ROS

Inhibitory Selectivity
Solubility

Catalog No.	Product Name	Solubility(25°C)
Catalog No.	Product Name	Water	DMSO	Alcohol
S1547	Febuxostat	<1 mg/mL	63 mg/mL	<1 mg/mL
S1623	Acetylcysteine	33 mg/mL	33 mg/mL	33 mg/mL
S1630	Allopurinol	4 mg/mL	27 mg/mL	3 mg/mL
S2605	Idebenone	<1 mg/mL	68 mg/mL	68 mg/mL
S2062	Tiopronin	32 mg/mL	32 mg/mL	32 mg/mL
S4723	(-)Epicatechin	<1 mg/mL	58 mg/mL	<1 mg/mL
S4722	(+)-Catechin	58 mg/mL	58 mg/mL	58 mg/mL
S4603	Gallic acid	7 mg/mL	34 mg/mL	34 mg/mL
S4580	Hydroquinone	22 mg/mL	22 mg/mL	22 mg/mL
S4511	6-Benzylaminopurine	<1 mg/mL	45 mg/mL	<1 mg/mL
S1631	Allopurinol Sodium	32 mg/mL	32 mg/mL	2 mg/mL
S4074	Sodium Nitrite	13 mg/mL	13 mg/mL	<1 mg/mL
S2332	Neohesperidin	<1 mg/mL	122 mg/mL	<1 mg/mL
S7551	Piperlongumine	<1 mg/mL	16 mg/mL	6 mg/mL
S7867	Oleuropein	100 mg/mL	100 mg/mL	100 mg/mL
S2363	Tangeretin	<1 mg/mL	8 mg/mL	<1 mg/mL

ROS Inhibitors (7)
ROS Chemicals (9)
New ROS Products

Catalog No.	Information	Product Use Citations	Product Validations
S1547	Febuxostat Febuxostat is a selective xanthine oxidase inhibitor with K_i of 0.6 nM.	Free Radic Biol Med, 2015, 10.1016/j.freeradbiomed.2015.02.016 Br J Pharmacol, 2016, 173(14):2290-302
S1623	Acetylcysteine Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.	J Cell Physiol, 2015, 230(9):2281-98 Cancer Biol Ther, 2014, 15(12):1646-57
S1630	Allopurinol Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.
S4603^New	Gallic acid Gallic acid is an organic acid found in a variety of foods and herbs that are well known as powerful antioxidants.
S1631	Allopurinol Sodium Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
S4074	Sodium Nitrite Sodium nitrite is a myeloperoxidase inhibitor with IC50 of 1.3 μM.
S7867	Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf. Phase 2.
S2605	Idebenone Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.
S2062	Tiopronin Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.
S4723^New	(-)Epicatechin (−)Epicatechin is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.
S4722^New	(+)-Catechin Cianidanol is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
S4580^New	Hydroquinone Hydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.
S4511^New	6-Benzylaminopurine 6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development.
S2332	Neohesperidin Neohesperidin, a flavanone glycoside found in citrus fruits, is an antioxidant agent.
S7551	Piperlongumine Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.	Oncotarget, 2016, 10.18632/oncotarget.10921 Oncotarget, 2016, 7(26):40531-40545	MPC cells were treated with the indicated concentrations of PL at 21% and 1% O2 for 24 hours. Total cell lysates were subjected to Western blot with antibodies against cleaved PARP, cleaved caspase 3, and caspase 3. β-tubulin was used as a loading control. A representative image (n=3) is shown.
S2363	Tangeretin Tangeretin, a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.

Catalog No.	Information	Product Use Citations	Product Validations
S1547	Febuxostat Febuxostat is a selective xanthine oxidase inhibitor with K_i of 0.6 nM.	Free Radic Biol Med, 2015, 10.1016/j.freeradbiomed.2015.02.016 Br J Pharmacol, 2016, 173(14):2290-302
S1623	Acetylcysteine Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.	J Cell Physiol, 2015, 230(9):2281-98 Cancer Biol Ther, 2014, 15(12):1646-57
S1630	Allopurinol Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.
S4603^New	Gallic acid Gallic acid is an organic acid found in a variety of foods and herbs that are well known as powerful antioxidants.
S1631	Allopurinol Sodium Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
S4074	Sodium Nitrite Sodium nitrite is a myeloperoxidase inhibitor with IC50 of 1.3 μM.
S7867	Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf. Phase 2.

Catalog No.	Information	Product Use Citations	Product Validations
S2605	Idebenone Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.
S2062	Tiopronin Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.
S4723^New	(-)Epicatechin (−)Epicatechin is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.
S4722^New	(+)-Catechin Cianidanol is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
S4580^New	Hydroquinone Hydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.
S4511^New	6-Benzylaminopurine 6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development.
S2332	Neohesperidin Neohesperidin, a flavanone glycoside found in citrus fruits, is an antioxidant agent.
S7551	Piperlongumine Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.	Oncotarget, 2016, 10.18632/oncotarget.10921 Oncotarget, 2016, 7(26):40531-40545	MPC cells were treated with the indicated concentrations of PL at 21% and 1% O2 for 24 hours. Total cell lysates were subjected to Western blot with antibodies against cleaved PARP, cleaved caspase 3, and caspase 3. β-tubulin was used as a loading control. A representative image (n=3) is shown.
S2363	Tangeretin Tangeretin, a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.

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