BI-D1870

Catalog No.S2843

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

Price Stock Quantity  
USD 272 In stock
USD 170 In stock
USD 270 In stock
USD 670 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

BI-D1870 Chemical Structure

BI-D1870 Chemical Structure
Molecular Weight: 391.42

Validation & Quality Control

2 customer reviews :

Quality Control & MSDS

Related Compound Libraries

BI-D1870 is available in the following compound libraries:

Product Information

  • Compare S6 Kinase Inhibitors
    Compare S6 Kinase Products
  • Research Area

Product Description

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
IC50 15 nM 18 nM 24 nM 31 nM
In vitro BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EW-3NXLoUZBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEjjWG9KSzVyPUCuNFM2QCEQvF2=NU\MNYhnW0GQR1XS
H9MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUexXGtnUUN3ME2wMlA3ODF7IN88US=>M3XjPXNCVkeHUh?=
KARPAS-45MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF\HfFNKSzVyPUCuNVY2OjVizszNMXvTRW5ITVJ?
NCI-H720MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnGwTWM2OD1yLkG3NVk1KM7:TR?=NVHReYJTW0GQR1XS
CTV-1NV24VnFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoO2TWM2OD1yLkS3PFczKM7:TR?=M322UHNCVkeHUh?=
DU-4475MoPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYXTOnN5UUN3ME2wMlUxPDF5IN88US=>NEn5dmlUSU6JRWK=
A172MnPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUH3ToRUUUN3ME2wMlUyPzB3IN88US=>NFraPFhUSU6JRWK=
EW-18MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWHJR|UxRTBwNkKyNVEh|ryPMWPTRW5ITVJ?
KU812M{XNXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmOyTWM2OD1yLk[yOlI{KM7:TR?=MX7TRW5ITVJ?
KP-N-YSNYD0R5VFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXO4cnJiUUN3ME2wMlY5OjJ|IN88US=>NYjRRWtHW0GQR1XS
SBC-1MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnjETWM2OD1yLk[5OVI1KM7:TR?=MmHmV2FPT0WU
ECC10MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mkm0TWM2OD1yLkewNFk1KM7:TR?=MmnGV2FPT0WU
GAMGMlLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHXGfIRKSzVyPUCuO|Q4OTdizszNNH:2UVJUSU6JRWK=
NCI-H209NX7VRo9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHHp[IpKSzVyPUCuO|Y5OiEQvF2=NFPSeFRUSU6JRWK=
MC-IXCM2DRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVjJR|UxRTBwN{m1PFkh|ryPMmLqV2FPT0WU
HSC-3NGC5dVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF[wOllKSzVyPUCuPFE4PjlizszNM3qy[HNCVkeHUh?=
IST-SL1M{HPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkTZTWM2OD1yLki0OVc1KM7:TR?=Mn62V2FPT0WU
LU-139M1Ptd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFnvVmVKSzVyPUCuPFQ6PThizszNNHfjeGpUSU6JRWK=
ML-2NEDaNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3L2cWlEPTB;MD64OVU4PSEQvF2=NE\sT2RUSU6JRWK=
CAL-62MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2rRS2lEPTB;MD64PFE2OiEQvF2=NIKyUpdUSU6JRWK=
HL-60MkPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{fTSGlEPTB;MD64PFM3OiEQvF2=M{H1dnNCVkeHUh?=
KY821MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NITJZ3RKSzVyPUCuPFg5OTJizszNMXnTRW5ITVJ?
ES7M2XPUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M37ZfmlEPTB;MD65NVYxPyEQvF2=NEXYemVUSU6JRWK=
MV-4-11Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEjNcJRKSzVyPUCuPVc5QTdizszNNWfEWmt2W0GQR1XS
DaoyM{jUZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2\XfGlEPTB;MD65PFc3PyEQvF2=MXjTRW5ITVJ?
EoL-1-cellNU\Cc2xFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmC2TWM2OD1zLkCxPFc5KM7:TR?=MoLtV2FPT0WU
TGWNY[0RWduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{iyR2lEPTB;MT6wOVEzPCEQvF2=M{fpV3NCVkeHUh?=
LAMA-84MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHLnNoFKSzVyPUGuNVI4QTRizszNMVPTRW5ITVJ?
KOSC-2MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml7ZTWM2OD1zLkGzN|g2KM7:TR?=NFrLWppUSU6JRWK=
A549NVXrXYY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWPJR|UxRTFwM{C5OVUh|ryPM3PlTHNCVkeHUh?=
CTB-1NGr2cndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXy1bmJLUUN3ME2xMlQ1Pjd7IN88US=>NWfyRpJrW0GQR1XS
NCI-H292MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYjJR|UxRTFwNE[wOlkh|ryPM3nGWnNCVkeHUh?=
LoVoNWCwPZBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUPJR|UxRTFwNE[3OVUh|ryPNWLkUpVqW0GQR1XS
BFTC-905NWDvfZUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NI\HUVBKSzVyPUGuOVY{OzJizszNMofXV2FPT0WU
BE-13M{HU[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVnJR|UxRTFwNUi3NFkh|ryPM{\wfXNCVkeHUh?=
KE-37Mom2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXnJR|UxRTFwNUm0O|gh|ryPMYPTRW5ITVJ?
HNMWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3exb2lEPTB;MT62NVM3QCEQvF2=NYe1TY9EW0GQR1XS
A3-KAWMnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH7DW4hKSzVyPUGuOlI5OzRizszNMWjTRW5ITVJ?
NEC8M1;vdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXfWeIFDUUN3ME2xMlcxOTF3IN88US=>NI[4NVRUSU6JRWK=
Ramos-2G6-4C10NGjJ[IZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{LSPWlEPTB;MT63NFQ1PCEQvF2=MlLmV2FPT0WU
NB10NWq4TGU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnvpTWM2OD1zLke3OlMh|ryPMl[0V2FPT0WU
NBsusSRMYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3e3UmlEPTB;MT64Nlk3OSEQvF2=MlTkV2FPT0WU
ES4M{\K[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUPzT2VnUUN3ME2xMlg2OTR|IN88US=>M1\VcXNCVkeHUh?=
ES8NUTybo81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXzJR|UxRTFwOEe3NlQh|ryPMkn1V2FPT0WU
CHL-1MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoDMTWM2OD1zLkm1O|kzKM7:TR?=MlvpV2FPT0WU
NCI-H2029MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXvTUml2UUN3ME2xMlk4OjRzIN88US=>NYfTPIVJW0GQR1XS
YKG-1NH[0eopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M373TGlEPTB;MT65PFQ{OiEQvF2=NGHCRlZUSU6JRWK=
BV-173MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3HaUWlEPTB;MT65PFY3PiEQvF2=NUHRfHZMW0GQR1XS
697MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV\JR|UxRTJwMEKyNlgh|ryPNX;5bpJEW0GQR1XS
SK-NEP-1MkPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWTyRoNxUUN3ME2yMlA1PCEQvF2=MnnCV2FPT0WU
LOXIMVINGTaOm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYDJR|UxRTJwMES0N|Qh|ryPMWHTRW5ITVJ?
QIMR-WILMX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGWzdJFKSzVyPUKuNFc5PDlizszNNGr3fYJUSU6JRWK=
DU-145M2LRSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnH4TWM2OD1{LkGxNFU3KM7:TR?=NGDxPGlUSU6JRWK=
NB14MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmrHTWM2OD1{LkGxN|IyKM7:TR?=MX3TRW5ITVJ?
G-361NXfoN4JWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4\BXGlEPTB;Mj6xNlIyKM7:TR?=NXnvSmJ{W0GQR1XS
BPH-1NXG4OHJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml7HTWM2OD1{LkGyPVU4KM7:TR?=MkLlV2FPT0WU
KYSE-150M4\NRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXv0fmd1UUN3ME2yMlE2OjN2IN88US=>NGe0S|VUSU6JRWK=
HMV-IIM{LKNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NH3vRpBKSzVyPUKuNVY3OzNizszNNWfte|hkW0GQR1XS
TE-9MkW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWLwXoVLUUN3ME2yMlE4Ozd4IN88US=>MlP0V2FPT0WU
8-MG-BANWm3fnczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEf5cpBKSzVyPUKuNlM1PjFizszNMW\TRW5ITVJ?
ES5MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M363SGlEPTB;Mj6yN|Y{OyEQvF2=MoTpV2FPT0WU
D-283MEDMV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUXDW2xuUUN3ME2yMlI{Pjl3IN88US=>MmjMV2FPT0WU
SK-N-ASM1;oe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEflb5RKSzVyPUKuNlkxPTlizszNM1y5S3NCVkeHUh?=
SW1710MnfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYnhSGx2UUN3ME2yMlMxPjZzIN88US=>MYTTRW5ITVJ?
GCTNHTQOIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYfJR|UxRTJwM{GzOVgh|ryPM3rJZnNCVkeHUh?=
AGSM2\Rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVjT[nlPUUN3ME2yMlM1PDB2IN88US=>M1POXHNCVkeHUh?=
HuO9M{nmNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF\6c5pKSzVyPUKuN|Y5OjRizszNMmnDV2FPT0WU
MN-60MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2XGZmlEPTB;Mj60OFg5OyEQvF2=M1v0ZnNCVkeHUh?=
NB6NVXTNlMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NITsOYNKSzVyPUKuOFU4PzlizszNM4jjT3NCVkeHUh?=
NCI-H1395NI\BNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{TkNGlEPTB;Mj60O|EzOSEQvF2=MYrTRW5ITVJ?
H4MmHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVOwdXhqUUN3ME2yMlQ5Ozl|IN88US=>MYHTRW5ITVJ?
HT-3M1PhR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1\QNmlEPTB;Mj61NVAzPCEQvF2=MmrQV2FPT0WU
P12-ICHIKAWAMkLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmnoTWM2OD1{LkWyOVU6KM7:TR?=MX7TRW5ITVJ?
COLO-800M4j2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NG\UcJBKSzVyPUKuOVQyPjZizszNNV7Ee3hNW0GQR1XS
DBM4HEV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV\JR|UxRTJwNUWwNVMh|ryPNXHlNZJUW0GQR1XS
LCLC-97TM1M2nlcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEPTT3hKSzVyPUKuOlAxOjhizszNM1HC[HNCVkeHUh?=
Ca9-22M1nHeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYrJR|UxRTJwNkW5N|Mh|ryPMl62V2FPT0WU
BeckerNWTPTXJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXvJR|UxRTJwNk[wO|gh|ryPM{L2bXNCVkeHUh?=
ACNNWHHXIZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3TFb2lEPTB;Mj62Olc6KM7:TR?=MnLpV2FPT0WU
SJSA-1Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3j2[WlEPTB;Mj62Olg4KM7:TR?=M{XIS3NCVkeHUh?=
NCI-H1048M3r0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXP5eYFVUUN3ME2yMlY5OzJzIN88US=>NWX6W2szW0GQR1XS
HELNFj0ZXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NW\MTZpzUUN3ME2yMlcxOjV2IN88US=>NH3tU5lUSU6JRWK=
NCI-H69MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYTJR|UxRTJwN{G2NFEh|ryPNIjJT4hUSU6JRWK=
639-VMlTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV7JR|UxRTJwN{G3NFMh|ryPNGf4W41USU6JRWK=
U251NEHjcm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXP0NVR7UUN3ME2yMlc{ODN{IN88US=>NFr5SYRUSU6JRWK=
NCI-H1792Ml7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWPxOnE3UUN3ME2yMlc{PzN6IN88US=>NEXNc2RUSU6JRWK=
EW-1M3\iXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGXMN4RKSzVyPUKuO|U{OjhizszNMYHTRW5ITVJ?
ME-180MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGLPbmhKSzVyPUKuO|c4OzZizszNNIf3SXZUSU6JRWK=
HHMmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MU\JR|UxRTJwOECwNFEh|ryPMknxV2FPT0WU
SW954MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIDpNJhKSzVyPUKuPFU5OyEQvF2=MW\TRW5ITVJ?
SF268Ml;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEH1dIlKSzVyPUKuPFczOjVizszNNEThc4xUSU6JRWK=
D-566MGM3vlb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4T6emlEPTB;Mj65NVI6PSEQvF2=MkTvV2FPT0WU
EM-2MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHfIbmVKSzVyPUKuPVIyQTNizszNMkXjV2FPT0WU
NCI-H1299MnH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFK4[3RKSzVyPUKuPVM4OzZizszNNVXofG9yW0GQR1XS
PSN1MljWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NE\a[HNKSzVyPUOuNFU4QDZizszNNUfKSnIzW0GQR1XS
JVM-3MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml;KTWM2OD1|LkC2O|U3KM7:TR?=M4nncnNCVkeHUh?=
D-502MGNH7YOZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFvhbXpKSzVyPUOuNFcxOTlizszNM4XQb3NCVkeHUh?=
SCC-4MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGXNdFJKSzVyPUOuNFkzPzZizszNNW\y[lhzW0GQR1XS
GMS-10NGPMSXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NI\YbYRKSzVyPUOuNFk{QDhizszNM1joUnNCVkeHUh?=
A427NEPSZ4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MojHTWM2OD1|LkGwPFc{KM7:TR?=NX7pVWV6W0GQR1XS
NH-12M4jNW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1HnSWlEPTB;Mz6xNVQ2PiEQvF2=MnnGV2FPT0WU
KM12MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVrJR|UxRTNwMUKyO|Mh|ryPNVn5dnJxW0GQR1XS
GI-1NVvYNHJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVfqXY52UUN3ME2zMlE2OjV3IN88US=>NH7uWoZUSU6JRWK=
TE-8NXTFcml5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3XmWWlEPTB;Mz6xPVI{OSEQvF2=M1XrS3NCVkeHUh?=
MKN1NY\xcYdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYfJR|UxRTNwMkC4O|Uh|ryPMYfTRW5ITVJ?
NCI-H810NEXy[mVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVfk[HNPUUN3ME2zMlIzOTV3IN88US=>M2S4cnNCVkeHUh?=
GOTOMmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYHzWZd2UUN3ME2zMlI5ODB2IN88US=>NWL2Tno2W0GQR1XS
T98GNILHTHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH3aTZpKSzVyPUOuNlgzOTZizszNM4nKTHNCVkeHUh?=
HD-MY-ZNHiyPXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEXoeWZKSzVyPUOuN|Y2PDJizszNM3HtU3NCVkeHUh?=
SNU-C2BMVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVTJR|UxRTNwM{mwPVch|ryPM4e2Z3NCVkeHUh?=
MOLT-4Mme0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFjab3JKSzVyPUOuN|kxQThizszNM37MR3NCVkeHUh?=
RPMI-7951M3e3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmfjTWM2OD1|LkO5O|Mh|ryPMYPTRW5ITVJ?
EW-11NHzTZ4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M33W[GlEPTB;Mz60NVIzPCEQvF2=NX;jdWNvW0GQR1XS
RDM2GybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHPyNJJKSzVyPUOuOFMyOzJizszNNX75fldjW0GQR1XS
SW48NYjSNoZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWrJR|UxRTNwNEOzOVgh|ryPM2LS[nNCVkeHUh?=
BB65-RCCMXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWXJR|UxRTNwNEWzPVYh|ryPNVPseml6W0GQR1XS
Ca-SkiMmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnnrTWM2OD1|LkS3OVE1KM7:TR?=MVfTRW5ITVJ?
CHP-134Mn\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVXJR|UxRTNwNEi3OVgh|ryPNGmyPGNUSU6JRWK=
CAL-33MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVXJR|UxRTNwNUOzOlIh|ryPNH[yOIdUSU6JRWK=
TYK-nuM4G1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlLtTWM2OD1|LkWzOlc3KM7:TR?=NFjCW|lUSU6JRWK=
LB831-BLCMoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3;2T2lEPTB;Mz61OFAyPiEQvF2=M1nqXXNCVkeHUh?=
KU-19-19NVrx[JN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1zUPGlEPTB;Mz62NFMxPCEQvF2=MX3TRW5ITVJ?
KG-1NWj6dnZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVnvVWtZUUN3ME2zMlYyOTB4IN88US=>M37lSnNCVkeHUh?=
COLO-829Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYXJR|UxRTNwNk[2NVgh|ryPMnOyV2FPT0WU
HUTU-80MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3rJS2lEPTB;Mz62OlYzOSEQvF2=NIi0NmRUSU6JRWK=
NCI-H446M33rSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFL3bI9KSzVyPUOuOlg{PCEQvF2=NHSxTJRUSU6JRWK=
LB2241-RCCMU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUDJR|UxRTNwNki2NlUh|ryPMXXTRW5ITVJ?
JEG-3NYfX[YxuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYLJR|UxRTNwNkmxPUDPxE1?NF74fIhUSU6JRWK=
LNCaP-Clone-FGCNGXSSnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVjJR|UxRTNwN{CwOFEh|ryPNYq4[HFjW0GQR1XS
M059JNVrFNIp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFLhd2JKSzVyPUOuO|E1PjhizszNNY\JTIdCW0GQR1XS
SK-MES-1MlfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NELZR3lKSzVyPUOuO|MxOyEQvF2=MYnTRW5ITVJ?
GT3TKBMUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEGzcWZKSzVyPUOuO|U3ODRizszNMXTTRW5ITVJ?
DOKNUjjOo5VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1e4Z2lEPTB;Mz63OlUzPiEQvF2=NHzjdJpUSU6JRWK=
HO-1-N-1MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUSxWGJuUUN3ME2zMlc6QDBzIN88US=>MYTTRW5ITVJ?
MZ1-PCM{TFWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYPNSG1DUUN3ME2zMlgzQDh|IN88US=>MlH3V2FPT0WU
8305CMmjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1fHXWlEPTB;Mz64PFk1OyEQvF2=MVXTRW5ITVJ?
CGTH-W-1Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmC2TWM2OD1|LkmzOVA1KM7:TR?=MWjTRW5ITVJ?
LU-134-ANWD3WndlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYDqZlR2UUN3ME2zMlk2PDJ{IN88US=>MkPnV2FPT0WU
C32M1mxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXrLTXVnUUN3ME2zMlk3PThzIN88US=>M174NXNCVkeHUh?=
MOLT-13NE\CbYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWDJR|UxRTNwOU[4OVYh|ryPNXS0e4E5W0GQR1XS
A375NWL4clhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYjmPIpNUUN3ME20MlA2OTZ{IN88US=>MUTTRW5ITVJ?
CAL-12TMXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnzTTWM2OD12LkC1O|k2KM7:TR?=MmDnV2FPT0WU
IGR-1NYDLWmptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkLHTWM2OD12LkGwNlc1KM7:TR?=NGHoWnNUSU6JRWK=
LB1047-RCCMojhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1H0Z2lEPTB;ND6xNFQ1OSEQvF2=NE\icJJUSU6JRWK=
BHT-101NX;2[4pGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3\OUGlEPTB;ND6xNFY5OyEQvF2=NFXlbo9USU6JRWK=
A431NIPh[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MU\JR|UxRTRwMUSwPFEh|ryPM1PlcXNCVkeHUh?=
EPLC-272HM4TrTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX\nVpFQUUN3ME20MlE4PTl4IN88US=>MnzQV2FPT0WU
HT-1376MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFS5OHBKSzVyPUSuNlMxPTlizszNMWrTRW5ITVJ?
HCC1954M4\zRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHnzcZJKSzVyPUSuNlU4PDZizszNMVrTRW5ITVJ?
KYSE-510Ml7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2rwVmlEPTB;ND6yOlA6KM7:TR?=MYDTRW5ITVJ?
PANC-03-27NXfGN3JRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYnJR|UxRTRwM{CwPFMh|ryPMlixV2FPT0WU
MDA-MB-157M2Szemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M13ZO2lEPTB;ND6zNFY2PiEQvF2=M2HoZnNCVkeHUh?=
HOP-62MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVHJR|UxRTRwM{C4OVYh|ryPMnmyV2FPT0WU
ETK-1MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYfJR|UxRTRwM{[yNFMh|ryPMlfiV2FPT0WU
MIA-PaCa-2NVLEfnpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mnf0TWM2OD12LkO2NlI4KM7:TR?=MluyV2FPT0WU
MHH-PREB-1MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVryelExUUN3ME20MlM6Pzd|IN88US=>MlrtV2FPT0WU
LXF-289MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEjWWnJKSzVyPUSuOFAzODJizszNMX\TRW5ITVJ?
ATN-1MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUPJR|UxRTRwNEKzOFEh|ryPMXjTRW5ITVJ?
8505CMk\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVfJR|UxRTRwNEW4NlUh|ryPMUPTRW5ITVJ?
HOSNFXHTW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIrqXndKSzVyPUSuOFY1PTNizszNNUfzV|h4W0GQR1XS
U-266NHrSWYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYD3Nod{UUN3ME20MlYyODN{IN88US=>MXXTRW5ITVJ?
5637Mn32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXvJR|UxRTRwNkG0OFQh|ryPMXLTRW5ITVJ?
GCIYMl\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUfJR|UxRTRwN{GwNVUh|ryPMVrTRW5ITVJ?
MDA-MB-231MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml[3TWM2OD12LkeyNVE2KM7:TR?=NVL0bXJSW0GQR1XS
RKONH;INmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF32d2dKSzVyPUSuO|I5OTdizszNM3PISXNCVkeHUh?=
COR-L23NYr3UWRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M37ibWlEPTB;ND63OFI2PiEQvF2=M{Tmc3NCVkeHUh?=
DJM-1MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnO3TWM2OD12Lke5O|I6KM7:TR?=M3XkTnNCVkeHUh?=
D-423MGMl\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVXJR|UxRTRwOEC4NFMh|ryPMknwV2FPT0WU
DMS-114MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFLqSYhKSzVyPUSuPFE{QDZizszNMl3jV2FPT0WU
MHH-ES-1NETT[4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFnrPXFKSzVyPUSuPFI2ODRizszNNUnHd3ZmW0GQR1XS
CAL-51M3nO[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUfJR|UxRTRwOE[4OFMh|ryPMX3TRW5ITVJ?
SW626NH;j[4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXvJR|UxRTRwOEm2PVch|ryPM3rGcXNCVkeHUh?=
COLO-824NIHVR4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYXJR|UxRTRwOUC0NFgh|ryPNUDOVHh1W0GQR1XS
NCI-H1437MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXrCfGVVUUN3ME20MlkzQTNizszNMnTlV2FPT0WU
CAL-39NF\wNFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIHjdXhKSzVyPUSuPVM6QDhizszNM1jkZnNCVkeHUh?=
PC-3NXTXUnY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NE[4b4NKSzVyPUSuPVQ3PDhizszNMULTRW5ITVJ?
A101DNVnjOJVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkXrTWM2OD12Lkm2PFY2KM7:TR?=NHTWTFBUSU6JRWK=
ES1M3nVfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVnIVXdVUUN3ME21MlAxOTNizszNMU\TRW5ITVJ?
TE-1MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHPNSGFKSzVyPUWuNFM3PjZizszNM{nRfnNCVkeHUh?=
KP-N-YNNU\EdGZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3rSb2lEPTB;NT6wOVY4KM7:TR?=MWfTRW5ITVJ?
EFO-27M4Pz[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVTJR|UxRTVwME[zNlkh|ryPMXzTRW5ITVJ?
BT-549MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{TuUmlEPTB;NT6wO|c{PiEQvF2=NUjrXIVqW0GQR1XS
HLENFfhU5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MknRTWM2OD13LkGxO|M1KM7:TR?=MWjTRW5ITVJ?
SW982NWPjZ491T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYrJR|UxRTVwMUOzO|Qh|ryPMmfxV2FPT0WU
SCC-25NWjwcFNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXvJR|UxRTVwMUmwOFYh|ryPM2\JZnNCVkeHUh?=
SK-MEL-28M3XFZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXT3OI5FUUN3ME21MlIxOzF|IN88US=>NXrG[YdJW0GQR1XS
CaR-1M{PCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX7JR|UxRTVwMkC3NlYh|ryPNITkSpZUSU6JRWK=
MLMANWfQNGRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIXkWHZKSzVyPUWuNlM1OzZizszNNYHkTnlZW0GQR1XS
VM-CUB-1NWe2U3IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX7JR|UxRTVwMkO0N|kh|ryPMmf0V2FPT0WU
KNS-42NXPxXGFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4TDU2lEPTB;NT6yOlE3KM7:TR?=MXjTRW5ITVJ?
TK10NVHTU457T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYjMbZVEUUN3ME21MlM3ODh4IN88US=>NWjlbHVFW0GQR1XS
MEG-01NULsXWJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXK2OI9TUUN3ME21MlM3Ojd2IN88US=>NUj2UFZlW0GQR1XS
DELMl33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV7JR|UxRTVwM{mwNlMh|ryPMXfTRW5ITVJ?
SJRH30NYXDTFZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnHNTWM2OD13LkO5NlE{KM7:TR?=MXPTRW5ITVJ?
SK-PN-DWMn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYPCV5JjUUN3ME21MlQ{PTh7IN88US=>MX3TRW5ITVJ?
TE-10NGjhRVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVjJR|UxRTVwNES4PVMh|ryPMonTV2FPT0WU
KNS-81-FDM2LEc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4rxdGlEPTB;NT61NFA6OiEQvF2=MnXBV2FPT0WU
BHYM2P5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnLoTWM2OD13LkWxNFch|ryPMVXTRW5ITVJ?
KYSE-270MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWnMU21mUUN3ME21MlU{PTN4IN88US=>M3vVe3NCVkeHUh?=
NCI-H650NWrNZo45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIHYWJdKSzVyPUWuOVcyOTRizszNNU\1c3VPW0GQR1XS
L-363NIq2RXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH;RS4xKSzVyPUWuOlk1PzZizszNNWS1W4RuW0GQR1XS
TCCSUPNGi4V4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mk\kTWM2OD13LkexO|c5KM7:TR?=MUDTRW5ITVJ?
SCHNVrRNFhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWDaeIFDUUN3ME21Mlc1PzZ5IN88US=>NVnCV5VWW0GQR1XS
HTC-C3NYPkUo17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2[zPGlEPTB;NT63O|Y1PCEQvF2=NGjhPFlUSU6JRWK=
J-RT3-T3-5MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVfrU24zUUN3ME21MlgxPzl2IN88US=>MVjTRW5ITVJ?
Hs-578-TM2LwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlHxTWM2OD13LkizOlA4KM7:TR?=MYjTRW5ITVJ?
M14NFn6fohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIfRfIRKSzVyPUWuPFY4OjZizszNMYTTRW5ITVJ?
HT-144MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkDJTWM2OD13Lki2PFMzKM7:TR?=Mm\RV2FPT0WU
CAL-54NXzmW4ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV7JR|UxRTVwOUOzNVQh|ryPM1faZXNCVkeHUh?=
T47DMWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{joc2lEPTB;NT65OlEzKM7:TR?=NH62SI5USU6JRWK=
GB-1M3PEdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlTETWM2OD14LkCyNFY5KM7:TR?=MYDTRW5ITVJ?
HSC-2M4HyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2LuVGlEPTB;Nj6xNlM2OyEQvF2=MlnuV2FPT0WU
SiHaNVrUR|NXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYPKXmVRUUN3ME22MlE1ODl5IN88US=>NI\0S3hUSU6JRWK=
OMC-1MoG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn7LTWM2OD14LkO1OFQyKM7:TR?=MljHV2FPT0WU
HGC-27M3XqZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{jX[GlEPTB;Nj6zOVc5PiEQvF2=MWjTRW5ITVJ?
FTC-133MnXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX;IWFdpUUN3ME22MlQ3PTVzIN88US=>MWLTRW5ITVJ?
KS-1MkLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX7JR|UxRTZwNUKxOFch|ryPNF;oelVUSU6JRWK=
HT-1080M4HSV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnXFTWM2OD14LkW0NFQzKM7:TR?=MmHiV2FPT0WU
SKG-IIIaMkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVnnXI1KUUN3ME22MlU3OjZ|IN88US=>MkX4V2FPT0WU
OCUB-MNFzBSY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1TXUmlEPTB;Nj62NFc4KM7:TR?=MlXCV2FPT0WU
MDA-MB-175-VIIMYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NE\WVVlKSzVyPU[uOlIxQSEQvF2=NHTwVZRUSU6JRWK=
BB30-HNCMXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3PJSWlEPTB;Nj62O|Q1PCEQvF2=M1;Oc3NCVkeHUh?=
D-542MGMYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmX6TWM2OD14LkezNFkh|ryPMYDTRW5ITVJ?
NCI-H2405NFjYZYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIOyZZZKSzVyPU[uO|Q5PTVizszNNGDJbYhUSU6JRWK=
SW1573MkTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFnrPJVKSzVyPU[uO|g{OTlizszNMV\TRW5ITVJ?
NCI-SNU-1MoO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlTzTWM2OD14Lke5NFIzKM7:TR?=MkXJV2FPT0WU
RT-112NYnjSHB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkTNTWM2OD14Lke5OFY{KM7:TR?=NFXGdVdUSU6JRWK=
COR-L88NVWxe4Z2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF3JU2xKSzVyPU[uO|k4QTFizszNMX;TRW5ITVJ?
SCC-9NFeyVoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX\U[odOUUN3ME22MlgzPTVizszNMoLRV2FPT0WU
U-87-MGNGTtVI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{XhWGlEPTB;Nj64N|gzPiEQvF2=M2ixfHNCVkeHUh?=
Detroit562MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUPJR|UxRTZwOEW5PVEh|ryPNEfjWZZUSU6JRWK=
LC-2-adMlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIfOe|hKSzVyPU[uPFYzQTJizszNM3npUnNCVkeHUh?=
IGROV-1NWHmUXl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{XBeGlEPTB;Nj65NlU5OyEQvF2=NIq2bHVUSU6JRWK=
OVCAR-8M{HRN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWHwPJF{UUN3ME22Mlk1OjJ7IN88US=>NGWzR3JUSU6JRWK=
SNU-387M4\XVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlrTTWM2OD14Lkm5OVE3KM7:TR?=NFPU[IFUSU6JRWK=
TGBC1TKBM1XJV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mk\xTWM2OD15LkG1Nlc4KM7:TR?=MVzTRW5ITVJ?
NOS-1Ml;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3T4WWlEPTB;Nz6yNFQyPSEQvF2=NUO4[nUxW0GQR1XS
HEC-1NYrQelMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlnXTWM2OD15LkK1N|g4KM7:TR?=MXXTRW5ITVJ?
GI-ME-NMmTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH\xRllKSzVyPUeuNlkyPThizszNMUnTRW5ITVJ?
KYSE-520NX70[|BTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NW\adIZ2UUN3ME23MlI6OjlizszNNUfre3ZUW0GQR1XS
SNU-423MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVnJR|UxRTdwMkm0OVIh|ryPMmDRV2FPT0WU
C-33-AMkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmixTWM2OD15LkS3PFIh|ryPMkC3V2FPT0WU
SK-UT-1NEfPVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX7JR|UxRTdwNUS4Nlkh|ryPMX7TRW5ITVJ?
OVCAR-4MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUPJR|UxRTdwNUWyOkDPxE1?MnTsV2FPT0WU
KYSE-450MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NG\WVYFKSzVyPUeuOlM4QTFizszNNXX2fWFOW0GQR1XS
RS4-11MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoHKTWM2OD15LkewNVk3KM7:TR?=MYjTRW5ITVJ?
OVCAR-5M4L1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmLqTWM2OD15LkiyN|I6KM7:TR?=M4ez[3NCVkeHUh?=
K5NXHBfWd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmXETWM2OD15Lki3OFIh|ryPMWPTRW5ITVJ?
786-0MkX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlL3TWM2OD16LkCzNFk2KM7:TR?=NY\qT4hSW0GQR1XS
NCI-H747MmHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGC0PVFKSzVyPUiuNFQ1PTdizszNMUHTRW5ITVJ?
CAL-27NYXvSZBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVraOolWUUN3ME24MlEzPzJizszNNYPVXpg4W0GQR1XS
FADUMnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUjJR|UxRThwMUe1OFMh|ryPNX3ye3psW0GQR1XS
SW780MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnH4TWM2OD16LkG4PFIyKM7:TR?=MV\TRW5ITVJ?
ACHNMkTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVnJR|UxRThwMkK1Nlkh|ryPNWfsc3RCW0GQR1XS
TE-6NVXHR2s1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYDMdYJUUUN3ME24MlI{Pzh6IN88US=>NHTZWVdUSU6JRWK=
NCI-H2087MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NETXW|ZKSzVyPUiuN|YyPThizszNNEO0PFlUSU6JRWK=
NCI-H2122NInodplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3O0VGlEPTB;OD60NFQ4QSEQvF2=MYPTRW5ITVJ?
SK-LU-1MlrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEDNW|JKSzVyPUiuOFM6QTdizszNNV[zTHk{W0GQR1XS
22RV1NWXyfJZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUfJR|UxRThwNkG3PFYh|ryPNHjzdVZUSU6JRWK=
MEL-JUSOMV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUnid3NkUUN3ME24MlY5Pjd3IN88US=>M4\CNXNCVkeHUh?=
UM-UC-3NH3hbnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYHJR|UxRThwN{GzPUDPxE1?NUi5[3RvW0GQR1XS
HuH-7MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYnJR|UxRThwN{OwNVIh|ryPMU\TRW5ITVJ?
SNU-449M{\VV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFT0ZoZKSzVyPUiuO|UzPjVizszNNFLWOZRUSU6JRWK=
RVH-421MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV;JR|UxRThwN{WzPVgh|ryPM4TBRXNCVkeHUh?=
MFM-223MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWHJR|UxRThwOEC3N|Uh|ryPMYHTRW5ITVJ?
CHP-212NF3zUohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVe3W494UUN3ME24MlgzOjZ5IN88US=>NVfwdYtCW0GQR1XS
NCI-H28M{fYdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M37TcmlEPTB;OD64OVE5PSEQvF2=M3HHNHNCVkeHUh?=
C8166Mn;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWH5c2RLUUN3ME24Mlg3Pzd{IN88US=>NITaVldUSU6JRWK=
SCC-15M{PJ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1:yfGlEPTB;OD64O|E6PiEQvF2=M3TYNnNCVkeHUh?=
DMS-273NYHFVW9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NY\Sfmx3UUN3ME24Mlg6PjJ|IN88US=>MUjTRW5ITVJ?
MPP-89MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3TyeGlEPTB;OD65NVM1OSEQvF2=M1zTPHNCVkeHUh?=
EW-22NHHiXGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml\KTWM2OD16LkmxN|gzKM7:TR?=NVXMNGNOW0GQR1XS
RCM-1MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3;ldWlEPTB;OD65OlQ5PiEQvF2=M3r6U3NCVkeHUh?=
BT-474M2n3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnfmTWM2OD16Lkm4PFczKM7:TR?=M3LJU3NCVkeHUh?=
TI-73M4njeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NE\ETY1KSzVyPUmuNFM1QTZizszNMlXKV2FPT0WU
ES3NGfMe3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkHVTWM2OD17LkC1NVU3KM7:TR?=M1vqTXNCVkeHUh?=
NB17MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV;JR|UxRTlwMUS1N|Uh|ryPMYLTRW5ITVJ?
MOLT-16NH7ZbnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHXwO49KSzVyPUmuNVY3PTVizszNM1zOeXNCVkeHUh?=
TGBC11TKBNHH1XlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXjnNZlHUUN3ME25MlE6OjB3IN88US=>MXHTRW5ITVJ?
NB12MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M17X[2lEPTB;OT6zOFA5OSEQvF2=MofTV2FPT0WU
MEL-HOM2rwdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkK2TWM2OD17LkSwNkDPxE1?Mne1V2FPT0WU
HuCCT1MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4fFZ2lEPTB;OT60O|QxPiEQvF2=MVHTRW5ITVJ?
A704NF64Xo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVPmS2I2UUN3ME25MlQ4PzR3IN88US=>Mmr0V2FPT0WU
SW756MnjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXrJR|UxRTlwNUWzOlEh|ryPNYnt[Gs2W0GQR1XS
SASMVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF;COldKSzVyPUmuOVg1PTVizszNM4\o[3NCVkeHUh?=
KINGS-1MofZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1nHfmlEPTB;OT62PVM4KM7:TR?=NFTGOZBUSU6JRWK=
NKM-1MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1n5S2lEPTB;OT64N|k3PCEQvF2=Mm\YV2FPT0WU
C2BBe1NEPiZ4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVPYTZdPUUN3ME25Mlg3OjB2IN88US=>NYCwe2hMW0GQR1XS
A204NXTWOYRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{ficmlEPTB;OT64PVc2PSEQvF2=NXrhTmhUW0GQR1XS
G-401NGXNPWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmjKTWM2OD17LkmwOFQ6KM7:TR?=MmfqV2FPT0WU
PFSK-1MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYXNSGJmUUN3ME25Mlk2PjZ7IN88US=>MUTTRW5ITVJ?
KYSE-410MkXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXzJR|UxRTFyLkC2NVUh|ryPNUPZRXN7W0GQR1XS
SK-MEL-2MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXLJR|UxRTFyLkG1PFgh|ryPMVnTRW5ITVJ?
NB5MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml\xTWM2OD1zMD61OFA2KM7:TR?=NU[4cpZWW0GQR1XS
NTERA-S-cl-D1M3\SVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGHGTmFKSzVyPUGwMlU1PzVizszNNF\DcY1USU6JRWK=
MZ2-MELM3jaU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWjJR|UxRTFyLk[2NkDPxE1?MYrTRW5ITVJ?
SF539M33hUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYHRWJdkUUN3ME2xNE44OTh6IN88US=>M2rtWXNCVkeHUh?=
CAL-120MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV:5cmRvUUN3ME2xNE44PTl5IN88US=>M3vYT3NCVkeHUh?=
GR-STMYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{G3c2lEPTB;MUGuNlk5KM7:TR?=M3\JbXNCVkeHUh?=
IA-LMNIDDUmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVjIV5dsUUN3ME2xNU4{PDh4IN88US=>M1vYOHNCVkeHUh?=
NCI-H2452NIXMPI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkLJTWM2OD1zMT6zPVI4KM7:TR?=M3n1SnNCVkeHUh?=
NCI-H1648M3H3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEHBZ|FKSzVyPUGxMlQ3OjlizszNNUDmdotiW0GQR1XS
YH-13NIPSWmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUDJR|UxRTFzLkS3OFIh|ryPNGm3cVlUSU6JRWK=
NCI-H2228NGS4RnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2H1V2lEPTB;MUGuOFkzQCEQvF2=MkPuV2FPT0WU
LN-405MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUXJR|UxRTFzLkW5Nlch|ryPNH64TYRUSU6JRWK=
647-VM1;j[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2nCS2lEPTB;MUGuOVk4PCEQvF2=NFTGd5NUSU6JRWK=
HCC1806M1:3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlGxTWM2OD1zMT62NVM1KM7:TR?=M1nSTXNCVkeHUh?=
HPAF-IIMXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NILo[|RKSzVyPUGxMlg{PTZizszNMkjWV2FPT0WU
BB49-HNCM3flVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWHJR|UxRTFzLkizO|Uh|ryPMYHTRW5ITVJ?
KGNNHHqZ45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnSwTWM2OD1zMT64OVg6KM7:TR?=M1nDSHNCVkeHUh?=
NOMO-1Ml3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnfYTWM2OD1zMT64OVk4KM7:TR?=M{HJcHNCVkeHUh?=
A388M1nNZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MofzTWM2OD1zMT64PFA5KM7:TR?=M{WwUnNCVkeHUh?=
Saos-2M1ixbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVXycoZXUUN3ME2xNk4zODB|IN88US=>M3n4S3NCVkeHUh?=
SK-HEP-1M2q3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVjJR|UxRTF{LkK2NVMh|ryPNXH6e5ZjW0GQR1XS
HCE-4M2H4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{DRcWlEPTB;MUKuNlY6QSEQvF2=M4XvVXNCVkeHUh?=
NCI-H1581NFzpZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn3CTWM2OD1zMj6yPFE6KM7:TR?=M13IRXNCVkeHUh?=
NCI-H23MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHvVRlNKSzVyPUGyMlMyOjVizszNMnHOV2FPT0WU
NCI-H596M37BT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUnRfINrUUN3ME2xNk41Pzl6IN88US=>MnvvV2FPT0WU
NB69NVPHXVlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXLifGpiUUN3ME2xNk44PTh3IN88US=>MoXFV2FPT0WU
ChaGo-K-1MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVftRohjUUN3ME2xNk44PjR7IN88US=>MVnTRW5ITVJ?
EFM-19MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEHiSItKSzVyPUGyMlc4OTdizszNMlH4V2FPT0WU
SW962MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH\hdIdKSzVyPUGyMlgzOjNizszNNGfmfnJUSU6JRWK=
KALS-1Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEW3V2tKSzVyPUGzMlA6PSEQvF2=M3jLbHNCVkeHUh?=
MDA-MB-415M3H2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmTlTWM2OD1zMz6xOlA6KM7:TR?=Mo\kV2FPT0WU
SW684MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHe1cWVKSzVyPUGzMlE5PjFizszNM{DWWHNCVkeHUh?=
NCI-H2052NGfKfFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVnGbJdLUUN3ME2xN{4{QDR6IN88US=>MULTRW5ITVJ?
HOP-92MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF3XZXNKSzVyPUGzMlc6QTdizszNMnvtV2FPT0WU
OE19MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYLJR|UxRTF2LkCwO|Uh|ryPNXrGUFNIW0GQR1XS
D-392MGMVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXrJR|UxRTF2LkGyNVEh|ryPM3vpVHNCVkeHUh?=
A253M{XUT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1n2dmlEPTB;MUSuNlI2KM7:TR?=MlvxV2FPT0WU
NCI-H1155NF\qW2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXPGT41KUUN3ME2xOE4zPzR5IN88US=>NF[4VpJUSU6JRWK=
SNB75NHzB[JdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEnIcXZKSzVyPUG0MlM5QTNizszNNVW4S5NkW0GQR1XS
23132-87M3LiWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2nWSmlEPTB;MUSuPFM2OyEQvF2=NWW3ZZVIW0GQR1XS
Calu-3MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWHJR|UxRTF2Lki3OFMh|ryPMWXTRW5ITVJ?
CW-2M1;Hemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3WxTmlEPTB;MUWuNFIzOyEQvF2=M3S5UXNCVkeHUh?=
COLO-679Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2HZdWlEPTB;MUWuNVAyOyEQvF2=MYTTRW5ITVJ?
NCI-SNU-5NWXsdI9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXfPUJdbUUN3ME2xOU42PTh7IN88US=>Mkf0V2FPT0WU
AN3-CAM1q0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVSySlhWUUN3ME2xOU43PDZ6IN88US=>NGXRVodUSU6JRWK=
SF126NGfjU3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NELueWxKSzVyPUG1MlczQDVizszNMn3wV2FPT0WU
D-247MGNXjDXooxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml:2TWM2OD1zNT64OVM{KM7:TR?=NFf2OHBUSU6JRWK=
UACC-62M4Pkbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{DpWGlEPTB;MUWuPVY3KM7:TR?=NEnvVYVUSU6JRWK=
GP5dMX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYXJR|UxRTF4LkGxO|Eh|ryPM2LkXXNCVkeHUh?=
HuO-3N1MlTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn7OTWM2OD1zNj6yOFc{KM7:TR?=NH\PO2xUSU6JRWK=
NCI-H1092MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mnz3TWM2OD1zNj62Nlk4KM7:TR?=NXTkZndGW0GQR1XS
HCC1187NXHXRY9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWG2VHRRUUN3ME2xOk43PTV5IN88US=>MknCV2FPT0WU
G-402NGTZU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV;6bFJkUUN3ME2xOk45PTZ3IN88US=>NGfEW5dUSU6JRWK=
HT55M4rQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFHiUHRKSzVyPUG2Mlg4PTFizszNMVrTRW5ITVJ?
NCI-H2009M4XQNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml3HTWM2OD1zNj65NlY3KM7:TR?=MWDTRW5ITVJ?
SH-4MnnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXPJR|UxRTF4Lkm5NkDPxE1?M2XlU3NCVkeHUh?=
SW1783NFHrdllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWDld3pzUUN3ME2xOk46QTl6IN88US=>MV7TRW5ITVJ?
HTNFrVToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2nMZWlEPTB;MUeuNVk3PCEQvF2=M2j1e3NCVkeHUh?=
CP66-MELNHHZNHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIT3O3VKSzVyPUG3MlMxOSEQvF2=M{TuO3NCVkeHUh?=
BENM{XvUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVvJR|UxRTF5LkW2NlYh|ryPNWmyOFQ1W0GQR1XS
HCC38Mkm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUfJR|UxRTF5Lke2PVgh|ryPNIK0[JhUSU6JRWK=
LAN-6NFTzZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFLUR5dKSzVyPUG3Mlg1QDVizszNMV7TRW5ITVJ?
RERF-LC-MSNGXMSWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3ftZ2lEPTB;MUeuPVEzQSEQvF2=MV;TRW5ITVJ?
NCI-H1770M2fIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYLJR|UxRTF5Lkm0PVEh|ryPNYfXW3ZRW0GQR1XS
LCLC-103HNX7HWZJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3u3ZWlEPTB;MUiuNFUyKM7:TR?=NUDXS|VyW0GQR1XS
NCI-H520MonLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3rQXmlEPTB;MUiuN|I5OSEQvF2=M{jje3NCVkeHUh?=
LU-65MojZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnXaTWM2OD1zOD60NFQ{KM7:TR?=NX3XSol3W0GQR1XS
SK-MEL-3MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHPnW5VKSzVyPUG4MlY3PzlizszNNUXDcJZRW0GQR1XS
LK-2MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlW3TWM2OD1zOD63O|I{KM7:TR?=M1\lfXNCVkeHUh?=
PANC-08-13MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH;COYNKSzVyPUG4Mlc5QDlizszNMl\KV2FPT0WU
NCI-H460MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3Tw[2lEPTB;MUiuPFQ3PiEQvF2=NVq2VXFuW0GQR1XS
COLO-684M3r3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX3JR|UxRTF6Lkm5OVYh|ryPNIXK[4dUSU6JRWK=
RPMI-2650MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVPJR|UxRTF7LkCxNkDPxE1?M3TQV3NCVkeHUh?=
NYM{S2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYDJR|UxRTF7LkG1Olch|ryPNXHMZnhDW0GQR1XS
NB7NWm3ZYxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXPZb3pJUUN3ME2xPU4yPzV|IN88US=>M3zZS3NCVkeHUh?=
NCI-H358M3TaWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3v6eGlEPTB;MUmuNlY4OyEQvF2=NGHNTmxUSU6JRWK=
MC116MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2jlNWlEPTB;MUmuOVM{OSEQvF2=MmHtV2FPT0WU
MS-1NF63dnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEnDZYNKSzVyPUG5MlYyODNizszNNETJcG9USU6JRWK=
NCI-H82NIPNUolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWLkRoh[UUN3ME2xPU43QDd6IN88US=>NXL3T4xqW0GQR1XS
OCI-AML2NGq5bGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3\Ic2lEPTB;MUmuO|A{OiEQvF2=M2fEfnNCVkeHUh?=
LS-123M2X3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4H1TGlEPTB;MkCuNFE6PCEQvF2=NH\GTY1USU6JRWK=
PC-14NF;GOVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHXYPZZKSzVyPUKwMlE5OzRizszNMVnTRW5ITVJ?
NCI-H1703NVL0OXlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWTJR|UxRTJyLkixO|Mh|ryPNV;me2F[W0GQR1XS
Calu-6MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX;JR|UxRTJzLkGwNFUh|ryPMljRV2FPT0WU
no-11MlPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHS1WGJKSzVyPUKxMlE3ODJizszNMon6V2FPT0WU
NCI-H727MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1f4[mlEPTB;MkGuN|Q6OyEQvF2=MnTQV2FPT0WU
DSH1MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXLJR|UxRTJzLkO4O|kh|ryPMYjTRW5ITVJ?
KYSE-140MkHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF;4bZlKSzVyPUKxMlczPzFizszNNE\oXpBUSU6JRWK=
RH-1NFTtbJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUDJR|UxRTJzLki4N{DPxE1?MlLkV2FPT0WU
HAL-01MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGHPT4dKSzVyPUKyMlA1OThizszNMmC1V2FPT0WU
RXF393MljxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml\STWM2OD1{Mj6yO|g6KM7:TR?=MUXTRW5ITVJ?
LS-411NM2e3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFHnUmtKSzVyPUKyMlI5PjlizszNM{HidnNCVkeHUh?=
no-10M2fvWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlPsTWM2OD1{Mj61NFA1KM7:TR?=M1;nO3NCVkeHUh?=
MKN7NF22epNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1vLR2lEPTB;MkKuOlg4KM7:TR?=M4DGd3NCVkeHUh?=
AU565M{Xk[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmfXTWM2OD1{Mj63OFc5KM7:TR?=Ml7lV2FPT0WU
NUGC-3NVPEdnU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUnJR|UxRTJ|LkGxPVkh|ryPMUXTRW5ITVJ?
EW-16MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Moj1TWM2OD1{ND6wPVI3KM7:TR?=MWXTRW5ITVJ?
HCC70MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIrCXVZKSzVyPUK0MlE{OjNizszNMVHTRW5ITVJ?
RPMI-8226NHf1VopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3TYNGlEPTB;MkSuN|E2PSEQvF2=MXTTRW5ITVJ?
CFPAC-1M3;vZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M13hfmlEPTB;MkSuOlI4OiEQvF2=MnPUV2FPT0WU
DoTc2-4510NIPqVIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXvRTGQxUUN3ME2yOE44PTd3IN88US=>Mni1V2FPT0WU
KNS-62M12zNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4nlcGlEPTB;MkWuNFE5KM7:TR?=NVPWRpN{W0GQR1XS
SK-N-DZNUnlZ2hwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnW2TWM2OD1{NT6wPVA1KM7:TR?=M{O5bHNCVkeHUh?=
CAL-85-1Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGrEdoVKSzVyPUK1MlE2PDRizszNNFzPTFRUSU6JRWK=
JVM-2MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVnTVVB7UUN3ME2yOU4zOTJ{IN88US=>MU\TRW5ITVJ?
NCI-H2347M1XJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{LNNGlEPTB;MkWuOFI1QSEQvF2=NEG3eIdUSU6JRWK=
P30-OHKNV7tVngyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIjJOG1KSzVyPUK1MlY{OThizszNNEO0dIZUSU6JRWK=
SK-N-FINGn1PVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXrJR|UxRTJ4LkGxOlIh|ryPMUXTRW5ITVJ?
CAMA-1NWfGOmtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4LLOGlEPTB;Mk[uOFg4PiEQvF2=M2LuNXNCVkeHUh?=
MHH-NB-11NILUZpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEL0boxKSzVyPUK2MlU5PTFizszNNXX5b3hsW0GQR1XS
IST-MEL1NXH6eXJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3;vbmlEPTB;Mk[uO|E4PyEQvF2=M13mVXNCVkeHUh?=
KARPAS-299MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NULkWoJGUUN3ME2yO{41PzBzIN88US=>NGTZRlZUSU6JRWK=
TE-11MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWrJR|UxRTJ5LkezOFIh|ryPMojrV2FPT0WU
769-PM3HPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mm[yTWM2OD1{OD60OVM{KM7:TR?=NHHqdVJUSU6JRWK=
CAL-72M{PCc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXHJR|UxRTJ6LkW1OlEh|ryPNGq5SZFUSU6JRWK=
NCI-H2342M2DaVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFntVo9KSzVyPUK5MlM5ODNizszNMX3TRW5ITVJ?
NCI-H1651MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIjxfVFKSzVyPUK5Mlg2ODNizszNNEDxbJhUSU6JRWK=
OE33MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXvJR|UxRTNyLkGzOFIh|ryPMnHOV2FPT0WU
HuP-T4M2LEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWHJR|UxRTNzLkS4N|ch|ryPNXfQenNzW0GQR1XS
U-118-MGNXXSNJczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2X5SWlEPTB;M{KuOVQ1OSEQvF2=NFfNTINUSU6JRWK=
SN12CMYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MULJR|UxRTN{Lki4NVUh|ryPNEfwR2FUSU6JRWK=
TE-5MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVnRfoU3UUN3ME2zN{4yOzZ6IN88US=>NWrCNmt7W0GQR1XS
KM-H2MmDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEfWb5JKSzVyPUOzMlE3QTlizszNMX7TRW5ITVJ?
OVCAR-3MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF;h[HBKSzVyPUOzMlQyOjdizszNNEntdlVUSU6JRWK=
NCI-H1304NIfBeoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH3nSo9KSzVyPUOzMlYxOzZizszNNGD6N2tUSU6JRWK=
LU-135NVXCTpo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkLUTWM2OD1|Mz63NFg3KM7:TR?=MoCzV2FPT0WU
S-117Mnr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVXJR|UxRTN|LkeyPFYh|ryPM1z4UnNCVkeHUh?=
NCI-H1755MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2LscmlEPTB;M{OuPFEyKM7:TR?=Mn\TV2FPT0WU
Mo-TNYPSR5I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYCxeo1UUUN3ME2zN{45PTl|IN88US=>M4fUOHNCVkeHUh?=
SK-OV-3M3[2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVHJR|UxRTN|Lki4OVQh|ryPM1LJe3NCVkeHUh?=
RCC10RGBM1P5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWL3T3VLUUN3ME2zN{46PDN|IN88US=>MU\TRW5ITVJ?
COLO-680NNYny[HNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3\xZWlEPTB;M{SuNVM6PyEQvF2=NHXzWXlUSU6JRWK=
KURAMOCHIM3uzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1;QemlEPTB;M{SuOlQzPSEQvF2=NHfr[4hUSU6JRWK=
NCI-H661NGHSUnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVjDcVR{UUN3ME2zOE45PDR6IN88US=>MYrTRW5ITVJ?
YAPCMoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF7FR3JKSzVyPUO1Mlk2OzNizszNM{eyfHNCVkeHUh?=
NCI-H526MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1S0eWlEPTB;M{euNlc4OiEQvF2=M4fDXHNCVkeHUh?=
A498NGrZT4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVnJR|UxRTN6LkC5OVQh|ryPNWX6Xnk6W0GQR1XS
VMRC-RCZNUHpb5lsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVv3enlbUUN3ME2zPU4xODV2IN88US=>NEfnV5RUSU6JRWK=
HCT-116MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYrJR|UxRTN7LkC1PEDPxE1?NYDPSFZTW0GQR1XS
COLO-320-HSRMV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUjySmZWUUN3ME20NE4xPDFizszNNVXBdXQ1W0GQR1XS
OAW-42NHmzSJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1LEW2lEPTB;NECuNFU1OiEQvF2=M1HweHNCVkeHUh?=
SK-MEL-1NYDZVpFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnH1TWM2OD12MD6yPVI4KM7:TR?=NVW4fnRGW0GQR1XS
IST-MES1NILmO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{PtW2lEPTB;NECuO|Y2OyEQvF2=MVnTRW5ITVJ?
CP50-MEL-BM33GTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVW4eHdGUUN3ME20NU4xPzl5IN88US=>M3TVcXNCVkeHUh?=
RMG-INVu0WXRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NU\IUpQ1UUN3ME20Nk41QTJzIN88US=>MU\TRW5ITVJ?
D-336MGMljJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWHBZ2ZXUUN3ME20N{4yOTV{IN88US=>M1jkbXNCVkeHUh?=
SHP-77MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWTKN21bUUN3ME20N{4yQDJ6IN88US=>M3m1enNCVkeHUh?=
SW872MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnHNTWM2OD12Mz6yNVI{KM7:TR?=MlrnV2FPT0WU
DBTRG-05MGNGjv[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1j6[2lEPTB;NESuOlk6PiEQvF2=NHzYPY5USU6JRWK=
COLO-678MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmjWTWM2OD12NT63NFMzKM7:TR?=M1naW3NCVkeHUh?=
EGI-1MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYHJR|UxRTR5LkG4N|Mh|ryPMV3TRW5ITVJ?
KYSE-70NUXqN|R6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4S4c2lEPTB;NEeuO|IzOiEQvF2=NHnYUG5USU6JRWK=
BALL-1NWjrT5lST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlnuTWM2OD12Nz64NlU1KM7:TR?=MVTTRW5ITVJ?
MDA-MB-361MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV3JR|UxRTR6LkC0OkDPxE1?M3S5TXNCVkeHUh?=
NCI-H1838MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYDJR|UxRTR6LkO0OVgh|ryPNYTGZXB[W0GQR1XS
NCI-H1573MnzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MULJR|UxRTR6Lk[3PFUh|ryPNF;zbmlUSU6JRWK=
HCC1395MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml7LTWM2OD12OD65PVIh|ryPM1TmV3NCVkeHUh?=
NCI-H2291MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmP1TWM2OD12OT61PVg5KM7:TR?=NF:2Zm9USU6JRWK=
RH-18M3LVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NInSZ4FKSzVyPUWwMlA5QDRizszNM4LvZ3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo
Features

Protocol(Only for Reference)

Kinase Assay: [2]

Protein kinase assays Purified His6–RSK1, His6–RSK2 or GST–RSK2 1–389:S381E (1–2 units/mL) are assayed for 10 min at 30 °C in a 50 μL assay mixture in Buffer A containing 30 μM substrate peptide (KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK), 10 mM magnesium acetate and 100 μM of [γ-32P]ATP. Reactions are terminated and analysed as described previously. The amount of enzyme that catalysed the phosphorylation of 1 nmol of substrate peptide in 1 min is termed one unit. In order to assay RSK and MSK1 in HEK-293 or Rat-2 cell lysates, these kinases are immunoprecipitated from the cell lysates (0.1 mg of lysate protein for RSK and 0.3 mg for MSK1) and for RSK assays the immunoprecipitates are washed twice with Buffer A containing 1 mM ATP and twice with Buffer A prior to the assay, as a precaution to ensure dissociation of BI-D1870 from the RSK isoforms.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.

Chemical Information

Download BI-D1870 SDF
Molecular Weight (MW) 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 78 mg/mL (199.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 6(5H)-Pteridinone, 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-

Customer Product Validation(2)


Click to enlarge
Rating
Source Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck
Method Western Blot
Cell Lines HeLa cells
Concentrations 10 μM
Incubation Time 3 h
Results BI-D1870 alone also reduced insulin-induced eIF4B S422 phosphorylation. Meanwhile, although rapamycin alone did not inhibit the eIF4B S422 phosphorylation, its combination with U0126 or BI-D1870 did.

Click to enlarge
Rating
Source J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck
Method Western Blot
Cell Lines N41/OX1R cells
Concentrations 1 μM 、10 μM
Incubation Time 1 h
Results BI-D1870 enhanced phosphorylation of RSK, but did not affect the orexin-stimulated mTORC1 activation.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related S6 Kinase Products

  • LY2584702

    LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.

  • LY2584702 Tosylate

    LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.

  • CHIR-99021 (CT99021)

    CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively.

  • PF-4708671

    PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

  • Rapamycin (Sirolimus)

    Rapamycin (Sirolimus) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.

  • MK-2206 2HCl

    MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

    Features:The first allosteric small molecule inhibitor of Akt to enter clinical development.

  • CHIR-99021 (CT99021) HCl

    CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM in cell-free assays; ability to distinguish between GSK-3 and its closest homologs Cdc2 and ERK2.

  • LY294002

    LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation.

  • 3-Methyladenine (3-MA)

    3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation.

  • Everolimus (RAD001)

    Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay.

Recently Viewed Items

Tags: buy BI-D1870 | BI-D1870 supplier | purchase BI-D1870 | BI-D1870 cost | BI-D1870 manufacturer | order BI-D1870 | BI-D1870 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us