Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

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In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
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Cited by 37 Publications

4 Customer Reviews

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 M4GwdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuwbFFUUUN3ME2wMlAxPTd{IN88US=> NULjdFN{W0GQR1XS
KASUMI-1 NVfVNYgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\KRWlEPTB;MD6wNFkyOSEQvF2= MXPTRW5ITVJ?
HCC2218 NYfvW5BLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEC5PFch|ryP M3PPS3NCVkeHUh?=
KARPAS-45 MorXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEG2O|Eh|ryP NIC5WGNUSU6JRWK=
HSC-4 NWHxfplET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPVbG9WUUN3ME2wMlAyPzR6IN88US=> MXTTRW5ITVJ?
CHL-1 M1vEeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjYfI1KSzVyPUCuNFE5OzlizszN M1;hOXNCVkeHUh?=
KY821 M4DBemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zYT2lEPTB;MD6wNlA3KM7:TR?= MVHTRW5ITVJ?
NCI-N87 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PZOmlEPTB;MD6wNlc4OyEQvF2= MnjTV2FPT0WU
DOK NHOySplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXXSmNkUUN3ME2wMlA{OTl2IN88US=> M3e3THNCVkeHUh?=
DSH1 NF7GOm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\VVVdKSzVyPUCuNFM{OTRizszN Ml\KV2FPT0WU
MDA-MB-175-VII MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXPWmxpUUN3ME2wMlA{PDF4IN88US=> MkP6V2FPT0WU
NCI-H2170 M4HOVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\PNmlEPTB;MD6wN|czQCEQvF2= NXrYdFdJW0GQR1XS
BT-474 NI\icHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMES5PFYh|ryP NHTzUmhUSU6JRWK=
EFO-27 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoKwTWM2OD1yLkC1NVgzKM7:TR?= M2HCW3NCVkeHUh?=
NCI-H720 MnL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDIOZk{UUN3ME2wMlA2OzJ3IN88US=> MULTRW5ITVJ?
PC-14 NXPGN29UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXXc4RFUUN3ME2wMlA2PjZ6IN88US=> NF\aTHZUSU6JRWK=
EC-GI-10 NHzJPJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfCTWM2OD1yLkC1PVEzKM7:TR?= MY\TRW5ITVJ?
KYSE-450 NXTHZpJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPqSHpKSzVyPUCuNFU6PzhizszN NXr0VohxW0GQR1XS
BPH-1 Mn7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjVS2tKSzVyPUCuNFU6QDhizszN MkTDV2FPT0WU
NCI-H292 NH\sVnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX1U4lxUUN3ME2wMlA3ODlizszN MYPTRW5ITVJ?
H9 MnnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnZ[nRKSzVyPUCuNFcyOzJizszN NVfoUlVJW0GQR1XS
NCI-H526 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPVNZFKSzVyPUCuNFc5OjNizszN MnHPV2FPT0WU
NCI-H1623 MorYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTzfXBKSzVyPUCuNFgxOjVizszN M2HZNnNCVkeHUh?=
KYSE-140 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:wSFBKSzVyPUCuNFg{OyEQvF2= NInI[llUSU6JRWK=
Ca9-22 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWiyT3hVUUN3ME2wMlA5OzV|IN88US=> NUm1XmRlW0GQR1XS
AU565 MkX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG4TWM2OD1yLkC4OVA1KM7:TR?= NVSxdHlZW0GQR1XS
ZR-75-30 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEm1OFUh|ryP NEH4em1USU6JRWK=
NCI-H1770 M2nHPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\Gd2lEPTB;MD6xNFI5KM7:TR?= NXexflBSW0GQR1XS
LB2241-RCC NIfHXnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD4TWM2OD1yLkGwPFg1KM7:TR?= MXXTRW5ITVJ?
CAL-39 NVqxUHlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrWclJNUUN3ME2wMlEyPzl{IN88US=> NXWy[m9[W0GQR1XS
UACC-893 NI[ydm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMUG4PFUh|ryP M2X3XXNCVkeHUh?=
LU-65 MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMUK2N|Mh|ryP MVzTRW5ITVJ?
HN NHjBZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m3OWlEPTB;MD6xN|A4PyEQvF2= Mn\QV2FPT0WU
TI-73 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLObFdjUUN3ME2wMlE1PzF3IN88US=> NFfHe3lUSU6JRWK=
KU812 MorNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7EXFluUUN3ME2wMlE2PDV4IN88US=> NG[2NmtUSU6JRWK=
SW13 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\xc2lEPTB;MD6xOlIyPiEQvF2= MVPTRW5ITVJ?
BB30-HNC NU\3Olk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;GR2lEPTB;MD6xOlU4PiEQvF2= MkmxV2FPT0WU
HSC-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\WdVNYUUN3ME2wMlE3QDN5IN88US=> MV\TRW5ITVJ?
BV-173 MonaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfjTWM2OD1yLkG3OVk3KM7:TR?= Mn6xV2FPT0WU
CAL-27 NUe4NXFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMUe2N|Yh|ryP NF\ONIJUSU6JRWK=
SBC-1 M2n3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTKTWM2OD1yLkG4PVU6KM7:TR?= MXXTRW5ITVJ?
CAL-33 MmXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMkCxPFQh|ryP MkLzV2FPT0WU
NCI-H209 NXT5bW0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrPT295UUN3ME2wMlIxPDZizszN NXjNeo1LW0GQR1XS
COR-L105 M4DDcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ftV2lEPTB;MD6yNVA5PCEQvF2= NV3tWlBSW0GQR1XS
HSC-3 MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWj2em5vUUN3ME2wMlIyOTl6IN88US=> NXXLXZk5W0GQR1XS
NCI-H69 M2fEbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe1b2ExUUN3ME2wMlIyPDVzIN88US=> MnrIV2FPT0WU
MOLT-13 MnrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnoXYd7UUN3ME2wMlI{QTd3IN88US=> MnTVV2FPT0WU
ML-2 MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq0TWM2OD1yLkK0PFAzKM7:TR?= MV7TRW5ITVJ?
IGROV-1 M{\D[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml72TWM2OD1yLkK1PVUzKM7:TR?= M1rNWXNCVkeHUh?=
TK10 M3rCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHznUVFKSzVyPUCuNlY4OzhizszN MUPTRW5ITVJ?
EoL-1-cell M3O3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWWzXY5nUUN3ME2wMlI3QDl{IN88US=> NV\3SFE3W0GQR1XS
HO-1-N-1 MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjCN|JNUUN3ME2wMlI4QDV|IN88US=> NEewTYZUSU6JRWK=
BHY NUPR[W9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7Efo5EUUN3ME2wMlI5PjV3IN88US=> M1P6[3NCVkeHUh?=
LU-139 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml:xTWM2OD1yLkOwOVEh|ryP NXTy[JBiW0GQR1XS
23132-87 MmXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PuXWlEPTB;MD6zNVkzOyEQvF2= NVT2c5dWW0GQR1XS
ACHN NILlUHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXW1dndGUUN3ME2wMlMyQTl2IN88US=> MnGwV2FPT0WU
DoTc2-4510 NIT6W|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPJTWM2OD1yLkOyNlE6KM7:TR?= NWT5SVg1W0GQR1XS
BB65-RCC MnLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWCxWGtJUUN3ME2wMlM1PTl|IN88US=> MnGyV2FPT0WU
HLE M{jTemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M172XGlEPTB;MD6zOVA1PiEQvF2= Moi3V2FPT0WU
HCC1419 NYTTSGw{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzETWM2OD1yLkO2OFA5KM7:TR?= MX\TRW5ITVJ?
A388 NELEPGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHLTWM2OD1yLkO2PFU4KM7:TR?= M2r5eHNCVkeHUh?=
NUGC-3 NInheGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\TTWM2OD1yLkO4N|c{KM7:TR?= MYDTRW5ITVJ?
KYSE-180 MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXpNJJKSzVyPUCuN|kxQDlizszN NYHUdmxSW0GQR1XS
TE-6 NVvHWng5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH4TWM2OD1yLkSwNlQ3KM7:TR?= NX;1cWlsW0GQR1XS
A498 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXzOo5KSzVyPUCuOFA3PzRizszN NVyzbmFGW0GQR1XS
NCI-H1648 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwNESxPFIh|ryP NHPlfIZUSU6JRWK=
DU-145 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV60fWFQUUN3ME2wMlQ1QDN|IN88US=> M2nMbHNCVkeHUh?=
CW-2 NITNPHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnvbYlKSzVyPUCuOFY6OTRizszN MWfTRW5ITVJ?
A431 NFz2T|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3TPFhKSzVyPUCuOFgzOzNizszN NIjoOINUSU6JRWK=
SAS MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPucW5KSzVyPUCuOFg{QThizszN MorNV2FPT0WU
NCI-H2126 MkC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nVO2lEPTB;MD61NVkzPiEQvF2= NHLrbYJUSU6JRWK=
NCI-H358 NEL2VIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwNUOyNUDPxE1? MXPTRW5ITVJ?
FADU NFHDWmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1noZmlEPTB;MD61OFQxPCEQvF2= MWHTRW5ITVJ?
ACN MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwNUWwPVQh|ryP MXzTRW5ITVJ?
HCC70 MoruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2G0WmlEPTB;MD61O|Y3OSEQvF2= NUjQToZRW0GQR1XS
NCI-H1838 MnXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWq0TpRkUUN3ME2wMlYxOjl7IN88US=> M2HuXHNCVkeHUh?=
CAL-54 MmXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\xZVk{UUN3ME2wMlYyPjJzIN88US=> MXfTRW5ITVJ?
NCI-H1975 NWPofJNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwNkG3Nlgh|ryP M1HR[HNCVkeHUh?=
COR-L88 NVq3T5pkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIn2cYpKSzVyPUCuOlQyOTNizszN MUTTRW5ITVJ?
CTV-1 M1;hc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwNkSzPVIh|ryP MnnZV2FPT0WU
EW-18 NYLwS|I4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4q1WWlEPTB;MD62PFY6QCEQvF2= MoP4V2FPT0WU
HCC1806 NYnwW3BHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVL6[INzUUN3ME2wMlY6PjZ4IN88US=> M4rkenNCVkeHUh?=
HuP-T4 NFHtSppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwNkm3OkDPxE1? NXL6N4ptW0GQR1XS
MDA-MB-361 M3TCe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwN{K2OlIh|ryP MYTTRW5ITVJ?
NCI-H1573 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzCTWM2OD1yLkezOlMh|ryP NX33XFRJW0GQR1XS
KU-19-19 NVnF[mtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPUOmZKSzVyPUCuO|c1PjRizszN MlvRV2FPT0WU
COLO-678 NI\ZN5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nRc2lEPTB;MD64NFg{PCEQvF2= NHXOWHdUSU6JRWK=
C-33-A MoDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jwOGlEPTB;MD64NVI6PyEQvF2= Mmm4V2FPT0WU
Calu-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwOEG0N|Qh|ryP NW\GU3lFW0GQR1XS
AGS NF2wNmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXuPVRLUUN3ME2wMlg{PjR6IN88US=> MXfTRW5ITVJ?
SCC-25 M1fSeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXEToRKSzVyPUCuPFQyPzFizszN Mo\TV2FPT0WU
JVM-2 NXzlTIJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwOEiyPVkh|ryP M1L6e3NCVkeHUh?=
HCE-T NVzQNW5CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHexblZKSzVyPUCuPFg1OjhizszN NXzzOnIyW0GQR1XS
ES4 NXe5Nmd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTrcppKSzVyPUCuPVc5OzZizszN M37LV3NCVkeHUh?=
EKVX NE\jZnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTFwMEGwOlQh|ryP MVHTRW5ITVJ?
D-542MG NWT4Z4p5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DUZWlEPTB;MT6wNVA3PCEQvF2= Mk\5V2FPT0WU
SW1116 NWnHT5VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHpNJZkUUN3ME2xMlAyOjh5IN88US=> MYTTRW5ITVJ?
5637 NXrhdnRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTFwMEG1NUDPxE1? Mm[yV2FPT0WU
HT-1376 M3PHcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[wTG1NUUN3ME2xMlAyPTF|IN88US=> M3vtSHNCVkeHUh?=
NB69 M2HhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFwMEK5OFUh|ryP M3P2Z3NCVkeHUh?=
YKG-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C4fmlEPTB;MT6wOVQyQSEQvF2= NFHvc3ZUSU6JRWK=
EW-3 Mn3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXwTWM2OD1zLkC3PFg{KM7:TR?= NIDDWmJUSU6JRWK=
GCIY MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{K4UWlEPTB;MT6wPFExPCEQvF2= M1nrO3NCVkeHUh?=
SK-MES-1 NHW1OZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\iTWM2OD1zLkGxOFg4KM7:TR?= M2f0SnNCVkeHUh?=
PANC-08-13 NE\4dlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mme5TWM2OD1zLkG2OFE3KM7:TR?= MkjEV2FPT0WU
SK-NEP-1 M1nKS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3sV5RKSzVyPUGuNVc2OTNizszN NEj2SYJUSU6JRWK=
SW954 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknHTWM2OD1zLkKwNlE1KM7:TR?= Mn3FV2FPT0WU
NCI-SNU-5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnFWZQxUUN3ME2xMlI{QSEQvF2= MWTTRW5ITVJ?
SW48 NV\hW5ZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUSxZWd1UUN3ME2xMlI2PDN{IN88US=> Moi3V2FPT0WU
HT-3 NELkRnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlP2TWM2OD1zLkK4O|U{KM7:TR?= NEHucGdUSU6JRWK=
ETK-1 NWH5enBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XVOmlEPTB;MT6zO|Q2PiEQvF2= NX\aOZF3W0GQR1XS
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KURAMOCHI NEG1VXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PXcmlEPTB;Nz65OFgyOSEQvF2= MYDTRW5ITVJ?
BE-13 NI\BcpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TkRmlEPTB;Nz65PFEyOiEQvF2= MUfTRW5ITVJ?
VMRC-RCZ M33NSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHlWFVKSzVyPUiuNFE3QTdizszN M{O2XXNCVkeHUh?=
NCI-H727 M3TsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRThwMUC0NkDPxE1? NWnWTnU2W0GQR1XS
SW1710 NVPwcJQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRThwMUi1NVUh|ryP MWPTRW5ITVJ?
D-502MG NVXDR5FGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvYeZhKSzVyPUiuNlkzQDJizszN MnLjV2FPT0WU
NCI-H1993 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;ITWM2OD16LkOzOlMyKM7:TR?= MV\TRW5ITVJ?
SCC-4 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XJNWlEPTB;OD60OFA2QSEQvF2= NGDMO5hUSU6JRWK=
HAL-01 M4HpTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TrSGlEPTB;OD61NVkyKM7:TR?= NXrQcWZ{W0GQR1XS
GT3TKB NFXrd2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfvTWM2OD16Lk[3PVY1KM7:TR?= M3iw[XNCVkeHUh?=
SK-OV-3 NV;Vc2wxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rTemlEPTB;OD63NVMzQSEQvF2= Mnr4V2FPT0WU
COLO-829 M3;qN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TDT2lEPTB;OD64NFk4PiEQvF2= NVjnNYJkW0GQR1XS
OCI-AML2 NUPYc|dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfKVlRTUUN3ME24Mlk2PDhzIN88US=> NUG4cXR7W0GQR1XS
OS-RC-2 NFHSSGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XB[WlEPTB;OT6wNlE6KM7:TR?= NXPTTVRXW0GQR1XS
BFTC-909 NWe3RYtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3:wcWlEPTB;OT6wOlc6QSEQvF2= MVnTRW5ITVJ?
EW-11 NUnaOINOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\qNYZUUUN3ME25MlE4PjV|IN88US=> NEK0OWdUSU6JRWK=
HCE-4 NXi0ZpBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf5TWM2OD17LkKxOVU5KM7:TR?= MnLoV2FPT0WU
BALL-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17GPWlEPTB;OT6yNVkxPyEQvF2= MXfTRW5ITVJ?
SF539 NHTPN2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7hTWM2OD17LkKzOVYzKM7:TR?= MX7TRW5ITVJ?
CAMA-1 M2rwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDqOIFWUUN3ME25MlI5OTJ6IN88US=> MYnTRW5ITVJ?
C32 NFfZd4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXoTWM2OD17LkOzNFY1KM7:TR?= NGfV[YFUSU6JRWK=
NCI-H1703 M1vUOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYSzUoptUUN3ME25MlM1Ozd3IN88US=> MnHsV2FPT0WU
NCI-H1650 M2jKXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIWzSmxKSzVyPUmuOlA6PDZizszN MV7TRW5ITVJ?
NCI-H1563 M3\KVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTlwN{[wN|Eh|ryP MmO1V2FPT0WU
CAL-85-1 Mn76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjUV|BKSzVyPUmuPFc{QDNizszN M2DQ[XNCVkeHUh?=
UM-UC-3 MmXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;DXGlEPTB;OT65OVA{KM7:TR?= M1;5R3NCVkeHUh?=
BxPC-3 NYPyZXpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K4ZmlEPTB;MUCuNFk4OiEQvF2= MkPxV2FPT0WU
MHH-PREB-1 NYf1V4VnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPPN|VKSzVyPUGwMlE6QTlizszN MV;TRW5ITVJ?
DEL MoXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnUU5lKSzVyPUGwMlM6PDZizszN MUjTRW5ITVJ?
HuCCT1 Ml3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofITWM2OD1zMD62NFM{KM7:TR?= MoXYV2FPT0WU
OVCAR-4 NYHzcGZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG2TpNKSzVyPUGwMlg5OzVizszN NHPLS2pUSU6JRWK=
CAL-72 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTFyLkmzPVEh|ryP NGmzSVRUSU6JRWK=
HCC1954 M{LRTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXwUJNKSzVyPUGxMlA4PTRizszN NWHMSWd7W0GQR1XS
EFO-21 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrtOGNYUUN3ME2xNU4yODR3IN88US=> NUXWWVY{W0GQR1XS
FTC-133 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ntb2lEPTB;MUGuNVQxPyEQvF2= MnPSV2FPT0WU
SK-MEL-24 MmXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInTcmxKSzVyPUGxMlI{PjZizszN NX\sPYR3W0GQR1XS
UACC-62 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFzLkKzOlgh|ryP MYfTRW5ITVJ?
NCI-H650 MoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXlcY5pUUN3ME2xNU4zPDF6IN88US=> M1rtTHNCVkeHUh?=
ALL-PO M3jHcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnHS25YUUN3ME2xNU4zPTF{IN88US=> NHzteG1USU6JRWK=
T84 M3rkbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvTeVNjUUN3ME2xNU4{QTB5IN88US=> MmPaV2FPT0WU
IST-MEL1 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDYcVRKSzVyPUGxMlQ2PTlizszN NYPHdWJ[W0GQR1XS
SW626 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHtTWM2OD1zMT61O|U2KM7:TR?= MXvTRW5ITVJ?
RPMI-2650 NFvnV|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfzO2RKSzVyPUGxMlU5QDVizszN MWHTRW5ITVJ?
MC-IXC NEDEW5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTFzLk[3Nlgh|ryP MXPTRW5ITVJ?
HOP-62 NXvZb25OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3mwbmlEPTB;MUGuOlc3PCEQvF2= MoHRV2FPT0WU
NOS-1 NHXZeIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr2TphKSzVyPUGxMlcyODlizszN MkLyV2FPT0WU
SW1573 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjESmRKSzVyPUGxMlczQTVizszN MWjTRW5ITVJ?
WM-115 NWizR4hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfxTWM2OD1zMT63OVg5KM7:TR?= M4qzUXNCVkeHUh?=
HuO9 M{jOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHldINKSzVyPUGxMlg4PzRizszN NUTo[HhWW0GQR1XS
YAPC M3q5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HINWlEPTB;MUGuPVI2QSEQvF2= M1fsTXNCVkeHUh?=
MDA-MB-453 NI[0O|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFzLkm1NVUh|ryP NX3udlNYW0GQR1XS
NCI-H596 M2jmbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfuT4hCUUN3ME2xNk4xOzZ7IN88US=> M{THcnNCVkeHUh?=
A172 NIX1UXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\tVWlEPTB;MUKuNFc6QCEQvF2= NHv1cnpUSU6JRWK=
RS4-11 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTpdJp2UUN3ME2xNk4yPzJ3IN88US=> MkK4V2FPT0WU
HCC1937 M3zTe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF{Lke1OlQh|ryP MXvTRW5ITVJ?
SW837 NHPxTppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn76TWM2OD1zMj65NFI5KM7:TR?= MY\TRW5ITVJ?
NMC-G1 NITrWXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{e4ZWlEPTB;MUKuPVI{PCEQvF2= MnPaV2FPT0WU
PFSK-1 Ml3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF|LkC2JO69VQ>? NYftR255W0GQR1XS
DBTRG-05MG MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjoVI5KSzVyPUGzMlA3OzJizszN MXrTRW5ITVJ?
SK-UT-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3OemJKSzVyPUGzMlExQDNizszN NVe3[WNiW0GQR1XS
OVCAR-5 NXrHOlU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnu2TWM2OD1zMz6xOVk{KM7:TR?= NI\rTnFUSU6JRWK=
8505C MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW1TWM2OD1zMz6yNFY4KM7:TR?= MYXTRW5ITVJ?
SK-MEL-1 NI\odHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF|LkexN|Uh|ryP MYTTRW5ITVJ?
LK-2 M2\sO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;sTGlEPTB;MUOuO|Y{QSEQvF2= M{jvTHNCVkeHUh?=
OE33 M2S3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\p[mFKSzVyPUGzMlc5PiEQvF2= M4mwT3NCVkeHUh?=
Ramos-2G6-4C10 M2HTVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF2LkCyNFIh|ryP M1K3Z3NCVkeHUh?=
EW-13 NH60WYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\hXI57UUN3ME2xOE4xOzV{IN88US=> MXXTRW5ITVJ?
NCI-H1793 NXTLZY57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLmNWJZUUN3ME2xOE4zODh5IN88US=> MYnTRW5ITVJ?
BHT-101 M2HlPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPkVFNKUUN3ME2xOE4zPDFizszN NVjrNYNZW0GQR1XS
RKO MnH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjT[oNKSzVyPUG0MlUxPzVizszN MoPrV2FPT0WU
NEC8 M1u0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTF2LkW0O|Ih|ryP M2\mRnNCVkeHUh?=
PANC-10-05 M2XHZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTF2Lk[yOFch|ryP NFzZb4hUSU6JRWK=
NCI-H2030 MnnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETjOYlKSzVyPUG0MlY1PDhizszN MYHTRW5ITVJ?
C2BBe1 M2ryO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1f4SWlEPTB;MUSuO|Y1KM7:TR?= M4jGeHNCVkeHUh?=
EM-2 Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrpTWM2OD1zND64OVc3KM7:TR?= NHnBSXZUSU6JRWK=
HCC1395 NESxfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLITmpKSzVyPUG0Mlk{OzhizszN NH;YTHVUSU6JRWK=
A2058 NGDBOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrp[3hKSzVyPUG1MlA1ODlizszN MlW0V2FPT0WU
SW1463 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTF3LkC0PFUh|ryP NITBZ41USU6JRWK=
J82 M4H1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LSVmlEPTB;MUWuNFU4KM7:TR?= MXXTRW5ITVJ?
CAL-120 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfPc|BKSzVyPUG1MlE1PDdizszN MnnpV2FPT0WU
COLO-824 NG\1SWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTF3LkG1O|kh|ryP M{TwOHNCVkeHUh?=
LNCaP-Clone-FGC NEL1fpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF3LkSyOFgh|ryP M1e1O3NCVkeHUh?=
CP66-MEL M4DLNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vpT2lEPTB;MUWuOFY5QCEQvF2= MWjTRW5ITVJ?
OC-314 MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjUc3NKSzVyPUG1MlQ4OTRizszN Ml35V2FPT0WU
OVCAR-8 NUjkXodZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjWfGJ6UUN3ME2xOU45QDZzIN88US=> Mm\FV2FPT0WU
MFE-280 M3f5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;nOFhnUUN3ME2xOk4xPDh6IN88US=> M1LY[XNCVkeHUh?=
MHH-NB-11 NXrEVJZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqwXYJoUUN3ME2xOk4xQDN7IN88US=> M{Ha[nNCVkeHUh?=
SW1990 NF3IWolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF4LkG3OVUh|ryP NV6y[VlqW0GQR1XS
U-266 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P3WmlEPTB;MU[uNlI6QSEQvF2= M2THOHNCVkeHUh?=
MFM-223 M4\BPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC4NHdIUUN3ME2xOk4{QTZ3IN88US=> M2nPWHNCVkeHUh?=
L-363 NYnGRoZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXSTWM2OD1zNj60OVc4KM7:TR?= NF7FWWRUSU6JRWK=
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SK-MEL-3 NETTVppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXaTWM2OD1zNj60O|g4KM7:TR?= NH3FPHZUSU6JRWK=
HH NGnuU|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXNNZpIUUN3ME2xOk42OTZ{IN88US=> M3HE[3NCVkeHUh?=
no-10 NWG5bnA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTF4Lk[zOFMh|ryP NXz5ZZRxW0GQR1XS
HuP-T3 NYfWV|dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLvTWM2OD1zNj62OVc3KM7:TR?= MXfTRW5ITVJ?
QIMR-WIL MmX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF4LkexNFUh|ryP MX\TRW5ITVJ?
NCI-H1092 M3\VW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\OdmlEPTB;MU[uPFMyPiEQvF2= MmXiV2FPT0WU
MZ2-MEL M37vSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjnWXpCUUN3ME2xOk45PDB|IN88US=> MYjTRW5ITVJ?
ES3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH70[4dKSzVyPUG2MlkyOzRizszN M2jIUnNCVkeHUh?=
COLO-684 MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XoVmlEPTB;MU[uPVQ4PyEQvF2= M1jKbHNCVkeHUh?=
NCI-H661 MnnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3VdJdKSzVyPUG2Mlk3QTRizszN MWfTRW5ITVJ?
CP50-MEL-B M1Lucmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTF5LkCzOFMh|ryP NF\KSm5USU6JRWK=
NCI-H2405 M3OyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTF5LkG5O|Qh|ryP MljZV2FPT0WU
U-2-OS MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHMNnFKSzVyPUG3MlU{ODdizszN MVjTRW5ITVJ?
RERF-LC-MS MlPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojzTWM2OD1zNz61OVA5KM7:TR?= MVXTRW5ITVJ?
NCI-H2342 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLHTWM2OD1zNz61OVch|ryP M13q[nNCVkeHUh?=
ES8 Mmi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XCTGlEPTB;MUeuOlA5PyEQvF2= MWXTRW5ITVJ?
MOLT-16 NWPwTZp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPUTWM2OD1zNz64PVM1KM7:TR?= NYLFWmJrW0GQR1XS
RH-18 M{HuSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTBO2ZpUUN3ME2xPE4xODN3IN88US=> MULTRW5ITVJ?
D-283MED NITYTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XScGlEPTB;MUiuNFA5QCEQvF2= MWPTRW5ITVJ?
RCC10RGB M{DlV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HpZWlEPTB;MUiuNFU2QSEQvF2= NIj1NVRUSU6JRWK=
NCI-H1437 MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TPPWlEPTB;MUiuNVY1OSEQvF2= M{i5b3NCVkeHUh?=
SW982 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTF6LkK2O|Eh|ryP MkPOV2FPT0WU
IST-MES1 NH3IVXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmq4TWM2OD1zOD60OFI5KM7:TR?= M{TCfHNCVkeHUh?=
A704 NVLhclhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mon5TWM2OD1zOD60O|U{KM7:TR?= M4rtSHNCVkeHUh?=
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SCH NEPUTJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjOOoVKSzVyPUG4MlY1PTZizszN NWfLS2c1W0GQR1XS
COLO-320-HSR Mni0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTyTWM2OD1zOD63OFYh|ryP M1zEcnNCVkeHUh?=
Mo-T NFfFcJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nyPWlEPTB;MUiuPFIxPCEQvF2= MlHlV2FPT0WU
Saos-2 M4PuZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLvTWM2OD1zOT6xNVYzKM7:TR?= NFryOWxUSU6JRWK=
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NCI-H2122 Mo[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHMTWM2OD1|ND6zOFcyKM7:TR?= M3nzVnNCVkeHUh?=
ABC-1 MkfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:xTWM2OD1|ND6zOlk{KM7:TR?= NHn4UYlUSU6JRWK=
NCI-H1355 NIHNcIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnTTWM2OD1|ND6zPFg6KM7:TR?= MYjTRW5ITVJ?
NOMO-1 M2K4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK1V2RKSzVyPUO0MlU4ODNizszN NYjWeVNIW0GQR1XS
MZ7-mel M{HKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUn6emRXUUN3ME2zOE43PDh5IN88US=> MoroV2FPT0WU
NCI-H810 NF\jeJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jiemlEPTB;M{SuO|I4QCEQvF2= NYDYcpl2W0GQR1XS
D-392MG NXrTRWViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTN3LkC1OlUh|ryP M3LFOnNCVkeHUh?=
LB771-HNC MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf0eIpKSzVyPUO1MlE3PThizszN Ml;uV2FPT0WU
COLO-679 M4n2emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrITWM2OD1|NT6zPFgh|ryP MW\TRW5ITVJ?
SK-PN-DW MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTN3LkSzOlkh|ryP NUfOWXZ7W0GQR1XS
VA-ES-BJ Mn\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\2c2lEPTB;M{WuOFY1QSEQvF2= Mk[5V2FPT0WU
KNS-42 NFnXNFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTN3LkW4NlYh|ryP MUfTRW5ITVJ?
RVH-421 M3TFVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3ndYJvUUN3ME2zOU44PjR3IN88US=> MUnTRW5ITVJ?
P30-OHK MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTN3Lki3OVIh|ryP MknqV2FPT0WU
G-402 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTN3Lkm4Olch|ryP NFPv[5NUSU6JRWK=
S-117 NIWxcmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vk[2lEPTB;M{[uN|AxQCEQvF2= NYK1Tm45W0GQR1XS
RXF393 Ml;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPjOlNKSzVyPUO2MlM4QDVizszN MYjTRW5ITVJ?
LCLC-103H NH\xcINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\V[3ZKSzVyPUO2Mlc5ODNizszN M3P2O3NCVkeHUh?=
U-118-MG M2HEZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jCUGlEPTB;M{[uPFg1PyEQvF2= NG[1TXFUSU6JRWK=
8-MG-BA MoHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTN4Lkm0PFMh|ryP NYPjNFNCW0GQR1XS
MFH-ino MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTN5LkOzO|Eh|ryP NGjQXmJUSU6JRWK=
NCI-H23 M4LxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTN5LkSxPVYh|ryP MonrV2FPT0WU
NCI-H446 MlPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLZTWM2OD1|Nz60PFYzKM7:TR?= NVHCe4pFW0GQR1XS
LU-99A MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmK2TWM2OD1|Nz61O|MyKM7:TR?= NEnDWHdUSU6JRWK=
KP-N-YN M3vVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN5Lk[xPVUh|ryP MnTsV2FPT0WU
SCC-9 MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTN5Lke4N|gh|ryP NF7yWGxUSU6JRWK=
EFM-19 NIS1[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTN5Lke5Olch|ryP M{O0W3NCVkeHUh?=
A427 NHnCVFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLn[I9CUUN3ME2zO{46OTB5IN88US=> MkW2V2FPT0WU
LB831-BLC NIjBdoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1u0UGlEPTB;M{iuOlA{QSEQvF2= MlrpV2FPT0WU
HOS NEnEeYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTN7Lk[yO|Mh|ryP MkXmV2FPT0WU
LAN-6 NUXtRotQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PTRWlEPTB;NECuNFEyOiEQvF2= NHmwS29USU6JRWK=
U251 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnNdZdKSzVyPUSwMlQxPTRizszN M{PCPHNCVkeHUh?=
SNU-387 M2WzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1z4U2lEPTB;NECuOFU2OyEQvF2= MWrTRW5ITVJ?
DMS-79 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fvXmlEPTB;NECuOVg5QSEQvF2= M3PIN3NCVkeHUh?=
SK-LU-1 MmPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NESwPFBKSzVyPUSwMlY2PjhizszN MXnTRW5ITVJ?
HT MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\OPWlEPTB;NECuOlY{QSEQvF2= NHzXRpJUSU6JRWK=
KP-N-YS MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTRyLk[3Olgh|ryP NXu0NWFxW0GQR1XS
DMS-114 NH[wWZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHRNW1jUUN3ME20NE45Ozd2IN88US=> MUTTRW5ITVJ?
HUTU-80 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37me2lEPTB;NEGuNFU3QSEQvF2= NVfy[YZsW0GQR1XS
ONS-76 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPUfGdKSzVyPUSxMlQ4ODlizszN M1PDUXNCVkeHUh?=
A673 NXzJNHhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\1bWRKSzVyPUSxMlUyPTdizszN NGXhbVFUSU6JRWK=
HPAF-II NFnIeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn72TWM2OD12MT62O|A6KM7:TR?= MXnTRW5ITVJ?
UACC-257 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M131T2lEPTB;NEGuO|M3QSEQvF2= NIDuZWlUSU6JRWK=
EW-22 M3XWdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq2eVh5UUN3ME20NU45Pjl5IN88US=> NIn6bJpUSU6JRWK=
NCI-H1755 NWLCT3h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC0TWM2OD12MT64O|I2KM7:TR?= Mnv2V2FPT0WU
KYSE-150 NI\Ke2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO0VWE{UUN3ME20Nk4yPzh{IN88US=> MkLuV2FPT0WU
CGTH-W-1 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTR{LkS5OVUh|ryP NYDsbJVLW0GQR1XS
NB13 M33LTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT2TWM2OD12Mj62NlE4KM7:TR?= M{PMUHNCVkeHUh?=
SW872 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mln4TWM2OD12Mj62N|MyKM7:TR?= MWXTRW5ITVJ?
KP-4 MnzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jIZmlEPTB;NEKuPFg{OiEQvF2= MVTTRW5ITVJ?
HCC38 NWjnT21mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnUTWM2OD12Mj65OlE5KM7:TR?= M3XtcHNCVkeHUh?=
BB49-HNC NXL2[Gg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L6RmlEPTB;NEOuNlM2PiEQvF2= NF;ScmtUSU6JRWK=
CAL-62 MkfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17hdmlEPTB;NEOuOFAzQCEQvF2= NFL0eYpUSU6JRWK=
NCI-H2029 M1G4Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzuTWM2OD12Mz61OVgyKM7:TR?= MX3TRW5ITVJ?
M14 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEH1ZnBKSzVyPUS0MlE{OzJizszN M2r5TXNCVkeHUh?=
COLO-680N MmrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPiS5BKSzVyPUS0MlM{QSEQvF2= M37IRnNCVkeHUh?=
Hs-578-T MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37r[2lEPTB;NEWuNFI6PCEQvF2= MnTCV2FPT0WU
MSTO-211H NGjZZmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjBdI5yUUN3ME20OU46PDh{IN88US=> Ml7FV2FPT0WU
EW-1 NWHuOG9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fScGlEPTB;NEWuPVY5QSEQvF2= NELOWnFUSU6JRWK=
SW948 NEPVNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jkVmlEPTB;NE[uOFQ3OiEQvF2= M4TteXNCVkeHUh?=
NCI-H460 M{DWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHqTWM2OD12Nj61NlMh|ryP MlXwV2FPT0WU
CAS-1 M4WwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfERWlKSzVyPUS2Mlc4ODFizszN NFnXV2pUSU6JRWK=
TGBC11TKB MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTR5LkG3O|ch|ryP NF7jcFFUSU6JRWK=
HD-MY-Z M3HDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzvTWM2OD12OD63PFYh|ryP MoDRV2FPT0WU
NCI-H226 NHrWRWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj6RXJKSzVyPUS5Mlc4QDVizszN NHjXWIZUSU6JRWK=
PA-1 NInxeoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfnenpIUUN3ME20PU45OzN3IN88US=> M133fXNCVkeHUh?=
LB2518-MEL M1THR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTR7Lki3NlMh|ryP NV3y[IdbW0GQR1XS
A101D NX;R[pU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof3TWM2OD12OT65OFI2KM7:TR?= M17vSHNCVkeHUh?=
NCI-H2087 M4nMeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi3SJY1UUN3ME20PU46Pjh{IN88US=> MmT1V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

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In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

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  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water <1 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 10mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • C1=C0/X C1: LOG(C1):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID