Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

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In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 570 In stock

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Cited by 35 Publications

3 Customer Reviews

  • Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;Xe2lEPTB;MD6wNFU4OiEQvF2= NH[2UoNUSU6JRWK=
KASUMI-1 NGrZcIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEC5NVEh|ryP M2PYbXNCVkeHUh?=
HCC2218 NXnyW|FWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEC5PFch|ryP NX[ySGYyW0GQR1XS
KARPAS-45 NITIdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEP6PGZKSzVyPUCuNFE3PzFizszN M2\1VnNCVkeHUh?=
HSC-4 NHnBVINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljoTWM2OD1yLkCxO|Q5KM7:TR?= MlnXV2FPT0WU
CHL-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTPTWM2OD1yLkCxPFM6KM7:TR?= M{C4PHNCVkeHUh?=
KY821 M1npeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjUbnpKSzVyPUCuNFIxPiEQvF2= M2LqZ3NCVkeHUh?=
NCI-N87 NHHEe2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELKWppKSzVyPUCuNFI4PzNizszN NF;WUlFUSU6JRWK=
DOK M1\tbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEOxPVQh|ryP NFfzPFZUSU6JRWK=
DSH1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEOzNVQh|ryP M16wZnNCVkeHUh?=
MDA-MB-175-VII NX32T2VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\VU2lKSzVyPUCuNFM1OTZizszN NUXYUJJHW0GQR1XS
NCI-H2170 NVvCOVB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\ETWM2OD1yLkCzO|I5KM7:TR?= NHLT[VJUSU6JRWK=
BT-474 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL2RXVKSzVyPUCuNFQ6QDZizszN M2DQPHNCVkeHUh?=
EFO-27 NWX0XWNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITCbHVKSzVyPUCuNFUyQDJizszN M2\FZnNCVkeHUh?=
NCI-H720 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jiOWlEPTB;MD6wOVMzPSEQvF2= NWfHVZdbW0GQR1XS
PC-14 NHjRTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEW2Olgh|ryP M17MVXNCVkeHUh?=
EC-GI-10 Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEW5NVIh|ryP NHrsVodUSU6JRWK=
KYSE-450 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEW5O|gh|ryP M4nUfHNCVkeHUh?=
BPH-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4i3OmlEPTB;MD6wOVk5QCEQvF2= MkfUV2FPT0WU
NCI-H292 MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzQWnRKUUN3ME2wMlA3ODlizszN NUHD[5RUW0GQR1XS
H9 NWnmPZY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf4emVKSzVyPUCuNFcyOzJizszN NFjqSGZUSU6JRWK=
NCI-H526 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMEe4NlMh|ryP MUDTRW5ITVJ?
NCI-H1623 NHPx[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMEiwNlUh|ryP M1TTZXNCVkeHUh?=
KYSE-140 MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDXXXlKSzVyPUCuNFg{OyEQvF2= NGP4NYJUSU6JRWK=
Ca9-22 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3LTWM2OD1yLkC4N|U{KM7:TR?= NYXC[ZFuW0GQR1XS
AU565 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGX4XmdKSzVyPUCuNFg2ODRizszN Mn3FV2FPT0WU
ZR-75-30 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPa[2RKSzVyPUCuNFk2PDVizszN MVfTRW5ITVJ?
NCI-H1770 M1\JZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTFWVhuUUN3ME2wMlExOjhizszN M3vqZ3NCVkeHUh?=
LB2241-RCC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fDVGlEPTB;MD6xNFg5PCEQvF2= MonKV2FPT0WU
CAL-39 NEH0SGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMUG3PVIh|ryP NV2yXlA4W0GQR1XS
UACC-893 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMUG4PFUh|ryP Ml3KV2FPT0WU
LU-65 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\VbWNKSzVyPUCuNVI3OzNizszN NFfZOFdUSU6JRWK=
HN M3\ifGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX2TWpDUUN3ME2wMlE{ODd5IN88US=> NWG2cpExW0GQR1XS
TI-73 NFzoSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofNTWM2OD1yLkG0O|E2KM7:TR?= NVvOOFJlW0GQR1XS
KU812 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{T3UmlEPTB;MD6xOVQ2PiEQvF2= NV3xZmZZW0GQR1XS
SW13 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMU[yNVYh|ryP MYjTRW5ITVJ?
BB30-HNC NX;NTop3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rmWWlEPTB;MD6xOlU4PiEQvF2= MWLTRW5ITVJ?
HSC-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mny5TWM2OD1yLkG2PFM4KM7:TR?= MnXOV2FPT0WU
BV-173 NUjoWGt5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF32O3BKSzVyPUCuNVc2QTZizszN M2fDfnNCVkeHUh?=
CAL-27 NXj6ZolMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vnUGlEPTB;MD6xO|Y{PiEQvF2= MnPlV2FPT0WU
SBC-1 NV\xNXRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jBcGlEPTB;MD6xPFk2QSEQvF2= MYrTRW5ITVJ?
CAL-33 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HCWWlEPTB;MD6yNFE5PCEQvF2= NFm4SVdUSU6JRWK=
NCI-H209 MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX1N204UUN3ME2wMlIxPDZizszN NFHsclVUSU6JRWK=
COR-L105 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;RTWM2OD1yLkKxNFg1KM7:TR?= M2n2SXNCVkeHUh?=
HSC-3 M{DWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMkGxPVgh|ryP MYHTRW5ITVJ?
NCI-H69 NGnSfI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\tfGJvUUN3ME2wMlIyPDVzIN88US=> MVfTRW5ITVJ?
MOLT-13 MlvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPZ[YdKSzVyPUCuNlM6PzVizszN NUfhd3pmW0GQR1XS
ML-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;JZ2lEPTB;MD6yOFgxOiEQvF2= M1XGXXNCVkeHUh?=
IGROV-1 NV\wSHpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMkW5OVIh|ryP MnLMV2FPT0WU
TK10 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMk[3N|gh|ryP M4T3RnNCVkeHUh?=
EoL-1-cell NF\BNndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMk[4PVIh|ryP M2\JWHNCVkeHUh?=
HO-1-N-1 NGfCOWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHJS4ZtUUN3ME2wMlI4QDV|IN88US=> M3GzenNCVkeHUh?=
BHY M3\COWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jxemlEPTB;MD6yPFY2PSEQvF2= MYTTRW5ITVJ?
LU-139 Ml7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfRXHhKSzVyPUCuN|A2OSEQvF2= M1f3Z3NCVkeHUh?=
23132-87 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfWTWM2OD1yLkOxPVI{KM7:TR?= Mn\VV2FPT0WU
ACHN M2izfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnLOnlEUUN3ME2wMlMyQTl2IN88US=> M1nCTnNCVkeHUh?=
DoTc2-4510 MorZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPSTWM2OD1yLkOyNlE6KM7:TR?= Mnj1V2FPT0WU
BB65-RCC MnLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwM{S1PVMh|ryP NWXyeVVbW0GQR1XS
HLE NYTDcIkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLxV|lKSzVyPUCuN|UxPDZizszN NIPhfGxUSU6JRWK=
HCC1419 NYXXXVk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1u1cmlEPTB;MD6zOlQxQCEQvF2= NFnlRmtUSU6JRWK=
A388 MmHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwM{[4OVch|ryP NY\jWmp[W0GQR1XS
NUGC-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwM{izO|Mh|ryP NWq2[XRmW0GQR1XS
KYSE-180 NX[zTmcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEniT5dKSzVyPUCuN|kxQDlizszN NGjGe5RUSU6JRWK=
TE-6 M3fUUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTmd29KSzVyPUCuOFAzPDZizszN MlHHV2FPT0WU
A498 M2\xb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHtcnBKSzVyPUCuOFA3PzRizszN MWrTRW5ITVJ?
NCI-H1648 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrtSGROUUN3ME2wMlQ1OTh{IN88US=> M3;sfXNCVkeHUh?=
DU-145 NX\4R49lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LmfGlEPTB;MD60OFg{OyEQvF2= NWfuU2NNW0GQR1XS
CW-2 NHTONHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXUTWM2OD1yLkS2PVE1KM7:TR?= M4n0NHNCVkeHUh?=
A431 M1\oUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDicZVKSzVyPUCuOFgzOzNizszN M3LPbXNCVkeHUh?=
SAS M2fqdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDBTWM2OD1yLkS4N|k5KM7:TR?= NI\jdmNUSU6JRWK=
NCI-H2126 NGX4[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTr[YF5UUN3ME2wMlUyQTJ4IN88US=> MnfFV2FPT0WU
NCI-H358 NVP5Nm1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoC2TWM2OD1yLkWzNlEh|ryP MmnkV2FPT0WU
FADU NV65clF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjiUlJOUUN3ME2wMlU1PDB2IN88US=> NFjueZBUSU6JRWK=
ACN M3LL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFm5Z25KSzVyPUCuOVUxQTRizszN MmSxV2FPT0WU
HCC70 MljNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;0RW1KSzVyPUCuOVc3PjFizszN MXnTRW5ITVJ?
NCI-H1838 M4\OSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rZeGlEPTB;MD62NFI6QSEQvF2= MXjTRW5ITVJ?
CAL-54 NGfkO2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDkUHZKSzVyPUCuOlE3OjFizszN M{TWXXNCVkeHUh?=
NCI-H1975 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\XTnZKSzVyPUCuOlE4OjhizszN M3f3NXNCVkeHUh?=
COR-L88 NFPzTIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XU[mlEPTB;MD62OFEyOyEQvF2= NUjiSZZWW0GQR1XS
CTV-1 M3S2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi5c2dKSzVyPUCuOlQ{QTJizszN NFvoPZJUSU6JRWK=
EW-18 M{X3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrpTmNKSzVyPUCuOlg3QThizszN MWnTRW5ITVJ?
HCC1806 NXnmfVlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO3RXRmUUN3ME2wMlY6PjZ4IN88US=> NYfhSG9LW0GQR1XS
HuP-T4 NE\GPXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPZ[nQxUUN3ME2wMlY6PzZizszN NE\DO|hUSU6JRWK=
MDA-MB-361 NGrZflZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwN{K2OlIh|ryP MWfTRW5ITVJ?
NCI-H1573 NVH2RVhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjGRotKSzVyPUCuO|M3OyEQvF2= NESyXoJUSU6JRWK=
KU-19-19 NFXVRlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3j2[GlEPTB;MD63O|Q3PCEQvF2= M2rCOXNCVkeHUh?=
COLO-678 NXzmbGJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml22TWM2OD1yLkiwPFM1KM7:TR?= NGLUeXpUSU6JRWK=
C-33-A Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f0UGlEPTB;MD64NVI6PyEQvF2= NF\GZYlUSU6JRWK=
Calu-3 M2noWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvsdYxkUUN3ME2wMlgyPDN2IN88US=> NIPwNHpUSU6JRWK=
AGS MnTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwOEO2OFgh|ryP M3H3NnNCVkeHUh?=
SCC-25 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TsdGlEPTB;MD64OFE4OSEQvF2= NHnxT2tUSU6JRWK=
JVM-2 M3fmRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[5TWM2OD1yLki4Nlk6KM7:TR?= MXHTRW5ITVJ?
HCE-T NGnWO|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETQPYVKSzVyPUCuPFg1OjhizszN Mne1V2FPT0WU
ES4 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn75TWM2OD1yLkm3PFM3KM7:TR?= M3v2bnNCVkeHUh?=
EKVX NFfQZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[xOmlEPTB;MT6wNVA3PCEQvF2= MWjTRW5ITVJ?
D-542MG MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\NU2lEPTB;MT6wNVA3PCEQvF2= M1PUV3NCVkeHUh?=
SW1116 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTXU5FOUUN3ME2xMlAyOjh5IN88US=> M{\V[XNCVkeHUh?=
5637 MkfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M321PGlEPTB;MT6wNVUyKM7:TR?= MnnpV2FPT0WU
HT-1376 NVLJSoo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzPTWM2OD1zLkCxOVE{KM7:TR?= M4TTV3NCVkeHUh?=
NB69 M2XLWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLLTWM2OD1zLkCyPVQ2KM7:TR?= MVzTRW5ITVJ?
YKG-1 M3POeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEn5Xm9KSzVyPUGuNFU1OTlizszN NET6bWpUSU6JRWK=
EW-3 M2nuUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnT[XIxUUN3ME2xMlA4QDh|IN88US=> M3zlTXNCVkeHUh?=
GCIY NIrFU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTwTWM2OD1zLkC4NVA1KM7:TR?= MUPTRW5ITVJ?
SK-MES-1 M2DIdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3KdmhFUUN3ME2xMlEyPDh5IN88US=> M4PvfXNCVkeHUh?=
PANC-08-13 NIS5WXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrNTWM2OD1zLkG2OFE3KM7:TR?= NVPOT|ZUW0GQR1XS
SK-NEP-1 M4PLRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTFwMUe1NVMh|ryP Mnq1V2FPT0WU
SW954 MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\MOnlKSzVyPUGuNlAzOTRizszN M3XRSXNCVkeHUh?=
NCI-SNU-5 Mm\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofYTWM2OD1zLkKzPUDPxE1? MXTTRW5ITVJ?
SW48 Mor5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f1XWlEPTB;MT6yOVQ{OiEQvF2= MoLWV2FPT0WU
HT-3 NF3qUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjydlFrUUN3ME2xMlI5PzV|IN88US=> NEm0bolUSU6JRWK=
ETK-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHNdJlZUUN3ME2xMlM4PDV4IN88US=> Mkm5V2FPT0WU
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KURAMOCHI NG\XbW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Pxc2lEPTB;Nz65OFgyOSEQvF2= M4HrTHNCVkeHUh?=
BE-13 M1PvTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTdwOUixNVIh|ryP MmXWV2FPT0WU
VMRC-RCZ M4TMOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRThwMEG2PVch|ryP MmfFV2FPT0WU
NCI-H727 NYK1b5hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3z4SWlEPTB;OD6xNFQzKM7:TR?= MYLTRW5ITVJ?
SW1710 NUPqXo1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRThwMUi1NVUh|ryP NYPMemJRW0GQR1XS
D-502MG NETLOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nuUmlEPTB;OD6yPVI5OiEQvF2= NEfCb4RUSU6JRWK=
NCI-H1993 NVnzRVYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRThwM{O2N|Eh|ryP MYrTRW5ITVJ?
SCC-4 Mn3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPGRlJwUUN3ME24MlQ1ODV7IN88US=> MlfpV2FPT0WU
HAL-01 NH24TFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ixbWlEPTB;OD61NVkyKM7:TR?= NHjifZBUSU6JRWK=
GT3TKB NVu3SpRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\0UJBiUUN3ME24MlY4QTZ2IN88US=> MXXTRW5ITVJ?
SK-OV-3 M2DxN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknHTWM2OD16LkexN|I6KM7:TR?= M4XZVHNCVkeHUh?=
COLO-829 Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRThwOEC5O|Yh|ryP Mn;zV2FPT0WU
OCI-AML2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHFTWM2OD16Lkm1OFgyKM7:TR?= MlK2V2FPT0WU
OS-RC-2 M2H0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXVTWM2OD17LkCyNVkh|ryP NUjWbm1KW0GQR1XS
BFTC-909 NEPsNVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTlwME[3PVkh|ryP MlX6V2FPT0WU
EW-11 MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTlwMUe2OVMh|ryP MmfNV2FPT0WU
HCE-4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXXSpF7UUN3ME25MlIyPTV6IN88US=> NVG5SIVrW0GQR1XS
BALL-1 MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTlwMkG5NFch|ryP MkHkV2FPT0WU
SF539 MoTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTlwMkO1OlIh|ryP MnjJV2FPT0WU
CAMA-1 Mmj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDn[3ZHUUN3ME25MlI5OTJ6IN88US=> Mn7PV2FPT0WU
C32 Ml:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjVeGZPUUN3ME25MlM{ODZ2IN88US=> NVz5dGNEW0GQR1XS
NCI-H1703 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37UU2lEPTB;OT6zOFM4PSEQvF2= Mm\SV2FPT0WU
NCI-H1650 NFTqcpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUP5eZhFUUN3ME25MlYxQTR4IN88US=> MWXTRW5ITVJ?
NCI-H1563 NXzKNW1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHWTY5KSzVyPUmuO|YxOzFizszN NWnOcVA3W0GQR1XS
CAL-85-1 NHzaRXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\6TWM2OD17Lki3N|g{KM7:TR?= MVPTRW5ITVJ?
UM-UC-3 NF76fYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTlwOUWwN{DPxE1? NWW5[Ip6W0GQR1XS
BxPC-3 NX;EZY5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXoOFNKSzVyPUGwMlA6PzJizszN NG\LblhUSU6JRWK=
MHH-PREB-1 M3u2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjrVHU6UUN3ME2xNE4yQTl7IN88US=> MXjTRW5ITVJ?
DEL NEDEN3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33ucWlEPTB;MUCuN|k1PiEQvF2= NFXnSpdUSU6JRWK=
HuCCT1 M2nrcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPUSFFKSzVyPUGwMlYxOzNizszN NH7kS|JUSU6JRWK=
OVCAR-4 MnfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLSTWM2OD1zMD64PFM2KM7:TR?= MWjTRW5ITVJ?
CAL-72 MlTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rvb2lEPTB;MUCuPVM6OSEQvF2= NEGxV|NUSU6JRWK=
HCC1954 NWG4bGFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr0TWM2OD1zMT6wO|U1KM7:TR?= M3HsZ3NCVkeHUh?=
EFO-21 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTFzLkGwOFUh|ryP M1TsXXNCVkeHUh?=
FTC-133 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTFzLkG0NFch|ryP MlSyV2FPT0WU
SK-MEL-24 M4nwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvXTWM2OD1zMT6yN|Y3KM7:TR?= NV2xNpN4W0GQR1XS
UACC-62 MmixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfhPY9pUUN3ME2xNU4zOzZ6IN88US=> NGnIbpdUSU6JRWK=
NCI-H650 NXK5NFdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljHTWM2OD1zMT6yOFE5KM7:TR?= NHXRdIdUSU6JRWK=
ALL-PO NWr1O5lVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjOTWM2OD1zMT6yOVEzKM7:TR?= NWjiT5BlW0GQR1XS
T84 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7GVIRKSzVyPUGxMlM6ODdizszN M3;OV3NCVkeHUh?=
IST-MEL1 MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFK0OY5KSzVyPUGxMlQ2PTlizszN NULONVZKW0GQR1XS
SW626 NInRSYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfyTWM2OD1zMT61O|U2KM7:TR?= NWraPYRxW0GQR1XS
RPMI-2650 M4jWR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojUTWM2OD1zMT61PFg2KM7:TR?= NGLQZXdUSU6JRWK=
MC-IXC NXPh[3lyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\VcXJRUUN3ME2xNU43PzJ6IN88US=> MVjTRW5ITVJ?
HOP-62 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\nTWM2OD1zMT62O|Y1KM7:TR?= M4LRSnNCVkeHUh?=
NOS-1 M2L2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWroS2FKUUN3ME2xNU44OTB7IN88US=> M1rNc3NCVkeHUh?=
SW1573 NWLIfZdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTFzLkeyPVUh|ryP MXPTRW5ITVJ?
WM-115 NU\Z[5V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3S5RWlEPTB;MUGuO|U5QCEQvF2= NFH2dY5USU6JRWK=
HuO9 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTFzLki3O|Qh|ryP M4LYSXNCVkeHUh?=
YAPC Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX[0V4Q5UUN3ME2xNU46OjV7IN88US=> NE\teotUSU6JRWK=
MDA-MB-453 NHfoTWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3ZTWM2OD1zMT65OVE2KM7:TR?= MnHvV2FPT0WU
NCI-H596 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HmUmlEPTB;MUKuNFM3QSEQvF2= NEPWRXNUSU6JRWK=
A172 NHHJc|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF{LkC3PVgh|ryP MoTTV2FPT0WU
RS4-11 NF3veGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT4TWM2OD1zMj6xO|I2KM7:TR?= NIPUT4lUSU6JRWK=
HCC1937 NUjPUogyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vjdmlEPTB;MUKuO|U3PCEQvF2= M3HIO3NCVkeHUh?=
SW837 M1;zeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jRSWlEPTB;MUKuPVAzQCEQvF2= NIfkTHlUSU6JRWK=
NMC-G1 NXG2fZpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1KwU2lEPTB;MUKuPVI{PCEQvF2= MlPkV2FPT0WU
PFSK-1 NFfrWIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnvRXJKSzVyPUGzMlA3KM7:TR?= NYfoU|l7W0GQR1XS
DBTRG-05MG NFTX[pBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:wTWM2OD1zMz6wOlMzKM7:TR?= MX7TRW5ITVJ?
SK-UT-1 NWL2XIhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPCRVNKSzVyPUGzMlExQDNizszN NFX5W2NUSU6JRWK=
OVCAR-5 NF\PSpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEL6fWtKSzVyPUGzMlE2QTNizszN NFvXZm1USU6JRWK=
8505C M2WwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XZeWlEPTB;MUOuNlA3PyEQvF2= M3PnXXNCVkeHUh?=
SK-MEL-1 NWTPcm9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXThUXBpUUN3ME2xN{44OTN3IN88US=> NXP1W293W0GQR1XS
LK-2 NHrKcIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXKTWM2OD1zMz63OlM6KM7:TR?= NGHXW|dUSU6JRWK=
OE33 M4r4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7NbJBQUUN3ME2xN{44QDZizszN NF:wTlBUSU6JRWK=
Ramos-2G6-4C10 M1fxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXsOFJKSzVyPUG0MlAzODJizszN M{nSZ3NCVkeHUh?=
EW-13 M334fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;GbJBKSzVyPUG0MlA{PTJizszN NIHOTXlUSU6JRWK=
NCI-H1793 NIrNUWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjSUYk2UUN3ME2xOE4zODh5IN88US=> MWrTRW5ITVJ?
BHT-101 NXHFUo9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInZeoxKSzVyPUG0MlI1OSEQvF2= MYrTRW5ITVJ?
RKO NGrRfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\ZOo5KSzVyPUG0MlUxPzVizszN NWWzVlNsW0GQR1XS
NEC8 NWj5UodbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PGSGlEPTB;MUSuOVQ4OiEQvF2= NEixWIdUSU6JRWK=
PANC-10-05 NI\V[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGToWYxKSzVyPUG0MlYzPDdizszN NGT1R4ZUSU6JRWK=
NCI-H2030 NEXKfYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvmd5ZKSzVyPUG0MlY1PDhizszN NInxfGtUSU6JRWK=
C2BBe1 NUTBc|M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\kTWM2OD1zND63OlQh|ryP MXzTRW5ITVJ?
EM-2 NUHScpF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTF2Lki1O|Yh|ryP M1Hk[nNCVkeHUh?=
HCC1395 M{\PdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml31TWM2OD1zND65N|M5KM7:TR?= M3ixeXNCVkeHUh?=
A2058 Ml:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7PTWM2OD1zNT6wOFA6KM7:TR?= NVSzRlZqW0GQR1XS
SW1463 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTF3LkC0PFUh|ryP Mo[4V2FPT0WU
J82 MkjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7xNIdrUUN3ME2xOU4xPTdizszN NEHFfpFUSU6JRWK=
CAL-120 MonwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHQbodKSzVyPUG1MlE1PDdizszN Ml\hV2FPT0WU
COLO-824 NVW5bItmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zXfmlEPTB;MUWuNVU4QSEQvF2= MnjtV2FPT0WU
LNCaP-Clone-FGC NIjHTYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXTTWM2OD1zNT60NlQ5KM7:TR?= MVzTRW5ITVJ?
CP66-MEL M1zmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrrZXBKSzVyPUG1MlQ3QDhizszN MoDvV2FPT0WU
OC-314 NIXqcHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LWVWlEPTB;MUWuOFcyPCEQvF2= NH3ZU5RUSU6JRWK=
OVCAR-8 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XLd2lEPTB;MUWuPFg3OSEQvF2= M1T2XHNCVkeHUh?=
MFE-280 MnHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7WN3NKSzVyPUG2MlA1QDhizszN MnfzV2FPT0WU
MHH-NB-11 NH3CflhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LHT2lEPTB;MU[uNFg{QSEQvF2= MkHHV2FPT0WU
SW1990 MorjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF4LkG3OVUh|ryP NV\VRoZPW0GQR1XS
U-266 NIHuOI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\0W2lEPTB;MU[uNlI6QSEQvF2= MV3TRW5ITVJ?
MFM-223 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF4LkO5OlUh|ryP NYrmdHQ{W0GQR1XS
L-363 NHzOTmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonpTWM2OD1zNj60OVc4KM7:TR?= Mn;pV2FPT0WU
MCF7 NV3PWYNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rDOGlEPTB;MU[uOFczOyEQvF2= NHfa[YRUSU6JRWK=
SK-MEL-3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF4LkS3PFch|ryP MXLTRW5ITVJ?
HH M{nDZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\lc3lKSzVyPUG2MlUyPjJizszN MXfTRW5ITVJ?
no-10 NF;kToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLySFZtUUN3ME2xOk43OzR|IN88US=> MYrTRW5ITVJ?
HuP-T3 NV3xWXBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF4Lk[1O|Yh|ryP MkD2V2FPT0WU
QIMR-WIL Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXSfIJLUUN3ME2xOk44OTB3IN88US=> M3nH[nNCVkeHUh?=
NCI-H1092 M4[5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[xTWM2OD1zNj64N|E3KM7:TR?= MWjTRW5ITVJ?
MZ2-MEL NE\ZTWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zxXWlEPTB;MU[uPFQxOyEQvF2= MWfTRW5ITVJ?
ES3 M{C3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TrPGlEPTB;MU[uPVE{PCEQvF2= MYHTRW5ITVJ?
COLO-684 MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX1XW44UUN3ME2xOk46PDd5IN88US=> MmHqV2FPT0WU
NCI-H661 NHjZNHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX0TWM2OD1zNj65Olk1KM7:TR?= NEjIW5ZUSU6JRWK=
CP50-MEL-B MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\kUoNKSzVyPUG3MlA{PDNizszN NVnGTJpjW0GQR1XS
NCI-H2405 MmeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nNfmlEPTB;MUeuNVk4PCEQvF2= MmLPV2FPT0WU
U-2-OS M2nR[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWezUIg{UUN3ME2xO{42OzB5IN88US=> M{HwdnNCVkeHUh?=
RERF-LC-MS NUmwXYRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTF5LkW1NFgh|ryP MoLEV2FPT0WU
NCI-H2342 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfMR|dSUUN3ME2xO{42PTdizszN NEnUdlBUSU6JRWK=
ES8 NEPWboZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nxPWlEPTB;MUeuOlA5PyEQvF2= M3flc3NCVkeHUh?=
MOLT-16 NUjMOJczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\QOmlEPTB;MUeuPFk{PCEQvF2= NYDqXJpLW0GQR1XS
RH-18 NVnyNphxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{noO2lEPTB;MUiuNFA{PSEQvF2= MWnTRW5ITVJ?
D-283MED NHjONIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2OyXWlEPTB;MUiuNFA5QCEQvF2= M1L4d3NCVkeHUh?=
RCC10RGB NUjib4x[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnBe2FKSzVyPUG4MlA2PTlizszN MX3TRW5ITVJ?
NCI-H1437 MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXy4eJZqUUN3ME2xPE4yPjRzIN88US=> MlzyV2FPT0WU
SW982 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnWW3RDUUN3ME2xPE4zPjdzIN88US=> MlXsV2FPT0WU
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A704 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnNTWM2OD1zOD60O|U{KM7:TR?= M1rSOnNCVkeHUh?=
ESS-1 Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TrbGlEPTB;MUiuOVIxPSEQvF2= M4flSnNCVkeHUh?=
SCH NW\3d2YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHIUG9KSzVyPUG4MlY1PTZizszN NXr6VVZyW0GQR1XS
COLO-320-HSR MlXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP6XGtCUUN3ME2xPE44PDZizszN MUXTRW5ITVJ?
Mo-T NVvPOYlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljGTWM2OD1zOD64NlA1KM7:TR?= NHu2[I5USU6JRWK=
Saos-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{O2W2lEPTB;MUmuNVE3OiEQvF2= NYXOOXRwW0GQR1XS
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LCLC-103H MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGr5dGJKSzVyPUO2Mlc5ODNizszN MVTTRW5ITVJ?
U-118-MG NWjDcI9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTN4Lki4OFch|ryP Mkj2V2FPT0WU
8-MG-BA NI\PeJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTN4Lkm0PFMh|ryP MXfTRW5ITVJ?
MFH-ino MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrufXJKSzVyPUO3MlM{PzFizszN M33pTHNCVkeHUh?=
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LU-99A NF7rcmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTN5LkW3N|Eh|ryP NYnYVGhVW0GQR1XS
KP-N-YN M{HmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HKcmlEPTB;M{euOlE6PSEQvF2= NGe1PHVUSU6JRWK=
SCC-9 NIO3OJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPQcZR7UUN3ME2zO{44QDN6IN88US=> M1PuTHNCVkeHUh?=
EFM-19 MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTN5Lke5Olch|ryP NIHLcnhUSU6JRWK=
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LAN-6 MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzEbG9KUUN3ME20NE4xOTF{IN88US=> M1T0VHNCVkeHUh?=
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SNU-387 M{\ic2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTRyLkS1OVMh|ryP MkPqV2FPT0WU
DMS-79 NVSzdXJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i1XGlEPTB;NECuOVg5QSEQvF2= M2\BcXNCVkeHUh?=
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HT NEDHe49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnmcJNKSzVyPUSwMlY3OzlizszN NXvL[nZqW0GQR1XS
KP-N-YS MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTRyLk[3Olgh|ryP NEXtUplUSU6JRWK=
DMS-114 MmTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfOTWM2OD12MD64N|c1KM7:TR?= NHXpWmxUSU6JRWK=
HUTU-80 MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHzc3BpUUN3ME20NU4xPTZ7IN88US=> M4SxWnNCVkeHUh?=
ONS-76 NV3zS2dST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\Xc2VnUUN3ME20NU41PzB7IN88US=> NYf0XpRDW0GQR1XS
A673 NEXEZmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;uO2N6UUN3ME20NU42OTV5IN88US=> NGTy[5pUSU6JRWK=
HPAF-II MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTRzLk[3NFkh|ryP NGToVoNUSU6JRWK=
UACC-257 M3vqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDrTWM2OD12MT63N|Y6KM7:TR?= M1O4S3NCVkeHUh?=
EW-22 NIDNXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfITWM2OD12MT64Olk4KM7:TR?= M1rzZnNCVkeHUh?=
NCI-H1755 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XCcmlEPTB;NEGuPFczPSEQvF2= NXjEUWVGW0GQR1XS
KYSE-150 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnHTWM2OD12Mj6xO|gzKM7:TR?= M1\DTHNCVkeHUh?=
CGTH-W-1 NHHkbFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[4OHJKSzVyPUSyMlQ6PTVizszN NWLFdpVVW0GQR1XS
NB13 MmjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkCxTWM2OD12Mj62NlE4KM7:TR?= M3u5V3NCVkeHUh?=
SW872 NFrhdlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\zU2lEPTB;NEKuOlM{OSEQvF2= NGXufVNUSU6JRWK=
KP-4 NX\zfXpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TG[mlEPTB;NEKuPFg{OiEQvF2= MYLTRW5ITVJ?
HCC38 M2LufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrwbpNUUUN3ME20Nk46PjF6IN88US=> M17Td3NCVkeHUh?=
BB49-HNC NUDUZppIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrZXJJKSzVyPUSzMlI{PTZizszN NWD2NnRMW0GQR1XS
CAL-62 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrzTWM2OD12Mz60NFI5KM7:TR?= MXvTRW5ITVJ?
NCI-H2029 NWf5VoEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rHeGlEPTB;NEOuOVU5OSEQvF2= NFfXe|JUSU6JRWK=
M14 NWXBd3dzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTGNpQ2UUN3ME20OE4yOzN{IN88US=> MoP4V2FPT0WU
COLO-680N NX\RdoNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTxTWM2OD12ND6zN|kh|ryP NF7KZY9USU6JRWK=
Hs-578-T MkO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHqdWo3UUN3ME20OU4xOjl2IN88US=> NEXiO5pUSU6JRWK=
MSTO-211H M3Xmemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LObmlEPTB;NEWuPVQ5OiEQvF2= NGH5bmdUSU6JRWK=
EW-1 MoPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTXTWM2OD12NT65Olg6KM7:TR?= NWn6c4FjW0GQR1XS
SW948 M2PPSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\pb2lEPTB;NE[uOFQ3OiEQvF2= MUXTRW5ITVJ?
NCI-H460 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTR4LkWyN{DPxE1? NEjkVWdUSU6JRWK=
CAS-1 NYXBVnBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDhfZZKSzVyPUS2Mlc4ODFizszN M4WxPHNCVkeHUh?=
TGBC11TKB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PMSGlEPTB;NEeuNVc4PyEQvF2= MnjqV2FPT0WU
HD-MY-Z NIrx[nJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn6TWM2OD12OD63PFYh|ryP NUPrUWZPW0GQR1XS
NCI-H226 MorJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTR7Lke3PFUh|ryP NH7Bco5USU6JRWK=
PA-1 NIDoV5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHzTWM2OD12OT64N|M2KM7:TR?= NFiwOo9USU6JRWK=
LB2518-MEL MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D2VGlEPTB;NEmuPFczOyEQvF2= M{jqdnNCVkeHUh?=
A101D NX;sWlE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf3TWM2OD12OT65OFI2KM7:TR?= Mnz1V2FPT0WU
NCI-H2087 NF7rPJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTR7Lkm2PFIh|ryP MkXYV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water <1 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 10mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID