ROS
- Inhibitory Selectivity
- Solubility
Catalog No. | Product Name | Solubility(25°C) | ||
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Water | DMSO | Alcohol | ||
S1547 | Febuxostat | <1 mg/mL | 63 mg/mL | <1 mg/mL |
S1623 | Acetylcysteine | 33 mg/mL | 33 mg/mL | 33 mg/mL |
S1630 | Allopurinol | 4 mg/mL | 27 mg/mL | 3 mg/mL |
S2605 | Idebenone | <1 mg/mL | 68 mg/mL | 68 mg/mL |
S2062 | Tiopronin | 32 mg/mL | 32 mg/mL | 32 mg/mL |
S3885 | Pyrogallol | -1 mg/mL | 25 mg/mL | -1 mg/mL |
S3838 | Carnosic acid | -1 mg/mL | 66 mg/mL | -1 mg/mL |
S3840 | Baohuoside I | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3973 | L-SelenoMethionine | 39 mg/mL | <1 mg/mL | -1 mg/mL |
S3954 | Alphalipoic acid | -1 mg/mL | 41 mg/mL | -1 mg/mL |
S3616 | Asiaticoside | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S3631 | (S)-Methylisothiourea sulfate | 27 mg/mL | <1 mg/mL | <1 mg/mL |
S3632 | Trichloroisocyanuric acid | 20 mg/mL | 46 mg/mL | 2 mg/mL |
S3607 | Sarsasapogenin | <1 mg/mL | <1 mg/mL | 5 mg/mL |
S4580 | Hydroquinone | 22 mg/mL | 22 mg/mL | 22 mg/mL |
S4603 | Gallic acid | 7 mg/mL | 34 mg/mL | 34 mg/mL |
S1631 | Allopurinol Sodium | 32 mg/mL | 32 mg/mL | 2 mg/mL |
S2399 | Dihydromyricetin | <1 mg/mL | 64 mg/mL | 64 mg/mL |
S4074 | Sodium Nitrite | 13 mg/mL | 13 mg/mL | <1 mg/mL |
S2332 | Neohesperidin | <1 mg/mL | 122 mg/mL | <1 mg/mL |
S4511 | 6-Benzylaminopurine | <1 mg/mL | 45 mg/mL | <1 mg/mL |
S7551 | Piperlongumine | <1 mg/mL | 16 mg/mL | 6 mg/mL |
S7867 | Oleuropein | 100 mg/mL | 100 mg/mL | 100 mg/mL |
S2363 | Tangeretin | <1 mg/mL | 8 mg/mL | <1 mg/mL |
S4722 | (+)-Catechin | 58 mg/mL | 58 mg/mL | 58 mg/mL |
S4723 | (-)Epicatechin | <1 mg/mL | 58 mg/mL | <1 mg/mL |
- ROS Inhibitors (26)
- New ROS Products
Catalog No. | Information | Product Use Citations | Product Validations |
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S1547 |
FebuxostatFebuxostat is a selective xanthine oxidase inhibitor with Ki of 0.6 nM. |
![]() ![]() NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM). |
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S1623 |
AcetylcysteineAcetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione. |
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S1630 |
AllopurinolAllopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid. |
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S2605 |
IdebenoneIdebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant. |
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S2062 |
TioproninTiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion. |
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S3885New |
PyrogallolPyrogallol, an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer. |
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S3838New |
Carnosic acidCarnosic acid is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries. |
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S3840New |
Baohuoside IBaohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway. |
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S3973New |
L-SelenoMethionineL-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense. |
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S3954New |
Alphalipoic acidAlpha lipoic acid, a naturally occurring dithiol compound, plays an essential role in mitochondrial bioenergetic reactions. It is a well-known antioxidant. |
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S3616New |
AsiaticosideAsiaticoside, the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF. |
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S3631New |
(S)-Methylisothiourea sulfate(S)-Methylisothiourea sulfate is a potent inhibitor of inducible NO synthase (iNOS). |
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S3632New |
Trichloroisocyanuric acidTrichloroisocyanuric acid (TCCA) is a safe and efficient reagent, useful for chlorination and oxidation reactions. |
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S3607New |
SarsasapogeninSarsasapogenin (SAR) is a steroidal sapogenin. It can provoke the generation of reactive oxygen species and activate unfolded protein response (UPR) signaling pathways. SAR potently inhibits NF-κB and MAPK activation, as well as IRAK1, TAK1, and IκBα phosphorylation in LPS-stimulated macrophages. |
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S4580 |
HydroquinoneHydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney. |
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S4603 |
Gallic acidGallic acid, known as powerful antioxidants, is an organic acid found in a variety of foods and herbs. |
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S1631 |
Allopurinol SodiumAllopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM. |
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S2399 |
DihydromyricetinDihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. |
![]() ![]() A. Cal27 cells transfected with GFP-LC3 plasmid were treated with different concentration of DHM for 24 h. The formation of GFP-LC3 puncta were examined using immunofluorescence and quantified. Scale bar 50 μm. |
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S4074 |
Sodium NitriteSodium nitrite is a myeloperoxidase inhibitor with IC50 of 1.3 μM. |
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S2332 |
NeohesperidinNeohesperidin, a flavanone glycoside found in citrus fruits, is an antioxidant agent. |
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S4511 |
6-Benzylaminopurine6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development. |
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S7551 |
PiperlonguminePiperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells. |
![]() ![]() a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. *P < 0.05; **P < 0.01; ***P < 0.001.
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S7867 |
OleuropeinOleuropein is an antioxidant polyphenol isolated from olive leaf. Phase 2. |
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S2363 |
TangeretinTangeretin, a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities. |
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S4722 |
(+)-CatechinCianidanol is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. |
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S4723 |
(-)Epicatechin(−)Epicatechin is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health. |