QNZ (EVP4593)

Catalog No.S4902

QNZ (EVP4593) Chemical Structure

Molecular Weight(MW): 356.42

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.

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USD 90 In stock
USD 370 In stock

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2 Customer Reviews

  • NF-κB partly mediated resveratrol (Res) inhibition on PKD inflammation. (A) Expression of p-p65, p65, p105, p50, TNF-α, MCP-1 and CFB in QNZ-treated OX161 cells. (B) OX161 cells were pretreated with QNZ for 2 h and followed by the treatment of resveratrol for 46 h. The expression of p-p65, p65, p105, p50, TNF-α, MCP-1 and CFB were evaluated by western blot. (C) MCP-1 or CFB of QNZ-and/or resveratroltreated OX161 cell supernatants were measured by ELISA. One representative of three independent experiments is shown.

    Nephrol Dial Transplant, 2016: 1–9.. QNZ (EVP4593) purchased from Selleck.

    (B-E) THP-1 cells were treated with or without NF-κB inhibitor QNZ and JNK inhibitor SP600125. (B-C) THP-1 cells treated with NF-κB inhibitor QNZ;

    Toxicol Appl Pharmacol, 2015, 289(2):133-41.. QNZ (EVP4593) purchased from Selleck.

Purity & Quality Control

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2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.
TNF-α [1]
(Jurkat T cells)
NF-κB [1]
(Jurkat T cells)
7 nM 11 nM
In vitro

EVP4593 inhibits TNF-a production from murine splenocytes stimulated with LPS with IC50 of 7 nM. [1] EVP4593 (300 nM) entails a significant decrease of amplitude of store-operated currents (approximately by 60%), induced by application of 1 μM thapsigargin in Htt138Q cells, thus prevents abnormal store-operated calcium entry. EVP4593 is able to inhibit the activity of channels containing TRPC1 as one of the subunits, but has no effect on homooligomer channels composed exclusively of TRPC1. [2] QNZ (40 nM) completely abolishes the enhancement of neurite number and length evoked by laminin treatment of the schwann cells. QNZ reduces the neurite length by 61.36% of the schwann cells. QNZ significantly inhibits laminin-induced neurite outgrowth. QNZ also greatly diminishes the neurite elongation after 72 hours culture implying that both initial sprouting and longer term growth and extension seen in response to schwann cells seeded on laminin is mediated by NF-κB. [3] QNZ (10 nM) abolishes LPS-induced up-regulation of CSE expression in rat neutrophil. [4] QNZ (100 nM) blocks the induction effects of GRO/KC on K currents in IB4-negative neurons. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Jurkat Ml\VT4lv[XOnIHHzd4F6 NHTNOGV,OTBizszN MXjjZZV{\XNiTl[t{tpDKEmwaHnibZRqd25id3n0bEBGSzVyIH;mJFkhdk1? NFK2SpgzOTdyMEKxNy=>
Jurkat NWm0R|dETnWwY4Tpc44h[XO|YYm= M37mbFMh|ryP NVP1O4ZI[2G3c3XzJHNQSyCLbnjpZol1cW:w M33HSlIyPzByMkGz
neurons NYHnS21tTnWwY4Tpc44h[XO|YYm= MY[zNFAhdk1? NGj1WXJqdmirYnn0JJN1d3KnLX;w[ZJifGWmIFPhNksh\W62com= MUiyNVcxODJzMx?=
SK-N-SH NU\4TnpOTnWwY4Tpc44h[XO|YYm= NY\2b4lEOzByIH7N MYrpcohq[mm2czDUVnBEOS2VdYDwc5J1\WRiU1;DJGNiOitiY4XydoVvfHN? MWSyNVcxODJzMx?=
neurons MXHGeY5kfGmxbjDhd5NigQ>? MXqzNFAhdk1? NFG5Roxxem:2ZXP0JHlCSzF{ODDNV24h\nKxbTDncJV1[W2jdHWgeI95cWOrdIm= NFHDZ4szOTdyMEKxNy=>
GABA MS-like neurons NVfkdXpNTnWwY4Tpc44h[XO|YYm= MXyxNFAhdk1? NGnNfIJz\XOldXXzJIFjdm:{bXHsJHNQSy2vZXTpZZRm\CClYXzjbZVuKGWwdIL5 NH7nXmMzPzB6MEGyPS=>
GABA MS-like neurons MVLGeY5kfGmxbjDhd5NigQ>? M{\WNlExODBibl2= MXzuc5Ju[WyrenXzJJRp\SCwdX3i[ZIhd2ZibInzc5NwdWW|L3H1eI9xcGGpb4PvcYV{ NVzsdYNROjdyOECxNlk>
GABA MS-like neurons M{WzfmZ2dmO2aX;uJIF{e2G7 NXvvdWlLOTByIH7N M2fUPJJme2O3ZYOgZYdqdmdibnX1do9veyCocn;tJINmdGxiZHXheIg> MmLRNlcxQDBzMkm=

... Click to View More Cell Line Experimental Data

In vivo EVP4593 (1 mg/kg, i.p.) dose-dependently inhibits carrageenin-induced paw edema in rats. [1]


Animal Research:[1]
+ Expand
  • Animal Models: male SD rats with carrageenin induced paw edema
  • Formulation: 0.5% hydroxypropyl cellulose
  • Dosages: 1 mg/kg
  • Administration: intraperitoneal injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 5 mg/mL (14.02 mM) warming
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 0.5% hydroxyethyl cellulose 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 356.42


CAS No. 545380-34-5
Storage powder
in solvent
Synonyms N/A

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NF-κB Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID