BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

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4 Customer Reviews

  • Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

    Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

    (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

  • HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

    Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 NEe5N4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PtOGlEPTB;MD6wN|U5KM7:TR?= NU[5fVdJW0GQR1XS
H9 MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr5TWM2OD1yLkC2NFE6KM7:TR?= NF;rfIFUSU6JRWK=
KARPAS-45 NVjnR217T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHLTnNKSzVyPUCuNVY2OjVizszN MoHFV2FPT0WU
NCI-H720 M4Pnbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XIVGlEPTB;MD6xO|E6PCEQvF2= Ml7tV2FPT0WU
CTV-1 MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M136NWlEPTB;MD60O|g4OiEQvF2= NILSeo5USU6JRWK=
DU-4475 MlLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzYTWM2OD1yLkWwOFE4KM7:TR?= NITOWlNUSU6JRWK=
A172 NX7Sd4VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwNUG3NFUh|ryP M{e4UnNCVkeHUh?=
EW-18 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrTNlNKSzVyPUCuOlIzOTFizszN MYHTRW5ITVJ?
KU812 NVjn[GVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLaPJpRUUN3ME2wMlYzPjJ|IN88US=> MkKzV2FPT0WU
KP-N-YS M1vTOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHS[ohKSzVyPUCuOlgzOjNizszN M2\lR3NCVkeHUh?=
SBC-1 M1\0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mon1TWM2OD1yLk[5OVI1KM7:TR?= M3\OTnNCVkeHUh?=
ECC10 MmHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwN{CwPVQh|ryP NH[1XZNUSU6JRWK=
GAMG NVvISYVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrMeVJPUUN3ME2wMlc1PzF5IN88US=> M3qzc3NCVkeHUh?=
NCI-H209 MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwN{[4NkDPxE1? Mn\HV2FPT0WU
MC-IXC NGr2Z|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwN{m1PFkh|ryP NHnDVodUSU6JRWK=
HSC-3 MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPacoVKSzVyPUCuPFE4PjlizszN Ml7HV2FPT0WU
IST-SL1 M33EOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13mcmlEPTB;MD64OFU4PCEQvF2= M3i2XXNCVkeHUh?=
LU-139 MmjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPtfFhKSzVyPUCuPFQ6PThizszN NYXmbHN3W0GQR1XS
ML-2 NFrxW2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwOEW1O|Uh|ryP NGDyOJNUSU6JRWK=
CAL-62 MlTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTiTWM2OD1yLki4NVUzKM7:TR?= MkGxV2FPT0WU
HL-60 NEXs[I5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPVe|QyUUN3ME2wMlg5OzZ{IN88US=> Ml:yV2FPT0WU
KY821 Ml;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP6TWM2OD1yLki4PFEzKM7:TR?= MUXTRW5ITVJ?
ES7 M2G5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwOUG2NFch|ryP M2[2N3NCVkeHUh?=
MV-4-11 M4HOUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLXTWM2OD1yLkm3PFk4KM7:TR?= MoXYV2FPT0WU
Daoy MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHy1NoZKSzVyPUCuPVg4PjdizszN NEfrc3hUSU6JRWK=
EoL-1-cell M1HEbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPZVVFKSzVyPUGuNFE5PzhizszN NUDZZmpLW0GQR1XS
TGW NWLKS2JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTFwMEWxNlQh|ryP NEn0[WdUSU6JRWK=
LAMA-84 NFPHfo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljHTWM2OD1zLkGyO|k1KM7:TR?= MXXTRW5ITVJ?
KOSC-2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fjN2lEPTB;MT6xN|M5PSEQvF2= MmrkV2FPT0WU
A549 NHvyTVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG[0TJNKSzVyPUGuN|A6PTVizszN MkOxV2FPT0WU
CTB-1 NYTiWmMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTFwNES2O|kh|ryP NF7XNWNUSU6JRWK=
NCI-H292 Moq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFwNE[wOlkh|ryP MWLTRW5ITVJ?
LoVo NGTaXVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;KRWZKSzVyPUGuOFY4PTVizszN MnL2V2FPT0WU
BFTC-905 NFrye5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TEWWlEPTB;MT61OlM{OiEQvF2= Mni5V2FPT0WU
BE-13 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\WUngxUUN3ME2xMlU5PzB7IN88US=> MlPvV2FPT0WU
KE-37 MmCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmiyTWM2OD1zLkW5OFc5KM7:TR?= MUPTRW5ITVJ?
HN M1fjUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD4WJV2UUN3ME2xMlYyOzZ6IN88US=> NG\0cpdUSU6JRWK=
A3-KAW NV7SV|VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLZeZN2UUN3ME2xMlYzQDN2IN88US=> NX\MUYVbW0GQR1XS
NEC8 MlPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13jbGlEPTB;MT63NFEyPSEQvF2= NUPPbVV6W0GQR1XS
Ramos-2G6-4C10 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTFwN{C0OFQh|ryP M2PvUnNCVkeHUh?=
NB10 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwN{e2N{DPxE1? MYLTRW5ITVJ?
NBsusSR MlTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTFwOEK5OlEh|ryP NIG3W2NUSU6JRWK=
ES4 NGTTOINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[2b2lEPTB;MT64OVE1OyEQvF2= NUXHV2ZsW0GQR1XS
ES8 NWLuNGNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPLXWlKSzVyPUGuPFc4OjRizszN NVPNb|VNW0GQR1XS
CHL-1 NXjTeVdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LUXGlEPTB;MT65OVc6OiEQvF2= Mmf3V2FPT0WU
NCI-H2029 NXnhVm1bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrpNVI3UUN3ME2xMlk4OjRzIN88US=> NVTxZYJ7W0GQR1XS
YKG-1 NXexfHQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTFwOUi0N|Ih|ryP M17reXNCVkeHUh?=
BV-173 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu3SnRoUUN3ME2xMlk5PjZ4IN88US=> NVP0TI5vW0GQR1XS
697 NWK0R4RwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPqTWM2OD1{LkCyNlI5KM7:TR?= Mm\zV2FPT0WU
SK-NEP-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLVTWM2OD1{LkC0OEDPxE1? MXjTRW5ITVJ?
LOXIMVI NYDWPGc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnDN|FKSzVyPUKuNFQ1OzRizszN MX7TRW5ITVJ?
QIMR-WIL NI\6UXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\zRVVKSzVyPUKuNFc5PDlizszN NWTw[Vd4W0GQR1XS
DU-145 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHHWXhKSzVyPUKuNVExPTZizszN Mmr3V2FPT0WU
NB14 MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jXWmlEPTB;Mj6xNVMzOSEQvF2= MXPTRW5ITVJ?
G-361 M1rp[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJwMUKyNUDPxE1? MYPTRW5ITVJ?
BPH-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLxNYhKSzVyPUKuNVI6PTdizszN MWPTRW5ITVJ?
KYSE-150 NGHaUIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:4OWlEPTB;Mj6xOVI{PCEQvF2= NXzoZWxVW0GQR1XS
HMV-II MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3O3N2lEPTB;Mj6xOlY{OyEQvF2= MUjTRW5ITVJ?
TE-9 NIXSe3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLwTWM2OD1{LkG3N|c3KM7:TR?= NGr2dXFUSU6JRWK=
8-MG-BA MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTJwMkO0OlEh|ryP NYL2W|lMW0GQR1XS
ES5 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\sN3F5UUN3ME2yMlI{PjN|IN88US=> NYjBfmlHW0GQR1XS
D-283MED MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHmwOGRKSzVyPUKuNlM3QTVizszN NFLOUFdUSU6JRWK=
SK-N-AS NWjXXHBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X0dWlEPTB;Mj6yPVA2QSEQvF2= MUDTRW5ITVJ?
SW1710 M1LNfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWWwfXp{UUN3ME2yMlMxPjZzIN88US=> MULTRW5ITVJ?
GCT M3S1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1q2eGlEPTB;Mj6zNVM2QCEQvF2= NH;6Sm5USU6JRWK=
AGS MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj1fmJKSzVyPUKuN|Q1ODRizszN MUXTRW5ITVJ?
HuO9 NG\sdFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PGfGlEPTB;Mj6zOlgzPCEQvF2= NEPrOXdUSU6JRWK=
MN-60 NWTk[JZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LPOmlEPTB;Mj60OFg5OyEQvF2= MofSV2FPT0WU
NB6 NWrocVBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\CN2lEPTB;Mj60OVc4QSEQvF2= MWPTRW5ITVJ?
NCI-H1395 MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PlcWlEPTB;Mj60O|EzOSEQvF2= NUHvNoJHW0GQR1XS
H4 NXH4dWtiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nhdWlEPTB;Mj60PFM6OyEQvF2= MljJV2FPT0WU
HT-3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HkWWlEPTB;Mj61NVAzPCEQvF2= NVjWXYk{W0GQR1XS
P12-ICHIKAWA MmnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTnT5JKSzVyPUKuOVI2PTlizszN M{nibnNCVkeHUh?=
COLO-800 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPpfGZpUUN3ME2yMlU1OTZ4IN88US=> MYTTRW5ITVJ?
DB MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLlSJh7UUN3ME2yMlU2ODF|IN88US=> Ml3XV2FPT0WU
LCLC-97TM1 Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Hm[GlEPTB;Mj62NFAzQCEQvF2= M2\yR3NCVkeHUh?=
Ca9-22 NE[1eIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX4V4gyUUN3ME2yMlY2QTN|IN88US=> NVPyT3A{W0GQR1XS
Becker NGK1O4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrIN5pOUUN3ME2yMlY3ODd6IN88US=> NI\tW4dUSU6JRWK=
ACN NGrIbppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi2d3ZKSzVyPUKuOlY4QSEQvF2= NEHvV4dUSU6JRWK=
SJSA-1 MoD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vPUmlEPTB;Mj62Olg4KM7:TR?= M1XqS3NCVkeHUh?=
NCI-H1048 M{m3[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moe0TWM2OD1{Lk[4N|IyKM7:TR?= MnTRV2FPT0WU
HEL M{fXXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnmTWM2OD1{LkewNlU1KM7:TR?= NWPsWHJOW0GQR1XS
NCI-H69 M3Xpcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX75cYd2UUN3ME2yMlcyPjBzIN88US=> NGDE[oFUSU6JRWK=
639-V M1vlSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m2[mlEPTB;Mj63NVcxOyEQvF2= NILnfnVUSU6JRWK=
U251 NHK1SpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TRW2lEPTB;Mj63N|A{OiEQvF2= MYPTRW5ITVJ?
NCI-H1792 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJwN{O3N|gh|ryP NEHsNo9USU6JRWK=
EW-1 NW\ZeohxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD0TWM2OD1{Lke1N|I5KM7:TR?= NWDncFZHW0GQR1XS
ME-180 NViyTG9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzB[pRuUUN3ME2yMlc4PzN4IN88US=> NV;NW5pXW0GQR1XS
HH MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j2OWlEPTB;Mj64NFAxOSEQvF2= Mn[5V2FPT0WU
SW954 M1S0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zPU2lEPTB;Mj64OVg{KM7:TR?= MXfTRW5ITVJ?
SF268 M2G5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTJwOEeyNlUh|ryP MlToV2FPT0WU
D-566MG M3zkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJwOUGyPVUh|ryP MVTTRW5ITVJ?
EM-2 MnfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELEPXNKSzVyPUKuPVIyQTNizszN MoTBV2FPT0WU
NCI-H1299 MkjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\hWm5JUUN3ME2yMlk{PzN4IN88US=> NXL1PGVRW0GQR1XS
PSN1 M2fSd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nudmlEPTB;Mz6wOVc5PiEQvF2= MlLJV2FPT0WU
JVM-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\WSmlEPTB;Mz6wOlc2PiEQvF2= MlHZV2FPT0WU
D-502MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHlTWM2OD1|LkC3NFE6KM7:TR?= NGHBRmdUSU6JRWK=
SCC-4 NY[zUmJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD5dYhQUUN3ME2zMlA6Ojd4IN88US=> NInvU25USU6JRWK=
GMS-10 M2SzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfL[Xh[UUN3ME2zMlA6Ozh6IN88US=> NF;xWJZUSU6JRWK=
A427 MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX5SWRNUUN3ME2zMlExQDd|IN88US=> NHXXWGNUSU6JRWK=
NH-12 Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTNwMUG0OVYh|ryP MoHNV2FPT0WU
KM12 M4Dy[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITwWmVKSzVyPUOuNVIzPzNizszN NFPCdppUSU6JRWK=
GI-1 M3K1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfFTWM2OD1|LkG1NlU2KM7:TR?= MXvTRW5ITVJ?
TE-8 M3fPeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTNwMUmyN|Eh|ryP Ml\pV2FPT0WU
MKN1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HyWmlEPTB;Mz6yNFg4PSEQvF2= NYXr[GhkW0GQR1XS
NCI-H810 MmTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvXTWM2OD1|LkKyNVU2KM7:TR?= MlPCV2FPT0WU
GOTO NF7jOWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q0dmlEPTB;Mz6yPFAxPCEQvF2= MU\TRW5ITVJ?
T98G M4fFN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\qZXRrUUN3ME2zMlI5OjF4IN88US=> NILrfm1USU6JRWK=
HD-MY-Z NWDXPZZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUC3cmhFUUN3ME2zMlM3PTR{IN88US=> NH33Uo5USU6JRWK=
SNU-C2B M1zabmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7FZ|BKSzVyPUOuN|kxQTdizszN NHPacnpUSU6JRWK=
MOLT-4 NIP1T|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPnWmdKSzVyPUOuN|kxQThizszN NH;UVJhUSU6JRWK=
RPMI-7951 Mmm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLOWXdKSzVyPUOuN|k4OyEQvF2= NFrJcZpUSU6JRWK=
EW-11 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:0TWM2OD1|LkSxNlI1KM7:TR?= MVnTRW5ITVJ?
RD M1HXbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTSTWM2OD1|LkSzNVMzKM7:TR?= MnfMV2FPT0WU
SW48 MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7Kcoc6UUN3ME2zMlQ{OzV6IN88US=> M{X0SnNCVkeHUh?=
BB65-RCC M3LqUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH0dVdKSzVyPUOuOFU{QTZizszN MnvxV2FPT0WU
Ca-Ski NGjyRWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nZVGlEPTB;Mz60O|UyPCEQvF2= MYnTRW5ITVJ?
CHP-134 MnHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XodmlEPTB;Mz60PFc2QCEQvF2= MYfTRW5ITVJ?
CAL-33 MorqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\jfmlEPTB;Mz61N|M3OiEQvF2= M3:5d3NCVkeHUh?=
TYK-nu MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXyTWM2OD1|LkWzOlc3KM7:TR?= M1LhR3NCVkeHUh?=
LB831-BLC NEPBO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTKTWM2OD1|LkW0NFE3KM7:TR?= MlfIV2FPT0WU
KU-19-19 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M12xVmlEPTB;Mz62NFMxPCEQvF2= MV;TRW5ITVJ?
KG-1 M33TRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkL2TWM2OD1|Lk[xNVA3KM7:TR?= Mk\EV2FPT0WU
COLO-829 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTNwNk[2NVgh|ryP NYTaSldOW0GQR1XS
HUTU-80 M3u2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TCcWlEPTB;Mz62OlYzOSEQvF2= NH3pZVhUSU6JRWK=
NCI-H446 Mo\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGiyNmFKSzVyPUOuOlg{PCEQvF2= NF\ae29USU6JRWK=
LB2241-RCC NXvnXnM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH71coRKSzVyPUOuOlg3OjVizszN NIGxVGRUSU6JRWK=
JEG-3 NIDybppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPlTWM2OD1|Lk[5NVkh|ryP MX7TRW5ITVJ?
LNCaP-Clone-FGC NED5c5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;sTWM2OD1|LkewNFQyKM7:TR?= M2HReXNCVkeHUh?=
M059J NEnGcIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPKU4RKSzVyPUOuO|E1PjhizszN M3vobXNCVkeHUh?=
SK-MES-1 M{O3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTNwN{OwN{DPxE1? MYLTRW5ITVJ?
GT3TKB NH3PNHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTvTWM2OD1|Lke1OlA1KM7:TR?= M1fHc3NCVkeHUh?=
DOK MlTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTNwN{[1NlYh|ryP NUj0eXB7W0GQR1XS
HO-1-N-1 NI\WNItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnZbFhKSzVyPUOuO|k5ODFizszN M1rzW3NCVkeHUh?=
MZ1-PC NXX0c3JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYL6UIUzUUN3ME2zMlgzQDh|IN88US=> NV3OclRkW0GQR1XS
8305C NY\mWJZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFva[FNKSzVyPUOuPFg6PDNizszN M1TmPHNCVkeHUh?=
CGTH-W-1 MnnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGi5OmZKSzVyPUOuPVM2ODRizszN NWjnTXBFW0GQR1XS
LU-134-A NFfyS4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4H2XWlEPTB;Mz65OVQzOiEQvF2= MnHhV2FPT0WU
C32 M{j4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\CXZY1UUN3ME2zMlk3PThzIN88US=> NVu2OG5DW0GQR1XS
MOLT-13 MmnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTNwOU[4OVYh|ryP MVrTRW5ITVJ?
A375 MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MornTWM2OD12LkC1NVYzKM7:TR?= MWPTRW5ITVJ?
CAL-12T NX36V4VST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTRwMEW3PVUh|ryP Ml7sV2FPT0WU
IGR-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X5WWlEPTB;ND6xNFI4PCEQvF2= MXnTRW5ITVJ?
LB1047-RCC NEjNc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHZZ3RKSzVyPUSuNVA1PDFizszN NHr3O3hUSU6JRWK=
BHT-101 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTRwMUC2PFMh|ryP NWrmSmhLW0GQR1XS
A431 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfzPFdKSzVyPUSuNVQxQDFizszN NWG4bXpuW0GQR1XS
EPLC-272H M1noUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33rNmlEPTB;ND6xO|U6PiEQvF2= MYDTRW5ITVJ?
HT-1376 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnhWG1kUUN3ME20MlI{ODV7IN88US=> MXTTRW5ITVJ?
HCC1954 MmDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDFTWM2OD12LkK1O|Q3KM7:TR?= Mn3nV2FPT0WU
KYSE-510 NGnRPGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPLTWM2OD12LkK2NFkh|ryP NFLQ[5RUSU6JRWK=
PANC-03-27 M4r1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37XWWlEPTB;ND6zNFA5OyEQvF2= NYnJeZlPW0GQR1XS
MDA-MB-157 Mn3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrIR|VGUUN3ME20MlMxPjV4IN88US=> NXfsT3hvW0GQR1XS
HOP-62 Mk\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTRwM{C4OVYh|ryP M3nk[HNCVkeHUh?=
ETK-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH2R5ZKSzVyPUSuN|YzODNizszN MX7TRW5ITVJ?
MIA-PaCa-2 NXfNV4pKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTRwM{[yNlch|ryP NUDnO5RJW0GQR1XS
MHH-PREB-1 M{nlfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjDbG06UUN3ME20MlM6Pzd|IN88US=> NV\YZnVmW0GQR1XS
LXF-289 NXz5V2t{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTRwNECyNFIh|ryP M2\5cHNCVkeHUh?=
ATN-1 NIPVRlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTRwNEKzOFEh|ryP MUnTRW5ITVJ?
8505C MmDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTRTno4UUN3ME20MlQ2QDJ3IN88US=> NUXVdWZFW0GQR1XS
HOS NH3zbnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfOTWM2OD12LkS2OFU{KM7:TR?= NWHwPYx1W0GQR1XS
U-266 M{XiT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\jUWlEPTB;ND62NVA{OiEQvF2= NHjn[mNUSU6JRWK=
5637 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DqN2lEPTB;ND62NVQ1PCEQvF2= MnvsV2FPT0WU
GCIY M3vvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTRwN{GwNVUh|ryP MYPTRW5ITVJ?
MDA-MB-231 M1nzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrKSY1KSzVyPUSuO|IyOTVizszN NX\iTJI3W0GQR1XS
RKO MnvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTRwN{K4NVch|ryP M4GxNXNCVkeHUh?=
COR-L23 NFTHS2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTRwN{SyOVYh|ryP MmTwV2FPT0WU
DJM-1 NFXubHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYO3[|lOUUN3ME20Mlc6PzJ7IN88US=> MknSV2FPT0WU
D-423MG MmrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTRwOEC4NFMh|ryP NFO3bmJUSU6JRWK=
DMS-114 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTRwOEGzPFYh|ryP NVL4V5I6W0GQR1XS
MHH-ES-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjRUJdKSzVyPUSuPFI2ODRizszN NWm1R495W0GQR1XS
CAL-51 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP6R3hQUUN3ME20Mlg3QDR|IN88US=> MYrTRW5ITVJ?
SW626 M4H3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTRwOEm2PVch|ryP M2jCW3NCVkeHUh?=
COLO-824 NHvwXodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnWWo1kUUN3ME20MlkxPDB6IN88US=> NVH0bmJ4W0GQR1XS
NCI-H1437 M{[5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjsOZZ{UUN3ME20MlkzQTNizszN M3fGe3NCVkeHUh?=
CAL-39 NFnoSFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDmTWM2OD12LkmzPVg5KM7:TR?= NU\BWlFCW0GQR1XS
PC-3 NXzzU5p{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHLdFBKSzVyPUSuPVQ3PDhizszN NGTsZXlUSU6JRWK=
A101D MlrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zT[WlEPTB;ND65Olg3PSEQvF2= M3TaVHNCVkeHUh?=
ES1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTVwMECxN{DPxE1? MUDTRW5ITVJ?
TE-1 NXTyXIRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\VRY9KSzVyPUWuNFM3PjZizszN NI[yTXBUSU6JRWK=
KP-N-YN MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e2UWlEPTB;NT6wOVY4KM7:TR?= MmDmV2FPT0WU
EFO-27 NEXXWYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\mTWM2OD13LkC2N|I6KM7:TR?= Ml\jV2FPT0WU
BT-549 MlfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTVwMEe3N|Yh|ryP MXrTRW5ITVJ?
HLE MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTVwMUG3N|Qh|ryP NULvWpo5W0GQR1XS
SW982 NGDkdIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX2TWM2OD13LkGzN|c1KM7:TR?= M{POfnNCVkeHUh?=
SCC-25 M1y4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTVwMUmwOFYh|ryP NEnub|dUSU6JRWK=
SK-MEL-28 NUH2ZVNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPYNpVKSzVyPUWuNlA{OTNizszN M1P1WnNCVkeHUh?=
CaR-1 MojyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\IN2FKSzVyPUWuNlA4OjZizszN MVPTRW5ITVJ?
MLMA MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO5TWM2OD13LkKzOFM3KM7:TR?= MVrTRW5ITVJ?
VM-CUB-1 M1TqS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTGTWM2OD13LkKzOFM6KM7:TR?= NHn6bYJUSU6JRWK=
KNS-42 M3yw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\adWlEPTB;NT6yOlE3KM7:TR?= NWP4Wo8xW0GQR1XS
TK10 NVnCVoNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXkZ4FKSzVyPUWuN|YxQDZizszN MVXTRW5ITVJ?
MEG-01 MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPZ[4JKSzVyPUWuN|YzPzRizszN NH:yOWJUSU6JRWK=
DEL MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\Jd2pKSzVyPUWuN|kxOjNizszN MY\TRW5ITVJ?
SJRH30 NXvLTJY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\KVWlEPTB;NT6zPVIyOyEQvF2= NFfQR5JUSU6JRWK=
SK-PN-DW NVLCOFFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknYTWM2OD13LkSzOVg6KM7:TR?= MmLyV2FPT0WU
TE-10 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTVwNES4PVMh|ryP NHrmUJlUSU6JRWK=
KNS-81-FD NH3XVFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTVwNUCwPVIh|ryP NUPzRW1SW0GQR1XS
BHY MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;zTWM2OD13LkWxNFch|ryP NX;HOG0xW0GQR1XS
KYSE-270 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLUN2dKSzVyPUWuOVM2OzZizszN NVvybnQ{W0GQR1XS
NCI-H650 M4r3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLqfYNKSzVyPUWuOVcyOTRizszN MkLNV2FPT0WU
L-363 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzvbnU4UUN3ME21MlY6PDd4IN88US=> MkD0V2FPT0WU
TCCSUP NFvCUmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPVTWM2OD13LkexO|c5KM7:TR?= MUPTRW5ITVJ?
SCH Mn6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[1NWlEPTB;NT63OFc3PyEQvF2= NFy2ZmlUSU6JRWK=
HTC-C3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjafGdmUUN3ME21Mlc4PjR2IN88US=> NEPxNZJUSU6JRWK=
J-RT3-T3-5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Xpd2lEPTB;NT64NFc6PCEQvF2= MU\TRW5ITVJ?
Hs-578-T NGTFcmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPnfYtKSzVyPUWuPFM3ODdizszN M2XTUXNCVkeHUh?=
M14 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;HTWM2OD13Lki2O|I3KM7:TR?= NF2wPG5USU6JRWK=
HT-144 Mn;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[ybFRKSzVyPUWuPFY5OzJizszN MkLqV2FPT0WU
CAL-54 MnqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT4TWM2OD13LkmzN|E1KM7:TR?= MUjTRW5ITVJ?
T47D MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTVwOU[xNkDPxE1? MYjTRW5ITVJ?
GB-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnzTWM2OD14LkCyNFY5KM7:TR?= NIDuOYxUSU6JRWK=
HSC-2 MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfW[WlKSzVyPU[uNVI{PTNizszN NVLOepdmW0GQR1XS
SiHa MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTZwMUSwPVch|ryP NXfxOFJTW0GQR1XS
OMC-1 MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTZwM{W0OFEh|ryP NUjZc3c{W0GQR1XS
HGC-27 MnrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP6TWM2OD14LkO1O|g3KM7:TR?= MXzTRW5ITVJ?
FTC-133 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHVTWM2OD14LkS2OVUyKM7:TR?= NHHLOGdUSU6JRWK=
KS-1 NXzWeXE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTZwNUKxOFch|ryP M1[ybXNCVkeHUh?=
HT-1080 MmfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\iemlEPTB;Nj61OFA1OiEQvF2= NEPadmtUSU6JRWK=
SKG-IIIa MojkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;w[2lEPTB;Nj61OlI3OyEQvF2= NVL2ToNjW0GQR1XS
OCUB-M Mk\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTZwNkC3O{DPxE1? MkTyV2FPT0WU
MDA-MB-175-VII NHm4[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjOWINKSzVyPU[uOlIxQSEQvF2= M{jUO3NCVkeHUh?=
BB30-HNC M4XCN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzpboVKSzVyPU[uOlc1PDRizszN MVPTRW5ITVJ?
D-542MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTqNXZRUUN3ME22Mlc{ODlizszN NX7pdnUzW0GQR1XS
NCI-H2405 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHm1TWpKSzVyPU[uO|Q5PTVizszN MmeyV2FPT0WU
SW1573 NFn2[mZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEWxW|lKSzVyPU[uO|g{OTlizszN NFrNcIhUSU6JRWK=
NCI-SNU-1 M4f0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi1Smx6UUN3ME22Mlc6ODJ{IN88US=> M4LFcHNCVkeHUh?=
RT-112 NXjVVIFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:1TWM2OD14Lke5OFY{KM7:TR?= NFH5clZUSU6JRWK=
COR-L88 Ml7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36ycWlEPTB;Nj63PVc6OSEQvF2= NXzOPGIzW0GQR1XS
SCC-9 M2roXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTZwOEK1OUDPxE1? NWLs[nROW0GQR1XS
U-87-MG MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\DTWM2OD14LkizPFI3KM7:TR?= M1OzOnNCVkeHUh?=
Detroit562 NEnCfZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXTfFNKSzVyPU[uPFU6QTFizszN M1nxZXNCVkeHUh?=
LC-2-ad MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTZwOE[yPVIh|ryP M2DEe3NCVkeHUh?=
IGROV-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HPUWlEPTB;Nj65NlU5OyEQvF2= M2qyZ3NCVkeHUh?=
OVCAR-8 NHPSfnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnCbWZiUUN3ME22Mlk1OjJ7IN88US=> M17OdnNCVkeHUh?=
SNU-387 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\tUZJLUUN3ME22Mlk6PTF4IN88US=> MlTKV2FPT0WU
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NCI-H1651 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHRV|ZHUUN3ME2yPU45PTB|IN88US=> MUjTRW5ITVJ?
OE33 NFPPNZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTNyLkGzOFIh|ryP MVTTRW5ITVJ?
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U-118-MG NI\vNGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorKTWM2OD1|Mj61OFQyKM7:TR?= MYTTRW5ITVJ?
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NCI-H1304 NIHsellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTN|Lk[wN|Yh|ryP NX3P[2ZlW0GQR1XS
LU-135 Mn;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTRTWM2OD1|Mz63NFg3KM7:TR?= MVvTRW5ITVJ?
S-117 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nzOGlEPTB;M{OuO|I5PiEQvF2= M2WyZ3NCVkeHUh?=
NCI-H1755 MkDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[yeIRWUUN3ME2zN{45OTFizszN MkfnV2FPT0WU
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SK-OV-3 NYrsbZY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP1TWM2OD1|Mz64PFU1KM7:TR?= NFXIWpJUSU6JRWK=
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COLO-680N MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDJTWM2OD1|ND6xN|k4KM7:TR?= NEm1W|RUSU6JRWK=
KURAMOCHI MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTN2Lk[0NlUh|ryP M4e2UnNCVkeHUh?=
NCI-H661 NHnBe2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjGfYVzUUN3ME2zOE45PDR6IN88US=> MUjTRW5ITVJ?
YAPC NFjFfHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS4SJFKSzVyPUO1Mlk2OzNizszN M2fKTnNCVkeHUh?=
NCI-H526 NGG3eoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofkTWM2OD1|Nz6yO|czKM7:TR?= NYX3S|d1W0GQR1XS
A498 NVjwcZhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHFdWhXUUN3ME2zPE4xQTV2IN88US=> NX61W2w3W0GQR1XS
VMRC-RCZ MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTN7LkCwOVQh|ryP NXvL[YJRW0GQR1XS
HCT-116 NUPhdIp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXsZmQyUUN3ME2zPU4xPThizszN M{\iSHNCVkeHUh?=
COLO-320-HSR MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTRyLkC0NUDPxE1? NWHNXI1[W0GQR1XS
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CP50-MEL-B NFv6e21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;VWGlEPTB;NEGuNFc6PyEQvF2= MV3TRW5ITVJ?
RMG-I MkfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTR{LkS5NlEh|ryP M13LcnNCVkeHUh?=
D-336MG M4nCbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTR|LkGxOVIh|ryP NYXiSZR7W0GQR1XS
SHP-77 NFPWWldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTR|LkG4Nlgh|ryP M2HmNXNCVkeHUh?=
SW872 NWG3W4hPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWr6cFBZUUN3ME20N{4zOTJ|IN88US=> MV\TRW5ITVJ?
DBTRG-05MG M1[2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XKW2lEPTB;NESuOlk6PiEQvF2= M13vcnNCVkeHUh?=
COLO-678 M2nsNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TNW2lEPTB;NEWuO|A{OiEQvF2= NV7HO4dXW0GQR1XS
EGI-1 M1j2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPZSmZiUUN3ME20O{4yQDN|IN88US=> NIDRU|ZUSU6JRWK=
KYSE-70 NUT1bZVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXBUWlKSzVyPUS3MlczOjJizszN MmXmV2FPT0WU
BALL-1 NYTFZYZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTR5LkiyOVQh|ryP NUT0fodZW0GQR1XS
MDA-MB-361 MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml34TWM2OD12OD6wOFYh|ryP MlXTV2FPT0WU
NCI-H1838 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTR6LkO0OVgh|ryP NX\QbVV2W0GQR1XS
NCI-H1573 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTR6Lk[3PFUh|ryP MVvTRW5ITVJ?
HCC1395 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTR6Lkm5NkDPxE1? NUDUUWI4W0GQR1XS
NCI-H2291 M1nER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PDTGlEPTB;NEmuOVk5QCEQvF2= MYrTRW5ITVJ?
RH-18 NHiw[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfqWmxKSzVyPUWwMlA5QDRizszN M3jqdXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    BI-D1870 (catalog No.S2843) is found as a racemic mixture?

  • Answer:

    Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID