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Methylthiouracil

Synonyms: NSC-193526, NSC-9378,MTU

Methylthiouracil (NSC-193526, NSC-9378,MTU) is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.

Methylthiouracil Chemical Structure

Methylthiouracil Chemical Structure

CAS: 56-04-2

Purity & Quality Control

Batch: S313801 DMSO] 28 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.53%
99.53

Methylthiouracil Related Products

Signaling Pathway

NF-κB Signaling Pathways

NF-κB Signaling Pathway

Choose Selective NF-κB Inhibitors

Biological Activity

Description Methylthiouracil (NSC-193526, NSC-9378,MTU) is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.
Targets
TNF-α [3] IL-6 [3] NF-κB [3] ERK1/2 [3]
In vitro
In vitro

Methylthiouracil acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland. Methylthiouracil is also used in combination with radioactive iodine.

Chemical Information & Solubility

Molecular Weight 142.18 Formula

C5H6N2OS
CAS No. 56-04-2 SDF Download Methylthiouracil SDF
Smiles CC1=CC(=O)NC(=S)N1
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 28 mg/mL ( (196.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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