Curcumin

Catalog No.S1848 Synonyms: Diferuloylmethane

Curcumin Chemical Structure

Molecular Weight(MW): 368.38

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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4 Customer Reviews

  • Effect of NC1, NC1-CUR, NC2 and NC2-CUR on SH-SY5Y cell viability. The cells were treated for 24 h with different dilutions(1:1, 1:2 and 1:4) of empty nanocapsules (NC1 and NC2) and nanocapsules containing curcumin (NC1-CUR and NC2-CUR) followed by measurement of cell viability by MTT reduction assay (panel A) and cell toxicity by LDH release assay (panel B). Data after normalization to vehicle-treated cells (100%, MTT assay) or to total LDH release (TritonX100-treated cells, 100%) are presented as a mean±SEM from 3-8 independent experiments with five replicates. *p < 0.05, **p < 0.01 and ***p<0.001 versus vehicle-treated cells; &&&p<0.001 NC1 versus NC1-CUR.

    Nanotechnology, 2016, 27(35):355101. Curcumin purchased from Selleck.

    Inhibition of [3H]uridine uptake in MIA PaCa-2 (A & B) and PANC-1 (C) cells by curcumin (CUR) and A13. Results are normalised to the disintegrations/min (dpm) of DMSO-only control and are means ±S.D. of n =3 independent experiments done in triplicates. ***P<0.001 significantly different from DMSO-control, calculated using one-way ANOVA and Dunnett's post-hoc test. NBMPR-Nitrobenzylthioinosine. Conc-concentration.

    Eur J Pharmacol, 2017, 803:167-173. Curcumin purchased from Selleck.

  • Oncol Res 2014 21(3), 137-44. Curcumin purchased from Selleck.

    Oncol Res 2014 21(3), 137-44. Curcumin purchased from Selleck.

Purity & Quality Control

Choose Selective Histone Acetyltransferase Inhibitors

Biological Activity

Description Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.
Targets
Nrf2 [1]
(Cell-free assay)
HDAC [7]
(Cell-free assay)
NF-κB [8]
(Cell-free assay)
p300 histone acetylatransferase [6]
(Cell-free assay)
~25 μM
In vitro

Curcumin induces the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibits cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1[2]. Curcumin induces endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells[3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human KBM5 cells M3zFSXBzd2yrZnXyZZRqd25iYYPzZZk> MYi3NkBp NWnrbYlsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLRm02KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;Mz64OEDPxE1? MoH4NlQzQDByNkm=
human Jurkat cells NUjyVFFGWHKxbHnm[ZJifGmxbjDhd5NigQ>? M2rYNFczKGh? NVXpTVE1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDKeZJs[XRiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20MlI6KM7:TR?= M{mxRVI1OjhyME[5
human U266 cells M{XnbXBzd2yrZnXyZZRqd25iYYPzZZk> MnG2O|IhcA>? MlvURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXMk[2JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Py53NzFOwG0> M2P3dlI1OjhyME[5
human A549 cells Mn7EVJJwdGmoZYLheIlwdiCjc4PhfS=> NXWzW4JpPzJiaB?= MoDPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OTdwMzFOwG0> NYi5c3JLOjR{OECwOlk>
human MCF7 cells NX;DVoFMS3m2b4TvfIlkyqCjc4PhfS=> MXSyOEBp M3XvTmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2zNk4zKM7:TR?= M3\NbFI3OTd2NUW1
human SKOV3 cells MY\DfZRwfG:6aXRCpIF{e2G7 MVqyOEBp MmW3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20N{43OyEQvF2= MljzNlYyPzR3NUW=

... Click to View More Cell Line Experimental Data

In vivo Chronic treatment with curcumin significantly reverses the CMS-induced behavioral abnormalities in stressed rats. Additionally, curcumin effectively inhibits cytokine gene expression at both the mRNA and the protein level and reduces the activation of NF-κB[4].

Protocol

Cell Research:

[5]

+ Expand
  • Cell lines: murine melanoma cell subline(B16-R)
  • Concentrations: 0-100 μM
  • Incubation Time: 24-48 h
  • Method:

    1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentrations from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay.


    (Only for Reference)
Animal Research:

[5]

+ Expand
  • Animal Models: Female B6D2F1 mice (6-8 weeks old)
  • Formulation: Dissolved in DMSO and diluted with 0.85% NaCl
  • Dosages: 25 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 73 mg/mL (198.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
10% DMSO+50% PEG 300+ddH2O
40mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 368.38
Formula

C21H20O6

CAS No. 458-37-7
Storage powder
Synonyms Diferuloylmethane

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02277223 Not yet recruiting Ulcerative Colitis Schneider Childrens Medical Center, Israel March 2017 Phase 3
NCT02908152 Not yet recruiting Type 2 Diabetes|Nonalcoholic Fatty Liver National Nutrition and Food Technology Institute February 2017 Phase 2|Phase 3
NCT03016039 Not yet recruiting Curcumin Use for Gynecological Conditions Meir Medical Center January 2017 --
NCT02978339 Not yet recruiting Primary Sclerosing Cholangitis Nicholas LaRusso|EuroPharma, Inc.|Mayo Clinic January 2017 Phase 1|Phase 2
NCT02944578 Recruiting Neoplasms Emory University October 2016 Phase 2
NCT02998918 Recruiting Inflammation|Atherosclerosis|Cardiovascular Disease University of South Carolina September 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Related Antibodies

Histone Acetyltransferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID