NF-κB

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S4902 QNZ (EVP4593) <1 mg/mL 5 mg/mL <1 mg/mL
S1848 Curcumin <1 mg/mL 73 mg/mL <1 mg/mL
S4073 Sodium 4-Aminosalicylate 42 mg/mL 42 mg/mL <1 mg/mL
S7351 JSH-23 <1 mg/mL 48 mg/mL 20 mg/mL
S7414 Caffeic Acid Phenethyl Ester <1 mg/mL 57 mg/mL 57 mg/mL
S3633 Pyrrolidinedithiocarbamate ammonium 32 mg/mL 32 mg/mL 32 mg/mL
S8484 GSK2982772 <1 mg/mL 75 mg/mL 30 mg/mL
S8261 GSK583 <1 mg/mL 79 mg/mL 28 mg/mL
S3137 Sodium salicylate 32 mg/mL 32 mg/mL <1 mg/mL
S7672 Omaveloxolone (RTA-408) <1 mg/mL 100 mg/mL 20 mg/mL
S2261 Andrographolide <1 mg/mL 70 mg/mL <1 mg/mL
S2382 Evodiamine <1 mg/mL <1 mg/mL <1 mg/mL
S2313 Indole-3-carbinol 7 mg/mL 29 mg/mL 29 mg/mL
S7273 SC75741 <1 mg/mL 35 mg/mL <1 mg/mL
S2321 Magnolol <1 mg/mL 53 mg/mL 53 mg/mL
S2341 (-)-Parthenolide <1 mg/mL 49 mg/mL 49 mg/mL
S3604 Triptolide (PG490) <1 mg/mL 72 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations
S4902

QNZ (EVP4593)

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.

S1848

Curcumin

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.

S4073

Sodium 4-Aminosalicylate

Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.

S7351

JSH-23

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.

S7414

Caffeic Acid Phenethyl Ester

Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.

S3633New

Pyrrolidinedithiocarbamate ammonium

Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor-κB (NF-κB) that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.

S8484New

GSK2982772

GSK2982772 is an ATP competitive receptor-interacting protein-1 (RIP1) kinase inhibitor with the IC50 value of 1 nM. It has exquisite kinase specificity and excellent activity in blocking many TNF-dependent cellular responses.

S8261New

GSK583

GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.

S3137

Sodium salicylate

Sodium salicylate is used in medicine as an analgesic and antipyretic.

S7672

Omaveloxolone (RTA-408)

Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.

S2261

Andrographolide

Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.

S2382

Evodiamine

Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells. It is shown to inhibit NF-kB activation through suppression of IkB kinase activity.

S2313

Indole-3-carbinol

Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation.

S7273

SC75741

SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM.

S2321

Magnolol

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.

S2341

(-)-Parthenolide

(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.

S3604

Triptolide (PG490)

Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein.

S4712

Diethylmaleate

Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.