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Other Immunology & Inflammation Related Inhibitors

CXCR AhR STING COX IL Receptor gp120/CD4 NOD NADPH-oxidase Nrf2 NOS
Cat.No. Product Name Information Product Use Citations Product Validations
S8978 MitoQ (Mitoquinone) Mesylate MitoQ (Mitoquinone) mesylate is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid.
Cancer Cell, 2025, 43(1):69-85.e11
Sci Adv, 2025, 11(35):eadw9952
bioRxiv, 2025, 2025.02.19.639120
S7873 Disodium (R)-2-Hydroxyglutarate Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 10.87 ± 1.85 mM.
NAR Cancer, 2025, 7(1):zcaf003
Nat Commun, 2023, 14(1):984
Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9
S1623 N-Acetylcysteine (NAC chemical, N-Acetyl-L-Cysteine) Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions are unstable and should be fresh-prepared.
Signal Transduct Target Ther, 2025, 10(1):341
J Exp Med, 2025, 222(3)e20241248
Adv Sci (Weinh), 2025, 12(36):e06150
Verified customer review of N-Acetylcysteine (NAC chemical, N-Acetyl-L-Cysteine)
S8661 CA3 (CIL56) CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).
Gastric Cancer, 2025, 10.1007/s10120-025-01630-w
Viruses, 2025, 17(3)400
Sci Rep, 2025, 15(1):26968
S7171 Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. This compound suppresses reactive oxygen species (ROS) production and partly inhibits ferroptosis.
Immunity, 2025, S1074-7613(25)00069-X
Int J Biol Sci, 2025, 21(5):2313-2329
Immunity, 2024, 57(1):52-67.e10
Verified customer review of Setanaxib (GKT137831)
S8674 GO-203 TFA GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function.
Clin Cancer Res, 2025, 31(24):5246-5260
JCI Insight, 2025, 10(14)e190924
Cell Death Discov, 2025, 11(1):372
S6871 Sodium oxamate Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. This compound induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
Adv Sci (Weinh), 2025, 12(8):e2411943
Nucleic Acids Res, 2025, 53(17)gkaf882
Cell Rep Med, 2025, 6(8):102292
S7551 Piperlongumine Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
Biochim Biophys Acta Mol Basis Dis, 2025, 1871(3):167687
Eur J Pharmacol, 2025, 997:177478
PLoS One, 2025, 20(9):e0333127
Verified customer review of Piperlongumine
S1630 Allopurinol Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.
Biomaterials, 2023, 23(4)
J Exp Clin Cancer Res, 2023, 42(1):249
J Exp Clin Cancer Res, 2023, 42(1):249
S9687 H2DCFDA (DCFH-DA) H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) production. It is de-esterified intracellularly and turns to highly fluorescent 2′,7′-dichlorofluorescein upon oxidation. This compound is used in sensitive and rapid quantitation of oxygen-reactive species in response to oxidative metabolism; microplate assay for detecting oxidative products in phagocytic cells, and quantitative multiwell myeloid differentiation assay.(Ex/Em=488/525 nm)
Nat Commun, 2024, 15(1):1750
J Exp Clin Cancer Res, 2023, 42(1):236
J Exp Clin Cancer Res, 2023, 42(1):236