-L88 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzMNFk5UUN3ME2wMlY1OTF|IN88US=> MYXTRW5ITVJ?
CTV-1 M1v0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEP5fmFKSzVyPUCuOlQ{QTJizszN NHL0SVJUSU6JRWK=
EW-18 M1HxUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrqTWM2OD1yLk[4Olk5KM7:TR?= Ml;ZV2FPT0WU
HCC1806 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjxTWM2OD1yLk[5OlY3KM7:TR?= NH;jXmRUSU6JRWK=
HuP-T4 MmfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\PNHZKSzVyPUCuOlk4PiEQvF2= NE\QWohUSU6JRWK=
MDA-MB-361 NFXueHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWK4bI5KUUN3ME2wMlczPjZ{IN88US=> MVLTRW5ITVJ?
NCI-H1573 NXHlSIFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwN{O2N{DPxE1? NGDxfJRUSU6JRWK=
KU-19-19 MkjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwN{e0OlQh|ryP MmLsV2FPT0WU
COLO-678 M2X2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS4W4tKSzVyPUCuPFA5OzRizszN NWPyVol4W0GQR1XS
C-33-A MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrNb|htUUN3ME2wMlgyOjl5IN88US=> M1H2T3NCVkeHUh?=
Calu-3 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXZTWM2OD1yLkixOFM1KM7:TR?= MUHTRW5ITVJ?
AGS MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIiwTZFKSzVyPUCuPFM3PDhizszN M4K5TnNCVkeHUh?=
SCC-25 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4H2OmlEPTB;MD64OFE4OSEQvF2= NHfNWoxUSU6JRWK=
JVM-2 NIq3elFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS0c5VbUUN3ME2wMlg5Ojl7IN88US=> M2\5dnNCVkeHUh?=
HCE-T M1vFemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW4TWM2OD1yLki4OFI5KM7:TR?= NIrpTo9USU6JRWK=
ES4 Mk\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fJW2lEPTB;MD65O|g{PiEQvF2= MWTTRW5ITVJ?
EKVX MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlraTWM2OD1zLkCxNFY1KM7:TR?= MmDzV2FPT0WU
D-542MG MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHETWM2OD1zLkCxNFY1KM7:TR?= M2XtdHNCVkeHUh?=
SW1116 MkTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjZTWM2OD1zLkCxNlg4KM7:TR?= Mm[yV2FPT0WU
5637 M2C1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37VdmlEPTB;MT6wNVUyKM7:TR?= MYLTRW5ITVJ?
HT-1376 NUn6dWlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37jfGlEPTB;MT6wNVUyOyEQvF2= MYnTRW5ITVJ?
NB69 M2XrT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTFwMEK5OFUh|ryP MkXTV2FPT0WU
YKG-1 MoXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;1OmRKSzVyPUGuNFU1OTlizszN NXrnV5V3W0GQR1XS
EW-3 NVXiS21iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3n5W2lEPTB;MT6wO|g5OyEQvF2= MmLiV2FPT0WU
GCIY M4SycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi0SJFyUUN3ME2xMlA5OTB2IN88US=> NEDjd2pUSU6JRWK=
SK-MES-1 NF3BO3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHqOYZ[UUN3ME2xMlEyPDh5IN88US=> M1nxe3NCVkeHUh?=
PANC-08-13 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe0[GV7UUN3ME2xMlE3PDF4IN88US=> M363eHNCVkeHUh?=
SK-NEP-1 NHLhT4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnPZnZMUUN3ME2xMlE4PTF|IN88US=> MlnNV2FPT0WU
SW954 MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTFwMkCyNVQh|ryP M3HMUHNCVkeHUh?=
NCI-SNU-5 NUO3XHl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojrTWM2OD1zLkKzPUDPxE1? MUDTRW5ITVJ?
SW48 MnHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTFwMkW0N|Ih|ryP NEXGOopUSU6JRWK=
HT-3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTFwMki3OVMh|ryP NW\ZUYZQW0GQR1XS
ETK-1 MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTFwM{e0OVYh|ryP MWPTRW5ITVJ?
SCC-15 MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nBcWlEPTB;MT6zPVQ2OSEQvF2= NX;kO25JW0GQR1XS
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BE-13 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\YTWM2OD15Lkm4NVEzKM7:TR?= MnnKV2FPT0WU
VMRC-RCZ M{fJdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jsTmlEPTB;OD6wNVY6PyEQvF2= MVrTRW5ITVJ?
NCI-H727 Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M32yV2lEPTB;OD6xNFQzKM7:TR?= NFmyNGxUSU6JRWK=
SW1710 M3TDU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjre4tKSzVyPUiuNVg2OTVizszN NWPyOJJKW0GQR1XS
D-502MG NEnKPJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRThwMkmyPFIh|ryP NFzhcFFUSU6JRWK=
NCI-H1993 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mor3TWM2OD16LkOzOlMyKM7:TR?= NFnxOmtUSU6JRWK=
SCC-4 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LkVWlEPTB;OD60OFA2QSEQvF2= MVHTRW5ITVJ?
HAL-01 NUjOeWpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X1TGlEPTB;OD61NVkyKM7:TR?= NXj3VHRMW0GQR1XS
GT3TKB M2TxVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\JZWlEPTB;OD62O|k3PCEQvF2= MYrTRW5ITVJ?
SK-OV-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfXSY5KSzVyPUiuO|E{OjlizszN NHLUepJUSU6JRWK=
COLO-829 NES5SnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRThwOEC5O|Yh|ryP NYn4d5dFW0GQR1XS
OCI-AML2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7wNGhKSzVyPUiuPVU1QDFizszN NYniSYJZW0GQR1XS
OS-RC-2 M3n0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTlwMEKxPUDPxE1? NW\BN41{W0GQR1XS
BFTC-909 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjYTWM2OD17LkC2O|k6KM7:TR?= M1LKT3NCVkeHUh?=
EW-11 NF\WU5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3jTWM2OD17LkG3OlU{KM7:TR?= NIr0PFhUSU6JRWK=
HCE-4 M4Pn[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O3ZmlEPTB;OT6yNVU2QCEQvF2= MVnTRW5ITVJ?
BALL-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\xUmlEPTB;OT6yNVkxPyEQvF2= M4TuS3NCVkeHUh?=
SF539 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTlwMkO1OlIh|ryP MnLDV2FPT0WU
CAMA-1 NID1TlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnJTGNKSzVyPUmuNlgyOjhizszN NW\OSW5OW0GQR1XS
C32 MlLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIK3T3NKSzVyPUmuN|MxPjRizszN NWHnS4ZMW0GQR1XS
NCI-H1703 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;uOVdKSzVyPUmuN|Q{PzVizszN M1u3NnNCVkeHUh?=
NCI-H1650 NU\5[4p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHZe2VKSzVyPUmuOlA6PDZizszN NInPRXpUSU6JRWK=
NCI-H1563 Moe2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvUW2tKSzVyPUmuO|YxOzFizszN NFXLNoVUSU6JRWK=
CAL-85-1 M3HCcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTlwOEezPFMh|ryP NULod|RNW0GQR1XS
UM-UC-3 NXe3bWZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7lTWM2OD17Lkm1NFMh|ryP NYjH[pBUW0GQR1XS
BxPC-3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{GyWmlEPTB;MUCuNFk4OiEQvF2= NXnvepdOW0GQR1XS
MHH-PREB-1 M4XHTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELlSFJKSzVyPUGwMlE6QTlizszN MVzTRW5ITVJ?
DEL NWnYVYN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlqxTWM2OD1zMD6zPVQ3KM7:TR?= MUHTRW5ITVJ?
HuCCT1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\neGlEPTB;MUCuOlA{OyEQvF2= MlztV2FPT0WU
OVCAR-4 MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnDemd[UUN3ME2xNE45QDN3IN88US=> NIDCN3NUSU6JRWK=
CAL-72 M3LmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TFSmlEPTB;MUCuPVM6OSEQvF2= MVrTRW5ITVJ?
HCC1954 Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnaSGk3UUN3ME2xNU4xPzV2IN88US=> NGHpSmFUSU6JRWK=
EFO-21 M134cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2S5OmlEPTB;MUGuNVA1PSEQvF2= MXTTRW5ITVJ?
FTC-133 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PUOWlEPTB;MUGuNVQxPyEQvF2= MnvTV2FPT0WU
SK-MEL-24 M3jxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[xbGlEPTB;MUGuNlM3PiEQvF2= MorDV2FPT0WU
UACC-62 MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXm4Z4hEUUN3ME2xNU4zOzZ6IN88US=> MU\TRW5ITVJ?
NCI-H650 NVPIfpJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DGcWlEPTB;MUGuNlQyQCEQvF2= MmHZV2FPT0WU
ALL-PO NFXRSFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjDTFd{UUN3ME2xNU4zPTF{IN88US=> M4\2[nNCVkeHUh?=
T84 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vWWGlEPTB;MUGuN|kxPyEQvF2= MmD0V2FPT0WU
IST-MEL1 M2DV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTFzLkS1OVkh|ryP Mor6V2FPT0WU
SW626 NIXLN|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT5SGE5UUN3ME2xNU42PzV3IN88US=> MYTTRW5ITVJ?
RPMI-2650 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnlb4VjUUN3ME2xNU42QDh3IN88US=> M3HNVnNCVkeHUh?=
MC-IXC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoS4TWM2OD1zMT62O|I5KM7:TR?= MUTTRW5ITVJ?
HOP-62 M3jKRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXIeJRKSzVyPUGxMlY4PjRizszN MlTSV2FPT0WU
NOS-1 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{njS2lEPTB;MUGuO|ExQSEQvF2= MWXTRW5ITVJ?
SW1573 M3rPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvxTWM2OD1zMT63Nlk2KM7:TR?= MoW3V2FPT0WU
WM-115 M{HEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTFzLke1PFgh|ryP M4P5V3NCVkeHUh?=
HuO9 MnSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvTTWM2OD1zMT64O|c1KM7:TR?= NULMU3ZjW0GQR1XS
YAPC NWLRWmJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi0ZXFKSzVyPUGxMlkzPTlizszN NFXiXVRUSU6JRWK=
MDA-MB-453 NUPVNo5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P6R2lEPTB;MUGuPVUyPSEQvF2= M1O4c3NCVkeHUh?=
NCI-H596 MnO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTF{LkCzOlkh|ryP MWHTRW5ITVJ?
A172 NHP1SZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml31TWM2OD1zMj6wO|k5KM7:TR?= NXXGe|R2W0GQR1XS
RS4-11 NX7LS|cyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjwb5RGUUN3ME2xNk4yPzJ3IN88US=> MmnYV2FPT0WU
HCC1937 M2nnSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\NN2tKSzVyPUGyMlc2PjRizszN MX3TRW5ITVJ?
SW837 MnrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjU[I9iUUN3ME2xNk46ODJ6IN88US=> NX\0NWtxW0GQR1XS
NMC-G1 NIm5e|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLrTWM2OD1zMj65NlM1KM7:TR?= M3zqbnNCVkeHUh?=
PFSK-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rvfWlEPTB;MUOuNFYh|ryP MlvhV2FPT0WU
DBTRG-05MG MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTF|LkC2N|Ih|ryP NVPyPFNxW0GQR1XS
SK-UT-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHqdIZKSzVyPUGzMlExQDNizszN Mn20V2FPT0WU
OVCAR-5 Mnn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDxNZZKSzVyPUGzMlE2QTNizszN NEH5XmJUSU6JRWK=
8505C NID2blZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XJe2lEPTB;MUOuNlA3PyEQvF2= NIjhVmtUSU6JRWK=
SK-MEL-1 NHG2UYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTF|LkexN|Uh|ryP M2LOfnNCVkeHUh?=
LK-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLDcGlKSzVyPUGzMlc3OzlizszN NF\NTlZUSU6JRWK=
OE33 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDRR|RKSzVyPUGzMlc5PiEQvF2= NXK0emJ6W0GQR1XS
Ramos-2G6-4C10 MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXCUHNXUUN3ME2xOE4xOjB{IN88US=> NYS0PXpYW0GQR1XS
EW-13 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Plb2lEPTB;MUSuNFM2OiEQvF2= NEHzWYRUSU6JRWK=
NCI-H1793 NILv[oRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWP1OZpOUUN3ME2xOE4zODh5IN88US=> MV7TRW5ITVJ?
BHT-101 NGfDbndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\XfY17UUN3ME2xOE4zPDFizszN MnPmV2FPT0WU
RKO Mlf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW3VXEyUUN3ME2xOE42ODd3IN88US=> MXLTRW5ITVJ?
NEC8 Mn[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX6N|RKSzVyPUG0MlU1PzJizszN Moi2V2FPT0WU
PANC-10-05 NI\PbI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DlR2lEPTB;MUSuOlI1PyEQvF2= MnTqV2FPT0WU
NCI-H2030 M1npVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETWRnVKSzVyPUG0MlY1PDhizszN NFz5fJdUSU6JRWK=
C2BBe1 Mnr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\1WIFKSzVyPUG0Mlc3PCEQvF2= NUPLTYduW0GQR1XS
EM-2 NH;RSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDpbWQ{UUN3ME2xOE45PTd4IN88US=> MnnOV2FPT0WU
HCC1395 M2ftTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHETWM2OD1zND65N|M5KM7:TR?= NV74[lU6W0GQR1XS
A2058 M2jCUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTEeJV2UUN3ME2xOU4xPDB7IN88US=> MoTaV2FPT0WU
SW1463 NGr0fWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTF3LkC0PFUh|ryP NH;5eXJUSU6JRWK=
J82 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTF3LkC1O{DPxE1? M4\HdHNCVkeHUh?=
CAL-120 NGPq[|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;0[VR1UUN3ME2xOU4yPDR5IN88US=> NWq2fnhHW0GQR1XS
COLO-824 NV62dpFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP5TWM2OD1zNT6xOVc6KM7:TR?= NWHxPXFQW0GQR1XS
LNCaP-Clone-FGC NF\HcFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF3LkSyOFgh|ryP MoHDV2FPT0WU
CP66-MEL M1TUc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjKRopKSzVyPUG1MlQ3QDhizszN MmXQV2FPT0WU
OC-314 NITUVlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXLd2FKSzVyPUG1MlQ4OTRizszN NEXaXFNUSU6JRWK=
OVCAR-8 MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTF3Lki4OlEh|ryP MVfTRW5ITVJ?
MFE-280 NFLtRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTHTWM2OD1zNj6wOFg5KM7:TR?= Mn\OV2FPT0WU
MHH-NB-11 MknOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTF4LkC4N|kh|ryP MmLKV2FPT0WU
SW1990 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP4TWM2OD1zNj6xO|U2KM7:TR?= NF65Rm5USU6JRWK=
U-266 NWeyemNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLHcXB2UUN3ME2xOk4zOjl7IN88US=> M4D2XnNCVkeHUh?=
MFM-223 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTF4LkO5OlUh|ryP M2L2c3NCVkeHUh?=
L-363 NXTkfJIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvmPGNWUUN3ME2xOk41PTd5IN88US=> MnnCV2FPT0WU
MCF7 MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPuTWM2OD1zNj60O|I{KM7:TR?= MWXTRW5ITVJ?
SK-MEL-3 NVyzVnpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnSTpNKSzVyPUG2MlQ4QDdizszN NGn0OnpUSU6JRWK=
HH Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLWemdwUUN3ME2xOk42OTZ{IN88US=> NWjJOotOW0GQR1XS
no-10 M3rTVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrm[mtlUUN3ME2xOk43OzR|IN88US=> MmjxV2FPT0WU
HuP-T3 NInzXYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\HVWlEPTB;MU[uOlU4PiEQvF2= M1TzdnNCVkeHUh?=
QIMR-WIL MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfYTWM2OD1zNj63NVA2KM7:TR?= MkLUV2FPT0WU
NCI-H1092 MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\RTWM2OD1zNj64N|E3KM7:TR?= NYqxb2dZW0GQR1XS
MZ2-MEL MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r1VmlEPTB;MU[uPFQxOyEQvF2= M4HFNnNCVkeHUh?=
ES3 MnzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle0TWM2OD1zNj65NVM1KM7:TR?= M3HDVHNCVkeHUh?=
COLO-684 NIHrNWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3s[ow2UUN3ME2xOk46PDd5IN88US=> MlPPV2FPT0WU
NCI-H661 M{OxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHqZ5JnUUN3ME2xOk46Pjl2IN88US=> NGjzRWpUSU6JRWK=
CP50-MEL-B NIXmT21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DTbmlEPTB;MUeuNFM1OyEQvF2= NYD5dGR{W0GQR1XS
NCI-H2405 M1y0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\pPFFKSzVyPUG3MlE6PzRizszN MXfTRW5ITVJ?
U-2-OS MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmCyTWM2OD1zNz61N|A4KM7:TR?= M1;UcHNCVkeHUh?=
RERF-LC-MS NIjHSo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF5LkW1NFgh|ryP M{DR[nNCVkeHUh?=
NCI-H2342 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInjXZFKSzVyPUG3MlU2PyEQvF2= MofsV2FPT0WU
ES8 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF20TnlKSzVyPUG3MlYxQDdizszN MXjTRW5ITVJ?
MOLT-16 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTF5Lki5N|Qh|ryP MUTTRW5ITVJ?
RH-18 M2PCdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PH[2lEPTB;MUiuNFA{PSEQvF2= NXTS[3d6W0GQR1XS
D-283MED M3jrc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{C4XGlEPTB;MUiuNFA5QCEQvF2= NWrqXIp[W0GQR1XS
RCC10RGB NF\4RWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjxTWM2OD1zOD6wOVU6KM7:TR?= M3rteXNCVkeHUh?=
NCI-H1437 M{W1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDMcIY1UUN3ME2xPE4yPjRzIN88US=> NGPiWnBUSU6JRWK=
SW982 NYX0UWxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTF6LkK2O|Eh|ryP NUSwV2RpW0GQR1XS
IST-MES1 M1zkbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml35TWM2OD1zOD60OFI5KM7:TR?= NWjz[nk2W0GQR1XS
A704 M4rpd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\hTWM2OD1zOD60O|U{KM7:TR?= NXrBWYI6W0GQR1XS
ESS-1 NUXONmFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\1fGlEPTB;MUiuOVIxPSEQvF2= NXjTbId6W0GQR1XS
SCH MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvNTWM2OD1zOD62OFU3KM7:TR?= MV7TRW5ITVJ?
COLO-320-HSR MlXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\1TWM2OD1zOD63OFYh|ryP M3HxcXNCVkeHUh?=
Mo-T MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX0TWM2OD1zOD64NlA1KM7:TR?= NXT2Z3dQW0GQR1XS
Saos-2 NGT6SmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DmVGlEPTB;MUmuNVE3OiEQvF2= NVjmVGhmW0GQR1XS
SW684 NYHMcZF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnmZZp1UUN3ME2xPU4yOzJ4IN88US=> NWDtdI5wW0GQR1XS
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ABC-1 M3vSSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[5TWM2OD1|ND6zOlk{KM7:TR?= MkTXV2FPT0WU
NCI-H1355 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XwUWlEPTB;M{SuN|g5QSEQvF2= NXXOcJRLW0GQR1XS
NOMO-1 NUHndJF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fnb2lEPTB;M{SuOVcxOyEQvF2= NIe5N5BUSU6JRWK=
MZ7-mel MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILVXGdKSzVyPUO0MlY1QDdizszN MnvhV2FPT0WU
NCI-H810 NYO4cGVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjNTWM2OD1|ND63Nlc5KM7:TR?= NUPObFJyW0GQR1XS
D-392MG NVS5UWF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTN3LkC1OlUh|ryP M3;XXnNCVkeHUh?=
LB771-HNC M1LGbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPBfIhKSzVyPUO1MlE3PThizszN NXmzPVB{W0GQR1XS
COLO-679 Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojpTWM2OD1|NT6zPFgh|ryP M1HaSXNCVkeHUh?=
SK-PN-DW MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHUdXZKSzVyPUO1MlQ{PjlizszN NH3ldIFUSU6JRWK=
VA-ES-BJ MnTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLhcVdKSzVyPUO1MlQ3PDlizszN NXS2[IpZW0GQR1XS
KNS-42 NVLEOFg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTN3LkW4NlYh|ryP MXTTRW5ITVJ?
RVH-421 M4myfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\YbFRKSzVyPUO1Mlc3PDVizszN NIn6UVNUSU6JRWK=
P30-OHK Ml3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTN3Lki3OVIh|ryP MX7TRW5ITVJ?
G-402 M2PhWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH5cVgxUUN3ME2zOU46QDZ5IN88US=> NVjKS3hOW0GQR1XS
S-117 MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PNd2lEPTB;M{[uN|AxQCEQvF2= MmfQV2FPT0WU
RXF393 MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTN4LkO3PFUh|ryP MVLTRW5ITVJ?
LCLC-103H NX\BfW5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m0dWlEPTB;M{[uO|gxOyEQvF2= M{\HfHNCVkeHUh?=
U-118-MG MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTN4Lki4OFch|ryP NHz3emdUSU6JRWK=
8-MG-BA MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPTWmFKSzVyPUO2Mlk1QDNizszN MVPTRW5ITVJ?
MFH-ino NVnBTJVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{KxXGlEPTB;M{euN|M4OSEQvF2= MYfTRW5ITVJ?
NCI-H23 NXL6bFY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mne0TWM2OD1|Nz60NVk3KM7:TR?= NEPmPYRUSU6JRWK=
NCI-H446 MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTN5LkS4OlIh|ryP NYnwT2VIW0GQR1XS
LU-99A M1S5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVH6RmluUUN3ME2zO{42PzNzIN88US=> NELSdlFUSU6JRWK=
KP-N-YN MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTTcHZxUUN3ME2zO{43OTl3IN88US=> M3rKXXNCVkeHUh?=
SCC-9 MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfmb3JTUUN3ME2zO{44QDN6IN88US=> MmHXV2FPT0WU
EFM-19 NVn2c2FGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYqweGI5UUN3ME2zO{44QTZ5IN88US=> NV71SXpMW0GQR1XS
A427 NIfFT5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTN5LkmxNFch|ryP NUjDUWQxW0GQR1XS
LB831-BLC NHnGeoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LwZ2lEPTB;M{iuOlA{QSEQvF2= MlvNV2FPT0WU
HOS MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTN7Lk[yO|Mh|ryP NGLCN49USU6JRWK=
LAN-6 NX3ZN5czT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\I[2lEPTB;NECuNFEyOiEQvF2= M3PPVXNCVkeHUh?=
U251 NH3xTW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;kO3pKSzVyPUSwMlQxPTRizszN M{\TVnNCVkeHUh?=
SNU-387 NYPhelFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUmxOlJDUUN3ME20NE41PTV|IN88US=> NX\YXYp{W0GQR1XS
DMS-79 M17uPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTaTWM2OD12MD61PFg6KM7:TR?= MVPTRW5ITVJ?
SK-LU-1 NGCyS29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj4NJBKSzVyPUSwMlY2PjhizszN MkDLV2FPT0WU
HT M1K2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuwfJE6UUN3ME20NE43PjN7IN88US=> NYHTWmlEW0GQR1XS
KP-N-YS M{S4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTRyLk[3Olgh|ryP M1vjZXNCVkeHUh?=
DMS-114 NIf0b2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYG0WGdzUUN3ME20NE45Ozd2IN88US=> M1\wb3NCVkeHUh?=
HUTU-80 M2L2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTlOoJnUUN3ME20NU4xPTZ7IN88US=> NYfVWIRRW0GQR1XS
ONS-76 MkfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvjTWM2OD12MT60O|A6KM7:TR?= NWTkcVBpW0GQR1XS
A673 NU\2OVBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXhRmZqUUN3ME20NU42OTV5IN88US=> NUflNXV{W0GQR1XS
HPAF-II M3\ZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TBdGlEPTB;NEGuOlcxQSEQvF2= NV3RdYF1W0GQR1XS
UACC-257 MkLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDMUVdKSzVyPUSxMlc{PjlizszN MVjTRW5ITVJ?
EW-22 NYT6U3F3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTRzLki2PVch|ryP MnXiV2FPT0WU
NCI-H1755 Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X6TGlEPTB;NEGuPFczPSEQvF2= MorFV2FPT0WU
KYSE-150 Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH21cWVKSzVyPUSyMlE4QDJizszN NY\YNZNrW0GQR1XS
CGTH-W-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXCTWM2OD12Mj60PVU2KM7:TR?= MoexV2FPT0WU
NB13 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7KTWM2OD12Mj62NlE4KM7:TR?= MlPRV2FPT0WU
SW872 M2PSPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1SzbWlEPTB;NEKuOlM{OSEQvF2= NYHHW45vW0GQR1XS
KP-4 NFL3Z5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTR{Lki4N|Ih|ryP M1rXWHNCVkeHUh?=
HCC38 NXjTfY1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i2T2lEPTB;NEKuPVYyQCEQvF2= MmDVV2FPT0WU
BB49-HNC MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2W5eGlEPTB;NEOuNlM2PiEQvF2= Mk\mV2FPT0WU
CAL-62 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTR|LkSwNlgh|ryP MVPTRW5ITVJ?
NCI-H2029 M1HVd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjBTWM2OD12Mz61OVgyKM7:TR?= MXzTRW5ITVJ?
M14 NF;mUlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTR2LkGzN|Ih|ryP NUK0R5FGW0GQR1XS
COLO-680N NX22[pVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzkTlNKSzVyPUS0MlM{QSEQvF2= NVzHRlVmW0GQR1XS
Hs-578-T NGXWZZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGH5dXhKSzVyPUS1MlAzQTRizszN NWrYRmVkW0GQR1XS
MSTO-211H Mn;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2WzemlEPTB;NEWuPVQ5OiEQvF2= MUPTRW5ITVJ?
EW-1 M4HPTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHTbWdtUUN3ME20OU46Pjh7IN88US=> M1XZenNCVkeHUh?=
SW948 NIToWnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXGVnY5UUN3ME20Ok41PDZ{IN88US=> M2K1NnNCVkeHUh?=
NCI-H460 NEfmRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NICxfY5KSzVyPUS2MlUzOyEQvF2= NILpXVRUSU6JRWK=
CAS-1 NELrNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTR4Lke3NFEh|ryP NYLy[WFjW0GQR1XS
TGBC11TKB NGjmdJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HOSGlEPTB;NEeuNVc4PyEQvF2= MkDQV2FPT0WU
HD-MY-Z NUi0cWRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTR6Lke4OkDPxE1? MWfTRW5ITVJ?
NCI-H226 M{KxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPM[HhKSzVyPUS5Mlc4QDVizszN MV3TRW5ITVJ?
PA-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV30OG9KUUN3ME20PU45OzN3IN88US=> MlnHV2FPT0WU
LB2518-MEL M2naZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLxTWM2OD12OT64O|I{KM7:TR?= MlyzV2FPT0WU
A101D MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUS1d2ZbUUN3ME20PU46PDJ3IN88US=> MnzMV2FPT0WU
NCI-H2087 NHzXTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;odlBKSzVyPUS5Mlk3QDJizszN NIrxd|FUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID