BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

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4 Customer Reviews

  • Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

    Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

    (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

  • HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

    Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq0TWM2OD1yLkCzOVgh|ryP MkexV2FPT0WU
H9 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDvfW5KSzVyPUCuNFYxOTlizszN MmjBV2FPT0WU
KARPAS-45 NFTsRWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMU[1NlUh|ryP NGW3blFUSU6JRWK=
NCI-H720 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnwZ4RzUUN3ME2wMlE4OTl2IN88US=> MmnaV2FPT0WU
CTV-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwNEe4O|Ih|ryP MXrTRW5ITVJ?
DU-4475 M2rUemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwNUC0NVch|ryP NHrXc4hUSU6JRWK=
A172 MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvQO4V{UUN3ME2wMlUyPzB3IN88US=> M3TUbHNCVkeHUh?=
EW-18 M2ezN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwNkKyNVEh|ryP M1HHd3NCVkeHUh?=
KU812 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjNUmR[UUN3ME2wMlYzPjJ|IN88US=> M{OzSHNCVkeHUh?=
KP-N-YS MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT5TWM2OD1yLk[4NlI{KM7:TR?= M2DqdXNCVkeHUh?=
SBC-1 NEHLN29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwNkm1NlQh|ryP M1\UOnNCVkeHUh?=
ECC10 NH:2c2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIL1eFlKSzVyPUCuO|AxQTRizszN NV7mbVdUW0GQR1XS
GAMG MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LndmlEPTB;MD63OFcyPyEQvF2= M2GxfXNCVkeHUh?=
NCI-H209 NYTROXpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnkZW9qUUN3ME2wMlc3QDJizszN M{TIVXNCVkeHUh?=
MC-IXC NHfHOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TvWWlEPTB;MD63PVU5QSEQvF2= MX;TRW5ITVJ?
HSC-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFO3RVhKSzVyPUCuPFE4PjlizszN NEPQ[WRUSU6JRWK=
IST-SL1 NUTV[Xp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X2e2lEPTB;MD64OFU4PCEQvF2= NFzwc2NUSU6JRWK=
LU-139 NU\sXWluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrWTWM2OD1yLki0PVU5KM7:TR?= NVX6eo5vW0GQR1XS
ML-2 MlvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPk[2FmUUN3ME2wMlg2PTd3IN88US=> Mn;nV2FPT0WU
CAL-62 NXvFUoRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwOEixOVIh|ryP NVjNZ2lYW0GQR1XS
HL-60 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLvZnBOUUN3ME2wMlg5OzZ{IN88US=> NIeyb4pUSU6JRWK=
KY821 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLkW4ZKSzVyPUCuPFg5OTJizszN NYHBXoNOW0GQR1XS
ES7 NWDXOphbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vpSWlEPTB;MD65NVYxPyEQvF2= NWfzNVJlW0GQR1XS
MV-4-11 MmLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPKcHpKSzVyPUCuPVc5QTdizszN NHjPfm1USU6JRWK=
Daoy MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwOUi3Olch|ryP MYjTRW5ITVJ?
EoL-1-cell MmnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7XTWM2OD1zLkCxPFc5KM7:TR?= M2S2NXNCVkeHUh?=
TGW MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XHVWlEPTB;MT6wOVEzPCEQvF2= NHjkd2lUSU6JRWK=
LAMA-84 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfFTWM2OD1zLkGyO|k1KM7:TR?= MWfTRW5ITVJ?
KOSC-2 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NImwcGNKSzVyPUGuNVM{QDVizszN M3XrfnNCVkeHUh?=
A549 NH\LeFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT4WlZKSzVyPUGuN|A6PTVizszN NGnxNHlUSU6JRWK=
CTB-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfUTWM2OD1zLkS0Olc6KM7:TR?= Mn[1V2FPT0WU
NCI-H292 NVPlVWpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYC2VGxSUUN3ME2xMlQ3ODZ7IN88US=> M4P5SnNCVkeHUh?=
LoVo MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\UWIEyUUN3ME2xMlQ3PzV3IN88US=> M1fNVnNCVkeHUh?=
BFTC-905 NF7KSXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1r5fWlEPTB;MT61OlM{OiEQvF2= NFmzUllUSU6JRWK=
BE-13 M{K5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnFTWM2OD1zLkW4O|A6KM7:TR?= NWTybXdYW0GQR1XS
KE-37 NYW4eVE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjzW4JKSzVyPUGuOVk1PzhizszN NUj2PIlkW0GQR1XS
HN MmC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;RTWM2OD1zLk[xN|Y5KM7:TR?= M3vtdnNCVkeHUh?=
A3-KAW M2[0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PKcWlEPTB;MT62Nlg{PCEQvF2= NU\MXlREW0GQR1XS
NEC8 Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PX[2lEPTB;MT63NFEyPSEQvF2= MXrTRW5ITVJ?
Ramos-2G6-4C10 NVXSTo1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoT6TWM2OD1zLkewOFQ1KM7:TR?= MnfFV2FPT0WU
NB10 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrqTWM2OD1zLke3OlMh|ryP MX\TRW5ITVJ?
NBsusSR MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLpTWM2OD1zLkiyPVYyKM7:TR?= MXnTRW5ITVJ?
ES4 M4nucmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LVVmlEPTB;MT64OVE1OyEQvF2= M2Gw[XNCVkeHUh?=
ES8 NV7tT29qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP1TWM2OD1zLki3O|I1KM7:TR?= M{\lSHNCVkeHUh?=
CHL-1 NXS5NHBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTFwOUW3PVIh|ryP NWfmPJlnW0GQR1XS
NCI-H2029 M{TyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7GOWwxUUN3ME2xMlk4OjRzIN88US=> M4fFcnNCVkeHUh?=
YKG-1 NF3KPGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HVWWlEPTB;MT65PFQ{OiEQvF2= M{\LbnNCVkeHUh?=
BV-173 MlX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjKfmdQUUN3ME2xMlk5PjZ4IN88US=> NYezWZJ4W0GQR1XS
697 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfqXpJKSzVyPUKuNFIzOjhizszN MUfTRW5ITVJ?
SK-NEP-1 NFu2d3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVP6emE5UUN3ME2yMlA1PCEQvF2= MUTTRW5ITVJ?
LOXIMVI MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv6eFNJUUN3ME2yMlA1PDN2IN88US=> NVrTPJNVW0GQR1XS
QIMR-WIL M{PFZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJwMEe4OFkh|ryP MYfTRW5ITVJ?
DU-145 NYnlVIdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof1TWM2OD1{LkGxNFU3KM7:TR?= NGPGeHpUSU6JRWK=
NB14 MnzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJwMUGzNlEh|ryP NXryPW5ZW0GQR1XS
G-361 NWqxfo1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13DSWlEPTB;Mj6xNlIyKM7:TR?= NV3pU2hSW0GQR1XS
BPH-1 NYXyWZJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJwMUK5OVch|ryP MV7TRW5ITVJ?
KYSE-150 MoTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly4TWM2OD1{LkG1NlM1KM7:TR?= NFXLbnJUSU6JRWK=
HMV-II MnOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVy3U2ZMUUN3ME2yMlE3PjN|IN88US=> MVXTRW5ITVJ?
TE-9 NXHTWmdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkK5TWM2OD1{LkG3N|c3KM7:TR?= MXTTRW5ITVJ?
8-MG-BA NY\j[pNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HQR2lEPTB;Mj6yN|Q3OSEQvF2= NHPCN4NUSU6JRWK=
ES5 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJwMkO2N|Mh|ryP NYizT|BVW0GQR1XS
D-283MED MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXP[HFzUUN3ME2yMlI{Pjl3IN88US=> NG\5UIdUSU6JRWK=
SK-N-AS MoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDsTWM2OD1{LkK5NFU6KM7:TR?= MVfTRW5ITVJ?
SW1710 Ml7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILQSmZKSzVyPUKuN|A3PjFizszN M{H2[nNCVkeHUh?=
GCT NVf2WlYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTmTWM2OD1{LkOxN|U5KM7:TR?= MnvyV2FPT0WU
AGS NXe0WGgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjzNZBKSzVyPUKuN|Q1ODRizszN NFO1c2FUSU6JRWK=
HuO9 M2jjVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TrcmlEPTB;Mj6zOlgzPCEQvF2= MlzCV2FPT0WU
MN-60 M3XkZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO0XYRKSzVyPUKuOFQ5QDNizszN Mn;6V2FPT0WU
NB6 M2PERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvBTWM2OD1{LkS1O|c6KM7:TR?= MlztV2FPT0WU
NCI-H1395 NIHvS5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\iUmlKSzVyPUKuOFcyOjFizszN M3rXeHNCVkeHUh?=
H4 M2j6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r3SmlEPTB;Mj60PFM6OyEQvF2= M3exZnNCVkeHUh?=
HT-3 NHPFdXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTmVFZNUUN3ME2yMlUyODJ2IN88US=> NIjGUm5USU6JRWK=
P12-ICHIKAWA MnTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJwNUK1OVkh|ryP MlewV2FPT0WU
COLO-800 MnjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnFNoEyUUN3ME2yMlU1OTZ4IN88US=> MYPTRW5ITVJ?
DB MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr0TWM2OD1{LkW1NFE{KM7:TR?= NXHNN|ZYW0GQR1XS
LCLC-97TM1 M1u2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETFOWNKSzVyPUKuOlAxOjhizszN NG\XTIpUSU6JRWK=
Ca9-22 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfnTWM2OD1{Lk[1PVM{KM7:TR?= M1ywSnNCVkeHUh?=
Becker Mk[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXMWWNKSzVyPUKuOlYxPzhizszN MYjTRW5ITVJ?
ACN MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofiTWM2OD1{Lk[2O|kh|ryP NIDt[YpUSU6JRWK=
SJSA-1 NG\Yd|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJwNk[4O{DPxE1? MmrkV2FPT0WU
NCI-H1048 NWXCS4tTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r6U2lEPTB;Mj62PFMzOSEQvF2= Ml3NV2FPT0WU
HEL NVjkR3VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPjTWM2OD1{LkewNlU1KM7:TR?= MWHTRW5ITVJ?
NCI-H69 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTiTWM2OD1{LkexOlAyKM7:TR?= M3m0VnNCVkeHUh?=
639-V NInOW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HsWmlEPTB;Mj63NVcxOyEQvF2= M{P2SnNCVkeHUh?=
U251 M1nDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fxc2lEPTB;Mj63N|A{OiEQvF2= Mn3CV2FPT0WU
NCI-H1792 NIjOVZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJwN{O3N|gh|ryP NITYfIxUSU6JRWK=
EW-1 M{HqZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUP2NGVjUUN3ME2yMlc2OzJ6IN88US=> MkDEV2FPT0WU
ME-180 Ml\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P1W2lEPTB;Mj63O|c{PiEQvF2= MlGyV2FPT0WU
HH NG\UTG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvKTWM2OD1{LkiwNFAyKM7:TR?= NVzGXZpmW0GQR1XS
SW954 M{XpWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHwT5p3UUN3ME2yMlg2QDNizszN NGL1XphUSU6JRWK=
SF268 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:4WoVrUUN3ME2yMlg4OjJ3IN88US=> M{\M[XNCVkeHUh?=
D-566MG NEP1SodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XtOmlEPTB;Mj65NVI6PSEQvF2= M2\tcXNCVkeHUh?=
EM-2 MmLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;h[mlEPTB;Mj65NlE6OyEQvF2= NGrF[YNUSU6JRWK=
NCI-H1299 M{[3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPYXGNKSzVyPUKuPVM4OzZizszN M{PWenNCVkeHUh?=
PSN1 M174cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzSTWM2OD1|LkC1O|g3KM7:TR?= NYO3eZZrW0GQR1XS
JVM-3 NETXdVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnnUYlvUUN3ME2zMlA3PzV4IN88US=> NWLQR3pWW0GQR1XS
D-502MG NVLLdGs3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv2O|lVUUN3ME2zMlA4ODF7IN88US=> NF\YbVFUSU6JRWK=
SCC-4 M1jhXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vRO2lEPTB;Mz6wPVI4PiEQvF2= M1T6dHNCVkeHUh?=
GMS-10 MlTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHYeoVKSzVyPUOuNFk{QDhizszN NUPXc3R2W0GQR1XS
A427 NYX0V4ZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDZfmYxUUN3ME2zMlExQDd|IN88US=> NV34NHdIW0GQR1XS
NH-12 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTNwMUG0OVYh|ryP M4PN[HNCVkeHUh?=
KM12 NWLYUIF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fIe2lEPTB;Mz6xNlI4OyEQvF2= M4nlcXNCVkeHUh?=
GI-1 NWW1So9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7rNZROUUN3ME2zMlE2OjV3IN88US=> NUH5SnJ3W0GQR1XS
TE-8 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHVO4xKSzVyPUOuNVkzOzFizszN NYXKTZhxW0GQR1XS
MKN1 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTNwMkC4O|Uh|ryP M4TXTHNCVkeHUh?=
NCI-H810 NYrOZ5BPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fpOGlEPTB;Mz6yNlE2PSEQvF2= MYDTRW5ITVJ?
GOTO M1vXcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\zPHNKSzVyPUOuNlgxODRizszN M1Ll[XNCVkeHUh?=
T98G M1fFRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTNwMkiyNVYh|ryP NF3LOWZUSU6JRWK=
HD-MY-Z MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\FPWlEPTB;Mz6zOlU1OiEQvF2= NXq2flZYW0GQR1XS
SNU-C2B NGK5c|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTNwM{mwPVch|ryP MWPTRW5ITVJ?
MOLT-4 NHO3flNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3FTWM2OD1|LkO5NFk5KM7:TR?= M2O4OnNCVkeHUh?=
RPMI-7951 NYPMPZlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DX[2lEPTB;Mz6zPVc{KM7:TR?= NXvvPIFEW0GQR1XS
EW-11 MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYL5UnNQUUN3ME2zMlQyOjJ2IN88US=> NVS1eG9PW0GQR1XS
RD MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zyWWlEPTB;Mz60N|E{OiEQvF2= MVLTRW5ITVJ?
SW48 NVPHTWNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\aNnhKSzVyPUOuOFM{PThizszN MXXTRW5ITVJ?
BB65-RCC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzCbY4xUUN3ME2zMlQ2Ozl4IN88US=> NX;DW|JkW0GQR1XS
Ca-Ski Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTzUFlRUUN3ME2zMlQ4PTF2IN88US=> NVu0TJJpW0GQR1XS
CHP-134 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ezVmlEPTB;Mz60PFc2QCEQvF2= NFv0WGNUSU6JRWK=
CAL-33 M3qxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr3bmFKSzVyPUOuOVM{PjJizszN NEH0b5VUSU6JRWK=
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LB831-BLC NYXh[5VvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTNwNUSwNVYh|ryP NFjpcXRUSU6JRWK=
KU-19-19 NWG4T2poT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTsUldkUUN3ME2zMlYxOzB2IN88US=> MYHTRW5ITVJ?
KG-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTNwNkGxNFYh|ryP NIjmZ3VUSU6JRWK=
COLO-829 NWS1fXVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDSNYRoUUN3ME2zMlY3PjF6IN88US=> MkfXV2FPT0WU
HUTU-80 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\uSpB[UUN3ME2zMlY3PjJzIN88US=> NXviTZJ6W0GQR1XS
NCI-H446 NIrOOXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vxXmlEPTB;Mz62PFM1KM7:TR?= NXL2RYg{W0GQR1XS
LB2241-RCC NH\zfHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH0VWhKSzVyPUOuOlg3OjVizszN M1XFVnNCVkeHUh?=
JEG-3 NWDkV|R6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3qb45wUUN3ME2zMlY6OTlizszN NETlW2FUSU6JRWK=
LNCaP-Clone-FGC M4HIU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjWbWxiUUN3ME2zMlcxODRzIN88US=> NGnRPVZUSU6JRWK=
M059J MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2i0NGlEPTB;Mz63NVQ3QCEQvF2= NFHK[IZUSU6JRWK=
SK-MES-1 M3;RNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;0RmlEPTB;Mz63N|A{KM7:TR?= M3zETHNCVkeHUh?=
GT3TKB NHe4SIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPCc|NKSzVyPUOuO|U3ODRizszN MV3TRW5ITVJ?
DOK MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnxS45iUUN3ME2zMlc3PTJ4IN88US=> Mk\xV2FPT0WU
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MZ1-PC NV;Kc5BKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjsTWM2OD1|LkiyPFg{KM7:TR?= NGrDU2dUSU6JRWK=
8305C NHnDOYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonuTWM2OD1|Lki4PVQ{KM7:TR?= M2\GXXNCVkeHUh?=
CGTH-W-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LwW2lEPTB;Mz65N|UxPCEQvF2= NF7oRllUSU6JRWK=
LU-134-A MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTNwOUW0NlIh|ryP NWfTZVNtW0GQR1XS
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MOLT-13 NX:1T2dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnidVJPUUN3ME2zMlk3QDV4IN88US=> M1jiPXNCVkeHUh?=
A375 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXle2hKSzVyPUSuNFUyPjJizszN MnfkV2FPT0WU
CAL-12T MmrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTRwMEW3PVUh|ryP M{fxPHNCVkeHUh?=
IGR-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHjO4E5UUN3ME20MlExOjd2IN88US=> Ml3YV2FPT0WU
LB1047-RCC NEDnepZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTRwMUC0OFEh|ryP M1T2[HNCVkeHUh?=
BHT-101 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4K1emlEPTB;ND6xNFY5OyEQvF2= M1zkWnNCVkeHUh?=
A431 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXhTWM2OD12LkG0NFgyKM7:TR?= MWXTRW5ITVJ?
EPLC-272H M1TIR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTRwMUe1PVYh|ryP Ml3pV2FPT0WU
HT-1376 M2Lp[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P5eWlEPTB;ND6yN|A2QSEQvF2= MmrlV2FPT0WU
HCC1954 NWjjVpROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXRNIJQUUN3ME20MlI2PzR4IN88US=> NUTXcIZHW0GQR1XS
KYSE-510 NFfuNmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF6wbmpKSzVyPUSuNlYxQSEQvF2= NF3JU3hUSU6JRWK=
PANC-03-27 NFnNcYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPRdmxKSzVyPUSuN|AxQDNizszN NIroN45USU6JRWK=
MDA-MB-157 NV:5NVZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HTbGlEPTB;ND6zNFY2PiEQvF2= MXzTRW5ITVJ?
HOP-62 M2\ndGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTRwM{C4OVYh|ryP NF3iXoVUSU6JRWK=
ETK-1 NXTsZ2twT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLETlExUUN3ME20MlM3OjB|IN88US=> NXPzWY5oW0GQR1XS
MIA-PaCa-2 NWHRc2x5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTkVGNKSzVyPUSuN|YzOjdizszN Mk\jV2FPT0WU
MHH-PREB-1 M3[zOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrvb4FKSzVyPUSuN|k4PzNizszN NH;ORZBUSU6JRWK=
LXF-289 NFPOXGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTRwNECyNFIh|ryP M1vaXnNCVkeHUh?=
ATN-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTQWWtKSzVyPUSuOFI{PDFizszN M17UeHNCVkeHUh?=
8505C NHqyWFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;qbYh4UUN3ME20MlQ2QDJ3IN88US=> Ml;LV2FPT0WU
HOS MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nRXWlEPTB;ND60OlQ2OyEQvF2= M1;iO3NCVkeHUh?=
U-266 M2rsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTwWXE3UUN3ME20MlYyODN{IN88US=> NWLqPYl2W0GQR1XS
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GCIY NH;HT2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HUWmlEPTB;ND63NVAyPSEQvF2= NXOyTZJZW0GQR1XS
MDA-MB-231 MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PMUGlEPTB;ND63NlEyPSEQvF2= NVj2blZSW0GQR1XS
RKO Mn7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrVblBVUUN3ME20MlczQDF5IN88US=> MY\TRW5ITVJ?
COR-L23 NVTocYhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUT4PGlkUUN3ME20Mlc1OjV4IN88US=> MW\TRW5ITVJ?
DJM-1 M{mzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPrN3RbUUN3ME20Mlc6PzJ7IN88US=> MVXTRW5ITVJ?
D-423MG M4LXVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTRwOEC4NFMh|ryP NGXEUXlUSU6JRWK=
DMS-114 MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjtTop[UUN3ME20MlgyOzh4IN88US=> MlH1V2FPT0WU
MHH-ES-1 MnzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHXdmxKSzVyPUSuPFI2ODRizszN MnrQV2FPT0WU
CAL-51 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[2TWM2OD12Lki2PFQ{KM7:TR?= NFGzVnNUSU6JRWK=
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NCI-H1437 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHPTWM2OD12LkmyPVMh|ryP M1XPZ3NCVkeHUh?=
CAL-39 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTRwOUO5PFgh|ryP MonPV2FPT0WU
PC-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUK5OlF3UUN3ME20Mlk1PjR6IN88US=> MYXTRW5ITVJ?
A101D M{fWOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TPZ2lEPTB;ND65Olg3PSEQvF2= NVPmc2d7W0GQR1XS
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KP-N-YN MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHERW1KSzVyPUWuNFU3PyEQvF2= MYTTRW5ITVJ?
EFO-27 Mm\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTVwME[zNlkh|ryP M3XtbHNCVkeHUh?=
BT-549 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjETWM2OD13LkC3O|M3KM7:TR?= MXHTRW5ITVJ?
HLE NVzCepdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\sbHdFUUN3ME21MlEyPzN2IN88US=> M4XiUnNCVkeHUh?=
SW982 MknXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVG2RYt[UUN3ME21MlE{Ozd2IN88US=> NEP0U3lUSU6JRWK=
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SK-MEL-28 Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTVwMkCzNVMh|ryP MVLTRW5ITVJ?
CaR-1 NHXNNHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPRTWM2OD13LkKwO|I3KM7:TR?= NXnCeGt4W0GQR1XS
MLMA MmnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fQe2lEPTB;NT6yN|Q{PiEQvF2= M{i4fnNCVkeHUh?=
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KNS-42 M2nnOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1yyU2lEPTB;NT6yOlE3KM7:TR?= MkLYV2FPT0WU
TK10 NY\SeplIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTVwM{[wPFYh|ryP MX\TRW5ITVJ?
MEG-01 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTFemVKSzVyPUWuN|YzPzRizszN MUXTRW5ITVJ?
DEL M4O5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTVwM{mwNlMh|ryP NXix[Gk3W0GQR1XS
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SK-PN-DW MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPrZY9LUUN3ME21MlQ{PTh7IN88US=> M2PlNHNCVkeHUh?=
TE-10 NH\3WIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTVwNES4PVMh|ryP M4SwfXNCVkeHUh?=
KNS-81-FD NI\TcZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LpV2lEPTB;NT61NFA6OiEQvF2= MlnZV2FPT0WU
BHY MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLhTWM2OD13LkWxNFch|ryP MVHTRW5ITVJ?
KYSE-270 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTVwNUO1N|Yh|ryP NXLBWFJ7W0GQR1XS
NCI-H650 MoSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH60UW9KSzVyPUWuOVcyOTRizszN NFvyWoNUSU6JRWK=
L-363 NEDTVJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;TZpdnUUN3ME21MlY6PDd4IN88US=> MV7TRW5ITVJ?
TCCSUP MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTVwN{G3O|gh|ryP MU\TRW5ITVJ?
SCH Ml;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInMPGNKSzVyPUWuO|Q4PjdizszN Mln5V2FPT0WU
HTC-C3 NH;IRVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTVwN{e2OFQh|ryP MnfvV2FPT0WU
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M14 M3r4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH0cWhvUUN3ME21Mlg3PzJ4IN88US=> MlLtV2FPT0WU
HT-144 M4CzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPTfohKSzVyPUWuPFY5OzJizszN MY\TRW5ITVJ?
CAL-54 NVP6VVRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\CWGlEPTB;NT65N|MyPCEQvF2= NIfsXpJUSU6JRWK=
T47D MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLMTWM2OD13Lkm2NVIh|ryP NHzKTGdUSU6JRWK=
GB-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTZwMEKwOlgh|ryP NIPYZXhUSU6JRWK=
HSC-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnP2TWM2OD14LkGyN|U{KM7:TR?= MmH3V2FPT0WU
SiHa MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7hXow1UUN3ME22MlE1ODl5IN88US=> NXe5bHNzW0GQR1XS
OMC-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfzWFE6UUN3ME22MlM2PDRzIN88US=> NVmyNYhTW0GQR1XS
HGC-27 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XwXmlEPTB;Nj6zOVc5PiEQvF2= NVLxZo55W0GQR1XS
FTC-133 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXFTWM2OD14LkS2OVUyKM7:TR?= NIDIT3ZUSU6JRWK=
KS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUSxNFlPUUN3ME22MlUzOTR5IN88US=> NELZWGFUSU6JRWK=
HT-1080 NHXqXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:4fo1KSzVyPU[uOVQxPDJizszN NVzCXVdvW0GQR1XS
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OCUB-M MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTDRY1KSzVyPU[uOlA4PyEQvF2= MVvTRW5ITVJ?
MDA-MB-175-VII MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX60WmRpUUN3ME22MlYzODlizszN M1O3PHNCVkeHUh?=
BB30-HNC Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTZwNke0OFQh|ryP Mm\PV2FPT0WU
D-542MG M4\oTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn2xTWM2OD14LkezNFkh|ryP MkHtV2FPT0WU
NCI-H2405 NEjDN41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TDZ2lEPTB;Nj63OFg2PSEQvF2= M3Oyb3NCVkeHUh?=
SW1573 Ml3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnDTI82UUN3ME22Mlc5OzF7IN88US=> NHjGVJBUSU6JRWK=
NCI-SNU-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrSZZZFUUN3ME22Mlc6ODJ{IN88US=> M4CxeXNCVkeHUh?=
RT-112 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTXe5c3UUN3ME22Mlc6PDZ|IN88US=> NYTNTFJnW0GQR1XS
COR-L88 NFvlfG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfIb3ZnUUN3ME22Mlc6PzlzIN88US=> Ml3kV2FPT0WU
SCC-9 NV7lT3ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr3NFdKSzVyPU[uPFI2PSEQvF2= NFmweW5USU6JRWK=
U-87-MG M{\2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\iTWM2OD14LkizPFI3KM7:TR?= MoTiV2FPT0WU
Detroit562 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTZwOEW5PVEh|ryP Mn3OV2FPT0WU
LC-2-ad NGfi[pBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTZwOE[yPVIh|ryP M3uy[3NCVkeHUh?=
IGROV-1 NH3ZNJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr4XYRKSzVyPU[uPVI2QDNizszN NV7xWVFMW0GQR1XS
OVCAR-8 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrRTWM2OD14Lkm0NlI6KM7:TR?= MXfTRW5ITVJ?
SNU-387 M{joSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUKzSYlVUUN3ME22Mlk6PTF4IN88US=> MWLTRW5ITVJ?
TGBC1TKB MkPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF31c2VKSzVyPUeuNVUzPzdizszN MoLVV2FPT0WU
NOS-1 M{jlPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTdwMkC0NVUh|ryP MY\TRW5ITVJ?
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OVCAR-4 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTdwNUWyOkDPxE1? M3yw[HNCVkeHUh?=
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NCI-H2087 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRThwM{[xOVgh|ryP MW\TRW5ITVJ?
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TI-73 M3zDVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H2[2lEPTB;OT6wN|Q6PiEQvF2= NGrLRnpUSU6JRWK=
ES3 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTlwMEWxOVYh|ryP M3HCdnNCVkeHUh?=
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NCI-H2452 M17FSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT5TWM2OD1zMT6zPVI4KM7:TR?= MXLTRW5ITVJ?
NCI-H1648 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjQcZg5UUN3ME2xNU41PjJ7IN88US=> NEHl[VJUSU6JRWK=
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... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    BI-D1870 (catalog No.S2843) is found as a racemic mixture?

  • Answer:

    Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID