BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

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4 Customer Reviews

  • Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

    Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

    (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

  • HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

    Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 NELR[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLMTWM2OD1yLkCzOVgh|ryP NGfPPJpUSU6JRWK=
H9 NWL5U217T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkT5TWM2OD1yLkC2NFE6KM7:TR?= NFHENWJUSU6JRWK=
KARPAS-45 MnL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjuWoZ7UUN3ME2wMlE3PTJ3IN88US=> MW\TRW5ITVJ?
NCI-H720 NF3Bd3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLrSHhKSzVyPUCuNVcyQTRizszN NFPtUWJUSU6JRWK=
CTV-1 M4P1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELSZ5ZKSzVyPUCuOFc5PzJizszN NYrUfGhXW0GQR1XS
DU-4475 Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj4TWM2OD1yLkWwOFE4KM7:TR?= NGe2fGdUSU6JRWK=
A172 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwNUG3NFUh|ryP MYrTRW5ITVJ?
EW-18 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3z0O2lEPTB;MD62NlIyOSEQvF2= NYXLdWREW0GQR1XS
KU812 Ml\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHaRYhKSzVyPUCuOlI3OjNizszN M2DDTHNCVkeHUh?=
KP-N-YS NWXMT3VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;3fXdKSzVyPUCuOlgzOjNizszN NUfwfVRMW0GQR1XS
SBC-1 MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDORW1TUUN3ME2wMlY6PTJ2IN88US=> NVX1SGFMW0GQR1XS
ECC10 MkP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HvVGlEPTB;MD63NFA6PCEQvF2= MlrJV2FPT0WU
GAMG NHn6XmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LTemlEPTB;MD63OFcyPyEQvF2= M1LVZnNCVkeHUh?=
NCI-H209 M{\aS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDuXlV3UUN3ME2wMlc3QDJizszN NXXibXpmW0GQR1XS
MC-IXC M{TITmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnqTWM2OD1yLke5OVg6KM7:TR?= NVO4Omw3W0GQR1XS
HSC-3 NEX2XZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwOEG3Olkh|ryP NV:yZ5p{W0GQR1XS
IST-SL1 NInRdFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHGwfFZKSzVyPUCuPFQ2PzRizszN NV;4OlUyW0GQR1XS
LU-139 NG\CVVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrWfGRKSzVyPUCuPFQ6PThizszN NYPRR|BWW0GQR1XS
ML-2 Ml[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK2TWM2OD1yLki1OVc2KM7:TR?= MV\TRW5ITVJ?
CAL-62 Mk\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\WSGlEPTB;MD64PFE2OiEQvF2= M2fSUHNCVkeHUh?=
HL-60 NFvZRW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwOEizOlIh|ryP MmXyV2FPT0WU
KY821 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7DTWM2OD1yLki4PFEzKM7:TR?= MYPTRW5ITVJ?
ES7 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7IW3JmUUN3ME2wMlkyPjB5IN88US=> MVrTRW5ITVJ?
MV-4-11 NWewe4x6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILBb|JKSzVyPUCuPVc5QTdizszN NHzRW5JUSU6JRWK=
Daoy M1fFb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwOUi3Olch|ryP NV3TTGRtW0GQR1XS
EoL-1-cell NILQc49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHHVZJPUUN3ME2xMlAyQDd6IN88US=> NF75OpVUSU6JRWK=
TGW NIjp[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknoTWM2OD1zLkC1NVI1KM7:TR?= Mn2xV2FPT0WU
LAMA-84 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwMUK3PVQh|ryP MX\TRW5ITVJ?
KOSC-2 NX;PTJRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\YOGlEPTB;MT6xN|M5PSEQvF2= Mn\aV2FPT0WU
A549 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TreWlEPTB;MT6zNFk2PSEQvF2= M{fsenNCVkeHUh?=
CTB-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Dv[2lEPTB;MT60OFY4QSEQvF2= MkjOV2FPT0WU
NCI-H292 M4fOfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTFwNE[wOlkh|ryP NHTYbppUSU6JRWK=
LoVo MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX32RWFlUUN3ME2xMlQ3PzV3IN88US=> MorpV2FPT0WU
BFTC-905 NWLSfFFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K1eWlEPTB;MT61OlM{OiEQvF2= MnXXV2FPT0WU
BE-13 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rTW2lEPTB;MT61PFcxQSEQvF2= MnPZV2FPT0WU
KE-37 MkXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLRTWM2OD1zLkW5OFc5KM7:TR?= MVLTRW5ITVJ?
HN NHHMeplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXX[nRWUUN3ME2xMlYyOzZ6IN88US=> MkP5V2FPT0WU
A3-KAW NEDpWJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;EOWlEPTB;MT62Nlg{PCEQvF2= M{\yVHNCVkeHUh?=
NEC8 NXfuellET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvzc5dZUUN3ME2xMlcxOTF3IN88US=> MV;TRW5ITVJ?
Ramos-2G6-4C10 MoC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXVVZNCUUN3ME2xMlcxPDR2IN88US=> NYCzelV3W0GQR1XS
NB10 NWHWeIJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDnTWM2OD1zLke3OlMh|ryP NFP4TpJUSU6JRWK=
NBsusSR MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jpUmlEPTB;MT64Nlk3OSEQvF2= M4W1NXNCVkeHUh?=
ES4 M4LQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLFTWM2OD1zLki1NVQ{KM7:TR?= MkLWV2FPT0WU
ES8 MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTFwOEe3NlQh|ryP MVfTRW5ITVJ?
CHL-1 NEm4ZYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXzTWM2OD1zLkm1O|kzKM7:TR?= NUDZZ5prW0GQR1XS
NCI-H2029 MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnwSnpKSzVyPUGuPVczPDFizszN MWLTRW5ITVJ?
YKG-1 MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES2TmxKSzVyPUGuPVg1OzJizszN MXfTRW5ITVJ?
BV-173 NH\DR3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP1bnlKSzVyPUGuPVg3PjZizszN MYXTRW5ITVJ?
697 NWf4Uno2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1yxdGlEPTB;Mj6wNlIzQCEQvF2= MYDTRW5ITVJ?
SK-NEP-1 M3Lm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHzTWM2OD1{LkC0OEDPxE1? NFLpVGtUSU6JRWK=
LOXIMVI MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm2TWM2OD1{LkC0OFM1KM7:TR?= MoPWV2FPT0WU
QIMR-WIL NEK5bWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYP3N4lpUUN3ME2yMlA4QDR7IN88US=> MWDTRW5ITVJ?
DU-145 M2XMZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3l[mNRUUN3ME2yMlEyODV4IN88US=> MXzTRW5ITVJ?
NB14 M2ruPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3vTGtKSzVyPUKuNVE{OjFizszN MXrTRW5ITVJ?
G-361 MlTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJwMUKyNUDPxE1? NXHzbVBuW0GQR1XS
BPH-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vXPWlEPTB;Mj6xNlk2PyEQvF2= NV;ScW1UW0GQR1XS
KYSE-150 Mn3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Kz[WlEPTB;Mj6xOVI{PCEQvF2= NGLHclZUSU6JRWK=
HMV-II NW\jSm06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfBTWM2OD1{LkG2OlM{KM7:TR?= NXnoT3lvW0GQR1XS
TE-9 M2LUNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W1UWlEPTB;Mj6xO|M4PiEQvF2= NGrqO4JUSU6JRWK=
8-MG-BA M3PsXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPZTWM2OD1{LkKzOFYyKM7:TR?= NG\kWFJUSU6JRWK=
ES5 NXrU[HhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX24TmlnUUN3ME2yMlI{PjN|IN88US=> MWTTRW5ITVJ?
D-283MED MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Ow[mlEPTB;Mj6yN|Y6PSEQvF2= MV\TRW5ITVJ?
SK-N-AS NFvqRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjuVVBKSzVyPUKuNlkxPTlizszN MVzTRW5ITVJ?
SW1710 NV;OeVBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJwM{C2OlEh|ryP NXzKfGRHW0GQR1XS
GCT NFrLVJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml76TWM2OD1{LkOxN|U5KM7:TR?= MmPQV2FPT0WU
AGS NUexUpppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXaTWM2OD1{LkO0OFA1KM7:TR?= NF[yOW9USU6JRWK=
HuO9 NV\KRWFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPjR5ZKSzVyPUKuN|Y5OjRizszN NWX6UFZLW0GQR1XS
MN-60 MmjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\qWmdKSzVyPUKuOFQ5QDNizszN MYjTRW5ITVJ?
NB6 NWnRPWZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfRTWM2OD1{LkS1O|c6KM7:TR?= MUTTRW5ITVJ?
NCI-H1395 M3m3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDGdVNKSzVyPUKuOFcyOjFizszN MYjTRW5ITVJ?
H4 NVLT[HZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTJwNEizPVMh|ryP NGr2SlJUSU6JRWK=
HT-3 NWHIVYdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rvUGlEPTB;Mj61NVAzPCEQvF2= MmezV2FPT0WU
P12-ICHIKAWA NFnVcXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJwNUK1OVkh|ryP NHO3PGhUSU6JRWK=
COLO-800 NEHBOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TiTWlEPTB;Mj61OFE3PiEQvF2= NXHaTGk6W0GQR1XS
DB M1W4Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XtU2lEPTB;Mj61OVAyOyEQvF2= MWPTRW5ITVJ?
LCLC-97TM1 NHPEbIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn24TWM2OD1{Lk[wNFI5KM7:TR?= MlK2V2FPT0WU
Ca9-22 NUXwcWNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJwNkW5N|Mh|ryP MkDYV2FPT0WU
Becker NXO4UGNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfyZ|NWUUN3ME2yMlY3ODd6IN88US=> M1r3fnNCVkeHUh?=
ACN MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJwNk[3PUDPxE1? MYLTRW5ITVJ?
SJSA-1 MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJwNk[4O{DPxE1? M4nHW3NCVkeHUh?=
NCI-H1048 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LH[mlEPTB;Mj62PFMzOSEQvF2= MoGzV2FPT0WU
HEL NGXFNYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7vb21KSzVyPUKuO|AzPTRizszN NEPwVW9USU6JRWK=
NCI-H69 M1jhemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV2zUG9sUUN3ME2yMlcyPjBzIN88US=> M4LZPHNCVkeHUh?=
639-V NInPZWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\yTWM2OD1{LkexO|A{KM7:TR?= M{jXd3NCVkeHUh?=
U251 MlG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUW5PWQ1UUN3ME2yMlc{ODN{IN88US=> M3roO3NCVkeHUh?=
NCI-H1792 MoXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWn4ZmxxUUN3ME2yMlc{PzN6IN88US=> NXvYUpdmW0GQR1XS
EW-1 M1HTbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnVWJVRUUN3ME2yMlc2OzJ6IN88US=> MnrjV2FPT0WU
ME-180 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LBeWlEPTB;Mj63O|c{PiEQvF2= NH:2U3VUSU6JRWK=
HH MnTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWWwcGxzUUN3ME2yMlgxODBzIN88US=> NYSyPI5jW0GQR1XS
SW954 M1zDWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLGXHlOUUN3ME2yMlg2QDNizszN MYDTRW5ITVJ?
SF268 MlzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHYTWM2OD1{Lki3NlI2KM7:TR?= Mo\DV2FPT0WU
D-566MG MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHVTWM2OD1{LkmxNlk2KM7:TR?= NFL1dXRUSU6JRWK=
EM-2 Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJwOUKxPVMh|ryP M1T4V3NCVkeHUh?=
NCI-H1299 MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHqeYhUUUN3ME2yMlk{PzN4IN88US=> NWS5[FFsW0GQR1XS
PSN1 NF3iNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFO1TmRKSzVyPUOuNFU4QDZizszN MXzTRW5ITVJ?
JVM-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTNwME[3OVYh|ryP MoTlV2FPT0WU
D-502MG MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTWTmxGUUN3ME2zMlA4ODF7IN88US=> NH\QRmNUSU6JRWK=
SCC-4 M17tR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETNO2NKSzVyPUOuNFkzPzZizszN NEDtNohUSU6JRWK=
GMS-10 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jjSmlEPTB;Mz6wPVM5QCEQvF2= M3HxSnNCVkeHUh?=
A427 NHO5fJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIWxPVNKSzVyPUOuNVA5PzNizszN M3vXd3NCVkeHUh?=
NH-12 MmrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjkXFlKSzVyPUOuNVE1PTZizszN NYHGXm9uW0GQR1XS
KM12 M3vHdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTNwMUKyO|Mh|ryP MVjTRW5ITVJ?
GI-1 M{\KO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jMR2lEPTB;Mz6xOVI2PSEQvF2= NYrVUXlQW0GQR1XS
TE-8 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELXdnZKSzVyPUOuNVkzOzFizszN M{H3[HNCVkeHUh?=
MKN1 MoTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XGdmlEPTB;Mz6yNFg4PSEQvF2= NYPDPVV{W0GQR1XS
NCI-H810 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPwTWM2OD1|LkKyNVU2KM7:TR?= NIX0RlJUSU6JRWK=
GOTO MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfDXYdKSzVyPUOuNlgxODRizszN MVrTRW5ITVJ?
T98G NGXIVVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mly0TWM2OD1|LkK4NlE3KM7:TR?= NVOzUJFsW0GQR1XS
HD-MY-Z M{fFZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDNTWM2OD1|LkO2OVQzKM7:TR?= Mn;4V2FPT0WU
SNU-C2B NYXXTYJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojITWM2OD1|LkO5NFk4KM7:TR?= Ml7PV2FPT0WU
MOLT-4 Mn\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7NTWM2OD1|LkO5NFk5KM7:TR?= M4i0fnNCVkeHUh?=
RPMI-7951 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml36TWM2OD1|LkO5O|Mh|ryP M1m2dHNCVkeHUh?=
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OVCAR-8 NEe4U2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDOTWM2OD14Lkm0NlI6KM7:TR?= NUfET2twW0GQR1XS
SNU-387 M1\MZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe2foN[UUN3ME22Mlk6PTF4IN88US=> NHjRSGxUSU6JRWK=
TGBC1TKB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPnTWM2OD15LkG1Nlc4KM7:TR?= NEDXcGZUSU6JRWK=
NOS-1 NHjjcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrYTWM2OD15LkKwOFE2KM7:TR?= MYHTRW5ITVJ?
HEC-1 NWHCd|NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H4N2lEPTB;Nz6yOVM5PyEQvF2= NUDUZmxNW0GQR1XS
GI-ME-N NIT6dnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTdwMkmxOVgh|ryP NH3qcpZUSU6JRWK=
KYSE-520 M3zmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXDdnBKSzVyPUeuNlkzQSEQvF2= NU\Vd25ZW0GQR1XS
SNU-423 NHTJVYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[xTWM2OD15LkK5OFUzKM7:TR?= NH;SOZFUSU6JRWK=
C-33-A NF;ITmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7DTWM2OD15LkS3PFIh|ryP NF\IV5JUSU6JRWK=
SK-UT-1 NYr5cXpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFX1NopKSzVyPUeuOVQ5OjlizszN NUX0Roh2W0GQR1XS
OVCAR-4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjsTWM2OD15LkW1NlYh|ryP NXjlXFUzW0GQR1XS
KYSE-450 MlK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTdwNkO3PVEh|ryP NUPxdJc2W0GQR1XS
RS4-11 MmLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rqPGlEPTB;Nz63NFE6PiEQvF2= Ml75V2FPT0WU
OVCAR-5 NITRNGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLTN4JKSzVyPUeuPFI{OjlizszN Mn;EV2FPT0WU
K5 M{HKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljCTWM2OD15Lki3OFIh|ryP M1TIN3NCVkeHUh?=
786-0 M2f6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrjTWM2OD16LkCzNFk2KM7:TR?= MWnTRW5ITVJ?
NCI-H747 NIe4enlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\UTWM2OD16LkC0OFU4KM7:TR?= NXXIbHZ[W0GQR1XS
CAL-27 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jR[mlEPTB;OD6xNlczKM7:TR?= M2Hu[3NCVkeHUh?=
FADU MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7FTWM2OD16LkG3OVQ{KM7:TR?= NGLubZZUSU6JRWK=
SW780 MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRThwMUi4NlEh|ryP NXvMTpl[W0GQR1XS
ACHN NV;nUWJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHWxR5pKSzVyPUiuNlI2OjlizszN NYWxU41OW0GQR1XS
TE-6 MlS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrlTWM2OD16LkKzO|g5KM7:TR?= NHXuTmtUSU6JRWK=
NCI-H2087 NHvPU4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRThwM{[xOVgh|ryP NH;pZnlUSU6JRWK=
NCI-H2122 NHHMcYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRThwNEC0O|kh|ryP NXvDO5hvW0GQR1XS
SK-LU-1 MnH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPsTWM2OD16LkSzPVk4KM7:TR?= MVTTRW5ITVJ?
22RV1 NYjKN3M{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LJdGlEPTB;OD62NVc5PiEQvF2= NYn2[5lJW0GQR1XS
MEL-JUSO Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljUTWM2OD16Lk[4Olc2KM7:TR?= NInwZVhUSU6JRWK=
UM-UC-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRThwN{GzPUDPxE1? M1i3enNCVkeHUh?=
HuH-7 NWfEWFh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NISyVVZKSzVyPUiuO|MxOTJizszN MnLNV2FPT0WU
SNU-449 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRThwN{WyOlUh|ryP MnzKV2FPT0WU
RVH-421 NUfZZXZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWSzOplZUUN3ME24Mlc2Ozl6IN88US=> NF\X[o1USU6JRWK=
MFM-223 NHvZcItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRThwOEC3N|Uh|ryP Mn\lV2FPT0WU
CHP-212 NHH2b4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkOyTWM2OD16LkiyNlY4KM7:TR?= Mlf5V2FPT0WU
NCI-H28 NHzjNWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TsVmlEPTB;OD64OVE5PSEQvF2= M1zRNXNCVkeHUh?=
C8166 M1fkUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;ET4xKSzVyPUiuPFY4PzJizszN MY\TRW5ITVJ?
SCC-15 NVzXT|dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRThwOEexPVYh|ryP Mmi2V2FPT0WU
DMS-273 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYe0PJBJUUN3ME24Mlg6PjJ|IN88US=> NXr1WnM1W0GQR1XS
MPP-89 NFvxTpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnkV|FKSzVyPUiuPVE{PDFizszN MoC3V2FPT0WU
EW-22 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fDPGlEPTB;OD65NVM5OiEQvF2= M4nC[nNCVkeHUh?=
RCM-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLmRmZrUUN3ME24Mlk3PDh4IN88US=> MoHvV2FPT0WU
BT-474 NXvrZ2ZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j6N2lEPTB;OD65PFg4OiEQvF2= M2S1bnNCVkeHUh?=
TI-73 M1\Cdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDXfllKSzVyPUmuNFM1QTZizszN Ml3JV2FPT0WU
ES3 NUfkOYFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXLNHZKSzVyPUmuNFUyPTZizszN MULTRW5ITVJ?
NB17 Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTlwMUS1N|Uh|ryP MVfTRW5ITVJ?
MOLT-16 NVPlbGNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\DN|lyUUN3ME25MlE3PjV3IN88US=> MYjTRW5ITVJ?
TGBC11TKB M1rzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTlwMUmyNFUh|ryP MUHTRW5ITVJ?
NB12 M{TZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjsXnVKSzVyPUmuN|QxQDFizszN NX3KboZ1W0GQR1XS
MEL-HO M3nWSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HvdGlEPTB;OT60NFIh|ryP NYrC[ZFjW0GQR1XS
HuCCT1 NEfTUopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XFcWlEPTB;OT60O|QxPiEQvF2= NWPvR2xsW0GQR1XS
A704 NIrOU|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTlwNEe3OFUh|ryP NIPJNXJUSU6JRWK=
SW756 NHjT[GRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLwTWM2OD17LkW1N|YyKM7:TR?= M1i2V3NCVkeHUh?=
SAS MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTlwNUi0OVUh|ryP MofQV2FPT0WU
KINGS-1 MojIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vYN2lEPTB;OT62PVM4KM7:TR?= MV\TRW5ITVJ?
NKM-1 NYjZR3l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTlwOEO5OlQh|ryP MlTLV2FPT0WU
C2BBe1 Mn76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlznTWM2OD17Lki2NlA1KM7:TR?= Mmm3V2FPT0WU
A204 MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTlbGtPUUN3ME25Mlg6PzV3IN88US=> MnW5V2FPT0WU
G-401 MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF62N4NKSzVyPUmuPVA1PDlizszN M{HFXnNCVkeHUh?=
PFSK-1 MlvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPiUGRKSzVyPUmuPVU3PjlizszN M1ruPHNCVkeHUh?=
KYSE-410 NIfzNoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TqeGlEPTB;MUCuNFYyPSEQvF2= NUGwTFI4W0GQR1XS
SK-MEL-2 MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz2TWM2OD1zMD6xOVg5KM7:TR?= MUDTRW5ITVJ?
NB5 M3ywTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTFyLkW0NFUh|ryP MY\TRW5ITVJ?
NTERA-S-cl-D1 NVPZT3RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHQRZJbUUN3ME2xNE42PDd3IN88US=> MULTRW5ITVJ?
MZ2-MEL MmfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jKUmlEPTB;MUCuOlYzKM7:TR?= MlXuV2FPT0WU
SF539 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTFyLkexPFgh|ryP NH76NY5USU6JRWK=
CAL-120 M2juNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHMRVdKSzVyPUGwMlc2QTdizszN MmfrV2FPT0WU
GR-ST NWW5bpo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXn[ItKSzVyPUGxMlI6QCEQvF2= NGmzfpRUSU6JRWK=
IA-LM NVW1dHEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTFzLkO0PFYh|ryP MlzNV2FPT0WU
NCI-H2452 NXLGTVh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\zVGlEPTB;MUGuN|kzPyEQvF2= MXLTRW5ITVJ?
NCI-H1648 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPYUpZnUUN3ME2xNU41PjJ7IN88US=> MmHQV2FPT0WU
YH-13 M4PMeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFv3[lNKSzVyPUGxMlQ4PDJizszN NECwWnlUSU6JRWK=
NCI-H2228 M3nLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7DU3NsUUN3ME2xNU41QTJ6IN88US=> MoDNV2FPT0WU
LN-405 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTFzLkW5Nlch|ryP M{G2ZnNCVkeHUh?=
647-V NILCXFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFzLkW5O|Qh|ryP MVrTRW5ITVJ?
HCC1806 MoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPWW2ZrUUN3ME2xNU43OTN2IN88US=> NG\R[ItUSU6JRWK=
HPAF-II NGfsPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\DOYtKSzVyPUGxMlg{PTZizszN NEjTN2RUSU6JRWK=
BB49-HNC MmjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorzTWM2OD1zMT64N|c2KM7:TR?= MXvTRW5ITVJ?
KGN NYWxZWduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEm5UoxKSzVyPUGxMlg2QDlizszN NHP2XoJUSU6JRWK=
NOMO-1 Mn7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzOTWM2OD1zMT64OVk4KM7:TR?= MXrTRW5ITVJ?
A388 NUjYcok6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDCOWJKSzVyPUGxMlg5ODhizszN MUHTRW5ITVJ?
Saos-2 MkjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\rTWM2OD1zMj6yNFA{KM7:TR?= Ml;CV2FPT0WU
SK-HEP-1 M{WxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHlTWM2OD1zMj6yOlE{KM7:TR?= NVn4b2ZqW0GQR1XS
HCE-4 NEeyeW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHZUHo3UUN3ME2xNk4zPjl7IN88US=> M2\KVXNCVkeHUh?=
NCI-H1581 NYS5Vmt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XCNmlEPTB;MUKuNlgyQSEQvF2= MoHiV2FPT0WU
NCI-H23 MmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TOTmlEPTB;MUKuN|EzPSEQvF2= M1L4XHNCVkeHUh?=
NCI-H596 NGfkOFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTF{LkS3PVgh|ryP NIfwdVNUSU6JRWK=
NB69 MkTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF{Lke1PFUh|ryP M{TxO3NCVkeHUh?=
ChaGo-K-1 M1rqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MluxTWM2OD1zMj63OlQ6KM7:TR?= NVnPWVFbW0GQR1XS
EFM-19 NUm3[ZdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjiUZhKSzVyPUGyMlc4OTdizszN MXrTRW5ITVJ?
SW962 MkmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fuZ2lEPTB;MUKuPFIzOyEQvF2= MWTTRW5ITVJ?
KALS-1 M4PyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF|LkC5OUDPxE1? MX;TRW5ITVJ?
MDA-MB-415 M36xfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGWzUlZKSzVyPUGzMlE3ODlizszN MnrKV2FPT0WU
SW684 NGW5fIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYn6[2o3UUN3ME2xN{4yQDZzIN88US=> NGPURWhUSU6JRWK=
NCI-H2052 Mnf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrQeHQzUUN3ME2xN{4{QDR6IN88US=> M2XZZ3NCVkeHUh?=
HOP-92 M4HaTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu3TWM2OD1zMz63PVk4KM7:TR?= MWHTRW5ITVJ?
OE19 NGrBZXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvMR2ZKSzVyPUG0MlAxPzVizszN M3fDTHNCVkeHUh?=
D-392MG MoHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTF2LkGyNVEh|ryP NHnuN2dUSU6JRWK=
A253 NYXkfIJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTF2LkKyOUDPxE1? Mn\nV2FPT0WU
NCI-H1155 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnFbFRKSzVyPUG0MlI4PDdizszN Mn\uV2FPT0WU
SNB75 MnTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTF2LkO4PVMh|ryP MnnhV2FPT0WU
23132-87 NFT5dGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPBTWM2OD1zND64N|U{KM7:TR?= MWjTRW5ITVJ?
Calu-3 MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojoTWM2OD1zND64O|Q{KM7:TR?= M4TPSHNCVkeHUh?=
CW-2 M4LMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LxWGlEPTB;MUWuNFIzOyEQvF2= M2X4[HNCVkeHUh?=
COLO-679 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrnTpgyUUN3ME2xOU4yODF|IN88US=> NW[5PIxtW0GQR1XS
NCI-SNU-5 M17J[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37mNGlEPTB;MUWuOVU5QSEQvF2= NEe2blJUSU6JRWK=
AN3-CA M4LlPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrBPHlKSzVyPUG1MlY1PjhizszN M2LENnNCVkeHUh?=
SF126 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomwTWM2OD1zNT63Nlg2KM7:TR?= MVnTRW5ITVJ?
D-247MG Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfEd2lxUUN3ME2xOU45PTN|IN88US=> NWHYelhPW0GQR1XS
UACC-62 NVvrS5dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILwSlVKSzVyPUG1Mlk3PiEQvF2= NHfhRnpUSU6JRWK=
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NCI-H1092 NWPJfG9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF4Lk[yPVch|ryP NIjoS|NUSU6JRWK=
HCC1187 Mn;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTF4Lk[1OVch|ryP M3LSWXNCVkeHUh?=
G-402 NX3CVId3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4WxN2lEPTB;MU[uPFU3PSEQvF2= M{DKenNCVkeHUh?=
HT55 Mnu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\INHc6UUN3ME2xOk45PzVzIN88US=> MlThV2FPT0WU
NCI-H2009 NWX0THNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7HU3hkUUN3ME2xOk46OjZ4IN88US=> NWfZPHl4W0GQR1XS
SH-4 M3vaNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlS0TWM2OD1zNj65PVIh|ryP MVjTRW5ITVJ?
SW1783 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLpUFlKSzVyPUG2Mlk6QThizszN NYP5eoNIW0GQR1XS
HT MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3tWHdKSzVyPUG3MlE6PjRizszN Mnv6V2FPT0WU
CP66-MEL NIL4coxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT0WlBKSzVyPUG3MlMxOSEQvF2= MYfTRW5ITVJ?
BEN M4HPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnHW5FEUUN3ME2xO{42PjJ4IN88US=> M4j4cnNCVkeHUh?=
HCC38 NUH3fllVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPpTWM2OD1zNz63Olk5KM7:TR?= M1;3enNCVkeHUh?=
LAN-6 M4WxOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTF5Lki0PFUh|ryP Mm\1V2FPT0WU
RERF-LC-MS MlnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r4fGlEPTB;MUeuPVEzQSEQvF2= NWTQTW1JW0GQR1XS
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NY MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mor1TWM2OD1zOT6xOVY4KM7:TR?= MYnTRW5ITVJ?
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NCI-H2342 M{XKZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL5cHVKSzVyPUK5MlM5ODNizszN MVvTRW5ITVJ?
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NCI-H1304 NHjjVW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXr5eVFQUUN3ME2zN{43ODN4IN88US=> MkPVV2FPT0WU
LU-135 NFXsRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HES2lEPTB;M{OuO|A5PiEQvF2= M13MXXNCVkeHUh?=
S-117 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33wdWlEPTB;M{OuO|I5PiEQvF2= M{XlcXNCVkeHUh?=
NCI-H1755 NH;GSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M363OGlEPTB;M{OuPFEyKM7:TR?= M4DWbHNCVkeHUh?=
Mo-T MmrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\BWWlKSzVyPUOzMlg2QTNizszN MofOV2FPT0WU
SK-OV-3 NGC1VWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDVcpo2UUN3ME2zN{45QDV2IN88US=> NWrmZWluW0GQR1XS
RCC10RGB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3EcG9KSzVyPUOzMlk1OzNizszN NEXYVYhUSU6JRWK=
COLO-680N NIfKZ5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDvTWM2OD1|ND6xN|k4KM7:TR?= Mn\uV2FPT0WU
KURAMOCHI M3jKUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLNTWM2OD1|ND62OFI2KM7:TR?= MYPTRW5ITVJ?
NCI-H661 NW\BS|dHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTzTWM2OD1|ND64OFQ5KM7:TR?= M2DSZ3NCVkeHUh?=
YAPC MmP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDhXnF{UUN3ME2zOU46PTN|IN88US=> NVexe2JsW0GQR1XS
NCI-H526 NFTkeI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LnZ2lEPTB;M{euNlc4OiEQvF2= M162ZXNCVkeHUh?=
A498 M2LpdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjTZ|hKSzVyPUO4MlA6PTRizszN NFy4[ldUSU6JRWK=
VMRC-RCZ MoH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\VTWM2OD1|OT6wNFU1KM7:TR?= MmLKV2FPT0WU
HCT-116 M2j1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\YZWlEPTB;M{muNFU5KM7:TR?= M3;DRnNCVkeHUh?=
COLO-320-HSR MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTRyLkC0NUDPxE1? MnT1V2FPT0WU
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SK-MEL-1 M3LFOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DwW2lEPTB;NECuNlkzPyEQvF2= MlPVV2FPT0WU
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CP50-MEL-B NX\Vcm12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSzT|dPUUN3ME20NU4xPzl5IN88US=> MX;TRW5ITVJ?
RMG-I M{nKVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvQUm9KSzVyPUSyMlQ6OjFizszN NGnlXnJUSU6JRWK=
D-336MG MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTR|LkGxOVIh|ryP MmrRV2FPT0WU
SHP-77 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3uOHU4UUN3ME20N{4yQDJ6IN88US=> MXfTRW5ITVJ?
SW872 NUHYTpF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHOydo5KSzVyPUSzMlIyOjNizszN M2rNcHNCVkeHUh?=
DBTRG-05MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnSTWM2OD12ND62PVk3KM7:TR?= M3rDfXNCVkeHUh?=
COLO-678 M1vj[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTnTWM2OD12NT63NFMzKM7:TR?= M{eyfnNCVkeHUh?=
EGI-1 NEnlcJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TJOWlEPTB;NEeuNVg{OyEQvF2= NWD0WG92W0GQR1XS
KYSE-70 NFXJUpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;rWmFKSzVyPUS3MlczOjJizszN NH61Xm5USU6JRWK=
BALL-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTR5LkiyOVQh|ryP NIjpNIpUSU6JRWK=
MDA-MB-361 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\IUmR4UUN3ME20PE4xPDZizszN MUnTRW5ITVJ?
NCI-H1838 NUfCZlc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTR6LkO0OVgh|ryP NFnzOZlUSU6JRWK=
NCI-H1573 M1q1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvGVHRKSzVyPUS4MlY4QDVizszN NV3NV2VoW0GQR1XS
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NCI-H2291 M3zkPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vp[2lEPTB;NEmuOVk5QCEQvF2= MV3TRW5ITVJ?
RH-18 NWnyPZFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L5eGlEPTB;NUCuNFg5PCEQvF2= M4XaPXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    BI-D1870 (catalog No.S2843) is found as a racemic mixture?

  • Answer:

    Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID