Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

Size Price Stock Quantity  
In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 570 In stock

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 37 Publications

3 Customer Reviews

  • Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

Click to view more

Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 M1HRemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH3TWM2OD1yLkCwOVczKM7:TR?= MlPOV2FPT0WU
KASUMI-1 NXvWSJdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILuNXNKSzVyPUCuNFA6OTFizszN NXzscos{W0GQR1XS
HCC2218 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMEC5PFch|ryP MVvTRW5ITVJ?
KARPAS-45 NWrxUm1PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEG2O|Eh|ryP Ml32V2FPT0WU
HSC-4 Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nPeGlEPTB;MD6wNVc1QCEQvF2= NEX1d3dUSU6JRWK=
CHL-1 NUnkTWp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMEG4N|kh|ryP NV\wTmFOW0GQR1XS
KY821 M2XhWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMEKwOkDPxE1? M1zI[HNCVkeHUh?=
NCI-N87 MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEK3O|Mh|ryP MUfTRW5ITVJ?
DOK NVmyb3MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITjVWtKSzVyPUCuNFMyQTRizszN M4rzNnNCVkeHUh?=
DSH1 NXja[|E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMEOzNVQh|ryP M1XYSnNCVkeHUh?=
MDA-MB-175-VII NUW5VFhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEO0NVYh|ryP MlTWV2FPT0WU
NCI-H2170 NUXzNIo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmn5TWM2OD1yLkCzO|I5KM7:TR?= NHf4U|lUSU6JRWK=
BT-474 NIe3WG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMES5PFYh|ryP Mo\hV2FPT0WU
EFO-27 NWLqdWxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDoU|NsUUN3ME2wMlA2OTh{IN88US=> NVjyUZQxW0GQR1XS
NCI-H720 M2rXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXGzeGhGUUN3ME2wMlA2OzJ3IN88US=> NE\PWIdUSU6JRWK=
PC-14 NUHKRW1MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XKZmlEPTB;MD6wOVY3QCEQvF2= MYfTRW5ITVJ?
EC-GI-10 NX7rcWFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PnWmlEPTB;MD6wOVkyOiEQvF2= NXXEbHlFW0GQR1XS
KYSE-450 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEW5O|gh|ryP M2fUfXNCVkeHUh?=
BPH-1 MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moi2TWM2OD1yLkC1PVg5KM7:TR?= MnrxV2FPT0WU
NCI-H292 M{\oZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfJTWM2OD1yLkC2NFkh|ryP M3HPWHNCVkeHUh?=
H9 NGLJSnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonQTWM2OD1yLkC3NVMzKM7:TR?= MY\TRW5ITVJ?
NCI-H526 NICzV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1G0b2lEPTB;MD6wO|gzOyEQvF2= M2TlW3NCVkeHUh?=
NCI-H1623 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17OTmlEPTB;MD6wPFAzPSEQvF2= MYLTRW5ITVJ?
KYSE-140 NFfOVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnOxTWM2OD1yLkC4N|Mh|ryP NH\teFFUSU6JRWK=
Ca9-22 M{G3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfOOWo1UUN3ME2wMlA5OzV|IN88US=> M3TIUXNCVkeHUh?=
AU565 M{S4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHGyO4JKSzVyPUCuNFg2ODRizszN MofsV2FPT0WU
ZR-75-30 M3XBTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPGZXNCUUN3ME2wMlA6PTR3IN88US=> MlS1V2FPT0WU
NCI-H1770 MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnYVXhNUUN3ME2wMlExOjhizszN M2fGc3NCVkeHUh?=
LB2241-RCC MkHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMUC4PFQh|ryP MXPTRW5ITVJ?
CAL-39 NUnzZ2puT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHmVo56UUN3ME2wMlEyPzl{IN88US=> MorkV2FPT0WU
UACC-893 MkjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LFNGlEPTB;MD6xNVg5PSEQvF2= MWfTRW5ITVJ?
LU-65 NVXX[Wg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HtcmlEPTB;MD6xNlY{OyEQvF2= NIPKXVlUSU6JRWK=
HN NFPxbIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMUOwO|ch|ryP MUjTRW5ITVJ?
TI-73 NEnvOm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvnRmxtUUN3ME2wMlE1PzF3IN88US=> MljlV2FPT0WU
KU812 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPrOldKSzVyPUCuNVU1PTZizszN Mn3aV2FPT0WU
SW13 M3\sTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXWTWM2OD1yLkG2NlE3KM7:TR?= NGix[HFUSU6JRWK=
BB30-HNC MmHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMU[1O|Yh|ryP NIrDT41USU6JRWK=
HSC-2 M2CzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPw[ZlDUUN3ME2wMlE3QDN5IN88US=> MX3TRW5ITVJ?
BV-173 MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrvUoJ7UUN3ME2wMlE4PTl4IN88US=> Mk\wV2FPT0WU
CAL-27 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLYTZJqUUN3ME2wMlE4PjN4IN88US=> NH20emVUSU6JRWK=
SBC-1 NXe2d4d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlW1TWM2OD1yLkG4PVU6KM7:TR?= NIjGNHBUSU6JRWK=
CAL-33 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITocIpKSzVyPUCuNlAyQDRizszN MXPTRW5ITVJ?
NCI-H209 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfzdGdKSzVyPUCuNlA1PiEQvF2= Mk\OV2FPT0WU
COR-L105 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETq[3VKSzVyPUCuNlExQDRizszN M3:3U3NCVkeHUh?=
HSC-3 MlPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7ZTWM2OD1yLkKxNVk5KM7:TR?= NYS3bpBUW0GQR1XS
NCI-H69 M2Kx[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMkG0OVEh|ryP NXjRb|JJW0GQR1XS
MOLT-13 MoHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7YTWM2OD1yLkKzPVc2KM7:TR?= MoDGV2FPT0WU
ML-2 NH65PIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMkS4NFIh|ryP M3PHd3NCVkeHUh?=
IGROV-1 M2TjZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fvfWlEPTB;MD6yOVk2OiEQvF2= NEHVe|ZUSU6JRWK=
TK10 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ftVWlEPTB;MD6yOlc{QCEQvF2= MVPTRW5ITVJ?
EoL-1-cell NH;oTnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrWT4RKSzVyPUCuNlY5QTJizszN MYPTRW5ITVJ?
HO-1-N-1 NUL6N4FsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{m2NmlEPTB;MD6yO|g2OyEQvF2= NX\rO2dJW0GQR1XS
BHY NVPVV5JpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXpTWM2OD1yLkK4OlU2KM7:TR?= M2nRWnNCVkeHUh?=
LU-139 Mlq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPITWM2OD1yLkOwOVEh|ryP MUTTRW5ITVJ?
23132-87 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwM{G5NlMh|ryP NUPNW5Y5W0GQR1XS
ACHN M2PZZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\ld2FKSzVyPUCuN|E6QTRizszN NYSwZ2Z5W0GQR1XS
DoTc2-4510 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjWUm9KSzVyPUCuN|IzOTlizszN MonYV2FPT0WU
BB65-RCC MlH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwM{S1PVMh|ryP MkT1V2FPT0WU
HLE M33TV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\hZXFKUUN3ME2wMlM2ODR4IN88US=> MkLzV2FPT0WU
HCC1419 MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHpWpVKSzVyPUCuN|Y1ODhizszN M3TwcnNCVkeHUh?=
A388 NHizNmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljjTWM2OD1yLkO2PFU4KM7:TR?= M3XwbHNCVkeHUh?=
NUGC-3 NGrLO2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXnTWM2OD1yLkO4N|c{KM7:TR?= NHzPbIhUSU6JRWK=
KYSE-180 M{DzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTUWGFqUUN3ME2wMlM6ODh7IN88US=> Mn7xV2FPT0WU
TE-6 NIHNPGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnf2TWM2OD1yLkSwNlQ3KM7:TR?= MXfTRW5ITVJ?
A498 NHrFRVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[3TlIyUUN3ME2wMlQxPjd2IN88US=> MoXMV2FPT0WU
NCI-H1648 NETsXnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF6xOZNKSzVyPUCuOFQyQDJizszN M3vRenNCVkeHUh?=
DU-145 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwNES4N|Mh|ryP NHW4V|NUSU6JRWK=
CW-2 M1XZe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XKb2lEPTB;MD60OlkyPCEQvF2= M1zscnNCVkeHUh?=
A431 NWS0ZmZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;4TWM2OD1yLkS4NlM{KM7:TR?= NWTYNZViW0GQR1XS
SAS NWC5SGl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLjd5FyUUN3ME2wMlQ5Ozl6IN88US=> NVzpZ2RbW0GQR1XS
NCI-H2126 NX3FdItTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPPTWM2OD1yLkWxPVI3KM7:TR?= NFPvb2FUSU6JRWK=
NCI-H358 NHT3OGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzwVY9xUUN3ME2wMlU{OjFizszN NHGzNYpUSU6JRWK=
FADU NWqxNYpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7vPHdKSzVyPUCuOVQ1ODRizszN NGK0NoFUSU6JRWK=
ACN MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDLTWM2OD1yLkW1NFk1KM7:TR?= NUTXN3N2W0GQR1XS
HCC70 NWLrXXdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInFXFBKSzVyPUCuOVc3PjFizszN NIH6VZlUSU6JRWK=
NCI-H1838 M3Hme2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\0O4tKSzVyPUCuOlAzQTlizszN NFSxb3hUSU6JRWK=
CAL-54 NWS3eFJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;6TmlEPTB;MD62NVYzOSEQvF2= M3rIe3NCVkeHUh?=
NCI-H1975 M1jxeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrPZ5dKSzVyPUCuOlE4OjhizszN MkDvV2FPT0WU
COR-L88 MnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG5PZFKSzVyPUCuOlQyOTNizszN MUPTRW5ITVJ?
CTV-1 MkPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;SUXNSUUN3ME2wMlY1Ozl{IN88US=> NGGxV|JUSU6JRWK=
EW-18 NFfPcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1viXWlEPTB;MD62PFY6QCEQvF2= MkHIV2FPT0WU
HCC1806 NH\jb2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwNkm2OlYh|ryP MlPRV2FPT0WU
HuP-T4 NY\jeIFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLHWmFKSzVyPUCuOlk4PiEQvF2= NVXMZ3ZxW0GQR1XS
MDA-MB-361 MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjITWM2OD1yLkeyOlYzKM7:TR?= NY[xSYVYW0GQR1XS
NCI-H1573 NGe5TYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nUOGlEPTB;MD63N|Y{KM7:TR?= MnnHV2FPT0WU
KU-19-19 MoTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnZSJhKSzVyPUCuO|c1PjRizszN NVzVbHBiW0GQR1XS
COLO-678 MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P5UWlEPTB;MD64NFg{PCEQvF2= MXrTRW5ITVJ?
C-33-A M4PUV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwOEGyPVch|ryP NFHuUIRUSU6JRWK=
Calu-3 NY\lUIZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWC2UXc2UUN3ME2wMlgyPDN2IN88US=> MlrJV2FPT0WU
AGS NEHkNGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEO4Oo5KSzVyPUCuPFM3PDhizszN M1\nUnNCVkeHUh?=
SCC-25 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwOESxO|Eh|ryP MoqwV2FPT0WU
JVM-2 MkPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP2TWM2OD1yLki4Nlk6KM7:TR?= NHvRVldUSU6JRWK=
HCE-T MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHsO3pKSzVyPUCuPFg1OjhizszN NWXwSpRYW0GQR1XS
ES4 M4K4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwOUe4N|Yh|ryP NXjIb2pZW0GQR1XS
EKVX M2TiNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XkXmlEPTB;MT6wNVA3PCEQvF2= MV3TRW5ITVJ?
D-542MG MlfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoS1TWM2OD1zLkCxNFY1KM7:TR?= MkjnV2FPT0WU
SW1116 M17xU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTFwMEGyPFch|ryP NHXPTFZUSU6JRWK=
5637 M4fXfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK5TWM2OD1zLkCxOVEh|ryP NHjKUYlUSU6JRWK=
HT-1376 NFfjfGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHsTWM2OD1zLkCxOVE{KM7:TR?= MoKxV2FPT0WU
NB69 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvPPXI3UUN3ME2xMlAzQTR3IN88US=> MXjTRW5ITVJ?
YKG-1 M{K1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zXemlEPTB;MT6wOVQyQSEQvF2= NHjPfHVUSU6JRWK=
EW-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzpUFVKSzVyPUGuNFc5QDNizszN NVLl[pNGW0GQR1XS
GCIY NFnKZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTFwMEixNFQh|ryP NE\sTZFUSU6JRWK=
SK-MES-1 MmTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTFwMUG0PFch|ryP NHz1XmNUSU6JRWK=
PANC-08-13 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETEbohKSzVyPUGuNVY1OTZizszN M322WXNCVkeHUh?=
SK-NEP-1 NVjZUmNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHlWZFPUUN3ME2xMlE4PTF|IN88US=> M2PlRXNCVkeHUh?=
SW954 MmT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrHOIRKSzVyPUGuNlAzOTRizszN M2O0UHNCVkeHUh?=
NCI-SNU-5 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXHTWM2OD1zLkKzPUDPxE1? NITJR4RUSU6JRWK=
SW48 NVzHVndIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPKfZFKSzVyPUGuNlU1OzJizszN MX3TRW5ITVJ?
HT-3 NF7KSZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nEU2lEPTB;MT6yPFc2OyEQvF2= MojTV2FPT0WU
ETK-1 M{S0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fINWlEPTB;MT6zO|Q2PiEQvF2= MmXjV2FPT0WU
SCC-15 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\HNmlEPTB;MT6zPVQ2OSEQvF2= NXPRfY06W0GQR1XS
DU-4475 MoSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwNECxNlEh|ryP NEnLNmZUSU6JRWK=
NB5 NULzXZVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYWwXlJJUUN3ME2xMlQyOzF5IN88US=> NEHjUnlUSU6JRWK=
CFPAC-1 NU\Q[4xtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEO3UWRKSzVyPUGuOFI1QTNizszN MWHTRW5ITVJ?
NCI-H630 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnqcJI3UUN3ME2xMlQ2PTh{IN88US=> NVjaeVlFW0GQR1XS
NCI-H82 NEXIfWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXzSZBoUUN3ME2xMlU1ODB4IN88US=> M4D4eHNCVkeHUh?=
ECC10 NVzTS|lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTFwNUWzOlkh|ryP M2D0XHNCVkeHUh?=
K5 NESzTYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrZfpg2UUN3ME2xMlU5OzV5IN88US=> MV3TRW5ITVJ?
ME-180 NEnaTXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn5NGtKSzVyPUGuOlExQTZizszN Mom4V2FPT0WU
KYSE-410 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTFwNkW2O|Ih|ryP MV3TRW5ITVJ?
G-401 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHLTWM2OD1zLk[3OFE{KM7:TR?= MlLEV2FPT0WU
TGBC24TKB MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37yOWlEPTB;MT62PFI{KM7:TR?= M4Xpe3NCVkeHUh?=
Detroit562 MkT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7lcGY3UUN3ME2xMlcxOTV{IN88US=> M1XRSXNCVkeHUh?=
OE19 M3\HSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HvfmlEPTB;MT63NVUyOiEQvF2= Mlq0V2FPT0WU
CAKI-1 NWfzT497T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHmTWM2OD1zLke4NlEyKM7:TR?= MVzTRW5ITVJ?
TE-12 NX[3[oQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTFwOEC0NVQh|ryP M4DmOnNCVkeHUh?=
NCI-H1666 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nndGlEPTB;MT64NFk1QCEQvF2= NE\i[2tUSU6JRWK=
TE-1 NF;xd|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLJTWM2OD1zLkixOFc2KM7:TR?= M{XKVXNCVkeHUh?=
CAL-12T M2XjSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7VTWM2OD1zLki4PVQ2KM7:TR?= M16yZnNCVkeHUh?=
TE-8 NVvVdZRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;NToxKSzVyPUGuPVE{PzdizszN NHLCW3NUSU6JRWK=
KYSE-270 NGn2W2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;PU2lEPTB;Mj6wNlc{OiEQvF2= MnO0V2FPT0WU
GMS-10 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnCTWM2OD1{LkCzOVE4KM7:TR?= MXHTRW5ITVJ?
A2780 NVrtW3NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYn6eoRPUUN3ME2yMlA3Ojl2IN88US=> MkKzV2FPT0WU
OMC-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HTSmlEPTB;Mj6wPFE3QSEQvF2= NEjJepFUSU6JRWK=
LoVo NXHx[5ZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLQTWM2OD1{LkGwO|k4KM7:TR?= NGfWXIVUSU6JRWK=
PANC-03-27 MlXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUC1Z25LUUN3ME2yMlE3PjNzIN88US=> NE[4XoZUSU6JRWK=
MDA-MB-157 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfuTFFKSzVyPUKuNlE5OjhizszN M1nkcHNCVkeHUh?=
CaR-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq4SWdKSzVyPUKuNlgzQDFizszN MX3TRW5ITVJ?
769-P NG\JV2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fDb2lEPTB;Mj6yPVA{PyEQvF2= MWnTRW5ITVJ?
NB7 NHrTNoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv6fWxKSzVyPUKuNlk3PzZizszN MkHpV2FPT0WU
MKN7 MoDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C2dGlEPTB;Mj6zOVM{PSEQvF2= M13EW3NCVkeHUh?=
NCI-H1048 Mnj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LOUWlEPTB;Mj60PVE2QCEQvF2= M2juVHNCVkeHUh?=
RCM-1 MmKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fjV2lEPTB;Mj61Nlk{QCEQvF2= Mk\RV2FPT0WU
HT55 MoLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[xOpJKSzVyPUKuOVc{QCEQvF2= MUHTRW5ITVJ?
HCC1569 M1HhV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJwNUiyPVch|ryP MUnTRW5ITVJ?
LXF-289 Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJwNkO1OlUh|ryP NVizXoVYW0GQR1XS
OVCAR-3 NV;Xb3FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[wTWM2OD1{Lk[3NVY4KM7:TR?= MVPTRW5ITVJ?
TE-10 NILSco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJwNkiwO|gh|ryP NIDtZlRUSU6JRWK=
SNU-C2B NHPxe|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37yT2lEPTB;Mj62PFYyPiEQvF2= NEjP[|VUSU6JRWK=
LB1047-RCC NGLXVolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL1[JVKSzVyPUKuO|Q5QDhizszN NXrvXI9EW0GQR1XS
SN12C NUfJfo0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJwOUG5OlQh|ryP NXzxOZE6W0GQR1XS
786-0 NXna[Hd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvnTWM2OD1|LkC2OFA5KM7:TR?= MVvTRW5ITVJ?
HT-29 M2\5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnMTWM2OD1|LkC3N|A6KM7:TR?= MXjTRW5ITVJ?
RPMI-7951 MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH3W5RKSzVyPUOuNFc2QSEQvF2= NWL3OJN{W0GQR1XS
NBsusSR MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTNwMUiyOVQh|ryP M{HIb3NCVkeHUh?=
NKM-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUK5TI4zUUN3ME2zMlE5PzR2IN88US=> MonWV2FPT0WU
Capan-2 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG2dnJKSzVyPUOuOFY5PzVizszN NFr6ZYJUSU6JRWK=
MKN1 NHn3UZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33FPGlEPTB;Mz60O|ExQCEQvF2= NYfjOFBmW0GQR1XS
OAW-42 NFHX[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3aTWM2OD1|LkWwNFI3KM7:TR?= M3f1eXNCVkeHUh?=
SKG-IIIa NYHPW|FHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTPWXhjUUN3ME2zMlUzOjN5IN88US=> MonGV2FPT0WU
no-11 NXOzSohwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHJb4pKSzVyPUOuOVM2PjRizszN M3XFT3NCVkeHUh?=
NY M{PjPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fQUWlEPTB;Mz61N|Y2PSEQvF2= MWLTRW5ITVJ?
HEC-1 M2\MTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHKTWM2OD1|LkW4PVUh|ryP MUjTRW5ITVJ?
NCI-H441 NEf5SYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\ZU2lEPTB;Mz61PVg1OSEQvF2= MmDuV2FPT0WU
NCI-H2009 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK5SVNKSzVyPUOuOlEzOTZizszN NHfIT49USU6JRWK=
T47D NFTjZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTNwNkKyNVch|ryP Mn;GV2FPT0WU
SNU-449 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTNwNkW4NlYh|ryP M1P5RnNCVkeHUh?=
NCI-SNU-1 NGS4ZYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLwbJBkUUN3ME2zMlY6PzN3IN88US=> M2KzUXNCVkeHUh?=
BT-20 NYS2PWY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXNNJpKSzVyPUOuOlk4QTVizszN MX3TRW5ITVJ?
LS-123 M3zD[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTkSFZFUUN3ME2zMlc1Ojh2IN88US=> MnXTV2FPT0WU
8305C MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTNwN{W5NVEh|ryP NFnMW2NUSU6JRWK=
OCUB-M NXntZWlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTNwN{[xPFch|ryP MUfTRW5ITVJ?
KOSC-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDjTWM2OD1|LkizOFUyKM7:TR?= MlvhV2FPT0WU
NCI-H1693 NHXzWZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfqTWM2OD1|Lki0NVgyKM7:TR?= NH3HNIVUSU6JRWK=
TE-9 NGjCVmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTNwOESzPFIh|ryP MmHNV2FPT0WU
MV-4-11 NIK0fHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrWTWM2OD1|Lki3PVk1KM7:TR?= MWXTRW5ITVJ?
GAMG MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInQdHJKSzVyPUOuPVE{OTRizszN Mn;3V2FPT0WU
KNS-62 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTNwOUS3N|Eh|ryP MlvEV2FPT0WU
MC116 MmrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTNwOUW0PFkh|ryP MUnTRW5ITVJ?
647-V NF32dpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPUVItKSzVyPUOuPVg1PTJizszN MmnGV2FPT0WU
U-87-MG MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlO4TWM2OD12LkGwOFgyKM7:TR?= NXvrTopMW0GQR1XS
RPMI-8226 NE[wToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;0PFZCUUN3ME20MlEyPjNzIN88US=> NH3FfVRUSU6JRWK=
SW1417 MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTRwMUKxOFch|ryP Mn;tV2FPT0WU
LAMA-84 M2fHRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzrTWM2OD12LkG3NFIh|ryP MWTTRW5ITVJ?
LS-513 NHS4Wo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH73PWZKSzVyPUSuN|EzOTdizszN NYfnUpBZW0GQR1XS
KLE NWPYPHFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TQPGlEPTB;ND60NFgyQSEQvF2= MmjGV2FPT0WU
HCT-116 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPacYNQUUN3ME20MlQyODB5IN88US=> NUnnfWJGW0GQR1XS
EPLC-272H MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljaTWM2OD12LkSxOVM{KM7:TR?= M3;KTHNCVkeHUh?=
KS-1 NWntPIpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTRwNUC4PFkh|ryP NUfsOo1HW0GQR1XS
HT-1197 NVTKPIhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTRwNUK2Olkh|ryP MknsV2FPT0WU
LCLC-97TM1 MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorTTWM2OD12LkWzOlg3KM7:TR?= NFvrVmpUSU6JRWK=
ES5 M4DUVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vS[GlEPTB;ND64N|czOyEQvF2= MmnmV2FPT0WU
CTB-1 MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4m0NmlEPTB;ND64OFg5KM7:TR?= NUDQUppSW0GQR1XS
HL-60 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrPfXdKSzVyPUSuPFY3OTFizszN NFvsUnpUSU6JRWK=
VM-CUB-1 MlvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvVTWM2OD12Lki2PFE6KM7:TR?= NEfITJNUSU6JRWK=
MEG-01 M2fXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\uTGlEPTB;ND65PVQxOyEQvF2= MknsV2FPT0WU
KYSE-520 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnYZmRKSzVyPUWuNlA5OzlizszN NH3ETJJUSU6JRWK=
HuO-3N1 NHnhV29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXPTWM2OD13LkK0NFQ{KM7:TR?= MnXEV2FPT0WU
SW620 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLzdItNUUN3ME21MlI1QTZ2IN88US=> NX3pSlFmW0GQR1XS
U031 M3Px[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrmTWM2OD13LkK1OFI1KM7:TR?= NI\Vd4xUSU6JRWK=
TE-5 MojOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTVwNEC4OUDPxE1? MlO4V2FPT0WU
NCI-H747 MnXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTVwNEK0O|Ih|ryP NInTN2RUSU6JRWK=
MG-63 M1PKcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTVwNEi3OlIh|ryP MUjTRW5ITVJ?
HC-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPBTWM2OD13LkWxPFM6KM7:TR?= NGCzNJZUSU6JRWK=
HCC2998 M3T2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7NdpJKSzVyPUWuOVI3OTVizszN MX7TRW5ITVJ?
NTERA-S-cl-D1 M4XxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1uwRWlEPTB;NT61OFU{PyEQvF2= MUTTRW5ITVJ?
KINGS-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTVwNkC5OFQh|ryP NInxeZNUSU6JRWK=
D-423MG MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLqTWM2OD13Lk[xO|A2KM7:TR?= MmT4V2FPT0WU
SW962 NH\FcYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTDO5hKSzVyPUWuOlIxOzJizszN MlfNV2FPT0WU
LOXIMVI M3nJ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTVwNkO4O|Mh|ryP NYPmW2dLW0GQR1XS
LS-411N M4jZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fRfmlEPTB;NT63PVQ1OSEQvF2= NGD0VlRUSU6JRWK=
NCI-H2291 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTNdIdKSzVyPUWuPVg6PDNizszN NX70VZRNW0GQR1XS
A549 M13tdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTZwMUK1OVMh|ryP M2rXfHNCVkeHUh?=
LS-1034 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn4XFhSUUN3ME22MlIxPzB4IN88US=> M1\3bnNCVkeHUh?=
NB14 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTZwNEO4N|Yh|ryP NYDaXI5[W0GQR1XS
NCI-H1299 M{XYW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;kRWlEPTB;Nj62N|E4OSEQvF2= NIHUd4VUSU6JRWK=
BT-549 NWD5R4FjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXHTWM2OD14Lk[2PFg6KM7:TR?= NFvSfW5USU6JRWK=
J-RT3-T3-5 M3O0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfnOVJwUUN3ME22Mlg3QSEQvF2= M2LjUnNCVkeHUh?=
SW756 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTZwOUGxO|Yh|ryP M{LlV3NCVkeHUh?=
DJM-1 M3:4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\Jdo1uUUN3ME22MlkzODF{IN88US=> MnnTV2FPT0WU
GP5d MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHy3V2ZKSzVyPU[uPVc{QTRizszN MVfTRW5ITVJ?
MOLT-4 NEO1NGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL3TWM2OD15LkCyNVM2KM7:TR?= M{[xVXNCVkeHUh?=
NCI-H28 MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXWVIxxUUN3ME23MlE3PDB3IN88US=> NIfwW3lUSU6JRWK=
MN-60 M{foPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW3TWM2OD15LkK4NFg6KM7:TR?= NFfXR|VUSU6JRWK=
RMG-I MnTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV76NWM3UUN3ME23MlM6Ojl4IN88US=> MVPTRW5ITVJ?
COLO-800 M{TUWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHYTWM2OD15LkSxOFQ3KM7:TR?= MnzDV2FPT0WU
DB NHGzb5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPyTWM2OD15Lk[xNFA2KM7:TR?= Ml\6V2FPT0WU
Ca-Ski MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTdwNkSyOVkh|ryP Mlm0V2FPT0WU
HEL MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTdwN{GyNFMh|ryP NULNSpRRW0GQR1XS
NH-12 NYK5cGFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nPXWlEPTB;Nz63NlgxQCEQvF2= NVSwT4ZDW0GQR1XS
LB373-MEL-D MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPzb3RKSzVyPUeuO|Y4PzFizszN NXzmV45SW0GQR1XS
SW900 NXzwbJNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLYTY5KSzVyPUeuPFIyOjFizszN M{n3fXNCVkeHUh?=
JVM-3 M3jMOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVy4UYdvUUN3ME23Mlg6PTl7IN88US=> MUDTRW5ITVJ?
OAW-28 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnVTWM2OD15Lkm0OVc5KM7:TR?= MlrZV2FPT0WU
KURAMOCHI MmnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XYcWlEPTB;Nz65OFgyOSEQvF2= MX\TRW5ITVJ?
BE-13 M3y5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLpfZVKSzVyPUeuPVgyOTJizszN MnfaV2FPT0WU
VMRC-RCZ M4j1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETyToNKSzVyPUiuNFE3QTdizszN M4\3d3NCVkeHUh?=
NCI-H727 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\2TWM2OD16LkGwOFIh|ryP NWLkeVliW0GQR1XS
SW1710 NWHoPJh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[5fFRKSzVyPUiuNVg2OTVizszN MlfGV2FPT0WU
D-502MG MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\YV|VKSzVyPUiuNlkzQDJizszN M3;jNHNCVkeHUh?=
NCI-H1993 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fxeGlEPTB;OD6zN|Y{OSEQvF2= M3ficHNCVkeHUh?=
SCC-4 M2\iemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrCTohkUUN3ME24MlQ1ODV7IN88US=> NH\1TXNUSU6JRWK=
HAL-01 Mmr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHq3cpZKSzVyPUiuOVE6OSEQvF2= NFLXd3hUSU6JRWK=
GT3TKB NUfS[ZQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRThwNke5OlQh|ryP NFXseGxUSU6JRWK=
SK-OV-3 NH;CfIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml21TWM2OD16LkexN|I6KM7:TR?= M4DqbXNCVkeHUh?=
COLO-829 M4jNUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[xTWM2OD16LkiwPVc3KM7:TR?= Ml36V2FPT0WU
OCI-AML2 NEHOVG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWq5bGtCUUN3ME24Mlk2PDhzIN88US=> MVfTRW5ITVJ?
OS-RC-2 NX;oepZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPYXpZKSzVyPUmuNFIyQSEQvF2= MW\TRW5ITVJ?
BFTC-909 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLrc2tRUUN3ME25MlA3Pzl7IN88US=> MV;TRW5ITVJ?
EW-11 NHjYdJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O5WWlEPTB;OT6xO|Y2OyEQvF2= MUDTRW5ITVJ?
HCE-4 M3HHcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfUe21[UUN3ME25MlIyPTV6IN88US=> NE[1TnpUSU6JRWK=
BALL-1 NVPaWY4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnvTWM2OD17LkKxPVA4KM7:TR?= Mmm0V2FPT0WU
SF539 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTMdZdNUUN3ME25MlI{PTZ{IN88US=> NWPCT3E{W0GQR1XS
CAMA-1 Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULzSplbUUN3ME25MlI5OTJ6IN88US=> NF74UolUSU6JRWK=
C32 NXqx[otRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjHRoJKSzVyPUmuN|MxPjRizszN NE[0ZpBUSU6JRWK=
NCI-H1703 NFv3c3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTyTWM2OD17LkO0N|c2KM7:TR?= Mor0V2FPT0WU
NCI-H1650 NXG5c2hFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DlWGlEPTB;OT62NFk1PiEQvF2= NFvqN3hUSU6JRWK=
NCI-H1563 M3:0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTlwN{[wN|Eh|ryP MV;TRW5ITVJ?
CAL-85-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHuenNKSzVyPUmuPFc{QDNizszN NYr0VZNNW0GQR1XS
UM-UC-3 M2rCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3FTWM2OD17Lkm1NFMh|ryP NVG2Wlk{W0GQR1XS
BxPC-3 MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrzbohKSzVyPUGwMlA6PzJizszN NXHMco44W0GQR1XS
MHH-PREB-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfxVnNKSzVyPUGwMlE6QTlizszN M4T3WXNCVkeHUh?=
DEL MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4raXWlEPTB;MUCuN|k1PiEQvF2= MXzTRW5ITVJ?
HuCCT1 MmDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XnN2lEPTB;MUCuOlA{OyEQvF2= MX3TRW5ITVJ?
OVCAR-4 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnKWmJFUUN3ME2xNE45QDN3IN88US=> NUe5e5UzW0GQR1XS
CAL-72 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\qd3ZKSzVyPUGwMlk{QTFizszN MVvTRW5ITVJ?
HCC1954 NH;ZV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTFzLkC3OVQh|ryP MUTTRW5ITVJ?
EFO-21 M1\wPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;GTWM2OD1zMT6xNFQ2KM7:TR?= MXHTRW5ITVJ?
FTC-133 MmK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPpTWM2OD1zMT6xOFA4KM7:TR?= MVnTRW5ITVJ?
SK-MEL-24 M2LIb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LtUWlEPTB;MUGuNlM3PiEQvF2= NVrDXY5NW0GQR1XS
UACC-62 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLoNotMUUN3ME2xNU4zOzZ6IN88US=> Mom3V2FPT0WU
NCI-H650 MmHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvLNVVKSzVyPUGxMlI1OThizszN NGW1VGxUSU6JRWK=
ALL-PO M4jGOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi3O29tUUN3ME2xNU4zPTF{IN88US=> MV\TRW5ITVJ?
T84 M2LKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTFzLkO5NFch|ryP Mn\jV2FPT0WU
IST-MEL1 MlXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HNPWlEPTB;MUGuOFU2QSEQvF2= NIrHUplUSU6JRWK=
SW626 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTFzLkW3OVUh|ryP M2jvZ3NCVkeHUh?=
RPMI-2650 MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFzLkW4PFUh|ryP NELDb45USU6JRWK=
MC-IXC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P6PWlEPTB;MUGuOlczQCEQvF2= M2PHTnNCVkeHUh?=
HOP-62 M1XLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D0emlEPTB;MUGuOlc3PCEQvF2= M{Tqd3NCVkeHUh?=
NOS-1 NXLmcmZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi3TWM2OD1zMT63NVA6KM7:TR?= MWTTRW5ITVJ?
SW1573 NXnUcpVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGT1[m9KSzVyPUGxMlczQTVizszN NH3Vc25USU6JRWK=
WM-115 MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;zbWVWUUN3ME2xNU44PTh6IN88US=> MnvBV2FPT0WU
HuO9 NGHWc3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr0TWM2OD1zMT64O|c1KM7:TR?= NFvaN4dUSU6JRWK=
YAPC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTFzLkmyOVkh|ryP MljFV2FPT0WU
MDA-MB-453 NGf5NGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTiNHNKSzVyPUGxMlk2OTVizszN NYn2VmlEW0GQR1XS
NCI-H596 M33sTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHlbIlSUUN3ME2xNk4xOzZ7IN88US=> MYrTRW5ITVJ?
A172 NW\HWWNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\UTWM2OD1zMj6wO|k5KM7:TR?= NEDqT3RUSU6JRWK=
RS4-11 M3j6Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvUTWM2OD1zMj6xO|I2KM7:TR?= NGq1RmtUSU6JRWK=
HCC1937 NWTxTGc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfjTWM2OD1zMj63OVY1KM7:TR?= NX;KVXBNW0GQR1XS
SW837 NIOxUoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nsOGlEPTB;MUKuPVAzQCEQvF2= NF7BbXBUSU6JRWK=
NMC-G1 NUewfo1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXuTWM2OD1zMj65NlM1KM7:TR?= NVWzZVVIW0GQR1XS
PFSK-1 MmDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTF|LkC2JO69VQ>? NXLYeZpxW0GQR1XS
DBTRG-05MG NIrVWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LReWlEPTB;MUOuNFY{OiEQvF2= MnnDV2FPT0WU
SK-UT-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq2SZduUUN3ME2xN{4yODh|IN88US=> NVzZc|l1W0GQR1XS
OVCAR-5 Mn[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTF|LkG1PVMh|ryP MoPWV2FPT0WU
8505C M3HhSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\QXIh2UUN3ME2xN{4zODZ5IN88US=> MVrTRW5ITVJ?
SK-MEL-1 NFHJZ3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTF|LkexN|Uh|ryP MXvTRW5ITVJ?
LK-2 M3;ETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTF|Lke2N|kh|ryP M3yyR3NCVkeHUh?=
OE33 MlLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHuwVY1KSzVyPUGzMlc5PiEQvF2= NYm3bI11W0GQR1XS
Ramos-2G6-4C10 MmPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTF2LkCyNFIh|ryP MmHiV2FPT0WU
EW-13 M3XtT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTF2LkCzOVIh|ryP M4HBW3NCVkeHUh?=
NCI-H1793 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTF2LkKwPFch|ryP MXTTRW5ITVJ?
BHT-101 NUfRZZRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;BTWM2OD1zND6yOFEh|ryP NIjwZ4pUSU6JRWK=
RKO M2i4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljxTWM2OD1zND61NFc2KM7:TR?= MYDTRW5ITVJ?
NEC8 MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\Vb45EUUN3ME2xOE42PDd{IN88US=> MVHTRW5ITVJ?
PANC-10-05 NXvIPFQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPxeG5KSzVyPUG0MlYzPDdizszN NXjBdYV7W0GQR1XS
NCI-H2030 NIDxeYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF2Lk[0OFgh|ryP M3G3WnNCVkeHUh?=
C2BBe1 M{KwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF2Lke2OEDPxE1? MXfTRW5ITVJ?
EM-2 NGSzSJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzJO5BKSzVyPUG0Mlg2PzZizszN NGT5WZJUSU6JRWK=
HCC1395 NIro[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ntN2lEPTB;MUSuPVM{QCEQvF2= NXPPXoJ1W0GQR1XS
A2058 NEHGcXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTF3LkC0NFkh|ryP M4PxSHNCVkeHUh?=
SW1463 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX5WIFKSzVyPUG1MlA1QDVizszN MmLoV2FPT0WU
J82 M{LiUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;TTWM2OD1zNT6wOVch|ryP NYjKWWg{W0GQR1XS
CAL-120 NVTmVm5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTF3LkG0OFch|ryP NHzscWNUSU6JRWK=
COLO-824 Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXFfZBKSzVyPUG1MlE2PzlizszN MkHIV2FPT0WU
LNCaP-Clone-FGC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTXRYtoUUN3ME2xOU41OjR6IN88US=> NGTob3pUSU6JRWK=
CP66-MEL M{fyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHNXZVKSzVyPUG1MlQ3QDhizszN MXLTRW5ITVJ?
OC-314 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;jTWM2OD1zNT60O|E1KM7:TR?= MVvTRW5ITVJ?
OVCAR-8 NV;IV4tWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle5TWM2OD1zNT64PFYyKM7:TR?= MYLTRW5ITVJ?
MFE-280 MnXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq0O2k1UUN3ME2xOk4xPDh6IN88US=> NVzaVpR4W0GQR1XS
MHH-NB-11 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPaRlBqUUN3ME2xOk4xQDN7IN88US=> Mm\LV2FPT0WU
SW1990 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPkTWM2OD1zNj6xO|U2KM7:TR?= MYjTRW5ITVJ?
U-266 NFnXSpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;NSlViUUN3ME2xOk4zOjl7IN88US=> NELIdY1USU6JRWK=
MFM-223 MnXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nr[GlEPTB;MU[uN|k3PSEQvF2= M3TnfHNCVkeHUh?=
L-363 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTF4LkS1O|ch|ryP NV3y[3VqW0GQR1XS
MCF7 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jwbmlEPTB;MU[uOFczOyEQvF2= NEf1NlRUSU6JRWK=
SK-MEL-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvETWM2OD1zNj60O|g4KM7:TR?= NUHXRXRSW0GQR1XS
HH NHX3empIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7JdoZKSzVyPUG2MlUyPjJizszN NUj5d2RIW0GQR1XS
no-10 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1[0bGlEPTB;MU[uOlM1OyEQvF2= NVPmPIdHW0GQR1XS
HuP-T3 M2\xVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[0SGlEPTB;MU[uOlU4PiEQvF2= M{n1O3NCVkeHUh?=
QIMR-WIL NYHHRmtuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jUUWlEPTB;MU[uO|ExPSEQvF2= M3PyWHNCVkeHUh?=
NCI-H1092 NEPoNpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\ZZ|cxUUN3ME2xOk45OzF4IN88US=> MYTTRW5ITVJ?
MZ2-MEL MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7KTWM2OD1zNj64OFA{KM7:TR?= MWLTRW5ITVJ?
ES3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DYUWlEPTB;MU[uPVE{PCEQvF2= MXnTRW5ITVJ?
COLO-684 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHhUmpKSzVyPUG2Mlk1PzdizszN MWnTRW5ITVJ?
NCI-H661 NXfYOFBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnzdpVKSzVyPUG2Mlk3QTRizszN MnviV2FPT0WU
CP50-MEL-B NEPYS2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPP[Jk5UUN3ME2xO{4xOzR|IN88US=> MXjTRW5ITVJ?
NCI-H2405 MnnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTF5LkG5O|Qh|ryP NUDDRVR3W0GQR1XS
U-2-OS NYK4b21JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTaNYh2UUN3ME2xO{42OzB5IN88US=> M17BenNCVkeHUh?=
RERF-LC-MS NYH1OZFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPpTWM2OD1zNz61OVA5KM7:TR?= NXXzc2dYW0GQR1XS
NCI-H2342 M3PROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjFZWFkUUN3ME2xO{42PTdizszN MlrZV2FPT0WU
ES8 NXu1NmN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r3W2lEPTB;MUeuOlA5PyEQvF2= M3PvSnNCVkeHUh?=
MOLT-16 M3;ibmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLMTWM2OD1zNz64PVM1KM7:TR?= MmPGV2FPT0WU
RH-18 NYLBWoExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTNTWM2OD1zOD6wNFM2KM7:TR?= NFfVc3JUSU6JRWK=
D-283MED NFPYUJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPETWM2OD1zOD6wNFg5KM7:TR?= M1zXcXNCVkeHUh?=
RCC10RGB Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO1ZWRKSzVyPUG4MlA2PTlizszN M4Lt[nNCVkeHUh?=
NCI-H1437 NVfZeI12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXyTWM2OD1zOD6xOlQyKM7:TR?= MWDTRW5ITVJ?
SW982 M4e2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{myVGlEPTB;MUiuNlY4OSEQvF2= NFPpepVUSU6JRWK=
IST-MES1 M2HGUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rCSmlEPTB;MUiuOFQzQCEQvF2= NWLOWHV5W0GQR1XS
A704 M2H0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoToTWM2OD1zOD60O|U{KM7:TR?= M{POe3NCVkeHUh?=
ESS-1 NF\BTHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe4TWM2OD1zOD61NlA2KM7:TR?= M4XUfnNCVkeHUh?=
SCH MlTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLobGNqUUN3ME2xPE43PDV4IN88US=> NEDBR49USU6JRWK=
COLO-320-HSR NHH2VZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojoTWM2OD1zOD63OFYh|ryP MX;TRW5ITVJ?
Mo-T MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV62[G5TUUN3ME2xPE45OjB2IN88US=> NUXROWxOW0GQR1XS
Saos-2 NYP3doNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr5R5lKSzVyPUG5MlEyPjJizszN NWHV[FdZW0GQR1XS
SW684 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jEW2lEPTB;MUmuNVMzPiEQvF2= MorCV2FPT0WU
KMOE-2 NYTtW3I3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnITWM2OD1zOT6yNlQzKM7:TR?= NXTyUVdiW0GQR1XS
MMAC-SF M{nTV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTF7LkK2NFch|ryP NYjWT|RVW0GQR1XS
JAR NFjGVWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nP[GlEPTB;MUmuNlk6KM7:TR?= Mof0V2FPT0WU
SK-MEL-28 MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K1XmlEPTB;MUmuN|M3OyEQvF2= MUTTRW5ITVJ?
KNS-81-FD NX60Vm51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fVOmlEPTB;MUmuOVQ3QCEQvF2= M2\jTHNCVkeHUh?=
ES7 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTF7Lk[yPVIh|ryP NUnqT5lWW0GQR1XS
AsPC-1 M4rOTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELsemdKSzVyPUG5MlY1PzFizszN MYjTRW5ITVJ?
NCI-H1155 M3fWUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTF7LkeyN|gh|ryP MmfpV2FPT0WU
KYSE-510 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTF7Lki3OFgh|ryP NVLSU3RXW0GQR1XS
ES1 MlfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn5SJVKSzVyPUG5MlkzOTNizszN NH7XVJFUSU6JRWK=
PC-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnwV5FKSzVyPUG5Mlk3ODRizszN MXfTRW5ITVJ?
GCT NEPoOWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrCV3hKSzVyPUKwMlMxOjZizszN NXrP[nF[W0GQR1XS
KARPAS-299 NHnLUJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jHXWlEPTB;MkCuN|QzOiEQvF2= NHzKZ3VUSU6JRWK=
DOHH-2 M1fncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;3TWM2OD1{MD61OFY{KM7:TR?= NVjVTGRCW0GQR1XS
COLO-741 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TucmlEPTB;MkCuOlYh|ryP M1rIbnNCVkeHUh?=
NCI-H1395 M{fIUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjJZZl2UUN3ME2yNE43Pjl5IN88US=> MXHTRW5ITVJ?
HCC1187 NXH2WHNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjMNXZHUUN3ME2yNE43PzN2IN88US=> MUXTRW5ITVJ?
Becker MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTsTWM2OD1{MD63NlAyKM7:TR?= MnPBV2FPT0WU
LU-134-A NViybHNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTJzLkGwNlYh|ryP M2rucXNCVkeHUh?=
MKN45 NV\YNFU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJzLkG1OVEh|ryP M2DzTXNCVkeHUh?=
LC-2-ad NXHH[pE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG2VVJYUUN3ME2yNU4zPzJ7IN88US=> MkDTV2FPT0WU
EW-24 NW\BSG51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJzLkO5OFUh|ryP MorMV2FPT0WU
SK-N-AS M2DlfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvFbGNKSzVyPUKxMlgzPzZizszN MUDTRW5ITVJ?
NCI-H2052 NH7JTIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJzLki5OlMh|ryP NH7BUZBUSU6JRWK=
A4-Fuk NXv5O2JQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJ{LkG0NVkh|ryP NHnJZ|JUSU6JRWK=
NB10 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjzeVg6UUN3ME2yNk4zOzdzIN88US=> MXvTRW5ITVJ?
CHP-212 MkPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HPNGlEPTB;MkKuN|IzOiEQvF2= M{frZnNCVkeHUh?=
KM12 NIO4V25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ{LkO1OkDPxE1? NGnWRWNUSU6JRWK=
JEG-3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17NfWlEPTB;MkKuN|c5KM7:TR?= M2\WenNCVkeHUh?=
LN-405 MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHMTWM2OD1{Mj61PVE{KM7:TR?= NFG5RmVUSU6JRWK=
HCT-15 M3HOe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP5TWM2OD1{Mj63OFQyKM7:TR?= MVvTRW5ITVJ?
MLMA NI\WVlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJ{Lke0O{DPxE1? MYHTRW5ITVJ?
GI-1 MlPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTJ{Lke2OVgh|ryP MV;TRW5ITVJ?
RT-112 NWDVRpA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17YR2lEPTB;MkKuPFYyPiEQvF2= MYjTRW5ITVJ?
MPP-89 M4jHNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2WzbGlEPTB;MkKuPFY3OSEQvF2= M{fTenNCVkeHUh?=
A3-KAW NInBWpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1m4dGlEPTB;MkOuNVAxOyEQvF2= Ml7HV2FPT0WU
KALS-1 MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HlcmlEPTB;MkOuNVQyPCEQvF2= M3rWeHNCVkeHUh?=
SF126 M1rNdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{G0fGlEPTB;MkOuOlkzPCEQvF2= NWr5W4NHW0GQR1XS
SiHa NV7tPHBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTJ|LkmzNlch|ryP NVLKcYEyW0GQR1XS
MDA-MB-415 NFHFSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGexUndKSzVyPUKzMlk1QTlizszN NVjXd5FnW0GQR1XS
Daoy MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PROWlEPTB;MkSuNVI3KM7:TR?= MVXTRW5ITVJ?
COR-L23 MorCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTtTWM2OD1{ND6xO|Y4KM7:TR?= NEjRPVRUSU6JRWK=
KG-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\Uc5FKSzVyPUK0MlE6OjhizszN M1zGeHNCVkeHUh?=
L-428 Mo[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonCTWM2OD1{ND61O|kyKM7:TR?= NVv2WppNW0GQR1XS
NCI-H520 Mn7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLhTWM2OD1{ND64PFYyKM7:TR?= MXLTRW5ITVJ?
COLO-792 MmnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\6bGlEPTB;MkWuNlc{OiEQvF2= NVPOco8zW0GQR1XS
NB12 NIDnSWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjNc3RJUUN3ME2yOU4zQTR5IN88US=> MXTTRW5ITVJ?
GAK MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fC[2lEPTB;MkWuNlk3OyEQvF2= MWjTRW5ITVJ?
SW780 M3n5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTyRll4UUN3ME2yOU4{OjZ2IN88US=> M1;CeXNCVkeHUh?=
GB-1 NH\BbGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnGxTWM2OD1{NT60NFY6KM7:TR?= NV\z[Yl2W0GQR1XS
P12-ICHIKAWA MlT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zUTmlEPTB;MkWuOFc5PSEQvF2= M1TGVXNCVkeHUh?=
NCI-H1651 M{\HXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvMTWM2OD1{NT61PVch|ryP NF;IWpdUSU6JRWK=
KE-37 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjOXYZKSzVyPUK1Mlc{OTVizszN MonQV2FPT0WU
CCRF-CEM NYnBWGxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PGPWlEPTB;MkWuPVY4KM7:TR?= MnK3V2FPT0WU
SF295 MoXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjtUpVKSzVyPUK2MlA1OjVizszN MnXZV2FPT0WU
G-361 MnG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTJ4LkGwNlch|ryP M2XWWXNCVkeHUh?=
HOP-92 MoWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofkTWM2OD1{Nj6xNlI3KM7:TR?= NWfxPYRkW0GQR1XS
UMC-11 NFvYTI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;ZZ3ZKSzVyPUK2MlQ2OTRizszN MXvTRW5ITVJ?
IST-SL1 NHPwW3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7FTWM2OD1{Nj62OVkyKM7:TR?= M1LN[3NCVkeHUh?=
TE-11 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoriTWM2OD1{Nj63O|UzKM7:TR?= MlzmV2FPT0WU
NCI-H1304 NHPZdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJ4LkmxNFgh|ryP NU\BVIh2W0GQR1XS
SJSA-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzD[4VKSzVyPUK3MlAyPzZizszN Mn;XV2FPT0WU
BCPAP MlHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjBS2JKUUN3ME2yO{4yOzdizszN MVnTRW5ITVJ?
HTC-C3 M2qwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX4TWM2OD1{Nz6yOVYyKM7:TR?= M1XvfHNCVkeHUh?=
EW-16 M2D1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJ5LkK5OFch|ryP NWXnfXlUW0GQR1XS
HT-144 NHW3eHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHuTWM2OD1{Nz60NFMzKM7:TR?= NWTIcHh4W0GQR1XS
MHH-ES-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnCTWM2OD1{Nz60OFQ4KM7:TR?= NX;DUW5PW0GQR1XS
T98G MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULiPYVrUUN3ME2yO{42QDR4IN88US=> NECwNJhUSU6JRWK=
RPMI-8866 NFrjOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zETGlEPTB;MkeuO|U3OiEQvF2= MmrHV2FPT0WU
BEN NVjkT4tsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLtWZBJUUN3ME2yO{45PTF5IN88US=> M{f3e3NCVkeHUh?=
MDA-MB-231 MmPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fVOWlEPTB;MkiuNlc6PSEQvF2= MY\TRW5ITVJ?
HuH-7 M2Pabmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XwbWlEPTB;MkiuOFAzQCEQvF2= M17HdHNCVkeHUh?=
SK-N-FI NEjxVnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;wTmVKSzVyPUK4MlQ{OyEQvF2= M3jGT3NCVkeHUh?=
AN3-CA NVnYfIY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLtTWM2OD1{OD60N|k2KM7:TR?= NEPQRlNUSU6JRWK=
EGI-1 NF7SVHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HKemlEPTB;MkiuOVkzQCEQvF2= MofQV2FPT0WU
697 NVfzWFgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3NcmZIUUN3ME2yPE43OzNzIN88US=> NGDKOG5USU6JRWK=
TCCSUP MnHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJ6Lk[0NVgh|ryP NHTudG5USU6JRWK=
GR-ST NXvl[YRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnlcZVKSzVyPUK4MlY3QTZizszN Ml\RV2FPT0WU
SK-N-DZ Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrzU3RvUUN3ME2yPE43QDh3IN88US=> M1PMVnNCVkeHUh?=
MIA-PaCa-2 NIHJU3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTJ6Lke5OVkh|ryP M2qxRnNCVkeHUh?=
IGR-1 NFrZfmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTJ6Lki4O|Qh|ryP M2\GSnNCVkeHUh?=
BFTC-905 M3e5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3kTWM2OD1{OT6yO|A2KM7:TR?= NXS3RmRHW0GQR1XS
NCI-H1581 NGDZR5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFSxVI5KSzVyPUK5MlMyPDVizszN M3q1OXNCVkeHUh?=
RD Mmr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJ7LkWyN|Mh|ryP NUDzWJh6W0GQR1XS
SF268 M1vHSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJ7LkW5N|Eh|ryP NH\3c3BUSU6JRWK=
SHP-77 NHf4RVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4K2VmlEPTB;MkmuOlE5OiEQvF2= NYjBWppoW0GQR1XS
D-566MG M4LFO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfaW5Y1UUN3ME2yPU46Ozl|IN88US=> NXm4fYJoW0GQR1XS
TGBC1TKB MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K4RWlEPTB;M{CuNVI{QCEQvF2= NEfFW3BUSU6JRWK=
MEL-HO NWrQblhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHkTWM2OD1|MD6xOFI{KM7:TR?= M3T6R3NCVkeHUh?=
SJRH30 M2PVXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTNyLkKxNFgh|ryP MUnTRW5ITVJ?
D-336MG MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjDbIlIUUN3ME2zNE4zQDl{IN88US=> NEjxTVFUSU6JRWK=
C3A NEXB[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTNyLkK5Nlch|ryP MW\TRW5ITVJ?
Calu-6 M131Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HrSWlEPTB;M{CuNlk3OyEQvF2= NH2xdnZUSU6JRWK=
MZ1-PC Mn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfPW|lKSzVyPUOwMlM6OyEQvF2= MVrTRW5ITVJ?
KYSE-70 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorvTWM2OD1|MD61NVE1KM7:TR?= MYrTRW5ITVJ?
CAPAN-1 NGrKWW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3oZZp{UUN3ME2zNE42OThzIN88US=> M1\qTHNCVkeHUh?=
DK-MG MkjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkP2TWM2OD1|MD61OFU3KM7:TR?= NH2zSlBUSU6JRWK=
SK-HEP-1 M1XLOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHCbJVKSzVyPUOwMlY{OjZizszN NVrCRZFyW0GQR1XS
MS-1 NHe0[XFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTNyLki4PFkh|ryP NV;ZS|J2W0GQR1XS
GI-ME-N MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrlTWM2OD1|MT6wOVcyKM7:TR?= MUXTRW5ITVJ?
NCI-H510A MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\WTWM2OD1|MT60NFA3KM7:TR?= NGHSdoJUSU6JRWK=
NB17 M{PtZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTRTWM2OD1|MT61NVg2KM7:TR?= MY\TRW5ITVJ?
639-V Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PrdGlEPTB;M{GuOVI1OyEQvF2= MnXPV2FPT0WU
CAL-51 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPrTWM2OD1|MT61OlY4KM7:TR?= M1jGNXNCVkeHUh?=
HGC-27 NW\ieZNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTNzLkW4O|Mh|ryP NVj3PZVJW0GQR1XS
GOTO Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTu[HM3UUN3ME2zNU45PTB4IN88US=> Mkm0V2FPT0WU
ChaGo-K-1 Mn[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTN{LkCwO{DPxE1? NUS1PGVkW0GQR1XS
RO82-W-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fuRWlEPTB;M{KuNVYxPCEQvF2= NVLEUWtDW0GQR1XS
SH-4 NHe0eVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnvTWM2OD1|Mj6xPFU5KM7:TR?= Mmn2V2FPT0WU
A204 NU\UfIRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rZPWlEPTB;M{KuOVA3QSEQvF2= NEjQNppUSU6JRWK=
DMS-273 M{e4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3RU4dKSzVyPUOyMlU{OjJizszN Mmj3V2FPT0WU
KGN MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITRNI9KSzVyPUOyMlY{OyEQvF2= MnvvV2FPT0WU
SK-MEL-2 NGnpellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTN{Lk[1Nlch|ryP MXPTRW5ITVJ?
NCI-H2228 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfQV|dbUUN3ME2zNk43PjB{IN88US=> M4TLXXNCVkeHUh?=
MKN28 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTN{Lke4N|gh|ryP M{fWd3NCVkeHUh?=
H-EMC-SS NELsWGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfuTWM2OD1|Mj65Olc5KM7:TR?= MmP5V2FPT0WU
ATN-1 NFi2fpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\1UFlKSzVyPUOzMlE1OTZizszN NXvj[GZYW0GQR1XS
D-263MG NGnqfZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDEXWdKSzVyPUOzMlg{PzhizszN NYrxUFZ{W0GQR1XS
LU-135 M13v[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrGVZVKSzVyPUOzMlg5OjlizszN M33sOnNCVkeHUh?=
C8166 Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\3PYpPUUN3ME2zN{45QDV2IN88US=> MWjTRW5ITVJ?
T-24 Moi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTNSZhKSzVyPUO0MlAzODVizszN NF;wRWxUSU6JRWK=
Mewo NHPWOIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTRTW42UUN3ME2zOE4yOzR7IN88US=> MYTTRW5ITVJ?
22RV1 NGDBcFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjyTWM2OD1|ND6xO|U1KM7:TR?= MVzTRW5ITVJ?
KM-H2 Moi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTN2LkG3O|kh|ryP MnvDV2FPT0WU
NCI-H2122 MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnkV4RQUUN3ME2zOE4{PDdzIN88US=> M4fne3NCVkeHUh?=
ABC-1 NXzrWXFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjLSFBKSzVyPUO0MlM3QTNizszN MVrTRW5ITVJ?
NCI-H1355 M3\3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonrTWM2OD1|ND6zPFg6KM7:TR?= NIjLeppUSU6JRWK=
NOMO-1 M1\z[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LUOGlEPTB;M{SuOVcxOyEQvF2= NWP2fpVzW0GQR1XS
MZ7-mel MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTXTWM2OD1|ND62OFg4KM7:TR?= MYrTRW5ITVJ?
NCI-H810 NW\yV3NwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGracnZKSzVyPUO0MlczPzhizszN NWC4NGxSW0GQR1XS
D-392MG M3zwc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTN3LkC1OlUh|ryP MWnTRW5ITVJ?
LB771-HNC NHPqe4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTOTWM2OD1|NT6xOlU5KM7:TR?= NHH4OZFUSU6JRWK=
COLO-679 NUPJdJp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXsTWM2OD1|NT6zPFgh|ryP NUXy[IVXW0GQR1XS
SK-PN-DW Mk\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj1TWM2OD1|NT60N|Y6KM7:TR?= MUnTRW5ITVJ?
VA-ES-BJ MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPEfnhpUUN3ME2zOU41PjR7IN88US=> MonLV2FPT0WU
KNS-42 NEHVN2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPYTWM2OD1|NT61PFI3KM7:TR?= MlvHV2FPT0WU
RVH-421 MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fPd2lEPTB;M{WuO|Y1PSEQvF2= M4jpdXNCVkeHUh?=
P30-OHK NYTxbmZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDidJJKSzVyPUO1Mlg4PTJizszN M1GxOnNCVkeHUh?=
G-402 M2nuTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfsTWM2OD1|NT65PFY4KM7:TR?= MXjTRW5ITVJ?
S-117 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PRfWlEPTB;M{[uN|AxQCEQvF2= NHzxVYRUSU6JRWK=
RXF393 NHm2c3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jPfmlEPTB;M{[uN|c5PSEQvF2= MlHTV2FPT0WU
LCLC-103H NFnpTVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPlOndLUUN3ME2zOk44QDB|IN88US=> NV\qVXFbW0GQR1XS
U-118-MG M3\HUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH32UVhKSzVyPUO2Mlg5PDdizszN NH65R2JUSU6JRWK=
8-MG-BA MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrNUnhtUUN3ME2zOk46PDh|IN88US=> NFe0eI5USU6JRWK=
MFH-ino M4nZdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPXcVN3UUN3ME2zO{4{OzdzIN88US=> MofoV2FPT0WU
NCI-H23 MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInkeXFKSzVyPUO3MlQyQTZizszN NX[wNIEzW0GQR1XS
NCI-H446 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTN5LkS4OlIh|ryP NFrPOm9USU6JRWK=
LU-99A MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjiTWM2OD1|Nz61O|MyKM7:TR?= NYHWVZV2W0GQR1XS
KP-N-YN MnP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f2OmlEPTB;M{euOlE6PSEQvF2= M1rOdHNCVkeHUh?=
SCC-9 NVyzTIFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTN5Lke4N|gh|ryP Ml:xV2FPT0WU
EFM-19 M2LBWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3FTWM2OD1|Nz63PVY4KM7:TR?= MYDTRW5ITVJ?
A427 Mke4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLjO2lqUUN3ME2zO{46OTB5IN88US=> NHP1Zo1USU6JRWK=
LB831-BLC NFPye|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml74TWM2OD1|OD62NFM6KM7:TR?= MV3TRW5ITVJ?
HOS MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4C0TGlEPTB;M{muOlI4OyEQvF2= NYLUU25DW0GQR1XS
LAN-6 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlOxTWM2OD12MD6wNVEzKM7:TR?= MkPtV2FPT0WU
U251 MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnFTWM2OD12MD60NFU1KM7:TR?= NVLZVGM2W0GQR1XS
SNU-387 NYPXbnZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTRyLkS1OVMh|ryP MkG3V2FPT0WU
DMS-79 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTRyLkW4PFkh|ryP M3Hm[HNCVkeHUh?=
SK-LU-1 M{TINmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHmRZFKSzVyPUSwMlY2PjhizszN MVvTRW5ITVJ?
HT NYiybZBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nIOGlEPTB;NECuOlY{QSEQvF2= M1LocHNCVkeHUh?=
KP-N-YS MnvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX1SIdKSzVyPUSwMlY4PjhizszN M3LnbHNCVkeHUh?=
DMS-114 M2PRT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTRyLkizO|Qh|ryP Ml3HV2FPT0WU
HUTU-80 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUn3c4RjUUN3ME20NU4xPTZ7IN88US=> M164OnNCVkeHUh?=
ONS-76 M2jFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrD[pNKSzVyPUSxMlQ4ODlizszN M4[1fXNCVkeHUh?=
A673 M4PIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTRzLkWxOVch|ryP NUjVVYZFW0GQR1XS
HPAF-II M3XzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HNeWlEPTB;NEGuOlcxQSEQvF2= NFvhZVFUSU6JRWK=
UACC-257 NXu3[WRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTaTWM2OD12MT63N|Y6KM7:TR?= MVLTRW5ITVJ?
EW-22 MlTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTRzLki2PVch|ryP MYjTRW5ITVJ?
NCI-H1755 MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS4TWM2OD12MT64O|I2KM7:TR?= MmW3V2FPT0WU
KYSE-150 Mn\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\2TWM2OD12Mj6xO|gzKM7:TR?= M1nlPHNCVkeHUh?=
CGTH-W-1 NGjKZVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnmTWM2OD12Mj60PVU2KM7:TR?= MV3TRW5ITVJ?
NB13 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV34eopmUUN3ME20Nk43OjF5IN88US=> NYHyTItmW0GQR1XS
SW872 MnnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHjRoVKSzVyPUSyMlY{OzFizszN MnrkV2FPT0WU
KP-4 M4PzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTR{Lki4N|Ih|ryP NF6yfoZUSU6JRWK=
HCC38 NHG1WYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fwW2lEPTB;NEKuPVYyQCEQvF2= M{K4OXNCVkeHUh?=
BB49-HNC MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTR|LkKzOVYh|ryP NWmy[W1{W0GQR1XS
CAL-62 NF;zUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTR|LkSwNlgh|ryP NFLkVmZUSU6JRWK=
NCI-H2029 M3fofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTR|LkW1PFEh|ryP MkXLV2FPT0WU
M14 NYLKTldDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTLZ4xZUUN3ME20OE4yOzN{IN88US=> NVPBbYhiW0GQR1XS
COLO-680N MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTR2LkOzPUDPxE1? MYrTRW5ITVJ?
Hs-578-T NYq2dnNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTR3LkCyPVQh|ryP MoDkV2FPT0WU
MSTO-211H NHHXTnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTZTWM2OD12NT65OFgzKM7:TR?= MXnTRW5ITVJ?
EW-1 M3[xN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\Lc2lEPTB;NEWuPVY5QSEQvF2= M3;6fHNCVkeHUh?=
SW948 M2\GSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTxTWM2OD12Nj60OFYzKM7:TR?= M1:z[nNCVkeHUh?=
NCI-H460 MmXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\LN5FKSzVyPUS2MlUzOyEQvF2= MVnTRW5ITVJ?
CAS-1 NEjnVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTwXXJOUUN3ME20Ok44PzBzIN88US=> NEfheIpUSU6JRWK=
TGBC11TKB MnuzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrpTWM2OD12Nz6xO|c4KM7:TR?= MV;TRW5ITVJ?
HD-MY-Z MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTR6Lke4OkDPxE1? NXraWopCW0GQR1XS
NCI-H226 MnW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHqdHFKSzVyPUS5Mlc4QDVizszN NGHyO2xUSU6JRWK=
PA-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXSWFh2UUN3ME20PU45OzN3IN88US=> MoK1V2FPT0WU
LB2518-MEL MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[yOoFKSzVyPUS5Mlg4OjNizszN Ml;LV2FPT0WU
A101D NEPT[45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13ZOmlEPTB;NEmuPVQzPSEQvF2= NIXUNHZUSU6JRWK=
NCI-H2087 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP1TWM2OD12OT65OlgzKM7:TR?= M37uSnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water <1 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 10mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

EGFR Signaling Pathway Map

EGFR Inhibitors with Unique Features

Related EGFR Products

Tags: buy Afatinib (BIBW2992) | Afatinib (BIBW2992) supplier | purchase Afatinib (BIBW2992) | Afatinib (BIBW2992) cost | Afatinib (BIBW2992) manufacturer | order Afatinib (BIBW2992) | Afatinib (BIBW2992) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID