Hydroquinone

Catalog No.S4580 Synonyms: Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ

Hydroquinone Chemical Structure

Molecular Weight(MW): 110.11

Hydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.

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Biological Activity

Description Hydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.
In vitro

At 50 µM HQ(Hydroquinone), R-28 cells show a significant decrease in cell viability compared with the dimethyl sulfoxide (DMSO)-treated controls. At the 100–500 µM concentrations, all three cell lines show significant cell death (P <0.001). In the ARPE-19, R-28, and HMVEC cultures, the caspase-3/7 activities are not increased at any of the HQ concentration. Neuroretinal R-28 cells are more sensitive to HQ than the ARPE-19 and HMVEC cultures[1].

In vivo In vivo exposure of rats to HQ results in changes of immune response mirrored by impairing allergic lung response to ovalbumin, an antigen unrelated to HQ. HQ exposure impairs the expression of CD45R and CD6 co-stimulatory molecules on activated spleen lymphocytes and diminishes the levels of OA(ovalbumin)-anaphylactic antibodies and the subsequent mast cell degranulation in sensitized rats challenged with OA[2].

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: ARPE-19, R-28, and HMVEC
  • Concentrations: 500 µM, 200 µM, 100 µM, 50 µM
  • Incubation Time: 24 h
  • Method:

    ARPE-19, R-28, and HMVEC are treated for 24 h with four different concentrations of HQ (500 µM, 200 µM, 100 µM, 50 µM). Cell viability, caspase-3/7 activation, DNA laddering patterns, and lactate dehydrogenase (LDH) levels are analyzed.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male Wistar rats
  • Formulation: dissolved in absolute ethanol (5% of the final solution) and the volume was completed with sterile saline solution
  • Dosages: 50 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 22 mg/mL (199.8 mM)
Water 22 mg/mL (199.8 mM)
Ethanol 22 mg/mL (199.8 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 110.11
Formula

C6H6O2

CAS No. 123-31-9
Storage powder
Synonyms Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID