BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

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In DMSO USD 272 In stock
USD 170 In stock
USD 270 In stock
USD 670 In stock
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3 Customer Reviews

  • (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

    HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

  • Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\Wb2lEPTB;MD6wN|U5KM7:TR?= NHjIbFZUSU6JRWK=
H9 Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXqZldKSzVyPUCuNFYxOTlizszN M1Lxe3NCVkeHUh?=
KARPAS-45 NY\LWI9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDyOZdKSzVyPUCuNVY2OjVizszN NFPUUmpUSU6JRWK=
NCI-H720 M2[5UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnOSmFKSzVyPUCuNVcyQTRizszN MV7TRW5ITVJ?
CTV-1 NH;6W45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwNEe4O|Ih|ryP M3\ScHNCVkeHUh?=
DU-4475 NETJeYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwNUC0NVch|ryP NHnSe29USU6JRWK=
A172 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;2NHZKSzVyPUCuOVE4ODVizszN M331U3NCVkeHUh?=
EW-18 MoXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmq1TWM2OD1yLk[yNlEyKM7:TR?= MlP1V2FPT0WU
KU812 NU\iZohoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDkbI1mUUN3ME2wMlYzPjJ|IN88US=> M{\DR3NCVkeHUh?=
KP-N-YS NUjsU4JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwNkiyNlMh|ryP NXW0U|QzW0GQR1XS
SBC-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\STWM2OD1yLk[5OVI1KM7:TR?= M2G2XHNCVkeHUh?=
ECC10 MoPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwN{CwPVQh|ryP MWjTRW5ITVJ?
GAMG M2Hjcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHs[Wt[UUN3ME2wMlc1PzF5IN88US=> NIfZR5JUSU6JRWK=
NCI-H209 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwN{[4NkDPxE1? NI\MVFhUSU6JRWK=
MC-IXC MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwN{m1PFkh|ryP NG\0RoxUSU6JRWK=
HSC-3 M4S0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHuTWM2OD1yLkixO|Y6KM7:TR?= MYHTRW5ITVJ?
IST-SL1 NIDJfYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjFTWM2OD1yLki0OVc1KM7:TR?= NYPnWGQxW0GQR1XS
LU-139 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUOwUXV7UUN3ME2wMlg1QTV6IN88US=> M4LNSXNCVkeHUh?=
ML-2 MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;1TWM2OD1yLki1OVc2KM7:TR?= NIX0WVVUSU6JRWK=
CAL-62 MkfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\yTWM2OD1yLki4NVUzKM7:TR?= NHS4O2FUSU6JRWK=
HL-60 M4j6dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTRRmJyUUN3ME2wMlg5OzZ{IN88US=> NITzSlJUSU6JRWK=
KY821 NUTOOHlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PIcmlEPTB;MD64PFgyOiEQvF2= NFfHZppUSU6JRWK=
ES7 MoO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXT4bXBvUUN3ME2wMlkyPjB5IN88US=> M3vHZXNCVkeHUh?=
MV-4-11 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInwSpdKSzVyPUCuPVc5QTdizszN NYPiSId1W0GQR1XS
Daoy NFPjepVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXHO2RrUUN3ME2wMlk5PzZ5IN88US=> MljnV2FPT0WU
EoL-1-cell MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4G2PGlEPTB;MT6wNVg4QCEQvF2= NHrITZZUSU6JRWK=
TGW M2jlWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTIOYpCUUN3ME2xMlA2OTJ2IN88US=> MoC2V2FPT0WU
LAMA-84 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFwMUK3PVQh|ryP Mo\oV2FPT0WU
KOSC-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7rTWM2OD1zLkGzN|g2KM7:TR?= NGS3XnJUSU6JRWK=
A549 NF7BVGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3zSYFKSzVyPUGuN|A6PTVizszN MX\TRW5ITVJ?
CTB-1 NVS5VlZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLQdI5xUUN3ME2xMlQ1Pjd7IN88US=> NWrtR4F7W0GQR1XS
NCI-H292 M2PNZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLuTJdKSzVyPUGuOFYxPjlizszN MVLTRW5ITVJ?
LoVo MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\QTWM2OD1zLkS2O|U2KM7:TR?= M3H6PXNCVkeHUh?=
BFTC-905 Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTFwNU[zN|Ih|ryP MlHhV2FPT0WU
BE-13 NYDiOmlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnSNFdKSzVyPUGuOVg4ODlizszN M1T2UnNCVkeHUh?=
KE-37 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDKTWM2OD1zLkW5OFc5KM7:TR?= MVnTRW5ITVJ?
HN NU\sO2l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jaWWlEPTB;MT62NVM3QCEQvF2= M{DVUHNCVkeHUh?=
A3-KAW MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7HVnhKSzVyPUGuOlI5OzRizszN NXrETnk1W0GQR1XS
NEC8 NWPIZ4M3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjp[JVKSzVyPUGuO|AyOTVizszN NXfvcJFyW0GQR1XS
Ramos-2G6-4C10 M3vnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTFwN{C0OFQh|ryP M{\x[HNCVkeHUh?=
NB10 M{LqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf2TWM2OD1zLke3OlMh|ryP MoTDV2FPT0WU
NBsusSR Ml\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\CTWM2OD1zLkiyPVYyKM7:TR?= Ml6yV2FPT0WU
ES4 MkT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nQbmlEPTB;MT64OVE1OyEQvF2= MmnKV2FPT0WU
ES8 NULDeWJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTFwOEe3NlQh|ryP M{[5dnNCVkeHUh?=
CHL-1 M1;OZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFwOUW3PVIh|ryP M2TTWnNCVkeHUh?=
NCI-H2029 NVPKUGtoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;yTWM2OD1zLkm3NlQyKM7:TR?= NE\TN3VUSU6JRWK=
YKG-1 M1zGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPCVplLUUN3ME2xMlk5PDN{IN88US=> NGHnfnlUSU6JRWK=
BV-173 NFPEdYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HxSGlEPTB;MT65PFY3PiEQvF2= Mn:3V2FPT0WU
697 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3RTWM2OD1{LkCyNlI5KM7:TR?= MUXTRW5ITVJ?
SK-NEP-1 M3Trbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVK3eFZ4UUN3ME2yMlA1PCEQvF2= MX7TRW5ITVJ?
LOXIMVI M36zRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfuXWNKSzVyPUKuNFQ1OzRizszN MmXJV2FPT0WU
QIMR-WIL MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJwMEe4OFkh|ryP MlvsV2FPT0WU
DU-145 M{myV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTwTWM2OD1{LkGxNFU3KM7:TR?= M3[2fHNCVkeHUh?=
NB14 M{[0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TGPGlEPTB;Mj6xNVMzOSEQvF2= NYW0SpZxW0GQR1XS
G-361 M{jTT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJwMUKyNUDPxE1? M{TTe3NCVkeHUh?=
BPH-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXDTWM2OD1{LkGyPVU4KM7:TR?= NVLYR4VOW0GQR1XS
KYSE-150 NGLsUmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jjZmlEPTB;Mj6xOVI{PCEQvF2= Mln0V2FPT0WU
HMV-II M3jFU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWH6cGlvUUN3ME2yMlE3PjN|IN88US=> NHnrVVlUSU6JRWK=
TE-9 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nOSmlEPTB;Mj6xO|M4PiEQvF2= MmDDV2FPT0WU
8-MG-BA MofuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfSd|A{UUN3ME2yMlI{PDZzIN88US=> NYrzRWlIW0GQR1XS
ES5 NHHMRpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJwMkO2N|Mh|ryP NX;UO2hKW0GQR1XS
D-283MED NHrlcVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJwMkO2PVUh|ryP NIDGcmpUSU6JRWK=
SK-N-AS M3PRVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGzRVRDUUN3ME2yMlI6ODV7IN88US=> MYDTRW5ITVJ?
SW1710 NILUWGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPQTWM2OD1{LkOwOlYyKM7:TR?= MXTTRW5ITVJ?
GCT M1XsUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJwM{GzOVgh|ryP NF;wPFZUSU6JRWK=
AGS MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHTcXhKSzVyPUKuN|Q1ODRizszN MljVV2FPT0WU
HuO9 MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJwM{[4NlQh|ryP NWjHeXF6W0GQR1XS
MN-60 NY\BZ2VuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGP0PWRKSzVyPUKuOFQ5QDNizszN M3zTb3NCVkeHUh?=
NB6 M1zoRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT6eVFPUUN3ME2yMlQ2Pzd7IN88US=> NUfxSJVJW0GQR1XS
NCI-H1395 NVPOfIs3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjJTWM2OD1{LkS3NVIyKM7:TR?= NHTjc|lUSU6JRWK=
H4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rqR2lEPTB;Mj60PFM6OyEQvF2= MUnTRW5ITVJ?
HT-3 M1rudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTEPZJKSzVyPUKuOVExOjRizszN NFjoU4lUSU6JRWK=
P12-ICHIKAWA NEnybolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJwNUK1OVkh|ryP NHnXS2ZUSU6JRWK=
COLO-800 M4L2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJwNUSxOlYh|ryP Mo\3V2FPT0WU
DB NGWx[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknUTWM2OD1{LkW1NFE{KM7:TR?= MlThV2FPT0WU
LCLC-97TM1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHiTWM2OD1{Lk[wNFI5KM7:TR?= M3jvOnNCVkeHUh?=
Ca9-22 M4XEZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYiyVoFyUUN3ME2yMlY2QTN|IN88US=> Mn2zV2FPT0WU
Becker MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j6PGlEPTB;Mj62OlA4QCEQvF2= MkfVV2FPT0WU
ACN M2nnS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL5U4JKSzVyPUKuOlY4QSEQvF2= Ml3zV2FPT0WU
SJSA-1 NWn6[mtmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfZXGhCUUN3ME2yMlY3QDdizszN NX7HdGFHW0GQR1XS
NCI-H1048 NXHZNZJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjRVWhKSzVyPUKuOlg{OjFizszN MmHwV2FPT0WU
HEL NHO1SGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\kTWM2OD1{LkewNlU1KM7:TR?= MkDMV2FPT0WU
NCI-H69 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzLTWM2OD1{LkexOlAyKM7:TR?= NGTxV41USU6JRWK=
639-V NYrVfoFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTJwN{G3NFMh|ryP Mn6zV2FPT0WU
U251 NHrSdY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrjTWM2OD1{LkezNFMzKM7:TR?= MX3TRW5ITVJ?
NCI-H1792 NWfocpNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrwfZZKSzVyPUKuO|M4OzhizszN MWfTRW5ITVJ?
EW-1 NIn0[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHWxUVVKSzVyPUKuO|U{OjhizszN MofFV2FPT0WU
ME-180 NEGwSZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Xic2lEPTB;Mj63O|c{PiEQvF2= NIiyZ2NUSU6JRWK=
HH NEH3NVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJwOECwNFEh|ryP M1HTenNCVkeHUh?=
SW954 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn6cXhKSzVyPUKuPFU5OyEQvF2= MUTTRW5ITVJ?
SF268 M13aTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3T3RWlEPTB;Mj64O|IzPSEQvF2= MmfGV2FPT0WU
D-566MG NWqx[oE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTJwOUGyPVUh|ryP MWnTRW5ITVJ?
EM-2 MlLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJwOUKxPVMh|ryP MkXwV2FPT0WU
NCI-H1299 MnvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PYW2lEPTB;Mj65N|c{PiEQvF2= NETjNWxUSU6JRWK=
PSN1 NWPTTHlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfRd|VEUUN3ME2zMlA2Pzh4IN88US=> M2CzPHNCVkeHUh?=
JVM-3 MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTNwME[3OVYh|ryP M{\lc3NCVkeHUh?=
D-502MG NXnJeYNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfCVW5SUUN3ME2zMlA4ODF7IN88US=> NWnPV2tIW0GQR1XS
SCC-4 M2Dvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M130[mlEPTB;Mz6wPVI4PiEQvF2= MlXLV2FPT0WU
GMS-10 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUS3XYRXUUN3ME2zMlA6Ozh6IN88US=> NX7x[Iw{W0GQR1XS
A427 NYHsbmpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTNwMUC4O|Mh|ryP MmrBV2FPT0WU
NH-12 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTNwMUG0OVYh|ryP MWLTRW5ITVJ?
KM12 NWWzfJB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjGeYhVUUN3ME2zMlEzOjd|IN88US=> M{PVR3NCVkeHUh?=
GI-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3iwPGlEPTB;Mz6xOVI2PSEQvF2= M{LEOnNCVkeHUh?=
TE-8 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfOfFJYUUN3ME2zMlE6OjNzIN88US=> MV7TRW5ITVJ?
MKN1 NXH3Tmh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInjXZJKSzVyPUOuNlA5PzVizszN NF;nUVZUSU6JRWK=
NCI-H810 NX7IcVBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTNwMkKxOVUh|ryP NF\6d5NUSU6JRWK=
GOTO MofRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnVTWM2OD1|LkK4NFA1KM7:TR?= M33hVHNCVkeHUh?=
T98G MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjZbJVKSzVyPUOuNlgzOTZizszN MV7TRW5ITVJ?
HD-MY-Z MkHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;yeHVpUUN3ME2zMlM3PTR{IN88US=> M1jUTnNCVkeHUh?=
SNU-C2B MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTNwM{mwPVch|ryP M{m4fHNCVkeHUh?=
MOLT-4 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTNwM{mwPVgh|ryP NYj6OZJPW0GQR1XS
RPMI-7951 NXHBe|VLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf6NnNKSzVyPUOuN|k4OyEQvF2= MoKwV2FPT0WU
EW-11 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDYfYZwUUN3ME2zMlQyOjJ2IN88US=> NULsOpk3W0GQR1XS
RD NGTlT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfXVHdSUUN3ME2zMlQ{OTN{IN88US=> NFfLcHJUSU6JRWK=
SW48 M37UZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTNwNEOzOVgh|ryP MUDTRW5ITVJ?
BB65-RCC M3\RR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHOV2ZKSzVyPUOuOFU{QTZizszN M{XuN3NCVkeHUh?=
Ca-Ski Ml7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTNwNEe1NVQh|ryP NYHnNVdjW0GQR1XS
CHP-134 Mn;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{i0[WlEPTB;Mz60PFc2QCEQvF2= M1[yfHNCVkeHUh?=
CAL-33 M2PVb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\2O|BKSzVyPUOuOVM{PjJizszN NEnlOnRUSU6JRWK=
TYK-nu MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXO[WlKSzVyPUOuOVM3PzZizszN Mm\LV2FPT0WU
LB831-BLC NEfpSXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PwVmlEPTB;Mz61OFAyPiEQvF2= NEnOSGtUSU6JRWK=
KU-19-19 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkiwTWM2OD1|Lk[wN|A1KM7:TR?= NX3KR4JHW0GQR1XS
KG-1 NV;tfGl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTNwNkGxNFYh|ryP MnXTV2FPT0WU
COLO-829 NF3KdYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HNOWlEPTB;Mz62OlYyQCEQvF2= MWXTRW5ITVJ?
HUTU-80 Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDNdIFKSzVyPUOuOlY3OjFizszN M1\NVXNCVkeHUh?=
NCI-H446 MnjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTNwNkizOEDPxE1? MWXTRW5ITVJ?
LB2241-RCC M{HPeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTNwNki2NlUh|ryP NVnve45DW0GQR1XS
JEG-3 MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTNwNkmxPUDPxE1? M3vGSHNCVkeHUh?=
LNCaP-Clone-FGC M{L5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTNwN{CwOFEh|ryP M{fyUHNCVkeHUh?=
M059J NIfpe4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;DTWM2OD1|LkexOFY5KM7:TR?= MmPNV2FPT0WU
SK-MES-1 NYLGfopJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1G3S2lEPTB;Mz63N|A{KM7:TR?= NVPsUVVZW0GQR1XS
GT3TKB MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInYVnZKSzVyPUOuO|U3ODRizszN M3XMfXNCVkeHUh?=
DOK NGHsc5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHsTWM2OD1|Lke2OVI3KM7:TR?= NYnUTFhLW0GQR1XS
HO-1-N-1 NHGxSpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\aTWM2OD1|Lke5PFAyKM7:TR?= NYnNcIV{W0GQR1XS
MZ1-PC M1XIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPPU4JKSzVyPUOuPFI5QDNizszN NXzsd24zW0GQR1XS
8305C NX\oc4RCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7rU2dKSzVyPUOuPFg6PDNizszN NFS0OFNUSU6JRWK=
CGTH-W-1 MnjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1y1OGlEPTB;Mz65N|UxPCEQvF2= NITu[XhUSU6JRWK=
LU-134-A MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTNwOUW0NlIh|ryP MnrVV2FPT0WU
C32 NWS2UGpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPpUHZKSzVyPUOuPVY2QDFizszN MVjTRW5ITVJ?
MOLT-13 NXzGZYFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfoTWM2OD1|Lkm2PFU3KM7:TR?= M3PpNnNCVkeHUh?=
A375 NUS0OXBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIL1eFRKSzVyPUSuNFUyPjJizszN NYjBVmNbW0GQR1XS
CAL-12T MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjzTWM2OD12LkC1O|k2KM7:TR?= NHPZNYNUSU6JRWK=
IGR-1 MkfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXWeHBmUUN3ME20MlExOjd2IN88US=> M33DdHNCVkeHUh?=
LB1047-RCC NVnETVAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTRwMUC0OFEh|ryP NVLjfnMzW0GQR1XS
BHT-101 M3f4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3LRWtmUUN3ME20MlExPjh|IN88US=> NH;N[ZBUSU6JRWK=
A431 NVrBXY5lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjCS2xKSzVyPUSuNVQxQDFizszN NF3PPWJUSU6JRWK=
EPLC-272H MlvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\LOXFZUUN3ME20MlE4PTl4IN88US=> Ml;vV2FPT0WU
HT-1376 MorjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnz0TWM2OD12LkKzNFU6KM7:TR?= MW\TRW5ITVJ?
HCC1954 M1LQS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWj4WoRkUUN3ME20MlI2PzR4IN88US=> M2nTUHNCVkeHUh?=
KYSE-510 NVnWblNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13mdmlEPTB;ND6yOlA6KM7:TR?= NVLXcGVXW0GQR1XS
PANC-03-27 NGezU49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rqS2lEPTB;ND6zNFA5OyEQvF2= M2nIbXNCVkeHUh?=
MDA-MB-157 M2\TOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XEZ2lEPTB;ND6zNFY2PiEQvF2= NVToNWFvW0GQR1XS
HOP-62 NGHBcpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTRwM{C4OVYh|ryP Mk\XV2FPT0WU
ETK-1 Mnf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTRwM{[yNFMh|ryP NEPUfIFUSU6JRWK=
MIA-PaCa-2 NWj3TJFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTRwM{[yNlch|ryP MlrTV2FPT0WU
MHH-PREB-1 NG[wT2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2K4TGlEPTB;ND6zPVc4OyEQvF2= NXzNNGFmW0GQR1XS
LXF-289 M{TDS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTRwNECyNFIh|ryP MWLTRW5ITVJ?
ATN-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGKyUmRKSzVyPUSuOFI{PDFizszN M3;FfHNCVkeHUh?=
8505C M37HTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTRwNEW4NlUh|ryP MYDTRW5ITVJ?
HOS M4jXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moq1TWM2OD12LkS2OFU{KM7:TR?= M1LiRnNCVkeHUh?=
U-266 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTRwNkGwN|Ih|ryP MWrTRW5ITVJ?
5637 NF[zNVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTRwNkG0OFQh|ryP NIfYUo9USU6JRWK=
GCIY MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlToTWM2OD12LkexNFE2KM7:TR?= NV\Ce49XW0GQR1XS
MDA-MB-231 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW2SmlKSzVyPUSuO|IyOTVizszN Mn;jV2FPT0WU
RKO M4rTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXv6T3lIUUN3ME20MlczQDF5IN88US=> MWfTRW5ITVJ?
COR-L23 NFe1S2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\UTGlEPTB;ND63OFI2PiEQvF2= NIXX[WRUSU6JRWK=
DJM-1 MoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjzfGpKSzVyPUSuO|k4OjlizszN M{\oc3NCVkeHUh?=
D-423MG NVrLe3VNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTIWHFyUUN3ME20MlgxQDB|IN88US=> M4HPW3NCVkeHUh?=
DMS-114 M1jZVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLPTWM2OD12LkixN|g3KM7:TR?= NVTnUIdQW0GQR1XS
MHH-ES-1 M2H6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHHN|dDUUN3ME20MlgzPTB2IN88US=> MkH2V2FPT0WU
CAL-51 NWXWZ5ZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTRwOE[4OFMh|ryP Ml\sV2FPT0WU
SW626 NHTpfHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrvTWM2OD12Lki5Olk4KM7:TR?= NXXTcnU4W0GQR1XS
COLO-824 NFfEUGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;rOGpKSzVyPUSuPVA1ODhizszN MWPTRW5ITVJ?
NCI-H1437 M1LmRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnwT|BKSzVyPUSuPVI6OyEQvF2= M2H0WnNCVkeHUh?=
CAL-39 NGjGOIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonmTWM2OD12LkmzPVg5KM7:TR?= NF[3U4xUSU6JRWK=
PC-3 NX3LZ21JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIqzS|FKSzVyPUSuPVQ3PDhizszN MWnTRW5ITVJ?
A101D NFvMW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3exRWlEPTB;ND65Olg3PSEQvF2= Ml3iV2FPT0WU
ES1 M4rmRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTVwMECxN{DPxE1? NE[5[pdUSU6JRWK=
TE-1 NHPJWodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:5TWM2OD13LkCzOlY3KM7:TR?= Mm\aV2FPT0WU
KP-N-YN M2TaSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTpTWM2OD13LkC1Olch|ryP NXLkN4RoW0GQR1XS
EFO-27 NXnpNndPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTzTWM2OD13LkC2N|I6KM7:TR?= MomwV2FPT0WU
BT-549 NH[5VVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfuTWM2OD13LkC3O|M3KM7:TR?= MofRV2FPT0WU
HLE M2rhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTVwMUG3N|Qh|ryP M1j1OnNCVkeHUh?=
SW982 NXvxOoFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fm[mlEPTB;NT6xN|M4PCEQvF2= NUK2d3NIW0GQR1XS
SCC-25 NWe1UW85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mor1TWM2OD13LkG5NFQ3KM7:TR?= M1r5VnNCVkeHUh?=
SK-MEL-28 NGH1bZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGO2TnZKSzVyPUWuNlA{OTNizszN MV\TRW5ITVJ?
CaR-1 NELaWItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInUTJBKSzVyPUWuNlA4OjZizszN MVrTRW5ITVJ?
MLMA Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHIc45sUUN3ME21MlI{PDN4IN88US=> NYi3NZM6W0GQR1XS
VM-CUB-1 NF\ReJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTVwMkO0N|kh|ryP M4fjcnNCVkeHUh?=
KNS-42 MlLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\oTWM2OD13LkK2NVYh|ryP NI\FNWlUSU6JRWK=
TK10 M3XFW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2H4TGlEPTB;NT6zOlA5PiEQvF2= NGXEOG5USU6JRWK=
MEG-01 NY\2cFRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDFUFZKSzVyPUWuN|YzPzRizszN M1;jOHNCVkeHUh?=
DEL MmnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPocG06UUN3ME21MlM6ODJ|IN88US=> NXL0b|JFW0GQR1XS
SJRH30 M3LjZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfuTWM2OD13LkO5NlE{KM7:TR?= MWjTRW5ITVJ?
SK-PN-DW NGrkTHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfFOmxKSzVyPUWuOFM2QDlizszN M{fm[nNCVkeHUh?=
TE-10 NY\6SXE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvRWVM3UUN3ME21MlQ1QDl|IN88US=> MXPTRW5ITVJ?
KNS-81-FD MnjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTVwNUCwPVIh|ryP M12ySXNCVkeHUh?=
BHY M3PTdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFToZ5lKSzVyPUWuOVExPyEQvF2= NV\ZfJI4W0GQR1XS
KYSE-270 NH\i[WxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rLPWlEPTB;NT61N|U{PiEQvF2= NYjaclJFW0GQR1XS
NCI-H650 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XCdmlEPTB;NT61O|EyPCEQvF2= MW\TRW5ITVJ?
L-363 M1\LSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjmW2NFUUN3ME21MlY6PDd4IN88US=> M4rlPXNCVkeHUh?=
TCCSUP NF2xcYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PqfGlEPTB;NT63NVc4QCEQvF2= MoXPV2FPT0WU
SCH M1rRbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\iTWM2OD13Lke0O|Y4KM7:TR?= MWfTRW5ITVJ?
HTC-C3 M4\yTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nZbWlEPTB;NT63O|Y1PCEQvF2= NInVeHBUSU6JRWK=
J-RT3-T3-5 NVv0bZNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvOb21JUUN3ME21MlgxPzl2IN88US=> NVTsSmdwW0GQR1XS
Hs-578-T NGn0[mRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr3cJdKSzVyPUWuPFM3ODdizszN NY\3RlVVW0GQR1XS
M14 NGr0TYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD2bmdPUUN3ME21Mlg3PzJ4IN88US=> NV\YUYVCW0GQR1XS
HT-144 Mmj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz5TWM2OD13Lki2PFMzKM7:TR?= MXzTRW5ITVJ?
CAL-54 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjXelBKSzVyPUWuPVM{OTRizszN MXjTRW5ITVJ?
T47D M1;SXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPzTWM2OD13Lkm2NVIh|ryP NGewepBUSU6JRWK=
GB-1 Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonSTWM2OD14LkCyNFY5KM7:TR?= M{KxeHNCVkeHUh?=
HSC-2 MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT6dIZHUUN3ME22MlEzOzV|IN88US=> NYLHc3pMW0GQR1XS
SiHa M4XEWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG0RZhEUUN3ME22MlE1ODl5IN88US=> M1L2XnNCVkeHUh?=
OMC-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTZwM{W0OFEh|ryP M4XTXHNCVkeHUh?=
HGC-27 Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD1VppKSzVyPU[uN|U4QDZizszN MlS3V2FPT0WU
FTC-133 NGWwcIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzZTWM2OD14LkS2OVUyKM7:TR?= MU\TRW5ITVJ?
KS-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH6TFdKSzVyPU[uOVIyPDdizszN NFnPWlJUSU6JRWK=
HT-1080 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPxfHJKSzVyPU[uOVQxPDJizszN NEPhbZFUSU6JRWK=
SKG-IIIa M2\I[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTZwNU[yOlMh|ryP M2eyb3NCVkeHUh?=
OCUB-M MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHSTWM2OD14Lk[wO|ch|ryP NXj6ZYQ5W0GQR1XS
MDA-MB-175-VII NHr0NJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTZwNkKwPUDPxE1? MWTTRW5ITVJ?
BB30-HNC M{nGeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv5TWM2OD14Lk[3OFQ1KM7:TR?= NV7RNJdZW0GQR1XS
D-542MG NVXWN|FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnaenZKSzVyPU[uO|MxQSEQvF2= MoC3V2FPT0WU
NCI-H2405 MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HvWWlEPTB;Nj63OFg2PSEQvF2= NF7wU3pUSU6JRWK=
SW1573 NULqcZZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEC2U2JKSzVyPU[uO|g{OTlizszN NIfibJVUSU6JRWK=
NCI-SNU-1 NYDKO|JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\4R2lEPTB;Nj63PVAzOiEQvF2= MnviV2FPT0WU
RT-112 NEj3VWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zKeGlEPTB;Nj63PVQ3OyEQvF2= NUDYc25HW0GQR1XS
COR-L88 NYjESod2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLRTWM2OD14Lke5O|kyKM7:TR?= NGfa[nlUSU6JRWK=
SCC-9 NFyzUmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HmWGlEPTB;Nj64NlU2KM7:TR?= MkXrV2FPT0WU
U-87-MG NULYUJc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUi3WGI6UUN3ME22Mlg{QDJ4IN88US=> M4HYcnNCVkeHUh?=
Detroit562 NF:zN4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf4c2RTUUN3ME22Mlg2QTlzIN88US=> MVLTRW5ITVJ?
LC-2-ad NFP5e|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVq1dZU3UUN3ME22Mlg3Ojl{IN88US=> NYHscoEzW0GQR1XS
IGROV-1 NX3HXZpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrlTWM2OD14LkmyOVg{KM7:TR?= MlnrV2FPT0WU
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NCI-H1755 NIjye4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVWzc5dnUUN3ME2zN{45OTFizszN NUjFTGxqW0GQR1XS
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COLO-680N M{S2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj0fmhKSzVyPUO0MlE{QTdizszN NXvlRYo5W0GQR1XS
KURAMOCHI MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTlSohqUUN3ME2zOE43PDJ3IN88US=> NEL1NolUSU6JRWK=
NCI-H661 NH7oUXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjad4NVUUN3ME2zOE45PDR6IN88US=> M3fuNnNCVkeHUh?=
YAPC Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTEcmRIUUN3ME2zOU46PTN|IN88US=> NFvaZnlUSU6JRWK=
NCI-H526 NGGycGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki4TWM2OD1|Nz6yO|czKM7:TR?= NXzCOWFZW0GQR1XS
A498 NYj0UodKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X3cGlEPTB;M{iuNFk2PCEQvF2= NHPwSpFUSU6JRWK=
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D-336MG NVjse2o{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2T2dWlEPTB;NEOuNVE2OiEQvF2= NFvSbZdUSU6JRWK=
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DBTRG-05MG NG\jfpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTDTWM2OD12ND62PVk3KM7:TR?= MljYV2FPT0WU
COLO-678 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXFfWNyUUN3ME20OU44ODN{IN88US=> NV64U2ZLW0GQR1XS
EGI-1 M2DQemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDNTWM2OD12Nz6xPFM{KM7:TR?= MmjMV2FPT0WU
KYSE-70 Ml:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnRS4hKSzVyPUS3MlczOjJizszN NEXFRmhUSU6JRWK=
BALL-1 M{H0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTR5LkiyOVQh|ryP MUHTRW5ITVJ?
MDA-MB-361 NETM[41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTKXGZKSzVyPUS4MlA1PiEQvF2= MV3TRW5ITVJ?
NCI-H1838 Ml\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTR6LkO0OVgh|ryP MnrKV2FPT0WU
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RH-18 NHXGVXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zPRmlEPTB;NUCuNFg5PCEQvF2= M1;zZ3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID