ROS

Inhibitory Selectivity
Solubility

Catalog No.	Product Name	Solubility(25°C)
Catalog No.	Product Name	Water	DMSO	Alcohol
S1547	Febuxostat	<1 mg/mL	63 mg/mL	<1 mg/mL
S1623	Acetylcysteine	33 mg/mL	33 mg/mL	33 mg/mL
S1630	Allopurinol	4 mg/mL	27 mg/mL	3 mg/mL
S2605	Idebenone	<1 mg/mL	68 mg/mL	68 mg/mL
S2062	Tiopronin	32 mg/mL	32 mg/mL	32 mg/mL
S4723	(-)Epicatechin	<1 mg/mL	58 mg/mL	<1 mg/mL
S4722	(+)-Catechin	58 mg/mL	58 mg/mL	58 mg/mL
S4603	Gallic acid	7 mg/mL	34 mg/mL	34 mg/mL
S4580	Hydroquinone	22 mg/mL	22 mg/mL	22 mg/mL
S1631	Allopurinol Sodium	32 mg/mL	32 mg/mL	2 mg/mL
S2399	Dihydromyricetin	<1 mg/mL	64 mg/mL	64 mg/mL
S4074	Sodium Nitrite	13 mg/mL	13 mg/mL	<1 mg/mL
S2332	Neohesperidin	<1 mg/mL	122 mg/mL	<1 mg/mL
S4511	6-Benzylaminopurine	<1 mg/mL	45 mg/mL	<1 mg/mL
S7551	Piperlongumine	<1 mg/mL	16 mg/mL	6 mg/mL
S7867	Oleuropein	100 mg/mL	100 mg/mL	100 mg/mL
S2363	Tangeretin	<1 mg/mL	8 mg/mL	<1 mg/mL

ROS Inhibitors (6)
ROS Modulators (1)
ROS Chemicals (10)
New ROS Products

Catalog No.	Information	Product Use Citations	Product Validations
S1547	Febuxostat Febuxostat is a selective xanthine oxidase inhibitor with K_i of 0.6 nM.	Free Radic Biol Med, 2015, 10.1016/j.freeradbiomed.2015.02.016 Br J Pharmacol, 2016, 173(14):2290-302	NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM).
S1623	Acetylcysteine Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.	J Cell Physiol, 2015, 230(9):2281-98 Cancer Biol Ther, 2014, 15(12):1646-57
S1630	Allopurinol Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.
S4603^New	Gallic acid Gallic acid is an organic acid found in a variety of foods and herbs that are well known as powerful antioxidants.
S1631	Allopurinol Sodium Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
S4074	Sodium Nitrite Sodium nitrite is a myeloperoxidase inhibitor with IC50 of 1.3 μM.
S2399	Dihydromyricetin Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.	Oncotarget, 2016, 10.18632/oncotarget.10836 Food Chem Toxicol, 2012, 50(7):2508-14	A. Cal27 cells transfected with GFP-LC3 plasmid were treated with different concentration of DHM for 24 h. The formation of GFP-LC3 puncta were examined using immunofluorescence and quantified. Scale bar 50 μm.
S2605	Idebenone Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.
S2062	Tiopronin Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.
S4723^New	(-)Epicatechin (−)Epicatechin is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.
S4722^New	(+)-Catechin Cianidanol is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
S4580^New	Hydroquinone Hydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.
S2332	Neohesperidin Neohesperidin, a flavanone glycoside found in citrus fruits, is an antioxidant agent.
S4511	6-Benzylaminopurine 6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development.
S7551	Piperlongumine Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.	Oncotarget, 2016, 10.18632/oncotarget.10921 Oncotarget, 2016, 7(26):40531-40545 Oncotarget, 2016, 7(35):56933-56943	a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. P < 0.05; P < 0.01; **P < 0.001.
S7867	Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf. Phase 2.
S2363	Tangeretin Tangeretin, a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.

Catalog No.	Information	Product Use Citations	Product Validations
S1547	Febuxostat Febuxostat is a selective xanthine oxidase inhibitor with K_i of 0.6 nM.	Free Radic Biol Med, 2015, 10.1016/j.freeradbiomed.2015.02.016 Br J Pharmacol, 2016, 173(14):2290-302	NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM).
S1623	Acetylcysteine Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.	J Cell Physiol, 2015, 230(9):2281-98 Cancer Biol Ther, 2014, 15(12):1646-57
S1630	Allopurinol Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.
S4603^New	Gallic acid Gallic acid is an organic acid found in a variety of foods and herbs that are well known as powerful antioxidants.
S1631	Allopurinol Sodium Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
S4074	Sodium Nitrite Sodium nitrite is a myeloperoxidase inhibitor with IC50 of 1.3 μM.

Catalog No.	Information	Product Use Citations	Product Validations
S2399	Dihydromyricetin Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.	Oncotarget, 2016, 10.18632/oncotarget.10836 Food Chem Toxicol, 2012, 50(7):2508-14	A. Cal27 cells transfected with GFP-LC3 plasmid were treated with different concentration of DHM for 24 h. The formation of GFP-LC3 puncta were examined using immunofluorescence and quantified. Scale bar 50 μm.

Catalog No.

Information

Product Use Citations

Product Validations

S2399

Dihydromyricetin

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.

Oncotarget, 2016, 10.18632/oncotarget.10836

Food Chem Toxicol, 2012, 50(7):2508-14

Catalog No.	Information	Product Use Citations	Product Validations
S2605	Idebenone Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.
S2062	Tiopronin Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.
S4723^New	(-)Epicatechin (−)Epicatechin is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.
S4722^New	(+)-Catechin Cianidanol is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
S4580^New	Hydroquinone Hydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.
S2332	Neohesperidin Neohesperidin, a flavanone glycoside found in citrus fruits, is an antioxidant agent.
S4511	6-Benzylaminopurine 6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development.
S7551	Piperlongumine Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.	Oncotarget, 2016, 10.18632/oncotarget.10921 Oncotarget, 2016, 7(26):40531-40545 Oncotarget, 2016, 7(35):56933-56943	a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. P < 0.05; P < 0.01; **P < 0.001.
S7867	Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf. Phase 2.
S2363	Tangeretin Tangeretin, a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.

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By Signaling Pathways

By product type

ROS

Febuxostat

Acetylcysteine

Allopurinol

Gallic acid

Allopurinol Sodium

Sodium Nitrite

Dihydromyricetin

Idebenone

Tiopronin

(-)Epicatechin

(+)-Catechin

Hydroquinone

Neohesperidin

6-Benzylaminopurine

Piperlongumine

Oleuropein

Tangeretin

Febuxostat

Acetylcysteine

Allopurinol

Gallic acid

Allopurinol Sodium

Sodium Nitrite

Dihydromyricetin

Idebenone

Tiopronin

(-)Epicatechin

(+)-Catechin

Hydroquinone

Neohesperidin

6-Benzylaminopurine

Piperlongumine

Oleuropein

Tangeretin