NF-κB

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

click to view more

Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S4902

QNZ (EVP4593)

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.

S4073

Sodium 4-Aminosalicylate

Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.

S7351

JSH-23

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.

S7414

Caffeic Acid Phenethyl Ester

Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.

S3137

Sodium salicylate

Sodium salicylate is used in medicine as an analgesic and antipyretic.

S8261New

GSK583

GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.

S4712New

Diethylmaleate

Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NFkB.

S7672

Omaveloxolone (RTA-408)

Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.

S2261

Andrographolide

Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.

S7273

SC75741

SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM.

Catalog No. Information Product Use Citations Product Validations
S4902

QNZ (EVP4593)

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.

S4073

Sodium 4-Aminosalicylate

Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.

S7351

JSH-23

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.

S7414

Caffeic Acid Phenethyl Ester

Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.

S3137

Sodium salicylate

Sodium salicylate is used in medicine as an analgesic and antipyretic.

S8261New

GSK583

GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.

S4712New

Diethylmaleate

Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NFkB.

S7672

Omaveloxolone (RTA-408)

Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.

S2261

Andrographolide

Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.

S7273

SC75741

SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM.