BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

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In DMSO USD 272 In stock
USD 170 In stock
USD 270 In stock
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3 Customer Reviews

  • (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

    HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

  • Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rRXmlEPTB;MD6wN|U5KM7:TR?= M4rIV3NCVkeHUh?=
H9 NVnPSXQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3QfGRKSzVyPUCuNFYxOTlizszN NGOybndUSU6JRWK=
KARPAS-45 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3GwOWlEPTB;MD6xOlUzPSEQvF2= M4LHe3NCVkeHUh?=
NCI-H720 NYC1XmEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XqRmlEPTB;MD6xO|E6PCEQvF2= M2ToW3NCVkeHUh?=
CTV-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjyTZdKSzVyPUCuOFc5PzJizszN M1zvOXNCVkeHUh?=
DU-4475 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDUTWM2OD1yLkWwOFE4KM7:TR?= M2DlNHNCVkeHUh?=
A172 NFTsd5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwNUG3NFUh|ryP NIDxfpFUSU6JRWK=
EW-18 MknGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwNkKyNVEh|ryP M{nLbXNCVkeHUh?=
KU812 NWD6d2g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HER2lEPTB;MD62NlYzOyEQvF2= M3jXWXNCVkeHUh?=
KP-N-YS M4rlV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1y0cGlEPTB;MD62PFIzOyEQvF2= MX7TRW5ITVJ?
SBC-1 NE\QU5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnJd5pKSzVyPUCuOlk2OjRizszN M1vib3NCVkeHUh?=
ECC10 NEDFOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HJT2lEPTB;MD63NFA6PCEQvF2= NGHHfWlUSU6JRWK=
GAMG NXq2epM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwN{S3NVch|ryP Mle2V2FPT0WU
NCI-H209 M4P6emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[wdmlEPTB;MD63OlgzKM7:TR?= MV7TRW5ITVJ?
MC-IXC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwN{m1PFkh|ryP NV[4N3A6W0GQR1XS
HSC-3 NWPwVZo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUH3[WxSUUN3ME2wMlgyPzZ7IN88US=> NV;ofFR1W0GQR1XS
IST-SL1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHvUY5KSzVyPUCuPFQ2PzRizszN M2XSNnNCVkeHUh?=
LU-139 NXO4VopsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3LTFNKSzVyPUCuPFQ6PThizszN M1jJOnNCVkeHUh?=
ML-2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwOEW1O|Uh|ryP NYC4Omt7W0GQR1XS
CAL-62 Mmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVyyW|J2UUN3ME2wMlg5OTV{IN88US=> MkDoV2FPT0WU
HL-60 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwOEizOlIh|ryP MnjrV2FPT0WU
KY821 NHL6V2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwOEi4NVIh|ryP M4X6[nNCVkeHUh?=
ES7 NVTiSJFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUGy[lFVUUN3ME2wMlkyPjB5IN88US=> NVq5ZlRCW0GQR1XS
MV-4-11 MoHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\Y[5ZKSzVyPUCuPVc5QTdizszN MnrrV2FPT0WU
Daoy MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17aS2lEPTB;MD65PFc3PyEQvF2= MVnTRW5ITVJ?
EoL-1-cell MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[4UGlEPTB;MT6wNVg4QCEQvF2= NH34OmpUSU6JRWK=
TGW NWL1PZllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX5UZdsUUN3ME2xMlA2OTJ2IN88US=> MlfmV2FPT0WU
LAMA-84 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nucWlEPTB;MT6xNlc6PCEQvF2= M1PYe3NCVkeHUh?=
KOSC-2 MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTFwMUOzPFUh|ryP M2DmRXNCVkeHUh?=
A549 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jHUWlEPTB;MT6zNFk2PSEQvF2= MVTTRW5ITVJ?
CTB-1 Ml[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzUTWM2OD1zLkS0Olc6KM7:TR?= NXWwfHFXW0GQR1XS
NCI-H292 M1P4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\ITWM2OD1zLkS2NFY6KM7:TR?= MWfTRW5ITVJ?
LoVo NXPTcXRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e3VGlEPTB;MT60Olc2PSEQvF2= NUHWXFBVW0GQR1XS
BFTC-905 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTFwNU[zN|Ih|ryP M4XIdXNCVkeHUh?=
BE-13 M2\hV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfGUnlKSzVyPUGuOVg4ODlizszN MV3TRW5ITVJ?
KE-37 NFuzPW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX0bnQzUUN3ME2xMlU6PDd6IN88US=> NIT6XGtUSU6JRWK=
HN MlvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTFwNkGzOlgh|ryP MXvTRW5ITVJ?
A3-KAW NIG3UI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PBRWlEPTB;MT62Nlg{PCEQvF2= NUjnT|FQW0GQR1XS
NEC8 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jlcWlEPTB;MT63NFEyPSEQvF2= M1;qVXNCVkeHUh?=
Ramos-2G6-4C10 NFfQOI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnMe2VwUUN3ME2xMlcxPDR2IN88US=> MX7TRW5ITVJ?
NB10 NYn5PIF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzqTWM2OD1zLke3OlMh|ryP MV;TRW5ITVJ?
NBsusSR NX;VNJNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTFwOEK5OlEh|ryP NUjzVmlUW0GQR1XS
ES4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTFwOEWxOFMh|ryP NWG5[VFFW0GQR1XS
ES8 NILoPJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTFwOEe3NlQh|ryP MmHyV2FPT0WU
CHL-1 NVXZRpR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jmfGlEPTB;MT65OVc6OiEQvF2= NI\wTGlUSU6JRWK=
NCI-H2029 M4[wVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTFwOUeyOFEh|ryP M13Z[nNCVkeHUh?=
YKG-1 M1znXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2n0dWlEPTB;MT65PFQ{OiEQvF2= MWjTRW5ITVJ?
BV-173 NXvQR|VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfwVXRHUUN3ME2xMlk5PjZ4IN88US=> NEC2b5lUSU6JRWK=
697 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC1c4tUUUN3ME2yMlAzOjJ6IN88US=> M3jxbnNCVkeHUh?=
SK-NEP-1 Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJwMES0JO69VQ>? M2HqcHNCVkeHUh?=
LOXIMVI MmnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJwMES0N|Qh|ryP NGXq[lRUSU6JRWK=
QIMR-WIL M2fGbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJwMEe4OFkh|ryP NFTrblJUSU6JRWK=
DU-145 NEjpPFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYT6OIxRUUN3ME2yMlEyODV4IN88US=> MonVV2FPT0WU
NB14 NHG5b2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJwMUGzNlEh|ryP MkXvV2FPT0WU
G-361 MlvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfWTWM2OD1{LkGyNlEh|ryP MWPTRW5ITVJ?
BPH-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnX6TWM2OD1{LkGyPVU4KM7:TR?= MoLRV2FPT0WU
KYSE-150 M2nKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTXTWM2OD1{LkG1NlM1KM7:TR?= NXfjWJFGW0GQR1XS
HMV-II MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJwMU[2N|Mh|ryP M333bnNCVkeHUh?=
TE-9 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLGTWM2OD1{LkG3N|c3KM7:TR?= NF;zbFJUSU6JRWK=
8-MG-BA NILrb4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTB[Hp4UUN3ME2yMlI{PDZzIN88US=> M4jy[3NCVkeHUh?=
ES5 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fN[WlEPTB;Mj6yN|Y{OyEQvF2= Mn:4V2FPT0WU
D-283MED NUfXcWZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTJwMkO2PVUh|ryP NV\ZcoF6W0GQR1XS
SK-N-AS Mof1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7oOnN5UUN3ME2yMlI6ODV7IN88US=> Mn7UV2FPT0WU
SW1710 M1LvSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjVTWM2OD1{LkOwOlYyKM7:TR?= MlLGV2FPT0WU
GCT MoOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvOTWM2OD1{LkOxN|U5KM7:TR?= MXHTRW5ITVJ?
AGS MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJwM{S0NFQh|ryP NIj6W3FUSU6JRWK=
HuO9 NFqxeXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPETWM2OD1{LkO2PFI1KM7:TR?= NHLlTJpUSU6JRWK=
MN-60 NXG2NGFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELxc4lKSzVyPUKuOFQ5QDNizszN MUnTRW5ITVJ?
NB6 NV3Uc3dlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJwNEW3O|kh|ryP NHfDbnZUSU6JRWK=
NCI-H1395 NXe2[IJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJwNEexNlEh|ryP MYLTRW5ITVJ?
H4 Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTJwNEizPVMh|ryP MoPkV2FPT0WU
HT-3 M{jmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIi2[Y1KSzVyPUKuOVExOjRizszN NELlTmZUSU6JRWK=
P12-ICHIKAWA M2P5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJwNUK1OVkh|ryP NXfPNmxKW0GQR1XS
COLO-800 Mo\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUi0N2VSUUN3ME2yMlU1OTZ4IN88US=> Mlq0V2FPT0WU
DB NGmxe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LHVGlEPTB;Mj61OVAyOyEQvF2= M2PWSXNCVkeHUh?=
LCLC-97TM1 NYjIOXgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHUXFdKSzVyPUKuOlAxOjhizszN MWHTRW5ITVJ?
Ca9-22 MlfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPudGVTUUN3ME2yMlY2QTN|IN88US=> M{nkOXNCVkeHUh?=
Becker M3nIemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLBbIFKSzVyPUKuOlYxPzhizszN M3LtdXNCVkeHUh?=
ACN M{XLdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnYTWM2OD1{Lk[2O|kh|ryP MYPTRW5ITVJ?
SJSA-1 MmDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEKwTGtKSzVyPUKuOlY5PyEQvF2= MnTXV2FPT0WU
NCI-H1048 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLQTWM2OD1{Lk[4N|IyKM7:TR?= NYXVeWV7W0GQR1XS
HEL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEOwWHZKSzVyPUKuO|AzPTRizszN NVr1NYJ7W0GQR1XS
NCI-H69 NF3RPZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPTOVBlUUN3ME2yMlcyPjBzIN88US=> MUfTRW5ITVJ?
639-V NUTpU3hGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OwXmlEPTB;Mj63NVcxOyEQvF2= MXjTRW5ITVJ?
U251 NGTEVVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXHNY5bUUN3ME2yMlc{ODN{IN88US=> MlLkV2FPT0WU
NCI-H1792 MoPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJwN{O3N|gh|ryP M3jiZ3NCVkeHUh?=
EW-1 NUXPZm9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7Gc3NKSzVyPUKuO|U{OjhizszN NGPTd5hUSU6JRWK=
ME-180 NVXxRo85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LVUGlEPTB;Mj63O|c{PiEQvF2= NVjVSXdWW0GQR1XS
HH NGWwTYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPOO|Q6UUN3ME2yMlgxODBzIN88US=> M3LxcHNCVkeHUh?=
SW954 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj3TWM2OD1{Lki1PFMh|ryP MkfhV2FPT0WU
SF268 NXL0fGhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrxTWM2OD1{Lki3NlI2KM7:TR?= MmfQV2FPT0WU
D-566MG M{LEUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFn6bFZKSzVyPUKuPVEzQTVizszN MoKzV2FPT0WU
EM-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXflPGJTUUN3ME2yMlkzOTl|IN88US=> MmfNV2FPT0WU
NCI-H1299 MnHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\y[ZlKSzVyPUKuPVM4OzZizszN NFjYWXhUSU6JRWK=
PSN1 M1zlVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1i1S2lEPTB;Mz6wOVc5PiEQvF2= NX\I[ZZSW0GQR1XS
JVM-3 Mn6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnr5TWM2OD1|LkC2O|U3KM7:TR?= M3PFWHNCVkeHUh?=
D-502MG NFP0clNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7HZmNKSzVyPUOuNFcxOTlizszN MnzyV2FPT0WU
SCC-4 Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvJcG5KSzVyPUOuNFkzPzZizszN NFy5c2pUSU6JRWK=
GMS-10 MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\kSWNKSzVyPUOuNFk{QDhizszN MVvTRW5ITVJ?
A427 M2DCSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTNwMUC4O|Mh|ryP M{P6PXNCVkeHUh?=
NH-12 MojSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MneyTWM2OD1|LkGxOFU3KM7:TR?= NEnxcFFUSU6JRWK=
KM12 MknBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXraWnZRUUN3ME2zMlEzOjd|IN88US=> MlrsV2FPT0WU
GI-1 M{fzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX4TWM2OD1|LkG1NlU2KM7:TR?= MWrTRW5ITVJ?
TE-8 NGnzXmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEW2dHFKSzVyPUOuNVkzOzFizszN MXHTRW5ITVJ?
MKN1 MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Hkb2lEPTB;Mz6yNFg4PSEQvF2= MXHTRW5ITVJ?
NCI-H810 NUTSbnBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG0eI5KSzVyPUOuNlIyPTVizszN NWnVVoVPW0GQR1XS
GOTO MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13EfmlEPTB;Mz6yPFAxPCEQvF2= Mk\KV2FPT0WU
T98G NY\DT2s3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTwOlBEUUN3ME2zMlI5OjF4IN88US=> MX;TRW5ITVJ?
HD-MY-Z NULqV4pVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LUbmlEPTB;Mz6zOlU1OiEQvF2= MUjTRW5ITVJ?
SNU-C2B Mn3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zWWGlEPTB;Mz6zPVA6PyEQvF2= MVzTRW5ITVJ?
MOLT-4 M2nkTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LteGlEPTB;Mz6zPVA6QCEQvF2= NIL0fm1USU6JRWK=
RPMI-7951 NYXNdYN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe0OGNiUUN3ME2zMlM6PzNizszN NXHMfWFCW0GQR1XS
EW-11 NFHDbldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTNwNEGyNlQh|ryP M{HFOXNCVkeHUh?=
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CAL-33 NHvYUY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LWNmlEPTB;Mz61N|M3OiEQvF2= Mk\OV2FPT0WU
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CAL-51 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnjdm5KSzVyPUSuPFY5PDNizszN MVfTRW5ITVJ?
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CAL-54 NGPPdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXYTWM2OD13LkmzN|E1KM7:TR?= MnzIV2FPT0WU
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... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water slightly soluble or insoluble
Ethanol slightly soluble or insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID