QNZ (EVP4593)

Catalog No.S4902

QNZ (EVP4593) Chemical Structure

Molecular Weight(MW): 356.42

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.

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USD 90 In stock
USD 370 In stock

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2 Customer Reviews

  • NF-κB partly mediated resveratrol (Res) inhibition on PKD inflammation. (A) Expression of p-p65, p65, p105, p50, TNF-α, MCP-1 and CFB in QNZ-treated OX161 cells. (B) OX161 cells were pretreated with QNZ for 2 h and followed by the treatment of resveratrol for 46 h. The expression of p-p65, p65, p105, p50, TNF-α, MCP-1 and CFB were evaluated by western blot. (C) MCP-1 or CFB of QNZ-and/or resveratroltreated OX161 cell supernatants were measured by ELISA. One representative of three independent experiments is shown.

    Nephrol Dial Transplant, 2016: 1–9.. QNZ (EVP4593) purchased from Selleck.

    (B-E) THP-1 cells were treated with or without NF-κB inhibitor QNZ and JNK inhibitor SP600125. (B-C) THP-1 cells treated with NF-κB inhibitor QNZ;

    Toxicol Appl Pharmacol, 2015, 289(2):133-41.. QNZ (EVP4593) purchased from Selleck.

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Biological Activity

Description QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.
Targets
TNF-α [1]
(Jurkat T cells)
NF-κB [1]
(Jurkat T cells)
7 nM 11 nM
In vitro

EVP4593 inhibits TNF-a production from murine splenocytes stimulated with LPS with IC50 of 7 nM. [1] EVP4593 (300 nM) entails a significant decrease of amplitude of store-operated currents (approximately by 60%), induced by application of 1 μM thapsigargin in Htt138Q cells, thus prevents abnormal store-operated calcium entry. EVP4593 is able to inhibit the activity of channels containing TRPC1 as one of the subunits, but has no effect on homooligomer channels composed exclusively of TRPC1. [2] QNZ (40 nM) completely abolishes the enhancement of neurite number and length evoked by laminin treatment of the schwann cells. QNZ reduces the neurite length by 61.36% of the schwann cells. QNZ significantly inhibits laminin-induced neurite outgrowth. QNZ also greatly diminishes the neurite elongation after 72 hours culture implying that both initial sprouting and longer term growth and extension seen in response to schwann cells seeded on laminin is mediated by NF-κB. [3] QNZ (10 nM) abolishes LPS-induced up-regulation of CSE expression in rat neutrophil. [4] QNZ (100 nM) blocks the induction effects of GRO/KC on K currents in IB4-negative neurons. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Jurkat MlTNT4lv[XOnIHHzd4F6 NX\BVWRZhjFyIN88US=> M172WINifXOnczDOSk3PwkJiSX7obYJqfGmxbjD3bZRpKEWFNUCgc4YhQSCwTR?= NXHlNVBYOjF5MECyNVM>
Jurkat NYLFTWF3TnWwY4Tpc44h[XO|YYm= M1GwWlMh|ryP NUTqNIhC[2G3c3XzJHNQSyCLbnjpZol1cW:w NFexOlEzOTdyMEKxNy=>
neurons M2D6NGZ2dmO2aX;uJIF{e2G7 MVOzNFAhdk1? MnfXbY5pcWKrdDDzeI9z\S2xcHXyZZRm\CCFYUKrJIVvfHK7 MWeyNVcxODJzMx?=
SK-N-SH Ml\aSpVv[3Srb36gZZN{[Xl? MVqzNFAhdk1? NX;DN|FWcW6qaXLpeJMhXFKSQ{GtV5VxeG:{dHXkJHNQSyCFYUKrJIN2enKnboTz NInnZ5EzOTdyMEKxNy=>
neurons NIXSO29HfW6ldHnvckBie3OjeR?= MkKyN|AxKG6P MXTwdo91\WO2IGnBR|EzQCCPU16g[pJwdSCpbIX0ZY1ifGVidH;4bYNqfHl? M4nkNVIyPzByMkGz
GABA MS-like neurons Mme5SpVv[3Srb36gZZN{[Xl? NGHyZZIyODBibl2= M2jiVpJme2O3ZYOgZYJvd3KvYXygV29ENW2nZHnheIVlKGOjbHPpeY0h\W62com= M2j1c|I4ODhyMUK5
GABA MS-like neurons NEm0OZRHfW6ldHnvckBie3OjeR?= NXPOdItvOTByMDDuUS=> NXnYTJJLdm:{bXHsbZpmeyC2aHWgcpVu[mW{IH;mJIx6e2:|b33ld{9ifXSxcHjh[49{d22ncx?= MXWyO|A5ODF{OR?=
GABA MS-like neurons MnvDSpVv[3Srb36gZZN{[Xl? NHH2N2gyODBibl2= NIfSZ4Jz\XOldXXzJIFocW6pIH7leZJwdnNiZoLvcUBk\WyuIHTlZZRp Ml[wNlcxQDBzMkm=

... Click to View More Cell Line Experimental Data

In vivo EVP4593 (1 mg/kg, i.p.) dose-dependently inhibits carrageenin-induced paw edema in rats. [1]

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: male SD rats with carrageenin induced paw edema
  • Formulation: 0.5% hydroxypropyl cellulose
  • Dosages: 1 mg/kg
  • Administration: intraperitoneal injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 5 mg/mL warmed (14.02 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 0.5% hydroxyethyl cellulose 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 356.42
Formula

C22H20N4O

CAS No. 545380-34-5
Storage powder
in solvent
Synonyms N/A

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NF-κB Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID