Research Area
Product Type
United States ( Change Country )
PD153035 HCl Chemical Structure
Recommended Products
BIBW2992 (Afatinib)
BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFR L858R , EGFR L858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM, 14 nM, respectively.
CI-1033 (Canertinib)
CI-1033 is a potent tyrosine kinase inhibitor of EGFR and erbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.
Erlotinib HCl
Erlotinib HCl also known as Tarceva, CP-358774, OSI-774, NSC-718781 is a HCL salt with IC50 of 2 nM for HER1/EGFR TK.
Gefitinib (Iressa)
Gefitinib (Iressa) also known as ZD-1839 & Iressa is a novel potent EGFR tyrosine kinase & Akt phosphorylations inhibitor with IC50 of 37, 26 and 57 nM.
Lapatinib Ditosylate (Tykerb)
Lapatinib Ditosylate (Tyverb, GW-572016, GW-2016) is a potent purified EGFR and ErbB-2 inhibitor with IC50 of 10.2 and 9.8 nM, respectively.
Vandetanib (Zactima)
Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.
BMS-599626 (AC480)
BMS-599626 (AC480) is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively.
XL647
Inhibitor of the EGFR and ErbB2 with IC50 0.3 and 16 nM respectively.
AG-490
AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8 μM for EGFR and JAK, respectively.
WZ3146
WZ3146 is an irreversiblely inhibitor against EGFR T790M.
Biological Activity
PD153035 hydrochloride is a hydrochloride acid salt form of PD153035 which is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM.PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2). [1][2]
References on PD153035 HCl
- [1] J. Med. Chem 1996;39:267-276
- [2] Clin Cancer Res 1997;3:2099-2106
Chemical Information
| Molecular Weight (WM): | 396.67 |
|---|---|
| Formula: | C16H14BrN3O2.HCl |
| CAS No.: | 183322-45-4 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO <1mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Receptor Tyrosine Kinase >> EGFR >> EGFR Inhibitors
Angiogenesis >> EGFR >> EGFR Inhibitors
JAK / STAT >> EGFR >> EGFR Inhibitors
Angiogenesis >> EGFR >> EGFR Inhibitors
JAK / STAT >> EGFR >> EGFR Inhibitors
Notes:
Related Inhibitors
Recommended Screening Libraries
Chemical Library
A collection of 864 bioactive compounds
Inhibitor Library
A collection of 481 inhibitors
Kinase Inhibitor Library
A collection of 194 kinase inhibitors
Tyrosine Kinase Inhibitor Library
A collection of 85 tyrosine kinase inhibitors.
FDA Approved Drug Library
A collection of 426 FDA approved drugs
Natural Product Library
A collection of 139 natural products
Chemotherapeutic Agent Library
A collection of 40 chemotherapeutic agents
Epigenetics Compound library
A unique collection of 17 small molecule modulators
Stem Cell Compound library
A unique collection of 47 small molecule inhibitors
GPCR Compound library
A unique collection of 63 GPCR small molecules
Selleck's high quality products have been used in several published research findings, including the following:
Inhibition of poxvirus spreading by the anti-tumor drug Gefitinib (Iressa™).
We have 1 customer reviews of PD153035 HCl.
- (1)
- (0)
- (0)
- (0)
- (0)
- (0)
- (0)
- (0)
- (0)
Average Customer Review
(1 customer reviews)
-
Click to enlarge
T47D cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of PD153035 for 24 hours.
T47D cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of PD153035 for 24 hours.
Data independently produced by Dr. Zhang of Tianjin Medical University PD153035 HCl purchased from Selleck
This product has been referenced in
Check our customer reviews
T47D cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of PD153035 for 24 hours.
|
Data independently produced by Dr. Zhang of Tianjin Medical University
We give free samples and rewards to people who would like to provide us useful scientific data(western blot, etc.) > See Details
Recently Viewed Items
Keywords:buy PD153035 HCl | PD153035 HCl supplier | purchase PD153035 HCl | PD153035 HCl cost | PD153035 HCl manufacturer | order PD153035 HCl | PD153035 HCl distributor