Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

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In DMSO USD 240 In stock
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USD 210 In stock
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Cited by 37 Publications

4 Customer Reviews

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 M4rCXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;JWoJKSzVyPUCuNFA2PzJizszN NXXlSm1XW0GQR1XS
KASUMI-1 NVrZVGlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrPO2RKSzVyPUCuNFA6OTFizszN NFnnfmlUSU6JRWK=
HCC2218 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEC5PFch|ryP NYfKZ2hCW0GQR1XS
KARPAS-45 MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEG2O|Eh|ryP M4TuZ3NCVkeHUh?=
HSC-4 Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHaTWM2OD1yLkCxO|Q5KM7:TR?= MXXTRW5ITVJ?
CHL-1 NULQUFF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHBOm5KSzVyPUCuNFE5OzlizszN NYTwWYZ3W0GQR1XS
KY821 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK2c2tKSzVyPUCuNFIxPiEQvF2= NUXDPGRPW0GQR1XS
NCI-N87 NIXa[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPEeIlGUUN3ME2wMlAzPzd|IN88US=> NHftcHhUSU6JRWK=
DOK MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXwTWM2OD1yLkCzNVk1KM7:TR?= NVXG[ZdRW0GQR1XS
DSH1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL6T3FKSzVyPUCuNFM{OTRizszN Mkj3V2FPT0WU
MDA-MB-175-VII NYX5Z4N[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjiRmFKSzVyPUCuNFM1OTZizszN M3i2OnNCVkeHUh?=
NCI-H2170 NFLkNI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e4SmlEPTB;MD6wN|czQCEQvF2= NELUUI5USU6JRWK=
BT-474 NYXrUFl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMES5PFYh|ryP M2PIUnNCVkeHUh?=
EFO-27 NHvVOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEK2c5pKSzVyPUCuNFUyQDJizszN M4P2eHNCVkeHUh?=
NCI-H720 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEWzNlUh|ryP NX3qWlY{W0GQR1XS
PC-14 NIfjRZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TMNGlEPTB;MD6wOVY3QCEQvF2= MonTV2FPT0WU
EC-GI-10 NGHMdIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEW5NVIh|ryP M2DXVXNCVkeHUh?=
KYSE-450 NXHJbldRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEW5O|gh|ryP NWDUNmp[W0GQR1XS
BPH-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjpTWM2OD1yLkC1PVg5KM7:TR?= MlPPV2FPT0WU
NCI-H292 M3n3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoC2TWM2OD1yLkC2NFkh|ryP MVrTRW5ITVJ?
H9 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TmRWlEPTB;MD6wO|E{OiEQvF2= MWjTRW5ITVJ?
NCI-H526 NXXnbGVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;wblVLUUN3ME2wMlA4QDJ|IN88US=> Mk\2V2FPT0WU
NCI-H1623 M4[yV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;oeGlEPTB;MD6wPFAzPSEQvF2= NWHZfm9IW0GQR1XS
KYSE-140 M2mxXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DuRWlEPTB;MD6wPFM{KM7:TR?= MoDTV2FPT0WU
Ca9-22 MnPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMEizOVMh|ryP NVTxbpZsW0GQR1XS
AU565 M1T1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEi1NFQh|ryP MYrTRW5ITVJ?
ZR-75-30 NELndo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmC4TWM2OD1yLkC5OVQ2KM7:TR?= NWPTTVFkW0GQR1XS
NCI-H1770 NUDWNIE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLBenpKSzVyPUCuNVAzQCEQvF2= MkTJV2FPT0WU
LB2241-RCC NEfSTGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljsTWM2OD1yLkGwPFg1KM7:TR?= M1\ORXNCVkeHUh?=
CAL-39 M4jzWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjGPXJKSzVyPUCuNVE4QTJizszN Ml;xV2FPT0WU
UACC-893 NFHES3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TwV2lEPTB;MD6xNVg5PSEQvF2= MWDTRW5ITVJ?
LU-65 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LMeWlEPTB;MD6xNlY{OyEQvF2= M1vJV3NCVkeHUh?=
HN Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorMTWM2OD1yLkGzNFc4KM7:TR?= M4XnfnNCVkeHUh?=
TI-73 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13O[WlEPTB;MD6xOFcyPSEQvF2= MlmyV2FPT0WU
KU812 NHvUZ4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfDOpJKSzVyPUCuNVU1PTZizszN MlTxV2FPT0WU
SW13 NVK4[4JRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle2TWM2OD1yLkG2NlE3KM7:TR?= NULjeIJxW0GQR1XS
BB30-HNC Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X1WmlEPTB;MD6xOlU4PiEQvF2= MnvsV2FPT0WU
HSC-2 Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknaTWM2OD1yLkG2PFM4KM7:TR?= MnH0V2FPT0WU
BV-173 Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\wTWM2OD1yLkG3OVk3KM7:TR?= MWLTRW5ITVJ?
CAL-27 NIDoPJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEi2V2tKSzVyPUCuNVc3OzZizszN MYDTRW5ITVJ?
SBC-1 Mk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMUi5OVkh|ryP MXPTRW5ITVJ?
CAL-33 NV75bHVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1exO2lEPTB;MD6yNFE5PCEQvF2= MmHzV2FPT0WU
NCI-H209 M1m5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTKOndJUUN3ME2wMlIxPDZizszN MWfTRW5ITVJ?
COR-L105 NYfpe3piT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3W1TmlEPTB;MD6yNVA5PCEQvF2= NXvSfotsW0GQR1XS
HSC-3 Mn3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXRSo54UUN3ME2wMlIyOTl6IN88US=> MXzTRW5ITVJ?
NCI-H69 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMkG0OVEh|ryP NEXJTGJUSU6JRWK=
MOLT-13 M3W2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXuOFZKSzVyPUCuNlM6PzVizszN NHPJUmxUSU6JRWK=
ML-2 M2PEVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nzXWlEPTB;MD6yOFgxOiEQvF2= MnfaV2FPT0WU
IGROV-1 NIrOXXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnftTWM2OD1yLkK1PVUzKM7:TR?= NGrzZlVUSU6JRWK=
TK10 NVfLSXZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMk[3N|gh|ryP NHrpd5BUSU6JRWK=
EoL-1-cell MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\vV3pMUUN3ME2wMlI3QDl{IN88US=> M4H1UHNCVkeHUh?=
HO-1-N-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMke4OVMh|ryP MVfTRW5ITVJ?
BHY NHqzU|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M321TWlEPTB;MD6yPFY2PSEQvF2= Mmr3V2FPT0WU
LU-139 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPJTWM2OD1yLkOwOVEh|ryP NYnHbZRxW0GQR1XS
23132-87 NIPqNHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX1Z3FKSzVyPUCuN|E6OjNizszN MnLBV2FPT0WU
ACHN NULjR|BvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf5[HVKSzVyPUCuN|E6QTRizszN NE[zZVhUSU6JRWK=
DoTc2-4510 MlzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rRXGlEPTB;MD6zNlIyQSEQvF2= M1[yUnNCVkeHUh?=
BB65-RCC Mke2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;rTWM2OD1yLkO0OVk{KM7:TR?= Mo\lV2FPT0WU
HLE MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkniTWM2OD1yLkO1NFQ3KM7:TR?= M2jrSnNCVkeHUh?=
HCC1419 NEfGS|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37TWmlEPTB;MD6zOlQxQCEQvF2= NF;oTGVUSU6JRWK=
A388 M4nHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwM{[4OVch|ryP M{DocHNCVkeHUh?=
NUGC-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXaTWM2OD1yLkO4N|c{KM7:TR?= NFi5VY9USU6JRWK=
KYSE-180 M{jN[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIW3[nJKSzVyPUCuN|kxQDlizszN MlfnV2FPT0WU
TE-6 Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jqZ2lEPTB;MD60NFI1PiEQvF2= M{nQV3NCVkeHUh?=
A498 NHHleJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3EUpJKSzVyPUCuOFA3PzRizszN M2DZT3NCVkeHUh?=
NCI-H1648 NVTrVWhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnywTWM2OD1yLkS0NVgzKM7:TR?= MWnTRW5ITVJ?
DU-145 MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3zW29OUUN3ME2wMlQ1QDN|IN88US=> MYHTRW5ITVJ?
CW-2 NGXYU2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\wTWM2OD1yLkS2PVE1KM7:TR?= NYiwSZI5W0GQR1XS
A431 M2HI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwNEiyN|Mh|ryP Mn7VV2FPT0WU
SAS MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrTd5RXUUN3ME2wMlQ5Ozl6IN88US=> MmH3V2FPT0WU
NCI-H2126 NULDTHJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XyVGlEPTB;MD61NVkzPiEQvF2= NX3veolnW0GQR1XS
NCI-H358 M2rrUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHX5UINKSzVyPUCuOVMzOSEQvF2= NFPTbnBUSU6JRWK=
FADU NHXNNGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXDUItoUUN3ME2wMlU1PDB2IN88US=> M4TTcXNCVkeHUh?=
ACN MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPRTWM2OD1yLkW1NFk1KM7:TR?= MWTTRW5ITVJ?
HCC70 NU\mU5ZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;1TWM2OD1yLkW3OlYyKM7:TR?= NHroO|FUSU6JRWK=
NCI-H1838 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;KTWM2OD1yLk[wNlk6KM7:TR?= MnvvV2FPT0WU
CAL-54 NVf5ZXlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonJTWM2OD1yLk[xOlIyKM7:TR?= MkOyV2FPT0WU
NCI-H1975 M336d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TNcGlEPTB;MD62NVczQCEQvF2= MYLTRW5ITVJ?
COR-L88 NVL4XpNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDsTI1KSzVyPUCuOlQyOTNizszN Mlv2V2FPT0WU
CTV-1 MmTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwNkSzPVIh|ryP NVnmN2N5W0GQR1XS
EW-18 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz3TWM2OD1yLk[4Olk5KM7:TR?= NV\RXotGW0GQR1XS
HCC1806 MkjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3G5OmlEPTB;MD62PVY3PiEQvF2= MULTRW5ITVJ?
HuP-T4 M2X5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnZ[41uUUN3ME2wMlY6PzZizszN NH3WTXJUSU6JRWK=
MDA-MB-361 NITjNItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwN{K2OlIh|ryP NVWzdmJLW0GQR1XS
NCI-H1573 NX;IVmN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nLfmlEPTB;MD63N|Y{KM7:TR?= MoDyV2FPT0WU
KU-19-19 M2Xrbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\lNYxHUUN3ME2wMlc4PDZ2IN88US=> MXvTRW5ITVJ?
COLO-678 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrTelR[UUN3ME2wMlgxQDN2IN88US=> M4TBT3NCVkeHUh?=
C-33-A M3fMTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13J[mlEPTB;MD64NVI6PyEQvF2= NXHSdJVwW0GQR1XS
Calu-3 NH21e5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHqR|hKSzVyPUCuPFE1OzRizszN Ml;pV2FPT0WU
AGS MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETaZppKSzVyPUCuPFM3PDhizszN NXjvXoRLW0GQR1XS
SCC-25 NXfiWo0yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlG3TWM2OD1yLki0NVcyKM7:TR?= MnrWV2FPT0WU
JVM-2 NVPqcXBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP5TWM2OD1yLki4Nlk6KM7:TR?= NYr2To9RW0GQR1XS
HCE-T NVK5fYlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2OxSGlEPTB;MD64PFQzQCEQvF2= MWnTRW5ITVJ?
ES4 NYPj[IF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwOUe4N|Yh|ryP M1OyeXNCVkeHUh?=
EKVX M2nlNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\2TWM2OD1zLkCxNFY1KM7:TR?= NUXUW3l5W0GQR1XS
D-542MG NGjFOWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7NPXJpUUN3ME2xMlAyODZ2IN88US=> MWjTRW5ITVJ?
SW1116 NUSwT5ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\wXmdoUUN3ME2xMlAyOjh5IN88US=> M2fTdXNCVkeHUh?=
5637 MlXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTFwMEG1NUDPxE1? NFzzeWxUSU6JRWK=
HT-1376 M4KxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Lkb2lEPTB;MT6wNVUyOyEQvF2= NUjxNYIzW0GQR1XS
NB69 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHyRXdKSzVyPUGuNFI6PDVizszN NUSwfJBDW0GQR1XS
YKG-1 MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjJXXhDUUN3ME2xMlA2PDF7IN88US=> NVTWZYtLW0GQR1XS
EW-3 NF3TOWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHtbYhzUUN3ME2xMlA4QDh|IN88US=> M3W0Z3NCVkeHUh?=
GCIY M2LlbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDoTWM2OD1zLkC4NVA1KM7:TR?= NITqSmJUSU6JRWK=
SK-MES-1 NFXlNXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml62TWM2OD1zLkGxOFg4KM7:TR?= NFzQRmhUSU6JRWK=
PANC-08-13 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILufIxKSzVyPUGuNVY1OTZizszN NInxcmdUSU6JRWK=
SK-NEP-1 M4HjW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\VUFdXUUN3ME2xMlE4PTF|IN88US=> M3rpd3NCVkeHUh?=
SW954 M{DnVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVy3bo5lUUN3ME2xMlIxOjF2IN88US=> MYjTRW5ITVJ?
NCI-SNU-5 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vn[GlEPTB;MT6yN|kh|ryP MUDTRW5ITVJ?
SW48 NYLUNZRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13ReGlEPTB;MT6yOVQ{OiEQvF2= MV\TRW5ITVJ?
HT-3 M3Hoemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDrfXUzUUN3ME2xMlI5PzV|IN88US=> NIrDO5VUSU6JRWK=
ETK-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFwM{e0OVYh|ryP MlPkV2FPT0WU
SCC-15 NWnqe3J6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnJcmRIUUN3ME2xMlM6PDVzIN88US=> MnmwV2FPT0WU
DU-4475 NYXqWo9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjRTWM2OD1zLkSwNVIyKM7:TR?= NF7JcpFUSU6JRWK=
NB5 M4fyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofvTWM2OD1zLkSxN|E4KM7:TR?= Mm\RV2FPT0WU
CFPAC-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonwTWM2OD1zLkSyOFk{KM7:TR?= MXPTRW5ITVJ?
NCI-H630 NFPHZ2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUH1VYp7UUN3ME2xMlQ2PTh{IN88US=> NIK3fW9USU6JRWK=
NCI-H82 NFrHelZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\kcZJKSzVyPUGuOVQxODZizszN NH6zTHFUSU6JRWK=
ECC10 NYqxU2lUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvvTWM2OD1zLkW1N|Y6KM7:TR?= M3zuV3NCVkeHUh?=
K5 NFjnNW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKzSIRKSzVyPUGuOVg{PTdizszN NYjmcIV4W0GQR1XS
ME-180 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTFwNkGwPVYh|ryP MXHTRW5ITVJ?
KYSE-410 M4rXeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TafmlEPTB;MT62OVY4OiEQvF2= MXLTRW5ITVJ?
G-401 MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXUVFEzUUN3ME2xMlY4PDF|IN88US=> MkXMV2FPT0WU
TGBC24TKB NXPkR|Y2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq3SWhUUUN3ME2xMlY5OjNizszN MWfTRW5ITVJ?
Detroit562 M2fXV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTFwN{CxOVIh|ryP MWjTRW5ITVJ?
OE19 M3vJTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTFwN{G1NVIh|ryP M4TiXnNCVkeHUh?=
CAKI-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;RXm4yUUN3ME2xMlc5OjFzIN88US=> NFHKXodUSU6JRWK=
TE-12 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3sTWM2OD1zLkiwOFE1KM7:TR?= MYDTRW5ITVJ?
NCI-H1666 NHPGc4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17xdmlEPTB;MT64NFk1QCEQvF2= NF7JSpdUSU6JRWK=
TE-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPM[ZdnUUN3ME2xMlgyPDd3IN88US=> MnPDV2FPT0WU
CAL-12T M1nR[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTFwOEi5OFUh|ryP MV;TRW5ITVJ?
TE-8 NXPBcHg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCwS5lqUUN3ME2xMlkyOzd5IN88US=> MVzTRW5ITVJ?
KYSE-270 MmXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHWxNZhKSzVyPUKuNFI4OzJizszN M4LQZnNCVkeHUh?=
GMS-10 MlPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPsT5l3UUN3ME2yMlA{PTF5IN88US=> NFnP[GpUSU6JRWK=
A2780 MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJwME[yPVQh|ryP MmfQV2FPT0WU
OMC-1 M1\NWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\vTWM2OD1{LkC4NVY6KM7:TR?= MXTTRW5ITVJ?
LoVo NEn3c|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmGzTWM2OD1{LkGwO|k4KM7:TR?= MmPDV2FPT0WU
PANC-03-27 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwMU[2N|Eh|ryP Ml;TV2FPT0WU
MDA-MB-157 MnTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJwMkG4Nlgh|ryP MlrHV2FPT0WU
CaR-1 M2XnW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK0cpFKSzVyPUKuNlgzQDFizszN NYXhOod{W0GQR1XS
769-P M2Dqbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXpdJZKSzVyPUKuNlkxOzdizszN MXPTRW5ITVJ?
NB7 NYHqPXNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofXTWM2OD1{LkK5Olc3KM7:TR?= NEPLXWtUSU6JRWK=
MKN7 M1zoSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\UdmwxUUN3ME2yMlM2OzN3IN88US=> MUfTRW5ITVJ?
NCI-H1048 NF3CdGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\WeGlEPTB;Mj60PVE2QCEQvF2= M4r6bnNCVkeHUh?=
RCM-1 NGLEeYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PLdWlEPTB;Mj61Nlk{QCEQvF2= MnPjV2FPT0WU
HT55 M1vpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUP6WnhSUUN3ME2yMlU4OzhizszN MmfWV2FPT0WU
HCC1569 NF31XWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\UbGlEPTB;Mj61PFI6PyEQvF2= NFrsVHVUSU6JRWK=
LXF-289 NU\vOJpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\tdXEzUUN3ME2yMlY{PTZ3IN88US=> MkHMV2FPT0WU
OVCAR-3 NXq5U3ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Hs[WlEPTB;Mj62O|E3PyEQvF2= M1fJXHNCVkeHUh?=
TE-10 M334Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTJwNkiwO|gh|ryP MnH3V2FPT0WU
SNU-C2B MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rjPWlEPTB;Mj62PFYyPiEQvF2= NUHvO28xW0GQR1XS
LB1047-RCC M3LCdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW3TWM2OD1{Lke0PFg5KM7:TR?= M1\G[XNCVkeHUh?=
SN12C MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlqyTWM2OD1{LkmxPVY1KM7:TR?= Ml3vV2FPT0WU
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HT-29 NHfwR2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTPU3JqUUN3ME2zMlA4OzB7IN88US=> NIXCSlBUSU6JRWK=
RPMI-7951 M1XqVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlroTWM2OD1|LkC3OVkh|ryP NITBVZpUSU6JRWK=
NBsusSR NHq2PYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTNwMUiyOVQh|ryP MVzTRW5ITVJ?
NKM-1 M3vKfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmGyTWM2OD1|LkG4O|Q1KM7:TR?= NX31bXZWW0GQR1XS
Capan-2 MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3GbIFKSzVyPUOuOFY5PzVizszN MnjXV2FPT0WU
MKN1 NYjWSZltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PpV2lEPTB;Mz60O|ExQCEQvF2= NVK5[YtIW0GQR1XS
OAW-42 NXfjNGxtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTNwNUCwNlYh|ryP NV7xb5V{W0GQR1XS
SKG-IIIa MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXoTWM2OD1|LkWyNlM4KM7:TR?= M3zZfXNCVkeHUh?=
no-11 NVrXSnJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfuVGNMUUN3ME2zMlU{PTZ2IN88US=> M2nXUXNCVkeHUh?=
NY M2HzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPwdlFTUUN3ME2zMlU{PjV3IN88US=> NIrNOZZUSU6JRWK=
HEC-1 NYL5fGRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIe1eVNKSzVyPUOuOVg6PSEQvF2= M4K2PHNCVkeHUh?=
NCI-H441 M1n5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWC1WW9mUUN3ME2zMlU6QDRzIN88US=> NXPyW4pJW0GQR1XS
NCI-H2009 M4DOZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITQZmlKSzVyPUOuOlEzOTZizszN NYLTOoYyW0GQR1XS
T47D MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnG2TWM2OD1|Lk[yNlE4KM7:TR?= NV\1W41uW0GQR1XS
SNU-449 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkCxTWM2OD1|Lk[1PFI3KM7:TR?= M4HMenNCVkeHUh?=
NCI-SNU-1 NYTBfXB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rhUGlEPTB;Mz62PVc{PSEQvF2= MWnTRW5ITVJ?
BT-20 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvxSpNkUUN3ME2zMlY6Pzl3IN88US=> Mnr5V2FPT0WU
LS-123 M37obmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTNwN{SyPFQh|ryP MX7TRW5ITVJ?
8305C M2PwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTNwN{W5NVEh|ryP M4DqdnNCVkeHUh?=
OCUB-M Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTNwN{[xPFch|ryP NHXjN3ZUSU6JRWK=
KOSC-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPmb|VMUUN3ME2zMlg{PDVzIN88US=> MXnTRW5ITVJ?
NCI-H1693 NFzxeVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTUVpc5UUN3ME2zMlg1OThzIN88US=> MYnTRW5ITVJ?
TE-9 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTNwOESzPFIh|ryP M2rTUnNCVkeHUh?=
MV-4-11 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13SfmlEPTB;Mz64O|k6PCEQvF2= NH;YcmFUSU6JRWK=
GAMG NIHyOY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTNwOUGzNVQh|ryP Mmf0V2FPT0WU
KNS-62 Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTjc4ltUUN3ME2zMlk1PzNzIN88US=> NYLvTIdxW0GQR1XS
MC116 M{nMd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\ScI5sUUN3ME2zMlk2PDh7IN88US=> MUDTRW5ITVJ?
647-V NH[zZmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;sTWM2OD1|Lkm4OFUzKM7:TR?= MoKxV2FPT0WU
U-87-MG NGPjZZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Lhe2lEPTB;ND6xNFQ5OSEQvF2= MmnqV2FPT0WU
RPMI-8226 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3hTWM2OD12LkGxOlMyKM7:TR?= M2X6cnNCVkeHUh?=
SW1417 M3y2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojuTWM2OD12LkGyNVQ4KM7:TR?= NIrlPVVUSU6JRWK=
LAMA-84 MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLITWM2OD12LkG3NFIh|ryP M4HIdnNCVkeHUh?=
LS-513 NVnM[XJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfoTWM2OD12LkOxNlE4KM7:TR?= NHz5VVVUSU6JRWK=
KLE NGfBdIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHuZXFKSzVyPUSuOFA5OTlizszN NXnublBCW0GQR1XS
HCT-116 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTRwNEGwNFch|ryP M3LJZ3NCVkeHUh?=
EPLC-272H MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTRwNEG1N|Mh|ryP Ml;HV2FPT0WU
KS-1 NF;1N2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTRwNUC4PFkh|ryP NYrDcmh5W0GQR1XS
HT-1197 MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzzdWhxUUN3ME20MlUzPjZ7IN88US=> MlzHV2FPT0WU
LCLC-97TM1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXeybHA6UUN3ME20MlU{Pjh4IN88US=> MVHTRW5ITVJ?
ES5 NFXKVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXHTWM2OD12LkizO|I{KM7:TR?= M{XYWXNCVkeHUh?=
CTB-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrTeGl1UUN3ME20Mlg1QDhizszN MYnTRW5ITVJ?
HL-60 NVz0eo82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP1[mlkUUN3ME20Mlg3PjFzIN88US=> MnvpV2FPT0WU
VM-CUB-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTRwOE[4NVkh|ryP MXnTRW5ITVJ?
MEG-01 NImySHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHmwPY9KSzVyPUSuPVk1ODNizszN MkfNV2FPT0WU
KYSE-520 NVLOcnoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrETWM2OD13LkKwPFM6KM7:TR?= M{CzVHNCVkeHUh?=
HuO-3N1 NUfvTm54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDiTWM2OD13LkK0NFQ{KM7:TR?= NY\1XXZEW0GQR1XS
SW620 M2\hb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DK[GlEPTB;NT6yOFk3PCEQvF2= M4PkTHNCVkeHUh?=
U031 NHTWPINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\BTWM2OD13LkK1OFI1KM7:TR?= M4j2UXNCVkeHUh?=
TE-5 NUP4SYsyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHXTWM2OD13LkSwPFUh|ryP MWHTRW5ITVJ?
NCI-H747 M4HWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDyTWM2OD13LkSyOFczKM7:TR?= NH3DTWNUSU6JRWK=
MG-63 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnpTWM2OD13LkS4O|YzKM7:TR?= MXnTRW5ITVJ?
HC-1 NXr2UZBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTVwNUG4N|kh|ryP M1vwdXNCVkeHUh?=
HCC2998 MorjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrRTFFuUUN3ME21MlUzPjF3IN88US=> NVXzUXVpW0GQR1XS
NTERA-S-cl-D1 NXvsfllJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTVwNUS1N|ch|ryP MWDTRW5ITVJ?
KINGS-1 Mn\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PoeWlEPTB;NT62NFk1PCEQvF2= NF;LZ5VUSU6JRWK=
D-423MG NH3COJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVK1WXlxUUN3ME21MlYyPzB3IN88US=> MWDTRW5ITVJ?
SW962 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLqS2RKSzVyPUWuOlIxOzJizszN M{HtSHNCVkeHUh?=
LOXIMVI M1X0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGryeHpKSzVyPUWuOlM5PzNizszN NGHXWnlUSU6JRWK=
LS-411N NXv0ZWg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvhTWM2OD13Lke5OFQyKM7:TR?= NESxcYdUSU6JRWK=
NCI-H2291 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;lTWM2OD13Lkm4PVQ{KM7:TR?= NHToXJZUSU6JRWK=
A549 NHPx[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\jTWM2OD14LkGyOVU{KM7:TR?= MXTTRW5ITVJ?
LS-1034 M4fqcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jqTGlEPTB;Nj6yNFcxPiEQvF2= NWrnUFA3W0GQR1XS
NB14 NEfuWJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfqUGZUUUN3ME22MlQ{QDN4IN88US=> MXnTRW5ITVJ?
NCI-H1299 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTZwNkOxO|Eh|ryP M4nvbHNCVkeHUh?=
BT-549 M4H0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTZwNk[4PFkh|ryP MnPCV2FPT0WU
J-RT3-T3-5 NFHwRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fhdGlEPTB;Nj64Olkh|ryP MnLGV2FPT0WU
SW756 NXjneIw6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrwVXBOUUN3ME22MlkyOTd4IN88US=> M3jOZXNCVkeHUh?=
DJM-1 NWXnVJFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjOTGxmUUN3ME22MlkzODF{IN88US=> MVTTRW5ITVJ?
GP5d NE\2bWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDUOlVKSzVyPU[uPVc{QTRizszN MUnTRW5ITVJ?
MOLT-4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXS2S5FNUUN3ME23MlAzOTN3IN88US=> MnriV2FPT0WU
NCI-H28 NFHmOnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfBNo5KSzVyPUeuNVY1ODVizszN MXnTRW5ITVJ?
MN-60 M{LsbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3pT|JKSzVyPUeuNlgxQDlizszN M1j2PHNCVkeHUh?=
RMG-I MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnQXm5KSzVyPUeuN|kzQTZizszN MnPRV2FPT0WU
COLO-800 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLtTWM2OD15LkSxOFQ3KM7:TR?= M2mw[HNCVkeHUh?=
DB NXq5PZd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlL3TWM2OD15Lk[xNFA2KM7:TR?= MnHDV2FPT0WU
Ca-Ski MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;jTWM2OD15Lk[0NlU6KM7:TR?= NFTPW2RUSU6JRWK=
HEL M4PkXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXUTWM2OD15LkexNlA{KM7:TR?= M{C3enNCVkeHUh?=
NH-12 NVTUeG9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHvTWM2OD15LkeyPFA5KM7:TR?= MoO0V2FPT0WU
LB373-MEL-D NGWxWI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\RU|lmUUN3ME23Mlc3PzdzIN88US=> NH3heHpUSU6JRWK=
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KM-H2 M1TUUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi2OWpjUUN3ME2zOE4yPzd7IN88US=> M2rle3NCVkeHUh?=
NCI-H2122 M3rrb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTN2LkO0O|Eh|ryP NITUephUSU6JRWK=
ABC-1 MmS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjnTWM2OD1|ND6zOlk{KM7:TR?= MlrUV2FPT0WU
NCI-H1355 Ml7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmKzTWM2OD1|ND6zPFg6KM7:TR?= NXvOOZU5W0GQR1XS
NOMO-1 NHT6dVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvZXVRKSzVyPUO0MlU4ODNizszN MnTCV2FPT0WU
MZ7-mel MlXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTN2Lk[0PFch|ryP MkXGV2FPT0WU
NCI-H810 NHHHR5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjhTWM2OD1|ND63Nlc5KM7:TR?= MYTTRW5ITVJ?
D-392MG MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;5XGpKSzVyPUO1MlA2PjVizszN NWHaeJFFW0GQR1XS
LB771-HNC NU[wO5dST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHZcY12UUN3ME2zOU4yPjV6IN88US=> MmXSV2FPT0WU
COLO-679 M4nOWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfKTWM2OD1|NT6zPFgh|ryP M1XuNHNCVkeHUh?=
SK-PN-DW M3XFd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTaXZNXUUN3ME2zOU41OzZ7IN88US=> NWrZfFBuW0GQR1XS
VA-ES-BJ Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTN3LkS2OFkh|ryP NIDZflJUSU6JRWK=
KNS-42 Ml[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTN3LkW4NlYh|ryP MW\TRW5ITVJ?
RVH-421 NH\BRYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXDTWM2OD1|NT63OlQ2KM7:TR?= NX35[5JxW0GQR1XS
P30-OHK M1TvcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrpTWM2OD1|NT64O|UzKM7:TR?= MXnTRW5ITVJ?
G-402 MojzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLGTWM2OD1|NT65PFY4KM7:TR?= MoTCV2FPT0WU
S-117 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrKU5pKSzVyPUO2MlMxODhizszN M2DsdXNCVkeHUh?=
RXF393 M4X5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTN4LkO3PFUh|ryP MUHTRW5ITVJ?
LCLC-103H MmiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTN4Lke4NFMh|ryP NUHQVmk{W0GQR1XS
U-118-MG MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF6xTGpKSzVyPUO2Mlg5PDdizszN MXLTRW5ITVJ?
8-MG-BA MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPpcnJKSzVyPUO2Mlk1QDNizszN MojvV2FPT0WU
MFH-ino NHm3c4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfNW2NKSzVyPUO3MlM{PzFizszN MXXTRW5ITVJ?
NCI-H23 MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rMSGlEPTB;M{euOFE6PiEQvF2= NVvwc2tQW0GQR1XS
NCI-H446 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTN5LkS4OlIh|ryP NGm0[GdUSU6JRWK=
LU-99A MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTN5LkW3N|Eh|ryP M4Lm[nNCVkeHUh?=
KP-N-YN NGfNcJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\uR3VxUUN3ME2zO{43OTl3IN88US=> Ml73V2FPT0WU
SCC-9 M{XIemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK3TWM2OD1|Nz63PFM5KM7:TR?= NIPhNItUSU6JRWK=
EFM-19 NXG2WopkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonlTWM2OD1|Nz63PVY4KM7:TR?= M2foUnNCVkeHUh?=
A427 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT2T2RnUUN3ME2zO{46OTB5IN88US=> M1r0NXNCVkeHUh?=
LB831-BLC Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\NOZNKSzVyPUO4MlYxOzlizszN MUDTRW5ITVJ?
HOS NF\1XopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\3Wmw6UUN3ME2zPU43Ojd|IN88US=> NUTuWGJbW0GQR1XS
LAN-6 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;BV4dmUUN3ME20NE4xOTF{IN88US=> NHzrdGJUSU6JRWK=
U251 MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe0Z2tPUUN3ME20NE41ODV2IN88US=> M4Pn[XNCVkeHUh?=
SNU-387 MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTVTWM2OD12MD60OVU{KM7:TR?= MlfaV2FPT0WU
DMS-79 MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPkTWM2OD12MD61PFg6KM7:TR?= NFiwdnJUSU6JRWK=
SK-LU-1 NHzrNWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3DbJBKSzVyPUSwMlY2PjhizszN NWjwXm43W0GQR1XS
HT MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTRyLk[2N|kh|ryP MlPOV2FPT0WU
KP-N-YS M{X3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PBW2lEPTB;NECuOlc3QCEQvF2= NEDnTopUSU6JRWK=
DMS-114 NX32dYtyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\HTWM2OD12MD64N|c1KM7:TR?= MY\TRW5ITVJ?
HUTU-80 M33jZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTRzLkC1Olkh|ryP NYDVO5Y2W0GQR1XS
ONS-76 NXjL[FZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnMTWM2OD12MT60O|A6KM7:TR?= NYriepNSW0GQR1XS
A673 M4XZNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DTfGlEPTB;NEGuOVE2PyEQvF2= NHL5XlFUSU6JRWK=
HPAF-II M{X4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTRzLk[3NFkh|ryP NWHkRnBOW0GQR1XS
UACC-257 M1K2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTRzLkezOlkh|ryP NIfVcopUSU6JRWK=
EW-22 MkXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4G3VGlEPTB;NEGuPFY6PyEQvF2= MnmxV2FPT0WU
NCI-H1755 MofwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHW3clVKSzVyPUSxMlg4OjVizszN Mlv6V2FPT0WU
KYSE-150 NVT3W5RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTR{LkG3PFIh|ryP M3rzZnNCVkeHUh?=
CGTH-W-1 NWjBVZo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTVTWM2OD12Mj60PVU2KM7:TR?= MlnyV2FPT0WU
NB13 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPqZY9uUUN3ME20Nk43OjF5IN88US=> MX;TRW5ITVJ?
SW872 NG\0PHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonITWM2OD12Mj62N|MyKM7:TR?= MorZV2FPT0WU
KP-4 NWKyZm5pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz6UmNKSzVyPUSyMlg5OzJizszN M3TNd3NCVkeHUh?=
HCC38 M{S4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvqc3RKSzVyPUSyMlk3OThizszN NVizdWhvW0GQR1XS
BB49-HNC M4DiPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjwSJRtUUN3ME20N{4zOzV4IN88US=> MnTRV2FPT0WU
CAL-62 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorYTWM2OD12Mz60NFI5KM7:TR?= NYLYO3VGW0GQR1XS
NCI-H2029 M2\ZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTR|LkW1PFEh|ryP M4T1ZXNCVkeHUh?=
M14 NFe5VZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\XTWM2OD12ND6xN|MzKM7:TR?= NXzaemNqW0GQR1XS
COLO-680N MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV23VYtFUUN3ME20OE4{OzlizszN NHntWohUSU6JRWK=
Hs-578-T M{TyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7DVYVKSzVyPUS1MlAzQTRizszN M1\jUHNCVkeHUh?=
MSTO-211H NXT4bZEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorqTWM2OD12NT65OFgzKM7:TR?= M3nyZ3NCVkeHUh?=
EW-1 NXnhZnp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoX3TWM2OD12NT65Olg6KM7:TR?= NXX5U2tLW0GQR1XS
SW948 NE\3R|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n4cWlEPTB;NE[uOFQ3OiEQvF2= MoTOV2FPT0WU
NCI-H460 NIXGc2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTyeZA1UUN3ME20Ok42OjNizszN NFG2dHZUSU6JRWK=
CAS-1 NFPwR3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfxTWM2OD12Nj63O|AyKM7:TR?= MlTRV2FPT0WU
TGBC11TKB NFrjWZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPlfGplUUN3ME20O{4yPzd5IN88US=> MYrTRW5ITVJ?
HD-MY-Z NU\MTmVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTR6Lke4OkDPxE1? Ml3KV2FPT0WU
NCI-H226 NEO2NY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkL6TWM2OD12OT63O|g2KM7:TR?= NW\XWY5lW0GQR1XS
PA-1 NHnUbY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTR7LkizN|Uh|ryP MUfTRW5ITVJ?
LB2518-MEL NVv6N5U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LEdWlEPTB;NEmuPFczOyEQvF2= NXrNeI1nW0GQR1XS
A101D M2jVU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\OO3o1UUN3ME20PU46PDJ3IN88US=> MXTTRW5ITVJ?
NCI-H2087 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTR7Lkm2PFIh|ryP NVPLdphlW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID