Acetylcysteine

Catalog No.S1623

Acetylcysteine Chemical Structure

Molecular Weight(MW): 163.19

Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 210 In stock
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Biological Activity

Description Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.
Targets
ROS/ROS1 [6] TNF-α [7]
In vitro

N-acetylcysteine inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes. N-acetylcysteine can also prevent apoptosis and promote cell survival by activating extracellular signal-regulated kinase pathway, a concept useful for treating certain degenerative diseases. N-acetylcysteine directly modifies the activity of several proteins by its reducing activity. [1] N-acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. N-acetylcysteine also prevents death of PC12 cells and sympathetic neurons. [2] N-acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. [3] N-acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. N-acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. N-acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. N-acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it was suggested that NAC interferes with redox-sensitive steps in the NGF mechanism. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
rat PC12 cells MXfGeY5kfGmxbjDhd5NigQ>? MoXxNlQhcA>? NETZT5lKdmirYnn0bY9vKG:oIHj5[JJw\2WwIIDldo95cWSnIHnu[JVk\WRiY4n0c5RwgGmlaYT5JIlvKHKjdDDQR|EzKGOnbHzzJJBz\XS{ZXH0[YQh\m:{IEK0JIhzeyCjc4Pld5Nm\CCjczDlcIV3[XSrb36gc4YhcW62cnHj[YxtfWyjcjDncJV1[XSqaX;u[UBt\X[nbB?= M37Ed|E4OTV6NEW0
HUVEC cells MnHoSpVv[3Srb36gZZN{[Xl? NYrUPJVkPSCvTR?= M{XLWVQhcA>? M3rKPWFvfGmxeHnkZY51KGGldHn2bZR6KGmwIFjVWmVEKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDINm8zNWmwZIXj[YQhT1OKIHHjeIl3cXS7IHH0JFUhdW2xbD;MJIlv[3WkYYTl[EA1KGi{czDwdolweiC2bzDINm8zKGOqYXzs[Y5o\SCvZXHzeZJm\CCjZoTldkAyOiCqcoO= M2fTdlIzQDRzMkiw
HUVEC cells NIjrdHRHfW6ldHnvckBie3OjeR?= MkLYOUBuVQ>? Ml\JOEBp MmfkTY5pcWKrdHnvckBw\iCKMl:yMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGmwIFjVWmVEKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIF1KDVibX3vcE9NKGmwY4XiZZRm\CB2IHjyd{BxemmxcjD0c{BJOk9{IHPoZYxt\W6pZTDt[YF{fXKnZDDh[pRmeiBzMjDodpMh[nliTWTUJIF{e2G7 M3K3OlIzQDRzMkiw

... Click to View More Cell Line Experimental Data

In vivo N-acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight. [5]

Protocol

Solubility (25°C)

In vitro DMSO 33 mg/mL (202.21 mM)
Water 33 mg/mL (202.21 mM)
Ethanol 33 mg/mL (202.21 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 163.19
Formula

C5H9NO3S

CAS No. 616-91-1
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01467466 Recruiting Acute Renal Failure|Kidney Disease|Coronary Artery Disease VA Office of Research and Development|The George Institute February 7, 2013 Phase 3
NCT02505477 Recruiting Schizophrenia|Cognitive Deficits|Schizophrenia; Negative Type University of California, Los Angeles February 6, 2017 Phase 4
NCT02362425 Suspended Neuromuscular Disease National Institute of Nursing Research (NINR)|National Institutes of Health Clinical Center (CC) January 21, 2015 Phase 1|Phase 2
NCT03018236 Recruiting Cocaine Addiction|Alcohol Addiction Hospital de Clinicas de Porto Alegre|Secretaria Nacional de Políticas sobre Drogas (SENAD) January 2017 Phase 4
NCT03008889 Not yet recruiting Autism Spectrum Disorder Emory University December 2016 Phase 2
NCT02882477 Not yet recruiting Diabetes Mellitus|Iron Metabolism Disorders|Gastroduodenal Ulcer|Optic Atrophy|Sensorineural Hearing Loss|Platelet Dysfunction Hadassah Medical Organization December 2016 Phase 2|Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID