BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

Size Price Stock Quantity  
In DMSO USD 272 In stock
USD 170 In stock
USD 270 In stock
USD 670 In stock

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3 Customer Reviews

  • (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

    HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

  • Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 NE\PUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEO1PEDPxE1? NFn1c4RUSU6JRWK=
H9 M4POXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH6yOIFKSzVyPUCuNFYxOTlizszN M4rVRnNCVkeHUh?=
KARPAS-45 Mlj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkCzTWM2OD1yLkG2OVI2KM7:TR?= MW\TRW5ITVJ?
NCI-H720 NYPER3FkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n2UGlEPTB;MD6xO|E6PCEQvF2= NVX3XoliW0GQR1XS
CTV-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH5SI1KSzVyPUCuOFc5PzJizszN NHL4OIpUSU6JRWK=
DU-4475 NHq2fGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fse2lEPTB;MD61NFQyPyEQvF2= MoDzV2FPT0WU
A172 NHzOTIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH4cXhGUUN3ME2wMlUyPzB3IN88US=> MnfUV2FPT0WU
EW-18 NHvxN4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\rOGhGUUN3ME2wMlYzOjFzIN88US=> MWPTRW5ITVJ?
KU812 NHjJfWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LoUGlEPTB;MD62NlYzOyEQvF2= MkPJV2FPT0WU
KP-N-YS M12yfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITpN4dKSzVyPUCuOlgzOjNizszN MU\TRW5ITVJ?
SBC-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwNkm1NlQh|ryP MXrTRW5ITVJ?
ECC10 M{PsTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULjc5Z5UUN3ME2wMlcxODl2IN88US=> NF\U[IJUSU6JRWK=
GAMG NX;1e|NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDrTWM2OD1yLke0O|E4KM7:TR?= MVLTRW5ITVJ?
NCI-H209 MoH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwN{[4NkDPxE1? MVTTRW5ITVJ?
MC-IXC MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[5[lc1UUN3ME2wMlc6PTh7IN88US=> NYfQcnNVW0GQR1XS
HSC-3 NWHwU4M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwOEG3Olkh|ryP M3nnNXNCVkeHUh?=
IST-SL1 M1PxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwOES1O|Qh|ryP NVSxTIR[W0GQR1XS
LU-139 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P5SWlEPTB;MD64OFk2QCEQvF2= MX;TRW5ITVJ?
ML-2 MmLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWKy[GxsUUN3ME2wMlg2PTd3IN88US=> NVqzW3hLW0GQR1XS
CAL-62 M3\zPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\FRnRmUUN3ME2wMlg5OTV{IN88US=> NVvOfHJ4W0GQR1XS
HL-60 NU\RdYU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rWbGlEPTB;MD64PFM3OiEQvF2= MnPKV2FPT0WU
KY821 Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;YTWM2OD1yLki4PFEzKM7:TR?= Mlm1V2FPT0WU
ES7 NGq2V41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwOUG2NFch|ryP Mn3pV2FPT0WU
MV-4-11 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUno[oM5UUN3ME2wMlk4QDl5IN88US=> MVTTRW5ITVJ?
Daoy NY\rd4d[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7jNYZQUUN3ME2wMlk5PzZ5IN88US=> MlvlV2FPT0WU
EoL-1-cell M2Trb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXwTWM2OD1zLkCxPFc5KM7:TR?= NVnUTYhoW0GQR1XS
TGW MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXmXm5CUUN3ME2xMlA2OTJ2IN88US=> MX3TRW5ITVJ?
LAMA-84 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTFwMUK3PVQh|ryP M3;YU3NCVkeHUh?=
KOSC-2 NGS2d4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17BNGlEPTB;MT6xN|M5PSEQvF2= Moj5V2FPT0WU
A549 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwM{C5OVUh|ryP MlPMV2FPT0WU
CTB-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DPTmlEPTB;MT60OFY4QSEQvF2= NULoUYNuW0GQR1XS
NCI-H292 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTFwNE[wOlkh|ryP MW\TRW5ITVJ?
LoVo Mn\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\0WWlEPTB;MT60Olc2PSEQvF2= NHnIRlNUSU6JRWK=
BFTC-905 M2TOb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTLd|l3UUN3ME2xMlU3OzN{IN88US=> NFXBfIFUSU6JRWK=
BE-13 M2jybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTFwNUi3NFkh|ryP NILQb4lUSU6JRWK=
KE-37 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTFwNUm0O|gh|ryP MUTTRW5ITVJ?
HN NVr0XWk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoSyTWM2OD1zLk[xN|Y5KM7:TR?= NWL4dW5vW0GQR1XS
A3-KAW M4jPfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnW5TWM2OD1zLk[yPFM1KM7:TR?= Mn7nV2FPT0WU
NEC8 NVXVWFF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTsTWM2OD1zLkewNVE2KM7:TR?= NXK1UZAxW0GQR1XS
Ramos-2G6-4C10 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTFwN{C0OFQh|ryP NILhXIRUSU6JRWK=
NB10 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTtTWM2OD1zLke3OlMh|ryP NYDlNXY4W0GQR1XS
NBsusSR M3TkWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT2S2lKSzVyPUGuPFI6PjFizszN M3HrcHNCVkeHUh?=
ES4 NVT0WZlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTFwOEWxOFMh|ryP MX3TRW5ITVJ?
ES8 M2XhOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Hoe2lEPTB;MT64O|czPCEQvF2= NWO3N4JLW0GQR1XS
CHL-1 M33mU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[zeZVKSzVyPUGuPVU4QTJizszN M3\LOnNCVkeHUh?=
NCI-H2029 NUfjNYxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHIVZJKSzVyPUGuPVczPDFizszN M3fwSXNCVkeHUh?=
YKG-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFwOUi0N|Ih|ryP NV;zNXZ3W0GQR1XS
BV-173 M3zIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHuyd5lKSzVyPUGuPVg3PjZizszN M37xOXNCVkeHUh?=
697 NET6NFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fOZmlEPTB;Mj6wNlIzQCEQvF2= M4jrbnNCVkeHUh?=
SK-NEP-1 NHTXSoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJwMES0JO69VQ>? NUn4c3p7W0GQR1XS
LOXIMVI MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3KXFR4UUN3ME2yMlA1PDN2IN88US=> NHXqeJlUSU6JRWK=
QIMR-WIL NHnpS2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJwMEe4OFkh|ryP M2fiSHNCVkeHUh?=
DU-145 MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLTTWM2OD1{LkGxNFU3KM7:TR?= M1nK[HNCVkeHUh?=
NB14 M4rITWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWiwWYV{UUN3ME2yMlEyOzJzIN88US=> MWPTRW5ITVJ?
G-361 NF\vXmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nJ[GlEPTB;Mj6xNlIyKM7:TR?= M4nsV3NCVkeHUh?=
BPH-1 MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJwMUK5OVch|ryP NYjLV4tEW0GQR1XS
KYSE-150 NIDZSmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfae25zUUN3ME2yMlE2OjN2IN88US=> MmrNV2FPT0WU
HMV-II NY\STWY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DDT2lEPTB;Mj6xOlY{OyEQvF2= NH25dY1USU6JRWK=
TE-9 M2\HTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LOVWlEPTB;Mj6xO|M4PiEQvF2= NULWdGI3W0GQR1XS
8-MG-BA MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{npU2lEPTB;Mj6yN|Q3OSEQvF2= M4\GcXNCVkeHUh?=
ES5 M1nSUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\ufWlEPTB;Mj6yN|Y{OyEQvF2= MYXTRW5ITVJ?
D-283MED M3Tqbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17tSGlEPTB;Mj6yN|Y6PSEQvF2= NYnCO4t4W0GQR1XS
SK-N-AS NFL4[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrEc2ZKSzVyPUKuNlkxPTlizszN Ml\IV2FPT0WU
SW1710 NHr6PZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPkTWM2OD1{LkOwOlYyKM7:TR?= MYjTRW5ITVJ?
GCT MknSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fucmlEPTB;Mj6zNVM2QCEQvF2= NVWyXFd[W0GQR1XS
AGS MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEmySnVKSzVyPUKuN|Q1ODRizszN NYO5XVliW0GQR1XS
HuO9 MnP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1[zR2lEPTB;Mj6zOlgzPCEQvF2= M1rTcnNCVkeHUh?=
MN-60 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rNcmlEPTB;Mj60OFg5OyEQvF2= Ml7YV2FPT0WU
NB6 NV7pXVQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\PTWM2OD1{LkS1O|c6KM7:TR?= MmjHV2FPT0WU
NCI-H1395 NV3hdJJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2f5OWlEPTB;Mj60O|EzOSEQvF2= MmLMV2FPT0WU
H4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrvRY9oUUN3ME2yMlQ5Ozl|IN88US=> M3ToTXNCVkeHUh?=
HT-3 M13rfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTJwNUGwNlQh|ryP MnLTV2FPT0WU
P12-ICHIKAWA NVO1XlU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\nWnBKUUN3ME2yMlUzPTV7IN88US=> MnXhV2FPT0WU
COLO-800 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LzNWlEPTB;Mj61OFE3PiEQvF2= NHzqTJNUSU6JRWK=
DB MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJwNUWwNVMh|ryP MWfTRW5ITVJ?
LCLC-97TM1 MkXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJwNkCwNlgh|ryP NH3hXIlUSU6JRWK=
Ca9-22 NE\ENmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPlVXJEUUN3ME2yMlY2QTN|IN88US=> MWHTRW5ITVJ?
Becker NXiyOGxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jCTmlEPTB;Mj62OlA4QCEQvF2= MnnhV2FPT0WU
ACN MlTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJwNk[3PUDPxE1? NHn6ellUSU6JRWK=
SJSA-1 MonMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G5S2lEPTB;Mj62Olg4KM7:TR?= M1j2[HNCVkeHUh?=
NCI-H1048 NVnnTpVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[3W2lEPTB;Mj62PFMzOSEQvF2= NGrpN3ZUSU6JRWK=
HEL NWDHWlAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJwN{CyOVQh|ryP NFXISVdUSU6JRWK=
NCI-H69 M3PsNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2X4NmlEPTB;Mj63NVYxOSEQvF2= NWfDOW1{W0GQR1XS
639-V NI\T[nVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGzS25HUUN3ME2yMlcyPzB|IN88US=> MX;TRW5ITVJ?
U251 NYfNfI1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPLUZVKSzVyPUKuO|MxOzJizszN MUXTRW5ITVJ?
NCI-H1792 NF\DVYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XQNGlEPTB;Mj63N|c{QCEQvF2= MkfMV2FPT0WU
EW-1 M{O5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\ZTWM2OD1{Lke1N|I5KM7:TR?= M2PmOXNCVkeHUh?=
ME-180 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvKdJhKSzVyPUKuO|c4OzZizszN MX7TRW5ITVJ?
HH NE\qPJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq2SXNKSzVyPUKuPFAxODFizszN NVXjdXY6W0GQR1XS
SW954 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXxXWpVUUN3ME2yMlg2QDNizszN MnS2V2FPT0WU
SF268 M17qTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:5TWM2OD1{Lki3NlI2KM7:TR?= NHLIfm5USU6JRWK=
D-566MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTJwOUGyPVUh|ryP MUDTRW5ITVJ?
EM-2 M2iwU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\YTWM2OD1{LkmyNVk{KM7:TR?= NGfUdVBUSU6JRWK=
NCI-H1299 NHv0b3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vsSWlEPTB;Mj65N|c{PiEQvF2= MkjEV2FPT0WU
PSN1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTNwMEW3PFYh|ryP MX;TRW5ITVJ?
JVM-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33yfmlEPTB;Mz6wOlc2PiEQvF2= MYLTRW5ITVJ?
D-502MG NUfsSpRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlS1TWM2OD1|LkC3NFE6KM7:TR?= NHqxU4xUSU6JRWK=
SCC-4 MknUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzWTWM2OD1|LkC5Nlc3KM7:TR?= NFHyOmJUSU6JRWK=
GMS-10 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnwVIpKSzVyPUOuNFk{QDhizszN MkDGV2FPT0WU
A427 NGXhdIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTNwMUC4O|Mh|ryP NHnzZ2pUSU6JRWK=
NH-12 NE\tTIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTUTWM2OD1|LkGxOFU3KM7:TR?= NFTZUFVUSU6JRWK=
KM12 M3La[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PFbmlEPTB;Mz6xNlI4OyEQvF2= NYr3[nlwW0GQR1XS
GI-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLjTWM2OD1|LkG1NlU2KM7:TR?= NHrYSXJUSU6JRWK=
TE-8 NIf5PIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWyXoRHUUN3ME2zMlE6OjNzIN88US=> NHexR3VUSU6JRWK=
MKN1 MlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTNwMkC4O|Uh|ryP MorqV2FPT0WU
NCI-H810 M1nFO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXrTWM2OD1|LkKyNVU2KM7:TR?= M1T2UnNCVkeHUh?=
GOTO M1PxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDJc2xKSzVyPUOuNlgxODRizszN M2PQZXNCVkeHUh?=
T98G M1[ySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7PeoZKSzVyPUOuNlgzOTZizszN NWLWWZE3W0GQR1XS
HD-MY-Z NXuy[3Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG3WFdKSzVyPUOuN|Y2PDJizszN NXS1cYF5W0GQR1XS
SNU-C2B M4\BU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTSTWM2OD1|LkO5NFk4KM7:TR?= NFnwXlJUSU6JRWK=
MOLT-4 NFPnS41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWwO4VKSzVyPUOuN|kxQThizszN NHfCd|VUSU6JRWK=
RPMI-7951 NEL5WXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\EUG9yUUN3ME2zMlM6PzNizszN MW\TRW5ITVJ?
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NCI-H1651 NFm2PI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJ7Lki1NFMh|ryP M3;SSnNCVkeHUh?=
OE33 M1i5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTNyLkGzOFIh|ryP M1rpUnNCVkeHUh?=
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Mo-T NVvGNW9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2D4SGlEPTB;M{OuPFU6OyEQvF2= Mmm0V2FPT0WU
SK-OV-3 MlfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTWXlFKSzVyPUOzMlg5PTRizszN NFvLZYhUSU6JRWK=
RCC10RGB NGX0T3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTN|Lkm0N|Mh|ryP MUnTRW5ITVJ?
COLO-680N NXrGW4tWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfvXXJNUUN3ME2zOE4yOzl5IN88US=> NWfSR2x5W0GQR1XS
KURAMOCHI M4\Id2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP2Z5hNUUN3ME2zOE43PDJ3IN88US=> MkXTV2FPT0WU
NCI-H661 MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;aeGlEPTB;M{SuPFQ1QCEQvF2= NWXwbIRlW0GQR1XS
YAPC MoLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm4VZpKSzVyPUO1Mlk2OzNizszN MXLTRW5ITVJ?
NCI-H526 MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnroTWM2OD1|Nz6yO|czKM7:TR?= M3jEOHNCVkeHUh?=
A498 NGraUYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTN6LkC5OVQh|ryP NFvrOotUSU6JRWK=
VMRC-RCZ MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvyTYZKSzVyPUO5MlAxPTRizszN M37td3NCVkeHUh?=
HCT-116 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEf4dpVKSzVyPUO5MlA2QCEQvF2= MUTTRW5ITVJ?
COLO-320-HSR M1PVbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTRyLkC0NUDPxE1? NVLaSpBWW0GQR1XS
OAW-42 M3nLbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofFTWM2OD12MD6wOVQzKM7:TR?= MmXvV2FPT0WU
SK-MEL-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIiye3NKSzVyPUSwMlI6OjdizszN NEHQSWlUSU6JRWK=
IST-MES1 NEHxTHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIC4fpNKSzVyPUSwMlc3PTNizszN NHHoWJFUSU6JRWK=
CP50-MEL-B NGfkd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzWTWM2OD12MT6wO|k4KM7:TR?= M2i5e3NCVkeHUh?=
RMG-I NWTtSFN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTWTWM2OD12Mj60PVIyKM7:TR?= MWrTRW5ITVJ?
D-336MG MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\FTmlEPTB;NEOuNVE2OiEQvF2= NVLTblFbW0GQR1XS
SHP-77 NXLkV4ZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPhWpdCUUN3ME20N{4yQDJ6IN88US=> NIf4dmJUSU6JRWK=
SW872 MnTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWKwVoRyUUN3ME20N{4zOTJ|IN88US=> Ml7EV2FPT0WU
DBTRG-05MG M4OxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjQTWM2OD12ND62PVk3KM7:TR?= NEDSNnhUSU6JRWK=
COLO-678 NILm[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn6cFV5UUN3ME20OU44ODN{IN88US=> NEnvZ5hUSU6JRWK=
EGI-1 NYLad2wzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoOyTWM2OD12Nz6xPFM{KM7:TR?= M2DV[3NCVkeHUh?=
KYSE-70 M{jmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTR5LkeyNlIh|ryP Mn;DV2FPT0WU
BALL-1 NES0ZZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfZSHpKSzVyPUS3MlgzPTRizszN Mm\yV2FPT0WU
MDA-MB-361 MoLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;tTWM2OD12OD6wOFYh|ryP M13IPXNCVkeHUh?=
NCI-H1838 M4[0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULOfFZ{UUN3ME20PE4{PDV6IN88US=> Mnf3V2FPT0WU
NCI-H1573 NFjKd3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXrdW9KSzVyPUS4MlY4QDVizszN MYfTRW5ITVJ?
HCC1395 NGr4XpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTR6Lkm5NkDPxE1? M3zFd3NCVkeHUh?=
NCI-H2291 M1;oNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTR7LkW5PFgh|ryP NFPjbplUSU6JRWK=
RH-18 Mn3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLWWYFKSzVyPUWwMlA5QDRizszN NH60S25USU6JRWK=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID