Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

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In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 570 In stock
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Cited by 37 Publications

4 Customer Reviews

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 M37sfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEC1O|Ih|ryP MVXTRW5ITVJ?
KASUMI-1 MmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TLSmlEPTB;MD6wNFkyOSEQvF2= MkPtV2FPT0WU
HCC2218 NH7nTm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X3NGlEPTB;MD6wNFk5PyEQvF2= NYqxfnBpW0GQR1XS
KARPAS-45 NYfsPFRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF31fFVKSzVyPUCuNFE3PzFizszN MlLSV2FPT0WU
HSC-4 M4jlZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHuZZpKSzVyPUCuNFE4PDhizszN NWizfIhYW0GQR1XS
CHL-1 NVrVOJhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXXXGl1UUN3ME2wMlAyQDN7IN88US=> MYnTRW5ITVJ?
KY821 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEKwOkDPxE1? MkTtV2FPT0WU
NCI-N87 M1HtRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTSc4tKSzVyPUCuNFI4PzNizszN MUnTRW5ITVJ?
DOK NIjjd3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEOxPVQh|ryP Mo\jV2FPT0WU
DSH1 M4\KN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHXVWt1UUN3ME2wMlA{OzF2IN88US=> NX\UNY81W0GQR1XS
MDA-MB-175-VII MkntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PuV2lEPTB;MD6wN|QyPiEQvF2= MnfnV2FPT0WU
NCI-H2170 NECzVmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYq5cZg2UUN3ME2wMlA{PzJ6IN88US=> M{\uOHNCVkeHUh?=
BT-474 NIOzOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\6UoFKSzVyPUCuNFQ6QDZizszN NU\jU|I5W0GQR1XS
EFO-27 M{WwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO5eIJKSzVyPUCuNFUyQDJizszN M3HEbHNCVkeHUh?=
NCI-H720 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEWzNlUh|ryP NV;hUYhFW0GQR1XS
PC-14 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMEW2Olgh|ryP MlHGV2FPT0WU
EC-GI-10 M4roT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnFd|N7UUN3ME2wMlA2QTF{IN88US=> M4PuWHNCVkeHUh?=
KYSE-450 NWD3NY55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEW5O|gh|ryP NVHGWFZDW0GQR1XS
BPH-1 NUfmXplzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzQTWM2OD1yLkC1PVg5KM7:TR?= NE\BdppUSU6JRWK=
NCI-H292 M1;EZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nOVmlEPTB;MD6wOlA6KM7:TR?= M3jRfnNCVkeHUh?=
H9 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rmcGlEPTB;MD6wO|E{OiEQvF2= MVfTRW5ITVJ?
NCI-H526 M4TWSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonCTWM2OD1yLkC3PFI{KM7:TR?= NIDifIlUSU6JRWK=
NCI-H1623 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMEiwNlUh|ryP MWjTRW5ITVJ?
KYSE-140 M2PQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rjR2lEPTB;MD6wPFM{KM7:TR?= MXHTRW5ITVJ?
Ca9-22 NEX3e2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXYdZdKSzVyPUCuNFg{PTNizszN MUDTRW5ITVJ?
AU565 NYTtUYNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;TN5RKSzVyPUCuNFg2ODRizszN M{DXSXNCVkeHUh?=
ZR-75-30 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2KyUmlEPTB;MD6wPVU1PSEQvF2= NILDTXlUSU6JRWK=
NCI-H1770 M4rRWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHa[mRHUUN3ME2wMlExOjhizszN NXSzN2xjW0GQR1XS
LB2241-RCC NGnibHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3rTWM2OD1yLkGwPFg1KM7:TR?= NYnM[Hc2W0GQR1XS
CAL-39 MlO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMUG3PVIh|ryP MnfuV2FPT0WU
UACC-893 NWrqNlY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorNTWM2OD1yLkGxPFg2KM7:TR?= Mni5V2FPT0WU
LU-65 M2\qeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTJTWM2OD1yLkGyOlM{KM7:TR?= NULCcWUzW0GQR1XS
HN MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LEOmlEPTB;MD6xN|A4PyEQvF2= NFPOO4ZUSU6JRWK=
TI-73 NXHGU3BET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TwS2lEPTB;MD6xOFcyPSEQvF2= MXnTRW5ITVJ?
KU812 NUi0Om1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfQcog6UUN3ME2wMlE2PDV4IN88US=> MUfTRW5ITVJ?
SW13 MmPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMU[yNVYh|ryP M33VcHNCVkeHUh?=
BB30-HNC Mm[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlryTWM2OD1yLkG2OVc3KM7:TR?= M{\D[nNCVkeHUh?=
HSC-2 NHznTFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELPPGhKSzVyPUCuNVY5OzdizszN NFezb5ZUSU6JRWK=
BV-173 NHPybpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPQcmxKSzVyPUCuNVc2QTZizszN MYDTRW5ITVJ?
CAL-27 NWfzdnk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn2VWFxUUN3ME2wMlE4PjN4IN88US=> MWHTRW5ITVJ?
SBC-1 NIrseYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDwepVFUUN3ME2wMlE5QTV7IN88US=> NEXYUpZUSU6JRWK=
CAL-33 MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHwTWM2OD1yLkKwNVg1KM7:TR?= NWq2PZh6W0GQR1XS
NCI-H209 NXrBOGV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1voVWlEPTB;MD6yNFQ3KM7:TR?= M{K3SnNCVkeHUh?=
COR-L105 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMkGwPFQh|ryP NVfqOnFFW0GQR1XS
HSC-3 M2O4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\3fGpKSzVyPUCuNlEyQThizszN M3:0RXNCVkeHUh?=
NCI-H69 NEWwNYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMkG0OVEh|ryP MUTTRW5ITVJ?
MOLT-13 NFS0[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYruXJpxUUN3ME2wMlI{QTd3IN88US=> MVfTRW5ITVJ?
ML-2 NWTudnhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PjSmlEPTB;MD6yOFgxOiEQvF2= MojwV2FPT0WU
IGROV-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvZTnNKSzVyPUCuNlU6PTJizszN MlrvV2FPT0WU
TK10 NGfYOYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD2TWM2OD1yLkK2O|M5KM7:TR?= NYS5eZQyW0GQR1XS
EoL-1-cell MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzwTWM2OD1yLkK2PFkzKM7:TR?= NHfNdZJUSU6JRWK=
HO-1-N-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlSwTWM2OD1yLkK3PFU{KM7:TR?= M1LZVXNCVkeHUh?=
BHY MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLkZolkUUN3ME2wMlI5PjV3IN88US=> M4LFUHNCVkeHUh?=
LU-139 NWLmT|c3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDETWM2OD1yLkOwOVEh|ryP MlmwV2FPT0WU
23132-87 NUHBcnpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TYRmlEPTB;MD6zNVkzOyEQvF2= NHKzdG5USU6JRWK=
ACHN M{fmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTHcIE{UUN3ME2wMlMyQTl2IN88US=> NYP3XHN2W0GQR1XS
DoTc2-4510 M{HNcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHaZm9rUUN3ME2wMlMzOjF7IN88US=> MoPGV2FPT0WU
BB65-RCC M2e1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwM{S1PVMh|ryP Mlv3V2FPT0WU
HLE NHPsV5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\UTWM2OD1yLkO1NFQ3KM7:TR?= NUfPd3NRW0GQR1XS
HCC1419 NXv6XG15T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nmVWlEPTB;MD6zOlQxQCEQvF2= MUjTRW5ITVJ?
A388 NEC5WohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ezSmlEPTB;MD6zOlg2PyEQvF2= MYDTRW5ITVJ?
NUGC-3 NFOzbnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon0TWM2OD1yLkO4N|c{KM7:TR?= MnnPV2FPT0WU
KYSE-180 NYjJRoxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwM{mwPFkh|ryP Ml\DV2FPT0WU
TE-6 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF:3fXNKSzVyPUCuOFAzPDZizszN MWnTRW5ITVJ?
A498 MkDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILlS4ZKSzVyPUCuOFA3PzRizszN NUHsPZNjW0GQR1XS
NCI-H1648 NH64OIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvGd|NKSzVyPUCuOFQyQDJizszN NVf6UHNUW0GQR1XS
DU-145 NXmwT4VST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwNES4N|Mh|ryP NH;yOZpUSU6JRWK=
CW-2 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkGwTWM2OD1yLkS2PVE1KM7:TR?= NXLudnA6W0GQR1XS
A431 M{THXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XFZWlEPTB;MD60PFI{OyEQvF2= MXvTRW5ITVJ?
SAS M{TIdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\iVmlEPTB;MD60PFM6QCEQvF2= Mnu5V2FPT0WU
NCI-H2126 M1i4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwNUG5NlYh|ryP NYjzUIJwW0GQR1XS
NCI-H358 MlK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK2TWM2OD1yLkWzNlEh|ryP NX\XOXJFW0GQR1XS
FADU MkXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwNUS0NFQh|ryP NFXBXWVUSU6JRWK=
ACN MoPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTw[pF4UUN3ME2wMlU2ODl2IN88US=> Mn[0V2FPT0WU
HCC70 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fKfWlEPTB;MD61O|Y3OSEQvF2= MYPTRW5ITVJ?
NCI-H1838 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnDTWM2OD1yLk[wNlk6KM7:TR?= MVfTRW5ITVJ?
CAL-54 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXjdZRMUUN3ME2wMlYyPjJzIN88US=> NUTIV2pMW0GQR1XS
NCI-H1975 MnXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwNkG3Nlgh|ryP NUXZcnpGW0GQR1XS
COR-L88 NHfmcoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwNkSxNVMh|ryP NFvVfY9USU6JRWK=
CTV-1 NITReGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEC1WW9KSzVyPUCuOlQ{QTJizszN MVvTRW5ITVJ?
EW-18 NHr6NVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\iSJdWUUN3ME2wMlY5Pjl6IN88US=> NHHOXVRUSU6JRWK=
HCC1806 NEXQb5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrPUFN4UUN3ME2wMlY6PjZ4IN88US=> M1PJdXNCVkeHUh?=
HuP-T4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPXT5dKSzVyPUCuOlk4PiEQvF2= MWnTRW5ITVJ?
MDA-MB-361 NWLse2FkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwN{K2OlIh|ryP M{nsXHNCVkeHUh?=
NCI-H1573 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;YdWlEPTB;MD63N|Y{KM7:TR?= NUS5RmpjW0GQR1XS
KU-19-19 MkTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jU[mlEPTB;MD63O|Q3PCEQvF2= NW\lV5hpW0GQR1XS
COLO-678 M1S4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LxbGlEPTB;MD64NFg{PCEQvF2= MlrQV2FPT0WU
C-33-A MoDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nJNWlEPTB;MD64NVI6PyEQvF2= NUD0Z24{W0GQR1XS
Calu-3 NVr4VZpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvySWZZUUN3ME2wMlgyPDN2IN88US=> NGXBdpdUSU6JRWK=
AGS NVq3S|loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTGTWM2OD1yLkizOlQ5KM7:TR?= NWnZVGRxW0GQR1XS
SCC-25 MoTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnRTItIUUN3ME2wMlg1OTdzIN88US=> MVzTRW5ITVJ?
JVM-2 M3rxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX2zWIs1UUN3ME2wMlg5Ojl7IN88US=> MmLkV2FPT0WU
HCE-T MlriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXLNVZKSzVyPUCuPFg1OjhizszN M1z1V3NCVkeHUh?=
ES4 NIHRcGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXCcYJ2UUN3ME2wMlk4QDN4IN88US=> NYnoT2dzW0GQR1XS
EKVX M4rDTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTETnFUUUN3ME2xMlAyODZ2IN88US=> NXuzclJJW0GQR1XS
D-542MG MlPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3pZ4VKSzVyPUGuNFExPjRizszN M4\BS3NCVkeHUh?=
SW1116 MmHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFi2eJdKSzVyPUGuNFEzQDdizszN NI\UZXBUSU6JRWK=
5637 MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnXTWM2OD1zLkCxOVEh|ryP NUXmW3V6W0GQR1XS
HT-1376 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTFwMEG1NVMh|ryP MVvTRW5ITVJ?
NB69 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwMEK5OFUh|ryP MYPTRW5ITVJ?
YKG-1 MofGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXhTWM2OD1zLkC1OFE6KM7:TR?= NXrZZnJxW0GQR1XS
EW-3 MnrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3jUFJlUUN3ME2xMlA4QDh|IN88US=> MWjTRW5ITVJ?
GCIY M1HSU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7kcGpKSzVyPUGuNFgyODRizszN M{HnSnNCVkeHUh?=
SK-MES-1 Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEP3dYZKSzVyPUGuNVE1QDdizszN NH7vV2hUSU6JRWK=
PANC-08-13 M3zi[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIToSlJKSzVyPUGuNVY1OTZizszN NED0RZNUSU6JRWK=
SK-NEP-1 NEnxOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i5fGlEPTB;MT6xO|UyOyEQvF2= M{XpfnNCVkeHUh?=
SW954 M1TRb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFwMkCyNVQh|ryP NIDJbVVUSU6JRWK=
NCI-SNU-5 Mli0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPBcmFKSzVyPUGuNlM6KM7:TR?= NFiwfFFUSU6JRWK=
SW48 NHzTbGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDL[JA2UUN3ME2xMlI2PDN{IN88US=> NYTDOoJlW0GQR1XS
HT-3 NIDhTZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[yd3NRUUN3ME2xMlI5PzV|IN88US=> MVXTRW5ITVJ?
ETK-1 NEPCfFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\ycWlEPTB;MT6zO|Q2PiEQvF2= M{X4O3NCVkeHUh?=
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BE-13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PiVWlEPTB;Nz65PFEyOiEQvF2= MkTSV2FPT0WU
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SW1710 NF7y[ndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jRSmlEPTB;OD6xPFUyPSEQvF2= MUnTRW5ITVJ?
D-502MG M3vYVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3KzT2lEPTB;OD6yPVI5OiEQvF2= M3vmcHNCVkeHUh?=
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BALL-1 M4PXd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfqbHE6UUN3ME25MlIyQTB5IN88US=> NU\2V4FpW0GQR1XS
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C32 MoK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7HTWM2OD17LkOzNFY1KM7:TR?= M3PwUHNCVkeHUh?=
NCI-H1703 NIi0cpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTlwM{SzO|Uh|ryP M3yxZ3NCVkeHUh?=
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DEL MoPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFyLkO5OFYh|ryP MUfTRW5ITVJ?
HuCCT1 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7MTWM2OD1zMD62NFM{KM7:TR?= MXTTRW5ITVJ?
OVCAR-4 MlvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\kWGlEPTB;MUCuPFg{PSEQvF2= MUTTRW5ITVJ?
CAL-72 M2XhRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3K5WWlEPTB;MUCuPVM6OSEQvF2= NWLCNnNNW0GQR1XS
HCC1954 MmG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLNN3BrUUN3ME2xNU4xPzV2IN88US=> M{PqeXNCVkeHUh?=
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ALL-PO NUT3eYJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zZSWlEPTB;MUGuNlUyOiEQvF2= NXXXV3loW0GQR1XS
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RPMI-2650 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7aN4d3UUN3ME2xNU42QDh3IN88US=> Mlj5V2FPT0WU
MC-IXC M2X4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH4WmllUUN3ME2xNU43PzJ6IN88US=> NEHCOmZUSU6JRWK=
HOP-62 NEXBZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzFWZJqUUN3ME2xNU43PzZ2IN88US=> MXjTRW5ITVJ?
NOS-1 M1;YcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXwRXVKSzVyPUGxMlcyODlizszN NXjjNFdKW0GQR1XS
SW1573 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{mzeGlEPTB;MUGuO|I6PSEQvF2= NX\ETGdqW0GQR1XS
WM-115 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTFzLke1PFgh|ryP MnjVV2FPT0WU
HuO9 MnXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTFzLki3O|Qh|ryP M1\tT3NCVkeHUh?=
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MDA-MB-453 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\NW|NKSzVyPUGxMlk2OTVizszN M1jOZXNCVkeHUh?=
NCI-H596 M4DNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW4TWM2OD1zMj6wN|Y6KM7:TR?= M1fWb3NCVkeHUh?=
A172 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zFc2lEPTB;MUKuNFc6QCEQvF2= M{XQRXNCVkeHUh?=
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HCC1937 NIPPfYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G4cWlEPTB;MUKuO|U3PCEQvF2= Ml72V2FPT0WU
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PFSK-1 MornS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvCUJB5UUN3ME2xN{4xPiEQvF2= MnHRV2FPT0WU
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SK-UT-1 M3fC[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XXTWlEPTB;MUOuNVA5OyEQvF2= MlHPV2FPT0WU
OVCAR-5 MojkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj6TWM2OD1zMz6xOVk{KM7:TR?= MW\TRW5ITVJ?
8505C M{DtcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzxRpZYUUN3ME2xN{4zODZ5IN88US=> M1TPeHNCVkeHUh?=
SK-MEL-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTF|LkexN|Uh|ryP MknmV2FPT0WU
LK-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjCb|ZKSzVyPUGzMlc3OzlizszN MVHTRW5ITVJ?
OE33 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH65[GRKSzVyPUGzMlc5PiEQvF2= NUWwR49MW0GQR1XS
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EW-13 Mm\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXGwRZU3UUN3ME2xOE4xOzV{IN88US=> NFjtdWRUSU6JRWK=
NCI-H1793 NHPjVpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG5TWM2OD1zND6yNFg4KM7:TR?= M3r0VnNCVkeHUh?=
BHT-101 Ml7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCyVXZKSzVyPUG0MlI1OSEQvF2= MX;TRW5ITVJ?
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NEC8 MnnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK3XWNFUUN3ME2xOE42PDd{IN88US=> NYDmU3NzW0GQR1XS
PANC-10-05 M3fDNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDrPFA4UUN3ME2xOE43OjR5IN88US=> NFjEN|BUSU6JRWK=
NCI-H2030 MmHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fkc2lEPTB;MUSuOlQ1QCEQvF2= Moj3V2FPT0WU
C2BBe1 Moe3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XIZ2lEPTB;MUSuO|Y1KM7:TR?= MXTTRW5ITVJ?
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HCC1395 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfSe|JJUUN3ME2xOE46OzN6IN88US=> NGKz[XlUSU6JRWK=
A2058 NEO1ZnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTF3LkC0NFkh|ryP M1j6VHNCVkeHUh?=
SW1463 MoPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrFTWM2OD1zNT6wOFg2KM7:TR?= M3fhb3NCVkeHUh?=
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CAL-120 M3;3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDmTWM2OD1zNT6xOFQ4KM7:TR?= NF7xNWNUSU6JRWK=
COLO-824 NYnKTHMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nMTGlEPTB;MUWuNVU4QSEQvF2= MlvpV2FPT0WU
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OC-314 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TLVWlEPTB;MUWuOFcyPCEQvF2= MWnTRW5ITVJ?
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MFE-280 MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\LTWM2OD1zNj6wOFg5KM7:TR?= MkLHV2FPT0WU
MHH-NB-11 MmjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;uTWM2OD1zNj6wPFM6KM7:TR?= NI\BfG1USU6JRWK=
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U-266 NH7OcnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LXfGlEPTB;MU[uNlI6QSEQvF2= M2q2cHNCVkeHUh?=
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QIMR-WIL MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\wZ3dkUUN3ME2xOk44OTB3IN88US=> NE\3OZJUSU6JRWK=
NCI-H1092 M4GyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTF4LkizNVYh|ryP M2DlNnNCVkeHUh?=
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COLO-684 M4DNfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTF4Lkm0O|ch|ryP NXriRXN1W0GQR1XS
NCI-H661 NX\Pc4tsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm1bnZ6UUN3ME2xOk46Pjl2IN88US=> M3X1S3NCVkeHUh?=
CP50-MEL-B NYnuOmlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXK0To9YUUN3ME2xO{4xOzR|IN88US=> MUHTRW5ITVJ?
NCI-H2405 M4L6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTF5LkG5O|Qh|ryP M4\3XHNCVkeHUh?=
U-2-OS NWP5VItQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nhbWlEPTB;MUeuOVMxPyEQvF2= MV3TRW5ITVJ?
RERF-LC-MS MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXXTWM2OD1zNz61OVA5KM7:TR?= MUfTRW5ITVJ?
NCI-H2342 M4XuU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnSTWM2OD1zNz61OVch|ryP NIXwUGRUSU6JRWK=
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MOLT-16 Mnn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLpUJBFUUN3ME2xO{45QTN2IN88US=> M2rLenNCVkeHUh?=
RH-18 MmDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\RTWM2OD1zOD6wNFM2KM7:TR?= MV7TRW5ITVJ?
D-283MED NHi0O2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTF6LkCwPFgh|ryP MlfnV2FPT0WU
RCC10RGB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zSSWlEPTB;MUiuNFU2QSEQvF2= MUPTRW5ITVJ?
NCI-H1437 NXjvVZRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2SyZmlEPTB;MUiuNVY1OSEQvF2= MXrTRW5ITVJ?
SW982 MkS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF6LkK2O|Eh|ryP MnXKV2FPT0WU
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A704 NWD1OFJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7STWM2OD1zOD60O|U{KM7:TR?= MVrTRW5ITVJ?
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SCH M4i0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TUU2lEPTB;MUiuOlQ2PiEQvF2= MkfMV2FPT0WU
COLO-320-HSR M2[zPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjrdHRKSzVyPUG4Mlc1PiEQvF2= MkXTV2FPT0WU
Mo-T NHPPXnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17CcWlEPTB;MUiuPFIxPCEQvF2= NX7MS|JpW0GQR1XS
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NCI-H2122 M{jreGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILWUYtKSzVyPUO0MlM1PzFizszN MULTRW5ITVJ?
ABC-1 M{TyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm3VYVKSzVyPUO0MlM3QTNizszN MnXaV2FPT0WU
NCI-H1355 NInEXIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHQbGR{UUN3ME2zOE4{QDh7IN88US=> MXLTRW5ITVJ?
NOMO-1 NVS2SoI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfGN2FKSzVyPUO0MlU4ODNizszN MXTTRW5ITVJ?
MZ7-mel M{\Lfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojZTWM2OD1|ND62OFg4KM7:TR?= MWfTRW5ITVJ?
NCI-H810 MlrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jhb2lEPTB;M{SuO|I4QCEQvF2= M4\Ib3NCVkeHUh?=
D-392MG NU\aOGltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;qSYlWUUN3ME2zOU4xPTZ3IN88US=> M2C5WHNCVkeHUh?=
LB771-HNC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTN3LkG2OVgh|ryP MWfTRW5ITVJ?
COLO-679 NH3LNXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHOTWM2OD1|NT6zPFgh|ryP NEjJOm5USU6JRWK=
SK-PN-DW M3;z[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3xTWM2OD1|NT60N|Y6KM7:TR?= M1vpUXNCVkeHUh?=
VA-ES-BJ NFW3bW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLaTWM2OD1|NT60OlQ6KM7:TR?= NXnNR3Q5W0GQR1XS
KNS-42 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;uR3g3UUN3ME2zOU42QDJ4IN88US=> M2ntNXNCVkeHUh?=
RVH-421 MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3BenRKSzVyPUO1Mlc3PDVizszN NF3D[nNUSU6JRWK=
P30-OHK Mnn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\td2lEPTB;M{WuPFc2OiEQvF2= M4LtbnNCVkeHUh?=
G-402 MoDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nWd2lEPTB;M{WuPVg3PyEQvF2= Mn3FV2FPT0WU
S-117 Mnq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2W2W2lEPTB;M{[uN|AxQCEQvF2= NIjlN4hUSU6JRWK=
RXF393 NHLn[5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:1TWM2OD1|Nj6zO|g2KM7:TR?= M4rpUnNCVkeHUh?=
LCLC-103H MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHtZ|ZKSzVyPUO2Mlc5ODNizszN MoXUV2FPT0WU
U-118-MG NYLHfnNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTN4Lki4OFch|ryP M4WxW3NCVkeHUh?=
8-MG-BA MonKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETvTnVKSzVyPUO2Mlk1QDNizszN NXrab3BCW0GQR1XS
MFH-ino NETVOoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlSzTWM2OD1|Nz6zN|cyKM7:TR?= M33L[HNCVkeHUh?=
NCI-H23 NV;nUm5CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3yzR2lEPTB;M{euOFE6PiEQvF2= MV\TRW5ITVJ?
NCI-H446 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjzTWM2OD1|Nz60PFYzKM7:TR?= M4SzNHNCVkeHUh?=
LU-99A MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoW5TWM2OD1|Nz61O|MyKM7:TR?= MlPDV2FPT0WU
KP-N-YN M4L1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITveVVKSzVyPUO3MlYyQTVizszN NXL2c3k6W0GQR1XS
SCC-9 MofZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HycGlEPTB;M{euO|g{QCEQvF2= NFHBZmlUSU6JRWK=
EFM-19 NEHQXnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn22TWM2OD1|Nz63PVY4KM7:TR?= NGXmRYpUSU6JRWK=
A427 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTN5LkmxNFch|ryP MlHjV2FPT0WU
LB831-BLC MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTN6Lk[wN|kh|ryP MVrTRW5ITVJ?
HOS NE[5OJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPoXlZoUUN3ME2zPU43Ojd|IN88US=> NEPk[IdUSU6JRWK=
LAN-6 NUTIbGFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\qVWlEPTB;NECuNFEyOiEQvF2= NGjiNJlUSU6JRWK=
U251 M3:4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTJXJdqUUN3ME20NE41ODV2IN88US=> MkLHV2FPT0WU
SNU-387 NGDGcVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFm4WpNKSzVyPUSwMlQ2PTNizszN NVzuWIMyW0GQR1XS
DMS-79 MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTRyLkW4PFkh|ryP NHLSfYpUSU6JRWK=
SK-LU-1 MkDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTRyLk[1Olgh|ryP NILRR2lUSU6JRWK=
HT MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfYVnZLUUN3ME20NE43PjN7IN88US=> M3vtUnNCVkeHUh?=
KP-N-YS NF;QXJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTRyLk[3Olgh|ryP MXnTRW5ITVJ?
DMS-114 Mlf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfPfXdWUUN3ME20NE45Ozd2IN88US=> MljwV2FPT0WU
HUTU-80 M3PTeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvMTWM2OD12MT6wOVY6KM7:TR?= MoLpV2FPT0WU
ONS-76 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXyxOWVzUUN3ME20NU41PzB7IN88US=> MlfFV2FPT0WU
A673 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrETWM2OD12MT61NVU4KM7:TR?= M1fSPHNCVkeHUh?=
HPAF-II MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTRzLk[3NFkh|ryP M1TzZXNCVkeHUh?=
UACC-257 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjwUJhtUUN3ME20NU44OzZ7IN88US=> MoPmV2FPT0WU
EW-22 NYLrU29xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW5RWZ{UUN3ME20NU45Pjl5IN88US=> NFvDb5JUSU6JRWK=
NCI-H1755 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2i3c2lEPTB;NEGuPFczPSEQvF2= NVW1dpBNW0GQR1XS
KYSE-150 MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlewTWM2OD12Mj6xO|gzKM7:TR?= NYT3Xo82W0GQR1XS
CGTH-W-1 NVmySY1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTR{LkS5OVUh|ryP NETjeWNUSU6JRWK=
NB13 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[2TW5KSzVyPUSyMlYzOTdizszN MV;TRW5ITVJ?
SW872 NF\KNFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjhb41KSzVyPUSyMlY{OzFizszN M4LT[nNCVkeHUh?=
KP-4 NEfWb4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTxdZJKSzVyPUSyMlg5OzJizszN MkG1V2FPT0WU
HCC38 M{Tnbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTR{Lkm2NVgh|ryP M1Pmd3NCVkeHUh?=
BB49-HNC NF;DR2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTR|LkKzOVYh|ryP NHewcmNUSU6JRWK=
CAL-62 NEG2T|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPmTnZFUUN3ME20N{41ODJ6IN88US=> MUDTRW5ITVJ?
NCI-H2029 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfHOHZKSzVyPUSzMlU2QDFizszN NEjNbJVUSU6JRWK=
M14 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTR2LkGzN|Ih|ryP NXfh[5oyW0GQR1XS
COLO-680N NHvuXnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33p[2lEPTB;NESuN|M6KM7:TR?= NF[zS2ZUSU6JRWK=
Hs-578-T MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD5c2tKSzVyPUS1MlAzQTRizszN MV\TRW5ITVJ?
MSTO-211H NIeyXWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4frcWlEPTB;NEWuPVQ5OiEQvF2= MlHXV2FPT0WU
EW-1 NF7HUHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G3PGlEPTB;NEWuPVY5QSEQvF2= MYnTRW5ITVJ?
SW948 MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTR4LkS0OlIh|ryP MmjmV2FPT0WU
NCI-H460 MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fw[GlEPTB;NE[uOVI{KM7:TR?= NYHteVNRW0GQR1XS
CAS-1 Mn;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLhbG53UUN3ME20Ok44PzBzIN88US=> NYfWfpc4W0GQR1XS
TGBC11TKB NGfseFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTR5LkG3O|ch|ryP NFLpXZZUSU6JRWK=
HD-MY-Z NXLDOIJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTR6Lke4OkDPxE1? M4jUb3NCVkeHUh?=
NCI-H226 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;ibpVPUUN3ME20PU44Pzh3IN88US=> MYnTRW5ITVJ?
PA-1 NUnHZlZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLJelhKSzVyPUS5Mlg{OzVizszN NETGU4dUSU6JRWK=
LB2518-MEL MorMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTR7Lki3NlMh|ryP MUXTRW5ITVJ?
A101D NFTxfI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fOc2lEPTB;NEmuPVQzPSEQvF2= MlPXV2FPT0WU
NCI-H2087 NXzkOJBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DEWmlEPTB;NEmuPVY5OiEQvF2= MWrTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID