Catalog No.S7551 Synonyms: PPLGM, Piplartine
Molecular Weight(MW): 317.34
Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
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a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. *P < 0.05; **P < 0.01; ***P < 0.001.
Oncotarget, 2016, 7(35):56933-56943. Piperlongumine purchased from Selleck.
MPC cells were treated with the indicated concentrations of PL at 21% and 1% O2 for 24 hours. Total cell lysates were subjected to Western blot with antibodies against cleaved PARP, cleaved caspase 3, and caspase 3. β-tubulin was used as a loading control. A representative image (n=3) is shown.
Oncotarget, 2016, 7(26):40531-40545. Piperlongumine purchased from Selleck.
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Choose Selective ROS Inhibitors
|Description||Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.|
Piperlongumine is a known ROS inducer which could induce pancreatic cancer cell death in cell culture As a thromboxane A(2) receptor antagonist, Piperlongumine inhibits platelet aggregation.  Piperlongumine also promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death. 
|In vivo||Piperlongumine (50 mg/kg i.p.) causes in vivo growth inhibition of tumor cells without leading to major changes in the biochemical, hematological and histopathological parameters. |
-  Dhillon H, et al. Toxicol Rep. 2014, 1:309-318.
-  Iwashita M, et al. Eur J Pharmacol. 2007, 570(1-3), 38-42.
-  Ryu J, et al. Nat Prod Res. 2014, 28(22), 2040-2043.
|In vitro||DMSO||16 mg/mL warmed (50.41 mM)|
|Ethanol||6 mg/mL warmed (18.9 mM)|
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