Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

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In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 570 In stock

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Cited by 35 Publications

3 Customer Reviews

  • Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 MmH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\HTWM2OD1yLkCwOVczKM7:TR?= MUjTRW5ITVJ?
KASUMI-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOyPIRoUUN3ME2wMlAxQTFzIN88US=> MYTTRW5ITVJ?
HCC2218 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rmNGlEPTB;MD6wNFk5PyEQvF2= NVXHdFBSW0GQR1XS
KARPAS-45 NYe0d|RLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHrTWM2OD1yLkCxOlcyKM7:TR?= MYXTRW5ITVJ?
HSC-4 NEXrWJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;iTWM2OD1yLkCxO|Q5KM7:TR?= NFvkNoRUSU6JRWK=
CHL-1 M4TKb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rDWWlEPTB;MD6wNVg{QSEQvF2= NWjjRno6W0GQR1XS
KY821 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnUNFdKUUN3ME2wMlAzODZizszN NH6zNI5USU6JRWK=
NCI-N87 M3jvUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1e3cmlEPTB;MD6wNlc4OyEQvF2= NV3RZYs1W0GQR1XS
DOK NFPZZ45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvMTWM2OD1yLkCzNVk1KM7:TR?= MkTyV2FPT0WU
DSH1 M1XIN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjZVnpKSzVyPUCuNFM{OTRizszN MXHTRW5ITVJ?
MDA-MB-175-VII MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHywdVJKSzVyPUCuNFM1OTZizszN NGnTeVRUSU6JRWK=
NCI-H2170 M3X1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrRTWM2OD1yLkCzO|I5KM7:TR?= MXzTRW5ITVJ?
BT-474 NHOx[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPQTWM2OD1yLkC0PVg3KM7:TR?= M1zTZnNCVkeHUh?=
EFO-27 NU[1U4R[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEWxPFIh|ryP M{OxUHNCVkeHUh?=
NCI-H720 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rGe2lEPTB;MD6wOVMzPSEQvF2= MoP0V2FPT0WU
PC-14 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT2[mhlUUN3ME2wMlA2PjZ6IN88US=> NH;jclFUSU6JRWK=
EC-GI-10 MkXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmmxTWM2OD1yLkC1PVEzKM7:TR?= NXezWZVTW0GQR1XS
KYSE-450 MnzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3mOohKSzVyPUCuNFU6PzhizszN MYrTRW5ITVJ?
BPH-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEW5PFgh|ryP NVjBUHd5W0GQR1XS
NCI-H292 M2X4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLwNHdKSzVyPUCuNFYxQSEQvF2= NUnJZnAxW0GQR1XS
H9 M1fPRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEexN|Ih|ryP NEHhT2hUSU6JRWK=
NCI-H526 NW\kOolRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMEe4NlMh|ryP MU\TRW5ITVJ?
NCI-H1623 NGnUS3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvuTWM2OD1yLkC4NFI2KM7:TR?= MnT0V2FPT0WU
KYSE-140 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEizN{DPxE1? NEHa[3hUSU6JRWK=
Ca9-22 M2mwN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mon4TWM2OD1yLkC4N|U{KM7:TR?= M1:zOHNCVkeHUh?=
AU565 MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HDXGlEPTB;MD6wPFUxPCEQvF2= NF;UOFlUSU6JRWK=
ZR-75-30 NFvRW5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TUU2lEPTB;MD6wPVU1PSEQvF2= MmPaV2FPT0WU
NCI-H1770 NWHXUXd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfHSWVKSzVyPUCuNVAzQCEQvF2= NYXPdFVJW0GQR1XS
LB2241-RCC NVvZZWhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHXPItKSzVyPUCuNVA5QDRizszN NVfmbHZxW0GQR1XS
CAL-39 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3ENZp1UUN3ME2wMlEyPzl{IN88US=> NXHrcYZNW0GQR1XS
UACC-893 Mo[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfXWGZXUUN3ME2wMlEyQDh3IN88US=> M3ewTnNCVkeHUh?=
LU-65 NH7vO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMUK2N|Mh|ryP M1OzS3NCVkeHUh?=
HN MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPwdJBHUUN3ME2wMlE{ODd5IN88US=> MYfTRW5ITVJ?
TI-73 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\YUYtIUUN3ME2wMlE1PzF3IN88US=> MUTTRW5ITVJ?
KU812 NHi3[YxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfUdmxHUUN3ME2wMlE2PDV4IN88US=> MlPjV2FPT0WU
SW13 MmjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjXXoNKSzVyPUCuNVYzOTZizszN M4HaXnNCVkeHUh?=
BB30-HNC NH34boZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Oyc2lEPTB;MD6xOlU4PiEQvF2= NFf3d2hUSU6JRWK=
HSC-2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLMdHlKSzVyPUCuNVY5OzdizszN NYHtOJNvW0GQR1XS
BV-173 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLWbJNKSzVyPUCuNVc2QTZizszN NW\UbW1yW0GQR1XS
CAL-27 M4fMZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr1XlA{UUN3ME2wMlE4PjN4IN88US=> NUj2dIRUW0GQR1XS
SBC-1 NE\q[pRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r6VmlEPTB;MD6xPFk2QSEQvF2= NXHGSoRzW0GQR1XS
CAL-33 NX7FNppjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\Ib2dlUUN3ME2wMlIxOTh2IN88US=> NV;xOZk3W0GQR1XS
NCI-H209 NVvENo9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\UTWM2OD1yLkKwOFYh|ryP NHm4SW5USU6JRWK=
COR-L105 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPETWM2OD1yLkKxNFg1KM7:TR?= MnLwV2FPT0WU
HSC-3 MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFe4eFNKSzVyPUCuNlEyQThizszN NF7P[WRUSU6JRWK=
NCI-H69 M3LHfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGwSFFNUUN3ME2wMlIyPDVzIN88US=> M1vDPHNCVkeHUh?=
MOLT-13 NHO4cmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7DOmE6UUN3ME2wMlI{QTd3IN88US=> NHm4bHlUSU6JRWK=
ML-2 Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMkS4NFIh|ryP NVHrU21VW0GQR1XS
IGROV-1 NGX6WHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LXd2lEPTB;MD6yOVk2OiEQvF2= NFHxZnpUSU6JRWK=
TK10 NG\WV4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzNTWM2OD1yLkK2O|M5KM7:TR?= Mn74V2FPT0WU
EoL-1-cell M1;3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMk[4PVIh|ryP MoXKV2FPT0WU
HO-1-N-1 MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvyeIVKSzVyPUCuNlc5PTNizszN NGrnUZBUSU6JRWK=
BHY NYfZXJIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzJe|BqUUN3ME2wMlI5PjV3IN88US=> NUT6b|ZwW0GQR1XS
LU-139 MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjuSIlKSzVyPUCuN|A2OSEQvF2= MUnTRW5ITVJ?
23132-87 NELxdGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnBUIxmUUN3ME2wMlMyQTJ|IN88US=> NXH1S4tvW0GQR1XS
ACHN NEPtXXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwM{G5PVQh|ryP MofCV2FPT0WU
DoTc2-4510 NFPk[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPzSIJUUUN3ME2wMlMzOjF7IN88US=> MULTRW5ITVJ?
BB65-RCC M1HaSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITvUIdKSzVyPUCuN|Q2QTNizszN MWPTRW5ITVJ?
HLE NYHJeGhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\HRVZKSzVyPUCuN|UxPDZizszN NUPkZY1jW0GQR1XS
HCC1419 NY\ue4N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILZOXdKSzVyPUCuN|Y1ODhizszN NUXZdlZHW0GQR1XS
A388 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\XTGlEPTB;MD6zOlg2PyEQvF2= MXLTRW5ITVJ?
NUGC-3 NFzqR3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInZeIpKSzVyPUCuN|g{PzNizszN M3\hOnNCVkeHUh?=
KYSE-180 MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\KPG5UUUN3ME2wMlM6ODh7IN88US=> NX;qW|k2W0GQR1XS
TE-6 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfSTWM2OD1yLkSwNlQ3KM7:TR?= NILocJhUSU6JRWK=
A498 MkLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHZTWM2OD1yLkSwOlc1KM7:TR?= M4nPPXNCVkeHUh?=
NCI-H1648 M{HTPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjGbmJKSzVyPUCuOFQyQDJizszN MlXKV2FPT0WU
DU-145 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPyfJJKUUN3ME2wMlQ1QDN|IN88US=> MkTHV2FPT0WU
CW-2 M4XiT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYCwd3lOUUN3ME2wMlQ3QTF2IN88US=> NWr4dnBlW0GQR1XS
A431 M2nFNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS4fXZKSzVyPUCuOFgzOzNizszN NWPlTJUxW0GQR1XS
SAS NHnuOmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnuTWM2OD1yLkS4N|k5KM7:TR?= MXfTRW5ITVJ?
NCI-H2126 NELM[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwNUG5NlYh|ryP NHXq[WlUSU6JRWK=
NCI-H358 NWDDN2VyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PKVWlEPTB;MD61N|IyKM7:TR?= M2CyVHNCVkeHUh?=
FADU M{\uXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrCT5VKSzVyPUCuOVQ1ODRizszN MXrTRW5ITVJ?
ACN MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:1VWlEPTB;MD61OVA6PCEQvF2= NVPxbm0yW0GQR1XS
HCC70 NWjmXJRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln4TWM2OD1yLkW3OlYyKM7:TR?= NUe0XYRMW0GQR1XS
NCI-H1838 MoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O4OGlEPTB;MD62NFI6QSEQvF2= NUDxTXdYW0GQR1XS
CAL-54 M1fIcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vVbGlEPTB;MD62NVYzOSEQvF2= NGTLe3RUSU6JRWK=
NCI-H1975 M3X2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jqXmlEPTB;MD62NVczQCEQvF2= NWDacVVzW0GQR1XS
COR-L88 NYHNNIZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DVdWlEPTB;MD62OFEyOyEQvF2= NHTuRplUSU6JRWK=
CTV-1 M3TrVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjMNJpMUUN3ME2wMlY1Ozl{IN88US=> NHr6UIdUSU6JRWK=
EW-18 NUDKV21jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnhU|AzUUN3ME2wMlY5Pjl6IN88US=> M1\HdnNCVkeHUh?=
HCC1806 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2faeGlEPTB;MD62PVY3PiEQvF2= MmnrV2FPT0WU
HuP-T4 MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PMNGlEPTB;MD62PVc3KM7:TR?= MY\TRW5ITVJ?
MDA-MB-361 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjtNpdKSzVyPUCuO|I3PjJizszN Ml\PV2FPT0WU
NCI-H1573 Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36zUGlEPTB;MD63N|Y{KM7:TR?= NUHVPVEzW0GQR1XS
KU-19-19 NVLmNm55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;DdZpKSzVyPUCuO|c1PjRizszN Ml7HV2FPT0WU
COLO-678 NYHJdollT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:yOnNWUUN3ME2wMlgxQDN2IN88US=> M2\RNHNCVkeHUh?=
C-33-A NYfUWnJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDyTWM2OD1yLkixNlk4KM7:TR?= M1LxWXNCVkeHUh?=
Calu-3 NIH6ToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwOEG0N|Qh|ryP MXrTRW5ITVJ?
AGS NF;4WJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O3VWlEPTB;MD64N|Y1QCEQvF2= NYnUbIlUW0GQR1XS
SCC-25 MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK5OYQ6UUN3ME2wMlg1OTdzIN88US=> MkfmV2FPT0WU
JVM-2 NFvObItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjZUWpKSzVyPUCuPFgzQTlizszN MkXCV2FPT0WU
HCE-T Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwOEi0Nlgh|ryP MlrlV2FPT0WU
ES4 MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2e2eWlEPTB;MD65O|g{PiEQvF2= M3PIVnNCVkeHUh?=
EKVX M{HtWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTFwMEGwOlQh|ryP M2Tae3NCVkeHUh?=
D-542MG M{DncGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\KOmlEPTB;MT6wNVA3PCEQvF2= NXOx[4tOW0GQR1XS
SW1116 NFLDcFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLYeZBKSzVyPUGuNFEzQDdizszN MVrTRW5ITVJ?
5637 Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnSNHZZUUN3ME2xMlAyPTFizszN NGLwd2tUSU6JRWK=
HT-1376 Ml3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTFwMEG1NVMh|ryP MnHMV2FPT0WU
NB69 NYXPd2xKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTOTWM2OD1zLkCyPVQ2KM7:TR?= NG\RTWVUSU6JRWK=
YKG-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnq2TWM2OD1zLkC1OFE6KM7:TR?= M3rCSnNCVkeHUh?=
EW-3 NFTDXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXZZo9KSzVyPUGuNFc5QDNizszN M2TBd3NCVkeHUh?=
GCIY MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorRTWM2OD1zLkC4NVA1KM7:TR?= NX\rRVZTW0GQR1XS
SK-MES-1 M3nU[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrITWM2OD1zLkGxOFg4KM7:TR?= MYPTRW5ITVJ?
PANC-08-13 NFjLfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTFwMU[0NVYh|ryP NWTmPItFW0GQR1XS
SK-NEP-1 MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHhTWM2OD1zLkG3OVE{KM7:TR?= NIrMSXZUSU6JRWK=
SW954 NWXx[IZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvzOY5FUUN3ME2xMlIxOjF2IN88US=> NUX1bJlsW0GQR1XS
NCI-SNU-5 MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnoSpNKSzVyPUGuNlM6KM7:TR?= NYPjNVBuW0GQR1XS
SW48 NX;iV5FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\ZNJRKSzVyPUGuNlU1OzJizszN NF6wVoRUSU6JRWK=
HT-3 Mn:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnOcW9vUUN3ME2xMlI5PzV|IN88US=> M{e2d3NCVkeHUh?=
ETK-1 NEjHTohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1SwTmlEPTB;MT6zO|Q2PiEQvF2= M4myUHNCVkeHUh?=
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NCI-H630 NFXX[lZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;kTWM2OD1zLkS1OVgzKM7:TR?= MoLkV2FPT0WU
NCI-H82 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG3flNNUUN3ME2xMlU1ODB4IN88US=> NFe2O3BUSU6JRWK=
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KYSE-410 NVz3eWxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17sOGlEPTB;MT62OVY4OiEQvF2= NHfZR2pUSU6JRWK=
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TE-8 MlvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fHdWlEPTB;MT65NVM4PyEQvF2= NYrDc4RRW0GQR1XS
KYSE-270 NH[4PJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknYTWM2OD1{LkCyO|MzKM7:TR?= MkWzV2FPT0WU
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RPMI-7951 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4L0fWlEPTB;Mz6wO|U6KM7:TR?= NYK2U4plW0GQR1XS
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NCI-H2009 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LBN2lEPTB;Mz62NVIyPiEQvF2= M3jHd3NCVkeHUh?=
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BT-20 NGrmNo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\iTJVjUUN3ME2zMlY6Pzl3IN88US=> M1\Pe3NCVkeHUh?=
LS-123 NXPDVHpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj4cGVpUUN3ME2zMlc1Ojh2IN88US=> NUfTWGt[W0GQR1XS
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MV-4-11 MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXROm9{UUN3ME2zMlg4QTl2IN88US=> M4r0UnNCVkeHUh?=
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KNS-62 NGHnZmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HD[GlEPTB;Mz65OFc{OSEQvF2= MWDTRW5ITVJ?
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SW1417 NFTv[GNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTRwMUKxOFch|ryP MoTiV2FPT0WU
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EPLC-272H M1jpNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWq0eoNqUUN3ME20MlQyPTN|IN88US=> M2GxR3NCVkeHUh?=
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HT-1197 M2j6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnPPIZlUUN3ME20MlUzPjZ7IN88US=> M3TmVnNCVkeHUh?=
LCLC-97TM1 MluzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTRwNUO2PFYh|ryP NVjXO41lW0GQR1XS
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MEG-01 NWrFbI9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;XPWlEPTB;ND65PVQxOyEQvF2= M4XUOHNCVkeHUh?=
KYSE-520 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X0O2lEPTB;NT6yNFg{QSEQvF2= NV;aV5IxW0GQR1XS
HuO-3N1 NVz3UVJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUe1cmZqUUN3ME21MlI1ODR|IN88US=> M4XW[XNCVkeHUh?=
SW620 NV;MWXpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkK4TWM2OD13LkK0PVY1KM7:TR?= NYj3SIFzW0GQR1XS
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TE-5 M{nhcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Oyb2lEPTB;NT60NFg2KM7:TR?= M1HOXHNCVkeHUh?=
NCI-H747 MkKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTVwNEK0O|Ih|ryP Mmm1V2FPT0WU
MG-63 NHH6THVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTVwNEi3OlIh|ryP NUXuPYRIW0GQR1XS
HC-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT6TWM2OD13LkWxPFM6KM7:TR?= MmPuV2FPT0WU
HCC2998 M2H2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTVwNUK2NVUh|ryP MVHTRW5ITVJ?
NTERA-S-cl-D1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXwTWM2OD13LkW0OVM4KM7:TR?= NHmxWHFUSU6JRWK=
KINGS-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjWTWM2OD13Lk[wPVQ1KM7:TR?= MYrTRW5ITVJ?
D-423MG NUnyV|d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjnTWM2OD13Lk[xO|A2KM7:TR?= MVfTRW5ITVJ?
SW962 M1y5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXoTWM2OD13Lk[yNFMzKM7:TR?= NGHUPINUSU6JRWK=
LOXIMVI NHTJc2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\T[VdlUUN3ME21MlY{QDd|IN88US=> M1PkTnNCVkeHUh?=
LS-411N M17HfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTVwN{m0OFEh|ryP NWjzT|k6W0GQR1XS
NCI-H2291 Mn7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTVwOUi5OFMh|ryP NGTjWYRUSU6JRWK=
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LS-1034 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;pNmlEPTB;Nj6yNFcxPiEQvF2= MWrTRW5ITVJ?
NB14 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLKbIZuUUN3ME22MlQ{QDN4IN88US=> NFWyc4pUSU6JRWK=
NCI-H1299 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTZwNkOxO|Eh|ryP NYW2OFJyW0GQR1XS
BT-549 MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrYTWM2OD14Lk[2PFg6KM7:TR?= MYnTRW5ITVJ?
J-RT3-T3-5 MnrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTZwOE[5JO69VQ>? Mk\jV2FPT0WU
SW756 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfDWYlKSzVyPU[uPVEyPzZizszN M3zvXHNCVkeHUh?=
DJM-1 M2nIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXDV5FKSzVyPU[uPVIxOTJizszN MkjtV2FPT0WU
GP5d MlLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPjenFPUUN3ME22Mlk4Ozl2IN88US=> MknCV2FPT0WU
MOLT-4 NXf0fpRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFm2SoRKSzVyPUeuNFIyOzVizszN MWrTRW5ITVJ?
NCI-H28 Ml3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPMN3JoUUN3ME23MlE3PDB3IN88US=> NUjiRYx{W0GQR1XS
MN-60 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;KNFNKSzVyPUeuNlgxQDlizszN MWTTRW5ITVJ?
RMG-I MlLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVG4cG5NUUN3ME23MlM6Ojl4IN88US=> NWO5SG95W0GQR1XS
COLO-800 MmDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTdwNEG0OFYh|ryP MmTVV2FPT0WU
DB NGrjSXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTdwNkGwNFUh|ryP M{XwZnNCVkeHUh?=
Ca-Ski M4foUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7lTWM2OD15Lk[0NlU6KM7:TR?= NIr6WmFUSU6JRWK=
HEL MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjHdVNFUUN3ME23MlcyOjB|IN88US=> MoDKV2FPT0WU
NH-12 NXTv[HpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDkTWM2OD15LkeyPFA5KM7:TR?= NHm4OI1USU6JRWK=
LB373-MEL-D MmLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTdwN{[3O|Eh|ryP NXjqSnp7W0GQR1XS
SW900 NF3HPJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml6yTWM2OD15LkiyNVIyKM7:TR?= MlrrV2FPT0WU
JVM-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;aT2dLUUN3ME23Mlg6PTl7IN88US=> MX7TRW5ITVJ?
OAW-28 NUXCSXAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm4dlhKUUN3ME23Mlk1PTd6IN88US=> M{C4PXNCVkeHUh?=
KURAMOCHI M{[5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXqTWM2OD15Lkm0PFEyKM7:TR?= NFTQUYtUSU6JRWK=
BE-13 NGDPcWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTdwOUixNVIh|ryP NGixbFRUSU6JRWK=
VMRC-RCZ M4P0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRThwMEG2PVch|ryP NF:yNGhUSU6JRWK=
NCI-H727 M{LxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRThwMUC0NkDPxE1? NITwb|VUSU6JRWK=
SW1710 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW1TWM2OD16LkG4OVE2KM7:TR?= MmLTV2FPT0WU
D-502MG M13Pemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRThwMkmyPFIh|ryP NXOwb2VsW0GQR1XS
NCI-H1993 NXfCSVdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Tv[GlEPTB;OD6zN|Y{OSEQvF2= MYHTRW5ITVJ?
SCC-4 M4D3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\JcWlEPTB;OD60OFA2QSEQvF2= NG\HNG1USU6JRWK=
HAL-01 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRThwNUG5NUDPxE1? M{\ZbnNCVkeHUh?=
GT3TKB MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRThwNke5OlQh|ryP NUHibHR6W0GQR1XS
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COLO-829 NHvpbVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRThwOEC5O|Yh|ryP M2fQNHNCVkeHUh?=
OCI-AML2 NYfmSXM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjIVJpqUUN3ME24Mlk2PDhzIN88US=> NYm1TIZQW0GQR1XS
OS-RC-2 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHCOHZKSzVyPUmuNFIyQSEQvF2= NHztdldUSU6JRWK=
BFTC-909 NXmx[2lDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zj[2lEPTB;OT6wOlc6QSEQvF2= NV;wd3J4W0GQR1XS
EW-11 MlvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LWemlEPTB;OT6xO|Y2OyEQvF2= NVvwZ4xGW0GQR1XS
HCE-4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TJVWlEPTB;OT6yNVU2QCEQvF2= NFGyO2lUSU6JRWK=
BALL-1 M3PpW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTlwMkG5NFch|ryP MmjlV2FPT0WU
SF539 M4L1U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfYWlFMUUN3ME25MlI{PTZ{IN88US=> MnLYV2FPT0WU
CAMA-1 MlfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnHcHZKSzVyPUmuNlgyOjhizszN MljYV2FPT0WU
C32 NELMcWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETYSWFKSzVyPUmuN|MxPjRizszN MmLEV2FPT0WU
NCI-H1703 NUXINJNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2f6VGlEPTB;OT6zOFM4PSEQvF2= Mlr6V2FPT0WU
NCI-H1650 M4XzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEf6ZlRKSzVyPUmuOlA6PDZizszN Mk[3V2FPT0WU
NCI-H1563 MkHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfoTWM2OD17Lke2NFMyKM7:TR?= MlfuV2FPT0WU
CAL-85-1 Mn7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrKeZZKSzVyPUmuPFc{QDNizszN NILZcpRUSU6JRWK=
UM-UC-3 NHfHPI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe1ZWZkUUN3ME25Mlk2ODNizszN M3TLUXNCVkeHUh?=
BxPC-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfNZ4NKSzVyPUGwMlA6PzJizszN M37te3NCVkeHUh?=
MHH-PREB-1 M2[5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK2TWM2OD1zMD6xPVk6KM7:TR?= NIHCOotUSU6JRWK=
DEL NH3YfWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFmwfIZKSzVyPUGwMlM6PDZizszN MUXTRW5ITVJ?
HuCCT1 NYDhVI9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnUTWM2OD1zMD62NFM{KM7:TR?= NX3jdXlLW0GQR1XS
OVCAR-4 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTFyLki4N|Uh|ryP NHnkfGdUSU6JRWK=
CAL-72 MnzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEntWZdKSzVyPUGwMlk{QTFizszN Mo[zV2FPT0WU
HCC1954 NGCyNppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTFzLkC3OVQh|ryP M2HRe3NCVkeHUh?=
EFO-21 M3;LXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{WxPGlEPTB;MUGuNVA1PSEQvF2= NELBcmtUSU6JRWK=
FTC-133 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r2WmlEPTB;MUGuNVQxPyEQvF2= NVXCemdMW0GQR1XS
SK-MEL-24 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHhTWM2OD1zMT6yN|Y3KM7:TR?= MknsV2FPT0WU
UACC-62 NFPPV2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\Nb|lbUUN3ME2xNU4zOzZ6IN88US=> NGnERWNUSU6JRWK=
NCI-H650 NUf3d3lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnsZlNKSzVyPUGxMlI1OThizszN NVXIZlQ5W0GQR1XS
ALL-PO MmnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTFzLkK1NVIh|ryP MV7TRW5ITVJ?
T84 NFjFO3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTVTWM2OD1zMT6zPVA4KM7:TR?= NHrLdFJUSU6JRWK=
IST-MEL1 M1nFUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTFzLkS1OVkh|ryP MWPTRW5ITVJ?
SW626 NH\KToZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTFzLkW3OVUh|ryP MWjTRW5ITVJ?
RPMI-2650 M3X6R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTFzLkW4PFUh|ryP NYLzc|FZW0GQR1XS
MC-IXC NEHlRlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\XXZNKSzVyPUGxMlY4OjhizszN MmnVV2FPT0WU
HOP-62 M{jjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3T0XWlEPTB;MUGuOlc3PCEQvF2= MmPpV2FPT0WU
NOS-1 M3rU[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTFzLkexNFkh|ryP NFThPGxUSU6JRWK=
SW1573 NYTMVJkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jJWmlEPTB;MUGuO|I6PSEQvF2= MVHTRW5ITVJ?
WM-115 NX7qTJZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTFzLke1PFgh|ryP MmnjV2FPT0WU
HuO9 M2HQZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETIXopKSzVyPUGxMlg4PzRizszN M{DqOXNCVkeHUh?=
YAPC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjqTFN1UUN3ME2xNU46OjV7IN88US=> M2nNTHNCVkeHUh?=
MDA-MB-453 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjkZ5pwUUN3ME2xNU46PTF3IN88US=> MkXnV2FPT0WU
NCI-H596 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTF{LkCzOlkh|ryP M3zUOHNCVkeHUh?=
A172 NVfEfFRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXIdHVKSzVyPUGyMlA4QThizszN MXzTRW5ITVJ?
RS4-11 NX\TNmRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjme|BKSzVyPUGyMlE4OjVizszN NIrjVo1USU6JRWK=
HCC1937 M{XFPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTF{Lke1OlQh|ryP NX;LWY01W0GQR1XS
SW837 MlfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jSeGlEPTB;MUKuPVAzQCEQvF2= MnPFV2FPT0WU
NMC-G1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTF{LkmyN|Qh|ryP MoPIV2FPT0WU
PFSK-1 MlHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TZRWlEPTB;MUOuNFYh|ryP M2XmenNCVkeHUh?=
DBTRG-05MG NFf1T4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknsTWM2OD1zMz6wOlMzKM7:TR?= NULaT41JW0GQR1XS
SK-UT-1 NEfQSGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTF|LkGwPFMh|ryP NIL1[oJUSU6JRWK=
OVCAR-5 NHTGPVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTF|LkG1PVMh|ryP MnTpV2FPT0WU
8505C MoDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XmSmlEPTB;MUOuNlA3PyEQvF2= M4ixZnNCVkeHUh?=
SK-MEL-1 Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;LNGNMUUN3ME2xN{44OTN3IN88US=> M2PyXXNCVkeHUh?=
LK-2 M125UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWC4VXB1UUN3ME2xN{44PjN7IN88US=> MXPTRW5ITVJ?
OE33 Mnj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\lTWM2OD1zMz63PFYh|ryP MmTmV2FPT0WU
Ramos-2G6-4C10 M1LBWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDEe4NKSzVyPUG0MlAzODJizszN MV\TRW5ITVJ?
EW-13 NGH2TY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTF2LkCzOVIh|ryP M33OfnNCVkeHUh?=
NCI-H1793 M17oVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIG3Wo5KSzVyPUG0MlIxQDdizszN NI\HTppUSU6JRWK=
BHT-101 MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnT[ZBKSzVyPUG0MlI1OSEQvF2= NWnVbnJ{W0GQR1XS
RKO MnvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXv4O3B6UUN3ME2xOE42ODd3IN88US=> NYLsNFlyW0GQR1XS
NEC8 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTFTWM2OD1zND61OFczKM7:TR?= MkDPV2FPT0WU
PANC-10-05 MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:xWpJKSzVyPUG0MlYzPDdizszN NYm2cFBTW0GQR1XS
NCI-H2030 NX6ydot{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\DN4IyUUN3ME2xOE43PDR6IN88US=> MnXLV2FPT0WU
C2BBe1 NITlV|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LlV2lEPTB;MUSuO|Y1KM7:TR?= MlXyV2FPT0WU
EM-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\0NpdvUUN3ME2xOE45PTd4IN88US=> MUXTRW5ITVJ?
HCC1395 Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K3[2lEPTB;MUSuPVM{QCEQvF2= NI\uSVRUSU6JRWK=
A2058 M2TteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTF3LkC0NFkh|ryP MYjTRW5ITVJ?
SW1463 M2\iRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH1TWM2OD1zNT6wOFg2KM7:TR?= MUHTRW5ITVJ?
J82 NULrZmlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\SZZJbUUN3ME2xOU4xPTdizszN MWTTRW5ITVJ?
CAL-120 M4DydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELJdnJKSzVyPUG1MlE1PDdizszN MV7TRW5ITVJ?
COLO-824 MnTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTF3LkG1O|kh|ryP NVuwT|djW0GQR1XS
LNCaP-Clone-FGC M3P2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\R[IJKSzVyPUG1MlQzPDhizszN NWn6fJZOW0GQR1XS
CP66-MEL NHz2OopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq2XFJKSzVyPUG1MlQ3QDhizszN NHfXPYVUSU6JRWK=
OC-314 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz3RYlmUUN3ME2xOU41PzF2IN88US=> NXzzO|BSW0GQR1XS
OVCAR-8 M4jpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkW1TWM2OD1zNT64PFYyKM7:TR?= M{fZOXNCVkeHUh?=
MFE-280 NXvuV|NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjUW4dKSzVyPUG2MlA1QDhizszN MX3TRW5ITVJ?
MHH-NB-11 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTF4LkC4N|kh|ryP M13TXnNCVkeHUh?=
SW1990 MnPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[0WmlEPTB;MU[uNVc2PSEQvF2= NFHXO2VUSU6JRWK=
U-266 NH3RcVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2S3N2lEPTB;MU[uNlI6QSEQvF2= MoG0V2FPT0WU
MFM-223 M2rJS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfye451UUN3ME2xOk4{QTZ3IN88US=> MYjTRW5ITVJ?
L-363 NWTWfIdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXlfndkUUN3ME2xOk41PTd5IN88US=> MV\TRW5ITVJ?
MCF7 NULxTm06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTF4LkS3NlMh|ryP NX;pUYJQW0GQR1XS
SK-MEL-3 M3[2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfFUJVKSzVyPUG2MlQ4QDdizszN NEDjSlZUSU6JRWK=
HH MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvLTWM2OD1zNj61NVYzKM7:TR?= NY\Bb2F5W0GQR1XS
no-10 MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LyPGlEPTB;MU[uOlM1OyEQvF2= MmDnV2FPT0WU
HuP-T3 M1nuTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TOS2lEPTB;MU[uOlU4PiEQvF2= MXfTRW5ITVJ?
QIMR-WIL NFjnfmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnhS4FKSzVyPUG2MlcyODVizszN NFHxT5FUSU6JRWK=
NCI-H1092 NVL5NYR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTF4LkizNVYh|ryP NWD5RoRuW0GQR1XS
MZ2-MEL Mn74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLjTWM2OD1zNj64OFA{KM7:TR?= M1jR[HNCVkeHUh?=
ES3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3JZ2ZKSzVyPUG2MlkyOzRizszN M{\3U3NCVkeHUh?=
COLO-684 MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDPcW02UUN3ME2xOk46PDd5IN88US=> MluyV2FPT0WU
NCI-H661 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF4Lkm2PVQh|ryP M4TGZXNCVkeHUh?=
CP50-MEL-B M1HKZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnK[YhKSzVyPUG3MlA{PDNizszN MXPTRW5ITVJ?
NCI-H2405 MmDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV21XpdDUUN3ME2xO{4yQTd2IN88US=> MWPTRW5ITVJ?
U-2-OS NV;WZmkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi2ZZJKSzVyPUG3MlU{ODdizszN NF3rdXVUSU6JRWK=
RERF-LC-MS NHvucFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF5LkW1NFgh|ryP MmXsV2FPT0WU
NCI-H2342 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTF5LkW1O{DPxE1? M1fKS3NCVkeHUh?=
ES8 NEjaXZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13KdWlEPTB;MUeuOlA5PyEQvF2= NV;hfZVLW0GQR1XS
MOLT-16 M1P0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGi2NG9KSzVyPUG3Mlg6OzRizszN MV\TRW5ITVJ?
RH-18 NYfnT2VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnz6TWM2OD1zOD6wNFM2KM7:TR?= MVfTRW5ITVJ?
D-283MED MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fyUGlEPTB;MUiuNFA5QCEQvF2= MnXqV2FPT0WU
RCC10RGB NXr0eGtCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTF6LkC1OVkh|ryP NV\EcmR1W0GQR1XS
NCI-H1437 M4q4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHQTWM2OD1zOD6xOlQyKM7:TR?= NF\n[3FUSU6JRWK=
SW982 MkLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PjWGlEPTB;MUiuNlY4OSEQvF2= NFjL[ZlUSU6JRWK=
IST-MES1 MmjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjJN2dKSzVyPUG4MlQ1OjhizszN MYjTRW5ITVJ?
A704 M3vGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTF6LkS3OVMh|ryP NYTNWVlOW0GQR1XS
ESS-1 NXLiTFdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnpcIFQUUN3ME2xPE42OjB3IN88US=> M2iwSHNCVkeHUh?=
SCH NVLBOnBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTF6Lk[0OVYh|ryP M1vweXNCVkeHUh?=
COLO-320-HSR M2LKS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\oTWM2OD1zOD63OFYh|ryP NVTld5p6W0GQR1XS
Mo-T MlTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfkPJRKSzVyPUG4MlgzODRizszN MXrTRW5ITVJ?
Saos-2 NHXlW|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF7LkGxOlIh|ryP NVizT4hOW0GQR1XS
SW684 M{\DUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfoTWM2OD1zOT6xN|I3KM7:TR?= NWLiToVbW0GQR1XS
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ABC-1 M3\qemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPMT|BKSzVyPUO0MlM3QTNizszN NWHvbWNpW0GQR1XS
NCI-H1355 MlTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;Se2gyUUN3ME2zOE4{QDh7IN88US=> MkjxV2FPT0WU
NOMO-1 Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rnVGlEPTB;M{SuOVcxOyEQvF2= M{X5VXNCVkeHUh?=
MZ7-mel NGD2TIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHIcm5KSzVyPUO0MlY1QDdizszN NFjMZpRUSU6JRWK=
NCI-H810 NFPmfW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LSe2lEPTB;M{SuO|I4QCEQvF2= M{nDVXNCVkeHUh?=
D-392MG MkPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTN3LkC1OlUh|ryP MWDTRW5ITVJ?
LB771-HNC NXzVb3czT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfQOmJFUUN3ME2zOU4yPjV6IN88US=> M2\mUXNCVkeHUh?=
COLO-679 NXnlXpl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInvOZJKSzVyPUO1MlM5QCEQvF2= M3;kW3NCVkeHUh?=
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VA-ES-BJ MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[2TWM2OD1|NT60OlQ6KM7:TR?= M3S0NnNCVkeHUh?=
KNS-42 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTLOJdkUUN3ME2zOU42QDJ4IN88US=> MYTTRW5ITVJ?
RVH-421 M17x[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\hPJBKSzVyPUO1Mlc3PDVizszN NYfjcZRCW0GQR1XS
P30-OHK M1rqS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTN3Lki3OVIh|ryP MU\TRW5ITVJ?
G-402 MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTN3Lkm4Olch|ryP NVLMOXVLW0GQR1XS
S-117 Ml3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnOU3lKSzVyPUO2MlMxODhizszN NEfwOWtUSU6JRWK=
RXF393 NGDLRo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LrNGlEPTB;M{[uN|c5PSEQvF2= M37tVHNCVkeHUh?=
LCLC-103H M{DGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTN4Lke4NFMh|ryP NHrBVGdUSU6JRWK=
U-118-MG NXziWmFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTN4Lki4OFch|ryP NIS0OGdUSU6JRWK=
8-MG-BA M2jvUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e4eWlEPTB;M{[uPVQ5OyEQvF2= NXLXOFZEW0GQR1XS
MFH-ino MlHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnhcGZ6UUN3ME2zO{4{OzdzIN88US=> NWS4V3djW0GQR1XS
NCI-H23 NV\sRoxtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvSOGVYUUN3ME2zO{41OTl4IN88US=> M3;PbHNCVkeHUh?=
NCI-H446 NYXuTYY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTXTWM2OD1|Nz60PFYzKM7:TR?= MUXTRW5ITVJ?
LU-99A NYfOTHp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTN5LkW3N|Eh|ryP NIjFd5JUSU6JRWK=
KP-N-YN M{jPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUWzVWR2UUN3ME2zO{43OTl3IN88US=> NHf6XmtUSU6JRWK=
SCC-9 NXPsWXN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HT[WlEPTB;M{euO|g{QCEQvF2= MYfTRW5ITVJ?
EFM-19 M3nqPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTN5Lke5Olch|ryP MVPTRW5ITVJ?
A427 Mn:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTN5LkmxNFch|ryP MUDTRW5ITVJ?
LB831-BLC MmLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTN6Lk[wN|kh|ryP MVzTRW5ITVJ?
HOS NILpc5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moj5TWM2OD1|OT62Nlc{KM7:TR?= MUHTRW5ITVJ?
LAN-6 M3:wdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTqZ4NKSzVyPUSwMlAyOTJizszN M1rSUXNCVkeHUh?=
U251 MlLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTRyLkSwOVQh|ryP MXXTRW5ITVJ?
SNU-387 MojQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TzSGlEPTB;NECuOFU2OyEQvF2= Mmj3V2FPT0WU
DMS-79 M4DlNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVviUHN5UUN3ME20NE42QDh7IN88US=> MXXTRW5ITVJ?
SK-LU-1 NXLvfFVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITi[YxKSzVyPUSwMlY2PjhizszN NUnucFFkW0GQR1XS
HT NEjKVWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4njZmlEPTB;NECuOlY{QSEQvF2= NVXQUnVnW0GQR1XS
KP-N-YS MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTRyLk[3Olgh|ryP NFm1T3lUSU6JRWK=
DMS-114 Mnz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\sOGlEPTB;NECuPFM4PCEQvF2= MVjTRW5ITVJ?
HUTU-80 NIP3WmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PqUWlEPTB;NEGuNFU3QSEQvF2= NUDiXGdDW0GQR1XS
ONS-76 NIDybVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4K4OGlEPTB;NEGuOFcxQSEQvF2= MoDPV2FPT0WU
A673 NXLUToJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTNTWM2OD12MT61NVU4KM7:TR?= NXnpNZdzW0GQR1XS
HPAF-II MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHzfWRvUUN3ME20NU43PzB7IN88US=> MmH1V2FPT0WU
UACC-257 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;QXmlEPTB;NEGuO|M3QSEQvF2= NEPMWmhUSU6JRWK=
EW-22 NHq1T25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTRzLki2PVch|ryP NEK3cFdUSU6JRWK=
NCI-H1755 Mni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPP[HNNUUN3ME20NU45PzJ3IN88US=> MmCxV2FPT0WU
KYSE-150 NGS2ZY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHDcWJKSzVyPUSyMlE4QDJizszN MX;TRW5ITVJ?
CGTH-W-1 MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfkVW5KSzVyPUSyMlQ6PTVizszN MkCxV2FPT0WU
NB13 NILXXZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTR{Lk[yNVch|ryP NILqbWhUSU6JRWK=
SW872 M4jzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\QTJJKSzVyPUSyMlY{OzFizszN MUHTRW5ITVJ?
KP-4 NFPZbFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7xTWM2OD12Mj64PFMzKM7:TR?= M3W5XHNCVkeHUh?=
HCC38 Mm\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DMXWlEPTB;NEKuPVYyQCEQvF2= NY\1eYdFW0GQR1XS
BB49-HNC MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PGZ2lEPTB;NEOuNlM2PiEQvF2= NHX1V29USU6JRWK=
CAL-62 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3CTWM2OD12Mz60NFI5KM7:TR?= MYLTRW5ITVJ?
NCI-H2029 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvXTWM2OD12Mz61OVgyKM7:TR?= NGfRXWNUSU6JRWK=
M14 M1rDNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i3RWlEPTB;NESuNVM{OiEQvF2= NFTJSHFUSU6JRWK=
COLO-680N MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTR2LkOzPUDPxE1? NVrVWY5QW0GQR1XS
Hs-578-T M3u1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4joO2lEPTB;NEWuNFI6PCEQvF2= MmHrV2FPT0WU
MSTO-211H NW\neVJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe3TWM2OD12NT65OFgzKM7:TR?= MUTTRW5ITVJ?
EW-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LuZmlEPTB;NEWuPVY5QSEQvF2= NInoSZVUSU6JRWK=
SW948 NILnWFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTR4LkS0OlIh|ryP MlTTV2FPT0WU
NCI-H460 M2T6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;5OFZKSzVyPUS2MlUzOyEQvF2= NYHBfFhZW0GQR1XS
CAS-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7UUpRKSzVyPUS2Mlc4ODFizszN MoDJV2FPT0WU
TGBC11TKB M4q2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTR5LkG3O|ch|ryP MUnTRW5ITVJ?
HD-MY-Z M4X4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS3TWM2OD12OD63PFYh|ryP Mo\1V2FPT0WU
NCI-H226 NUL2b25WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3kOWVKSzVyPUS5Mlc4QDVizszN MV\TRW5ITVJ?
PA-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nQTWlEPTB;NEmuPFM{PSEQvF2= NWXIVXg6W0GQR1XS
LB2518-MEL NIWzSZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLkNFBSUUN3ME20PU45PzJ|IN88US=> MW\TRW5ITVJ?
A101D M3TNbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[5TWM2OD12OT65OFI2KM7:TR?= NEDBXItUSU6JRWK=
NCI-H2087 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTR7Lkm2PFIh|ryP NGLJco5USU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water <1 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 10mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • C1=C0/X C1: LOG(C1):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID