PDTC (Pyrrolidinedithiocarbamate ammonium)

Synonyms: APDC, Pyrrolidine dithiocarbamic acid ammonium salt

PDTC (Pyrrolidinedithiocarbamate ammonium) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.

PDTC (Pyrrolidinedithiocarbamate ammonium) Chemical Structure

PDTC (Pyrrolidinedithiocarbamate ammonium) Chemical Structure

CAS: 5108-96-3

Selleck's PDTC (Pyrrolidinedithiocarbamate ammonium) has been cited by 82 publications

Purity & Quality Control

Batch: Purity: 99.95%
99.95

PDTC (Pyrrolidinedithiocarbamate ammonium) Related Products

Signaling Pathway

Choose Selective NF-κB Inhibitors

Biological Activity

Description PDTC (Pyrrolidinedithiocarbamate ammonium) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.
Targets
NF-κB [1]
In vitro
In vitro Ammonium pyrrolidine dithiocarbamate (PDTC) can inhibit the role of NF-κB by inhibiting IκB phosphorylation, thus blocking NF-κB translocation to the nucleus, reducing the expression of downstream cytokines[1].
Experimental Result Images Methods Biomarkers Images PMID
Western blot CCR2 / CCR5 / CXCR4 p-IKKβ / IKKβ / p-IκBα / IκBα p-p65 / p65 / p50 10716998
Immunofluorescence p65 / p50 29956738

Chemical Information & Solubility

Molecular Weight 164.29 Formula

C5H9NS2.H3N

CAS No. 5108-96-3 SDF Download PDTC (Pyrrolidinedithiocarbamate ammonium) SDF
Smiles C1CCN(C1)C(=S)[S-].[NH4+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (194.77 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 32 mg/mL

Ethanol : 32 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy PDTC (Pyrrolidinedithiocarbamate ammonium) | PDTC (Pyrrolidinedithiocarbamate ammonium) supplier | purchase PDTC (Pyrrolidinedithiocarbamate ammonium) | PDTC (Pyrrolidinedithiocarbamate ammonium) cost | PDTC (Pyrrolidinedithiocarbamate ammonium) manufacturer | order PDTC (Pyrrolidinedithiocarbamate ammonium) | PDTC (Pyrrolidinedithiocarbamate ammonium) distributor