Catalog No.S1848 Synonyms: Diferuloylmethane
Molecular Weight(MW): 368.38
Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM） and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.
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Effect of NC1, NC1-CUR, NC2 and NC2-CUR on SH-SY5Y cell viability. The cells were treated for 24 h with different dilutions(1:1, 1:2 and 1:4) of empty nanocapsules (NC1 and NC2) and nanocapsules containing curcumin (NC1-CUR and NC2-CUR) followed by measurement of cell viability by MTT reduction assay (panel A) and cell toxicity by LDH release assay (panel B). Data after normalization to vehicle-treated cells (100%, MTT assay) or to total LDH release (TritonX100-treated cells, 100%) are presented as a mean±SEM from 3-8 independent experiments with five replicates. *p < 0.05, **p < 0.01 and ***p<0.001 versus vehicle-treated cells; &&&p<0.001 NC1 versus NC1-CUR.
Nanotechnology, 2016, 27(35):355101. Curcumin purchased from Selleck.
Inhibition of [3H]uridine uptake in MIA PaCa-2 (A & B) and PANC-1 (C) cells by curcumin (CUR) and A13. Results are normalised to the disintegrations/min (dpm) of DMSO-only control and are means ±S.D. of n =3 independent experiments done in triplicates. ***P<0.001 significantly different from DMSO-control, calculated using one-way ANOVA and Dunnett's post-hoc test. NBMPR-Nitrobenzylthioinosine. Conc-concentration.
Eur J Pharmacol, 2017, 803:167-173. Curcumin purchased from Selleck.
Purity & Quality Control
Choose Selective Histone Acetyltransferase Inhibitors
|Description||Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM） and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.|
Curcumin induces the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibits cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1. Curcumin induces endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells.
|In vivo||Chronic treatment with curcumin significantly reverses the CMS-induced behavioral abnormalities in stressed rats. Additionally, curcumin effectively inhibits cytokine gene expression at both the mRNA and the protein level and reduces the activation of NF-κB.|
-  Gao S, et al. Food Chem Toxicol. 2013, 59:739-47.
-  Nasiri M, et al. Asian Pac J Cancer Prev. 2013, 14(6):3449-3453.
-  Cao A, et al. Apoptosis. 2013, 18(11):1391-1402.
-  Jiang H, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2013, 47:33-39.
-  Odot J, et al. Int J Cancer. 2004, 111(3):381-387.
-  Balasubramanyam K, et al. J Biol Chem. 2004, 279(49):51163-71.
-  Chen Y, et al. Basic Clin Pharmacol Toxicol. 2007, 101(6):427-33.
-  Singh S, et al. J Biol Chem. 1995, 270(42):24995-5000.
|In vitro||DMSO||73 mg/mL (198.16 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
10% DMSO+50% PEG 300+ddH2O
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02277223||Not yet recruiting||Ulcerative Colitis||Schneider Childrens Medical Center, Israel||March 2017||Phase 3|
|NCT02908152||Not yet recruiting||Type 2 Diabetes|Nonalcoholic Fatty Liver||National Nutrition and Food Technology Institute||February 2017||Phase 2|Phase 3|
|NCT03016039||Not yet recruiting||Curcumin Use for Gynecological Conditions||Meir Medical Center||January 2017||--|
|NCT02978339||Not yet recruiting||Primary Sclerosing Cholangitis||Nicholas LaRusso|EuroPharma, Inc.|Mayo Clinic||January 2017||Phase 1|Phase 2|
|NCT02944578||Recruiting||Neoplasms||Emory University||October 2016||Phase 2|
|NCT02998918||Recruiting||Inflammation|Atherosclerosis|Cardiovascular Disease||University of South Carolina||September 2016||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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