BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

Size Price Stock Quantity  
In DMSO USD 272 In stock
USD 170 In stock
USD 270 In stock
USD 670 In stock

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2 Customer Reviews

  • HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

    Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzqS3dRUUN3ME2wMlA{PThizszN NEPtTIdUSU6JRWK=
H9 NIrkdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr5[IZKSzVyPUCuNFYxOTlizszN MVrTRW5ITVJ?
KARPAS-45 MmrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojOTWM2OD1yLkG2OVI2KM7:TR?= MlPEV2FPT0WU
NCI-H720 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHLNllNUUN3ME2wMlE4OTl2IN88US=> Mlv2V2FPT0WU
CTV-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHrTWM2OD1yLkS3PFczKM7:TR?= NVXlZ2xoW0GQR1XS
DU-4475 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37ZV2lEPTB;MD61NFQyPyEQvF2= NIXmT3lUSU6JRWK=
A172 MmrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LhbmlEPTB;MD61NVcxPSEQvF2= M1OyN3NCVkeHUh?=
EW-18 NEHqcXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17mUGlEPTB;MD62NlIyOSEQvF2= MmLFV2FPT0WU
KU812 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwNkK2NlMh|ryP MVHTRW5ITVJ?
KP-N-YS NFLqfWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\ZS2lEPTB;MD62PFIzOyEQvF2= M4C1Z3NCVkeHUh?=
SBC-1 M{DQfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnuTWM2OD1yLk[5OVI1KM7:TR?= M{LaS3NCVkeHUh?=
ECC10 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwN{CwPVQh|ryP M33MW3NCVkeHUh?=
GAMG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD1SlRKSzVyPUCuO|Q4OTdizszN MYHTRW5ITVJ?
NCI-H209 NGnrd4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\qTWM2OD1yLke2PFIh|ryP MkHzV2FPT0WU
MC-IXC MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvSflFKSzVyPUCuO|k2QDlizszN NUPLdI5KW0GQR1XS
HSC-3 MkHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2KzU2lEPTB;MD64NVc3QSEQvF2= MXvTRW5ITVJ?
IST-SL1 Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\OdIpYUUN3ME2wMlg1PTd2IN88US=> M3HUc3NCVkeHUh?=
LU-139 NVfsOldNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDpTWM2OD1yLki0PVU5KM7:TR?= NUX0S5F[W0GQR1XS
ML-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7SWXFKSzVyPUCuPFU2PzVizszN MWnTRW5ITVJ?
CAL-62 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzrWlBVUUN3ME2wMlg5OTV{IN88US=> NHjjeGxUSU6JRWK=
HL-60 NUDqOVRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPaTWM2OD1yLki4N|YzKM7:TR?= NFfnd4FUSU6JRWK=
KY821 MkjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwOEi4NVIh|ryP NYHmTFBsW0GQR1XS
ES7 M4HTZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlS3TWM2OD1yLkmxOlA4KM7:TR?= MkjXV2FPT0WU
MV-4-11 M{jHcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwOUe4PVch|ryP Ml3zV2FPT0WU
Daoy NWf4cnNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnq5TWM2OD1yLkm4O|Y4KM7:TR?= NWX0fJdSW0GQR1XS
EoL-1-cell MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFW4OWdKSzVyPUGuNFE5PzhizszN NWfF[XFWW0GQR1XS
TGW MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHkNnJUUUN3ME2xMlA2OTJ2IN88US=> NGDBUnpUSU6JRWK=
LAMA-84 MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[zbHBiUUN3ME2xMlEzPzl2IN88US=> NYDLWFR2W0GQR1XS
KOSC-2 NVvxdnhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTFwMUOzPFUh|ryP NI\hWHVUSU6JRWK=
A549 NIG3[mZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTFwM{C5OVUh|ryP NFn3cIZUSU6JRWK=
CTB-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHMRZRXUUN3ME2xMlQ1Pjd7IN88US=> NXXXdHFVW0GQR1XS
NCI-H292 NVLY[ZN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj5OYRKSzVyPUGuOFYxPjlizszN M1;uc3NCVkeHUh?=
LoVo NX63RZJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHOTWM2OD1zLkS2O|U2KM7:TR?= NI\hRXBUSU6JRWK=
BFTC-905 M2jaXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPiUFNKSzVyPUGuOVY{OzJizszN NV\Dd5hvW0GQR1XS
BE-13 NHP6VGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHROGRKSzVyPUGuOVg4ODlizszN MWLTRW5ITVJ?
KE-37 MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1j5WWlEPTB;MT61PVQ4QCEQvF2= MkTWV2FPT0WU
HN NH;GfHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTFwNkGzOlgh|ryP M{nlcHNCVkeHUh?=
A3-KAW M2PBbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HXPWlEPTB;MT62Nlg{PCEQvF2= NWPEO|NJW0GQR1XS
NEC8 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXpfYdKSzVyPUGuO|AyOTVizszN NYO2SZo{W0GQR1XS
Ramos-2G6-4C10 Mk[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\UTWM2OD1zLkewOFQ1KM7:TR?= MUjTRW5ITVJ?
NB10 M3P4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4mzeGlEPTB;MT63O|Y{KM7:TR?= NW\H[XhlW0GQR1XS
NBsusSR NXy3epAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr5TWM2OD1zLkiyPVYyKM7:TR?= MVTTRW5ITVJ?
ES4 NGXOSmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTFwOEWxOFMh|ryP M1TrSXNCVkeHUh?=
ES8 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrFXmVKSzVyPUGuPFc4OjRizszN NYrmU2pqW0GQR1XS
CHL-1 Ml\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrre25KSzVyPUGuPVU4QTJizszN NVrp[ZhIW0GQR1XS
NCI-H2029 NFn2NnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\RTWM2OD1zLkm3NlQyKM7:TR?= MYfTRW5ITVJ?
YKG-1 NV73[2g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXkO|FKSzVyPUGuPVg1OzJizszN M2XOR3NCVkeHUh?=
BV-173 NYK4RWlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTFwOUi2OlYh|ryP NXLhZ|BnW0GQR1XS
697 M4G2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJwMEKyNlgh|ryP Mn25V2FPT0WU
SK-NEP-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkOyTWM2OD1{LkC0OEDPxE1? NEDhfW9USU6JRWK=
LOXIMVI NVLDNJk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfP[YtKSzVyPUKuNFQ1OzRizszN NI\sUWtUSU6JRWK=
QIMR-WIL NEjmZVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2T3WmlEPTB;Mj6wO|g1QSEQvF2= MUnTRW5ITVJ?
DU-145 M1TiSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJwMUGwOVYh|ryP M1;pc3NCVkeHUh?=
NB14 Ml;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XFNGlEPTB;Mj6xNVMzOSEQvF2= NYP5XYh5W0GQR1XS
G-361 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjGR5lKSzVyPUKuNVIzOSEQvF2= M1GzcHNCVkeHUh?=
BPH-1 MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTWWphKSzVyPUKuNVI6PTdizszN Mk\UV2FPT0WU
KYSE-150 MkfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rqU2lEPTB;Mj6xOVI{PCEQvF2= NHXabXdUSU6JRWK=
HMV-II NVLZSoxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJwMU[2N|Mh|ryP M3fIe3NCVkeHUh?=
TE-9 NHiwemdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XITGlEPTB;Mj6xO|M4PiEQvF2= MYnTRW5ITVJ?
8-MG-BA NGqzVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJwMkO0OlEh|ryP MoLtV2FPT0WU
ES5 M1HJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[3TWM2OD1{LkKzOlM{KM7:TR?= NVjnWmRTW0GQR1XS
D-283MED MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInnWZJKSzVyPUKuNlM3QTVizszN MmXKV2FPT0WU
SK-N-AS M1fJemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrvNHlXUUN3ME2yMlI6ODV7IN88US=> MmTYV2FPT0WU
SW1710 MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJwM{C2OlEh|ryP M1vJNnNCVkeHUh?=
GCT M4TZZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;WUWlEPTB;Mj6zNVM2QCEQvF2= MXPTRW5ITVJ?
AGS MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2W1[mlEPTB;Mj6zOFQxPCEQvF2= NX;pdo9tW0GQR1XS
HuO9 M37IWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFK3TZZKSzVyPUKuN|Y5OjRizszN NGTtfHpUSU6JRWK=
MN-60 NHXk[4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYH6RVlyUUN3ME2yMlQ1QDh|IN88US=> NWezW2kxW0GQR1XS
NB6 NGC0WFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTJwNEW3O|kh|ryP NGT0S3NUSU6JRWK=
NCI-H1395 MkfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTJwNEexNlEh|ryP NHTzTJpUSU6JRWK=
H4 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jtN2lEPTB;Mj60PFM6OyEQvF2= NInmcIlUSU6JRWK=
HT-3 NXvKR4tVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnLTWM2OD1{LkWxNFI1KM7:TR?= MWXTRW5ITVJ?
P12-ICHIKAWA M2jEO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJwNUK1OVkh|ryP M4jtVHNCVkeHUh?=
COLO-800 M2HuSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[3emlEPTB;Mj61OFE3PiEQvF2= M4W0XnNCVkeHUh?=
DB MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTJwNUWwNVMh|ryP NVjPTZE{W0GQR1XS
LCLC-97TM1 NIrxTJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnpRWRKSzVyPUKuOlAxOjhizszN MVjTRW5ITVJ?
Ca9-22 M1HlRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFu4S|RKSzVyPUKuOlU6OzNizszN NFPodYdUSU6JRWK=
Becker MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJwNk[wO|gh|ryP MX3TRW5ITVJ?
ACN M3zPN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfTTWM2OD1{Lk[2O|kh|ryP NFL1d5pUSU6JRWK=
SJSA-1 M3XQbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHJcI9KSzVyPUKuOlY5PyEQvF2= NGS3OZJUSU6JRWK=
NCI-H1048 M3TBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XybWlEPTB;Mj62PFMzOSEQvF2= NH75O2FUSU6JRWK=
HEL MnPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJwN{CyOVQh|ryP NIPjXI9USU6JRWK=
NCI-H69 NWPoXWFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjNOnNEUUN3ME2yMlcyPjBzIN88US=> MX3TRW5ITVJ?
639-V MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnOU4RKSzVyPUKuO|E4ODNizszN Mn;WV2FPT0WU
U251 MmXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfmT2NKSzVyPUKuO|MxOzJizszN NUjLcYVSW0GQR1XS
NCI-H1792 Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTZeXVrUUN3ME2yMlc{PzN6IN88US=> NUf5d|h4W0GQR1XS
EW-1 NFHCNnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnOcHFKSzVyPUKuO|U{OjhizszN M2DS[HNCVkeHUh?=
ME-180 NHHnRVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXTT4ZKSzVyPUKuO|c4OzZizszN M4L3S3NCVkeHUh?=
HH M4TmWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PhV2lEPTB;Mj64NFAxOSEQvF2= MkXXV2FPT0WU
SW954 MmDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJwOEW4N{DPxE1? NVzpfGpbW0GQR1XS
SF268 NVjtS45bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjQXG9KSzVyPUKuPFczOjVizszN MoW5V2FPT0WU
D-566MG M3zQSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4KxXGlEPTB;Mj65NVI6PSEQvF2= M4fEe3NCVkeHUh?=
EM-2 M4nJdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJwOUKxPVMh|ryP NGnEZnVUSU6JRWK=
NCI-H1299 MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHyzZ|dKSzVyPUKuPVM4OzZizszN M3vtTnNCVkeHUh?=
PSN1 MoP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDRTWM2OD1|LkC1O|g3KM7:TR?= Mk\3V2FPT0WU
JVM-3 M1zENWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLGTWM2OD1|LkC2O|U3KM7:TR?= NX[2T4toW0GQR1XS
D-502MG M{LvWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TWTmlEPTB;Mz6wO|AyQSEQvF2= NFfrdG9USU6JRWK=
SCC-4 NX\R[oxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfQPWFKSzVyPUOuNFkzPzZizszN NYf5ZlN1W0GQR1XS
GMS-10 NGq4[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33S[WlEPTB;Mz6wPVM5QCEQvF2= NID6eIZUSU6JRWK=
A427 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PoSGlEPTB;Mz6xNFg4OyEQvF2= MYjTRW5ITVJ?
NH-12 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC3U41KSzVyPUOuNVE1PTZizszN NYDzNVh3W0GQR1XS
KM12 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn32TWM2OD1|LkGyNlc{KM7:TR?= M2qxU3NCVkeHUh?=
GI-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DQWGlEPTB;Mz6xOVI2PSEQvF2= NEXpdIxUSU6JRWK=
TE-8 M1LyW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnSb5NKSzVyPUOuNVkzOzFizszN MYfTRW5ITVJ?
MKN1 NITTXGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvrT5RKSzVyPUOuNlA5PzVizszN MkPVV2FPT0WU
NCI-H810 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P5bWlEPTB;Mz6yNlE2PSEQvF2= MoPLV2FPT0WU
GOTO NXPwWppFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXSwcXg{UUN3ME2zMlI5ODB2IN88US=> MYrTRW5ITVJ?
T98G NXfhUYFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTNwMkiyNVYh|ryP NIrKbFZUSU6JRWK=
HD-MY-Z M2\UPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfJemFKSzVyPUOuN|Y2PDJizszN M3fBZ3NCVkeHUh?=
SNU-C2B Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfEeWhWUUN3ME2zMlM6ODl5IN88US=> NES5b3lUSU6JRWK=
MOLT-4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTNwM{mwPVgh|ryP MY\TRW5ITVJ?
RPMI-7951 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjicldKSzVyPUOuN|k4OyEQvF2= NF3adpRUSU6JRWK=
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CAL-33 MkftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmX5TWM2OD1|LkWzN|YzKM7:TR?= MWHTRW5ITVJ?
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KU-19-19 NYPueYV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXXT5dTUUN3ME2zMlYxOzB2IN88US=> NXfiSXF2W0GQR1XS
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LB2241-RCC MlH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTNwNki2NlUh|ryP M1\DXHNCVkeHUh?=
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SCC-25 Ml7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvUTFVwUUN3ME21MlE6ODR4IN88US=> MoPsV2FPT0WU
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RH-1 MmSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHYUoNKSzVyPUKxMlg5OyEQvF2= MVfTRW5ITVJ?
HAL-01 NITae25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fEb2lEPTB;MkKuNFQyQCEQvF2= NF7TU3pUSU6JRWK=
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LS-411N MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJ{LkK4Olkh|ryP NVXOfFJPW0GQR1XS
no-10 NGCweHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJ{LkWwNFQh|ryP MWfTRW5ITVJ?
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NUGC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HleGlEPTB;MkOuNVE6QSEQvF2= NF;IN4NUSU6JRWK=
EW-16 Mm[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{m4c2lEPTB;MkSuNFkzPiEQvF2= MWXTRW5ITVJ?
HCC70 M4rJfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjYZXJKSzVyPUK0MlE{OjNizszN MoHvV2FPT0WU
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CFPAC-1 NIPiRVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ2Lk[yO|Ih|ryP MmCzV2FPT0WU
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NCI-H2347 NFyxSW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPDTWM2OD1{NT60NlQ6KM7:TR?= NHriT2tUSU6JRWK=
P30-OHK MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HNR2lEPTB;MkWuOlMyQCEQvF2= NI\VcHFUSU6JRWK=
SK-N-FI NFjHeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXKTWM2OD1{Nj6xNVYzKM7:TR?= MULTRW5ITVJ?
CAMA-1 NU\DbpdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7UTWM2OD1{Nj60PFc3KM7:TR?= MV\TRW5ITVJ?
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KARPAS-299 NH7jN2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnITWM2OD1{Nz60O|AyKM7:TR?= MkDIV2FPT0WU
TE-11 NV\CXotkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTJ5LkezOFIh|ryP NV7DVZVjW0GQR1XS
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NCI-H2342 M3XkXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnBTWM2OD1{OT6zPFA{KM7:TR?= NGDXPIlUSU6JRWK=
NCI-H1651 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ7Lki1NFMh|ryP Mlm3V2FPT0WU
OE33 M2\tZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:yTWM2OD1|MD6xN|QzKM7:TR?= NInV[W1USU6JRWK=
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SN12C M2PGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL2TWM2OD1|Mj64PFE2KM7:TR?= NYXQWFlCW0GQR1XS
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OVCAR-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH64S2xKSzVyPUOzMlQyOjdizszN M3XLeHNCVkeHUh?=
NCI-H1304 NILEWJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;ySFlKSzVyPUOzMlYxOzZizszN M2i0[nNCVkeHUh?=
LU-135 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHv[XFVUUN3ME2zN{44ODh4IN88US=> MY\TRW5ITVJ?
S-117 Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjae5FjUUN3ME2zN{44Ojh4IN88US=> MYTTRW5ITVJ?
NCI-H1755 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV6yWHdXUUN3ME2zN{45OTFizszN NI\hdJFUSU6JRWK=
Mo-T NGfheFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfYTWM2OD1|Mz64OVk{KM7:TR?= Mof0V2FPT0WU
SK-OV-3 NHLQdIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe5TWM2OD1|Mz64PFU1KM7:TR?= NHjlUYRUSU6JRWK=
RCC10RGB NVzJV5UyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfzTWM2OD1|Mz65OFM{KM7:TR?= NFTlbpdUSU6JRWK=
COLO-680N NED3cIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XzbmlEPTB;M{SuNVM6PyEQvF2= MnnTV2FPT0WU
KURAMOCHI NHTNZ|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTN2Lk[0NlUh|ryP NYXrXmp7W0GQR1XS
NCI-H661 Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTN2Lki0OFgh|ryP M1jWVnNCVkeHUh?=
YAPC NWjhTmR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ntSmlEPTB;M{WuPVU{OyEQvF2= M{XUTnNCVkeHUh?=
NCI-H526 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf5U25FUUN3ME2zO{4zPzd{IN88US=> M2PL[nNCVkeHUh?=
A498 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTN6LkC5OVQh|ryP NHPZTXdUSU6JRWK=
VMRC-RCZ MmX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkG4TWM2OD1|OT6wNFU1KM7:TR?= NI[xU2lUSU6JRWK=
HCT-116 NEjWSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTGR|lTUUN3ME2zPU4xPThizszN M3;wSnNCVkeHUh?=
COLO-320-HSR MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7WUWdtUUN3ME20NE4xPDFizszN MWnTRW5ITVJ?
OAW-42 M1PDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHi0bIlKSzVyPUSwMlA2PDJizszN MoCwV2FPT0WU
SK-MEL-1 NUj0UmFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHi3T3lKSzVyPUSwMlI6OjdizszN NIHTRm5USU6JRWK=
IST-MES1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHoTWM2OD12MD63OlU{KM7:TR?= MoPVV2FPT0WU
CP50-MEL-B MlLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[xTWM2OD12MT6wO|k4KM7:TR?= NX\RepczW0GQR1XS
RMG-I NIPIPWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\GdmlEPTB;NEKuOFkzOSEQvF2= NGfpVWxUSU6JRWK=
D-336MG NGW2V2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDTTWM2OD12Mz6xNVUzKM7:TR?= NUT2dGNVW0GQR1XS
SHP-77 M4PwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGr2Z5dKSzVyPUSzMlE5OjhizszN MmPoV2FPT0WU
SW872 MlnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\jTWM2OD12Mz6yNVI{KM7:TR?= MkLIV2FPT0WU
DBTRG-05MG M2r2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELnclRKSzVyPUS0MlY6QTZizszN Ml;OV2FPT0WU
COLO-678 M{nGemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkL5TWM2OD12NT63NFMzKM7:TR?= NFr6RXVUSU6JRWK=
EGI-1 NFfHUYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDTTWM2OD12Nz6xPFM{KM7:TR?= MluwV2FPT0WU
KYSE-70 MoPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXBTWM2OD12Nz63NlIzKM7:TR?= M2OwXXNCVkeHUh?=
BALL-1 M2\Yfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDHdnZKSzVyPUS3MlgzPTRizszN NFrqb5dUSU6JRWK=
MDA-MB-361 M32yVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\hXWlEPTB;NEiuNFQ3KM7:TR?= NUj2[XIxW0GQR1XS
NCI-H1838 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1O1WmlEPTB;NEiuN|Q2QCEQvF2= MmnwV2FPT0WU
NCI-H1573 M4\STGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXBO2NtUUN3ME20PE43Pzh3IN88US=> NUjhb4RIW0GQR1XS
HCC1395 M4npW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYGzSmcxUUN3ME20PE46QTJizszN M4PtWnNCVkeHUh?=
NCI-H2291 M{ntPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfITWM2OD12OT61PVg5KM7:TR?= M17ieXNCVkeHUh?=
RH-18 NH35bYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDZepA4UUN3ME21NE4xQDh2IN88US=> MXjTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID